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AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer.
Saha, V; Lillington, D M; Shelling, A N; Chaplin, T; Yaspo, M L; Ganesan, T S; Young, B D
Genes Chromosomes Cancer. 1995;14(3):220-2.
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Abstract
Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.