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Dr Adam Hurlstone (MA, PhD) - publications

List of publications


  • Nikki R. Paul, Jennifer L. Allen, Anna Chapman, Maria Morlan-Mairal, Egor Zindy, Guillaume Jacquemet, Laura Fernandez del Ama, Nermina Ferizovic, David M. Green, Jonathan D. Howe, Elisabeth Ehler, Adam Hurlstone and Patrick T. Caswell. (2015). α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3. J C B, 10(6), 1013-1031. eScholarID:271414 | DOI:10.1083/jcb.201502040
  • Barriuso, J., Nagaraju, R. & Hurlstone, A (2015). Zebrafish: A New Companion for Translational Research in Oncology. Clin Cancer Res, eScholarID:247537 | PMID:25573382 | DOI:10.1158/1078-0432.CCR-14-2921
  • Herrero, A., Pinto, A., Colón-Bolea, P., Casar, B., Jones, M., Agudo-Ibáñez, L., Vidal, R., Tenbaum, S., Nuciforo, P., Valdizán, E., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H., Hurlstone, A. & Crespo, P (2015). Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell, 28(2), 170-82. eScholarID:271395 | PMID:26267534 | DOI:10.1016/j.ccell.2015.07.001
  • Vaughan, L., Tan, C., Chapman, A., Nonaka, D., Mack, N., Smith, D., Booton, R., Hurlstone, A. & Malliri, A (2015). HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion. Cell Rep, 10(1), 88-102. eScholarID:247499 | PMID:25543140 | DOI:10.1016/j.celrep.2014.12.012


  • Burgon, J., Robertson, A., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L., Walker, P., Hoggett, E., Ward, J., Farrow, S., Zuercher, W., Jeffrey, P., Savage, C., Ingham, P., Hurlstone, A., Whyte, M. & Renshaw, S (2014). Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol, 192(4), 1796-805. eScholarID:234071 | PMID:24431232 | DOI:10.4049/jimmunol.1300087
  • Chapman, A., Fernandez Del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C. & Hurlstone, A (2014). Heterogeneous tumor subpopulations cooperate to drive invasion. Cell Rep, 8(3), 688-95. eScholarID:234073 | PMID:25066122 | DOI:10.1016/j.celrep.2014.06.045
  • Hurlstone, A. & Wellbrock, C (2014). TP53 in the UV spotlight: a bona fide driver of melanoma. Pigment Cell Melanoma Res, eScholarID:234072 | PMID:25102761 | DOI:10.1111/pcmr.12302


  • Dalton, L., Kamarashev, J., Ramirez, I., White, G., Malliri, A. & Hurlstone, A (2013). Constitutive Rac Activation is not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression. J Invest Dermatol, 133(6), 1572-1581. eScholarID:185968 | PMID:23337888 | DOI:10.1038/jid.2013.23
  • Smith, M., Ferguson, J., Arozarena, I., Hayward, R., Marais, R., Chapman, A., Hurlstone, A. & Wellbrock, C (2013). Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma. J Natl Cancer Inst, 105(1), 33-46. eScholarID:185969 | PMID:23250956 | DOI:10.1093/jnci/djs471


  • Goonesinghe, A., Luan, X., Hurlstone, A. & Garrod, D (2012). Desmosomal cadherins in zebrafish epiboly and gastrulation. BMC Dev Biol, 12, 1. eScholarID:160124 | PMID:22235774 | DOI:10.1186/1471-213X-12-1
  • Ramirez, I., Pietka, G., Jones, D., Divecha, N., Alia, A., Baraban, S., Hurlstone, A. & Lowe, M (2012). Impaired neural development in a zebrafish model for Lowe syndrome. Human molecular genetics, 21(8), 1744. eScholarID:160126 | PMID:22210625 | DOI:10.1093/hmg/ddr608


  • Haud N, Kara F, Diekmann S, Henneke M, Willer JR, Hillwig MH, Gregg RB, MacIntosh GC., Gärtner J, Alia A, and Hurlstone A. (2011). rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences of the United States of America, 108(3), 1099-1103. eScholarID:95577 | DOI:10.1073/pnas.1009811107
  • Kelly, A. & Hurlstone, A (2011). The use of RNAi technologies for gene knockdown in zebrafish. Brief Funct Genomics, 10(4), 189-96. eScholarID:147840 | PMID:21525144 | DOI:10.1093/bfgp/elr014


  • Wellbrock C and Hurlstone A. (2010). BRAF as therapeutic target in melanoma. Biochemical Pharmacology, eScholarID:76638
  • Kabli S, He S, Spaink HP, Hurlstone A, Snaar Jagalska E, De Groot HJM, and Alia A. (2010). In Vivo Magnetic Resonance Imaging to Detect Malignant Melanoma in Adult Zebrafish. Zebrafish, 7(2), 143-148. eScholarID:76636 | DOI:10.1089/zeb.2009.0649
  • Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A, Köster RW, Hurlstone A, and Mione MC. (2010). Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS ONE, 5(21), e15170. eScholarID:95579 | DOI:10.1371/journal.pone.0015170
  • Feng Y, Santoriello C, Mione M, Hurlstone A, and Martin P. (2010). Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biology, 8(12), e1000562. eScholarID:95578 | DOI:10.1371/journal.pbio.1000562
  • Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, and Lawson ND. (2010). MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature, 464(7292), 1196-1200. eScholarID:76634 | DOI:10.1038/nature08889


  • Michailidou CM, Jones M, Walker P, Kamarashev J, Kelly A, Hurlstone A. (2009). Dissecting the roles of Raf- and PI3k-signalling pathways in melanoma formation and progression in a zebrafish model. Disease Models and Mechanisms, 2(7/8), eScholarID:1c8472 | DOI:10.1242/dmm.001149


  • Chen, J. & Hurlstone, A (2008). Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics. Zebrafish, 5(3), 193-195. eScholarID:160125 | PMID:20798783 | DOI:10.1089/zeb.2008.0543


  • Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H. (2007). T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. EMBO reports, 8(10), 966-73. eScholarID:1c6979 | PMID:17823612 | DOI:10.1038/sj.embor.7401071


  • Garin G, Zibara K, Aguilar F, Lo M, Hurlstone A, Poston R, McGregor JL. (2006). 6A3-5/Osa2 is an Early Activated Gene Implicated in the Control of Vascular Smooth Muscle Cell Functions. Journal of biomedicine & biotechnology, 2006(5), 97287. eScholarID:1c6980 | PMID:17489020 | DOI:10.1155/JBB/2006/97287
  • Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M, Offerhaus GJ, Clevers HC. (2006). Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO reports, 7(4), 444-9. eScholarID:1c6981 | PMID:16439994 | DOI:10.1038/sj.embor.7400638
  • Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ. (2006). Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio). BMC cell biology [electronic resource], 7, 24. eScholarID:1c5345 | PMID:16787535 | DOI:10.1186/1471-2121-7-24
  • Malliri A, Rygiel TP, van der Kammen RA, Song J-Y, Engers R, Hurlstone AFL, Clevers H, and John G Collard. (2006). The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumour development. Journal of Biological Chemistry, 281, 543-548. eScholarID:1c4370 | DOI:10.1074/jbc.M507582200


  • Giraud S, Hurlstone A, Avril S, Coqueret O. (2004). Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene. Oncogene, 23(44), 7391-7398. eScholarID:1c2609 | DOI:10.1038/sj.onc.1207972


  • Garin G, Badid C, McGregor B, Vincent M, Guerret S, Zibara K, Hurlstone A, Laville M, McGregor JL. (2003). Ischemia induces early expression of a new transcription factor (6A3-5) in kidney vascular smooth muscle cells: studies in rat and human renal pathology. The American journal of pathology, 163(6), 2485-94. eScholarID:1c6982 | PMID:14633620 | DOI:10.1016/S0002-9440(10)63603-6
  • Hurlstone A.F., Haramis A.P., Wienholds E., Begthel H., Korving J., Van Eeden F., Cuppen E., Zivkovic D., Plasterk R.H., Clevers H. (2003). The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature, 425, 633-637. eScholarID:1c2404 | DOI:10.1038/nature02028


  • Hurlstone AF, Olave IA, Barker N, van Noort M, Clevers H. (2002). Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. The Biochemical journal, 364(Pt 1), 255-64. eScholarID:1c6984 | PMID:11988099
  • Hurlstone A., Clevers H. (2002). T-cell factors: turn-ons and turn-offs. The EMBO journal, 21, 2303-2311. eScholarID:1c2402 | DOI:10.1093/emboj/21.10.2303
  • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H. (2002). The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell, 111(2), 241-50. eScholarID:1c6983 | PMID:12408868 | DOI:10.1016/S0092-8674(02)01014-0


  • Hughes K.A., Hurlstone A.F., Tobias E.S., McFarlane R., Black D.M. (2001). Absence of ST7 mutations in tumor-derived cell lines and tumors. Nat.Genet, 29, 380-381. eScholarID:1c2401 | DOI:10.1038/ng783
  • Tobias E.S., Hurlstone A.F., MacKenzie E., McFarlane R., Black D.M. (2001). The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene, 20, 2844-2853. eScholarID:1c2405 | DOI:10.1038/sj.onc.1204433
  • Barker N., Hurlstone A., Musisi H., Miles A., Bienz M., Clevers H. (2001). The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. The EMBO journal, 20(17), 4935-4943. eScholarID:1c2400 | DOI:10.1093/emboj/20.17.4935


  • Hurlstone A.F., Reid G., Reeves J.R., Fraser J., Strathdee G., Rahilly M., Parkinson E.K., Black D.M. (1999). Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene, 18, 1881. eScholarID:1c2403 | DOI:10.1038/sj.onc.1202491


  • Hurlstone A, Black DM. (1998). Prostate cancer: new therapies in the pipeline? Current biology, 8(12), eScholarID:1c6986 | PMID:9637916
  • Malliri A, Symons M, Hennigan RF, Hurlstone AF, Lamb RF, Wheeler T, Ozanne BW. (1998). The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. The Journal of cell biology, 143(4), 1087-99. eScholarID:1c6985 | PMID:9817764