In April 2016 Manchester eScholar was replaced by the University of Manchester’s new Research Information Management System, Pure. In the autumn the University’s research outputs will be available to search and browse via a new Research Portal. Until then the University’s full publication record can be accessed via a temporary portal and the old eScholar content is available to search and browse via this archive.

Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study.

Anderson, Ian M; Del-Ben, Cristina M; Mckie, Shane; Richardson, Paul; Williams, Stephen R; Elliott, Rebecca; Deakin, J F William

Neuroreport. 2007;18(13):1351-5.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:

Full-text held externally

Abstract

This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
18
Issue:
13
Pagination:
1351-5
Digital Object Identifier:
10.1097/WNR.0b013e3282742115
Pubmed Identifier:
17762711
Pii Identifier:
00001756-200708270-00010
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:85512
Created by:
Deakin, Bill
Created:
4th July, 2010, 13:17:09
Last modified by:
Deakin, Bill
Last modified:
14th August, 2012, 04:20:40

Can we help?

The library chat service will be available from 11am-3pm Monday to Friday (excluding Bank Holidays). You can also email your enquiry to us.