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Methotrexate for psoriasis in the era of biological therapy.

Warren, R B; Chalmers, R J G; Griffiths, C E M; Menter, A

Clinical and experimental dermatology. 2008;33(5):551-4.

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Abstract

Methotrexate's traditional role as a first line agent for moderate to severe psoriasis is being challenged by the rapid and growing use of biological therapies. A recent study comparing adalimumab with methotrexate showed significantly superior efficacy of adalimumab over methotrexate over 16 weeks. Although it is inexpensive, the future use of methotrexate may be compromised by its unpredictable response and toxicity, and by the introduction of newer, more effective biological therapies. However, recent advances in the screening of liver fibrosis by monitoring serum levels of the aminoterminal peptide fragment of type III procollagen have reduced the need for liver biopsy. Furthermore, the potential for personalized methotrexate use by application of modern pharmacogenetics and pharmacokinetics may ensure its place as a first-line agent for the treatment of psoriasis for the foreseeable future.

Bibliographic metadata

Content type:
Published date:
Language:
eng
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
33
Issue:
5
Pagination:
551-4
Digital Object Identifier:
10.1111/j.1365-2230.2008.02976.x
Pubmed Identifier:
18801095
Pii Identifier:
CED2976
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:79534
Created by:
Warren, Richard
Created:
24th April, 2010, 20:05:45
Last modified by:
Warren, Richard
Last modified:
24th April, 2010, 20:05:45

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