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Genomic-driven insights into changes in aging skin.

Robinson, Michael K; Binder, Robert L; Griffiths, Christopher E M

J Drugs Dermatol. 2009;8(7 Suppl):s8-11.

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Abstract

Like all tissues, the skin ages due to the passage of time (chronologic aging). However, skin is also exposed to external insults, such as sunlight. Aging due to chronic sun exposure (photoaging) is characterized clinically by wrinkling, dyspigmentation and other changes. Chronologic and photoaging of skin have been distinguished at the structural, cellular and molecular levels. However, many underlying mechanisms remain a mystery. Recent sequencing of the human genome and development of genome-wide microarray platforms now permit analysis of skin aging at the level of gene expression. Analysis of gene expression differences between young and older sun-protected and sun-exposed skin showed that photoaging produces many similar (but more severe) changes in gene expression versus chronologic aging. However, some changes are unique to one form of aging or the other. Bioinformatics tools also enable an integrated analysis of gene expression themes and pathways, which may provide new insights into the mechanisms of skin aging and possible interventions.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
8
Issue:
7 Suppl
Pagination:
s8-11
Pubmed Identifier:
19623778
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:81264
Created by:
Griffiths, Christopher
Created:
18th May, 2010, 10:23:03
Last modified by:
Griffiths, Christopher
Last modified:
1st March, 2014, 12:52:26

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