In April 2016 Manchester eScholar was replaced by the University of Manchester’s new Research Information Management System, Pure. In the autumn the University’s research outputs will be available to search and browse via a new Research Portal. Until then the University’s full publication record can be accessed via a temporary portal and the old eScholar content is available to search and browse via this archive.

Fluctuation of knee pain and changes in bone marrow lesions, effusions and synovitis on MRI: The most study.

Zhang, Yuqing; Nevitt, Michael; Niu, Jingbo; Lewis, Cora; Torner, James; Guermazi, Ali; Roemer, Frank; McCulloch, Charles; Felson, David

Arthritis and rheumatism. 2011;63(3):691-699.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:

Full-text held externally

Abstract

OBJECTIVE: Fluctuations in pain among persons with knee osteoarthritis are both common and risk factors for pain fluctuation are poorly understood. To best identify structural causes of fluctuations, multiple assessments of pain status and structural lesions are needed. Therapeutic evidence may be best gleaned if pain resolution is accompanied by diminution of lesions. METHODS: Subjects in the Multicenter Osteoarthritis Study were queried about their knee pain by interview and had knee magnetic resonance imaging at baseline, 15-month, and 30-month clinic visits. Among the knees experiencing pain fluctuation over three clinic visits we examined the relation of bone marrow lesions (BMLs), synovitis, and effusion to frequent knee pain and pain severity using conditional logistic regression. RESULTS: Included in the analysis were 570 subjects (651 knees). When the BML score changed from 0 to 1, 2, 3, 4, 5-6 and 7-18, the odds ratios (OR) for frequent knee pain were 1.2, 1.2, 1.5, 2.2, 2.4, and 2.5, respectively (P for trend=0.006). The corresponding ORs were 1.5, 1.5, and 2.4 when synovitis score changed from 0 to 1, 2, and 3-6 (P for trend=0.045). No significant association was found between effusion and frequent knee pain. Diminishing size of BMLs was associated with resolution of knee pain (P=0.007). Similar associations were also observed between these structural lesions and knee pain severity. CONCLUSION: Changes of BMLs and synovitis are associated with the fluctuation of knee pain. Pain resolution occurs more frequently when BMLs become smaller.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
Abbreviated journal title:
ISSN:
Volume:
63
Issue:
3
Start page:
691
End page:
699
Digital Object Identifier:
10.1002/art.30148
Pubmed Identifier:
21080361
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:95989
Created by:
Ingram, Mary
Created:
24th November, 2010, 11:29:44
Last modified by:
Ingram, Mary
Last modified:
12th April, 2011, 14:11:41

Can we help?

The library chat service will be available from 11am-3pm Monday to Friday (excluding Bank Holidays). You can also email your enquiry to us.