Skip to navigation | Skip to main content | Skip to footer
Menu Search the University of Manchester siteSearch
Search type

Alternatively, use our A–Z index

Dr Adam Hurlstone (MA, PhD) - publications

List of publications


  • Fernandez Del Ama, L., Jones, M., Walker, P., Chapman, A., Braun, J., & Hurlstone, A. (2016). Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics. Oncotarget. . Publication link: 321df19b-9014-44fb-969e-482e71a2270b
  • Abdel Mouti, M., Dee, C., Coupland, S. E., & Hurlstone, A. (2016). Minimal Contribution of ERK1/2-MAPK Signalling towards the Maintenance of Oncogenic GNAQQ209P-driven Uveal Melanomas in Zebrafish. Oncotarget. . Publication link: 7f067cb4-b8d2-455e-bb2b-bd69907eb4ce




  • Chapman, A., FernandezdelAma, L., Ferguson, J., Kamarashev, J., Wellbrock, C., & Hurlstone, A. (2013). Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion. Cell Reports. DOI:10.1016/j.celrep.2014.06.045. Publication link: 12f2fab7-7bc3-4fc9-af32-1d26661adc61 | PubMed:25066122
  • Dalton, L. E., Kamarashev, J., Barinaga-Rementeria Ramirez, I., White, G., Malliri, A., & Hurlstone, A. (2013). Constitutive rac activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Journal of Investigative Dermatology, 133(6), 1572-1581. DOI:10.1038/jid.2013.23. Publication link: ab3b52c8-e5f3-4830-8ed6-934067c5bfa9 | PubMed:23337888
  • Smith, M. P., Ferguson, J., Arozarena, I., Hayward, R., Marais, R., Chapman, A., ... Wellbrock, C. (2013). Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma. Journal of the National Cancer Institute, 105(1), 33-46. DOI:10.1093/jnci/djs471. Publication link: d1c4cbcb-e90c-41ee-b090-22c9ef1bc025 | PubMed:23250956



  • Haud, N., Kar, F., Diekmann, S., Henneke, M., Willer, J. R., Hillwig, M. S., ... Hurlstone, A. F. L. (2011). rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences of the United States of America, 108(3), 1099-1103. DOI:10.1073/pnas.1009811107. Publication link: a331d4bf-9619-41d1-8dc1-2c03d97adc26
  • Kelly, A., & Hurlstone, A. F. (2011). The use of RNAi technologies for gene knockdown in zebrafish. Briefings in Functional Genomics, 10(4), 189-196. [elr014]. DOI:10.1093/bfgp/elr014. Publication link: 209c555f-2539-4981-bc16-1d75de7db26c | PubMed:21525144



  • Michailidou, C., Jones, M., Walker, P., Kamarashev, J., Kelly, A., & Hurlstone, A. F. L. (2009). Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. DMM Disease Models and Mechanisms, 2(7-8), 399-411. DOI:10.1242/dmm.001149. Publication link: fdddcceb-11e0-49ec-9d84-6e9b01f0adf4




  • Haramis, A. P. G., Hurlstone, A., van der Velden, Y., Begthel, H., van den Born, M., Offerhaus, G. J. A., & Clevers, H. C. (2006). Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO Reports, 7(4), 444-449. DOI:10.1038/sj.embor.7400638. Publication link: 65997f06-6a07-4a48-a702-8f6dc50e9ec3 | PubMed:16439994
  • Mould, A. P., McLeish, J. A., Huxley-Jones, J., Goonesinghe, A. C., Hurlstone, A. F. L., Boot-Handford, R. P., & Humphries, M. J. (2006). Identification of multiple integrin β1 homologs in zebrafish (Danio rerio). BMC Cell Biology, 7, [24]. DOI:10.1186/1471-2121-7-24. Publication link: 21b7baba-317f-414d-8943-8aa3cf56c5ed | PubMed:16787535
  • Malliri, A., Rygiel, T. P., Van Der Kammen, R. A., Song, J. Y., Engers, R., Hurlstone, A. F. L., ... Collard, J. G. (2006). The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. Journal of Biological Chemistry, 281(1), 543-548. DOI:10.1074/jbc.M507582200. Publication link: da8986b1-459f-40de-945b-035bd8fc5d13
  • Garin, G., Zibara, K., Aguilar, F., Lo, M., Hurlstone, A., Poston, R., & Mcgregor, J. L. (2006). 6A3-5/Osa2 is an early activated gene implicated in the control of vascular smooth muscle cell functions. Journal of Biomedicine and Biotechnology, 2006, [97287]. DOI:10.1155/JBB/2006/97287. Publication link: 8ac02305-7e1e-4033-a183-2a287a4bef61 | PubMed:17489020



  • Hurlstone, A. F. L., Haramis, A. P. G., Wienholds, E., Begthel, H., Korving, J., Van Eeden, F., ... Clevers, H. (2003). The Wnt/β-catenin pathway regulates cardiac valve formation. Nature, 425(6958), 633-637. DOI:10.1038/nature02028. Publication link: 858a5a17-3bdc-4b7b-bea7-75e44468e394
  • Garin, G., Badid, C., McGregor, B., Vincent, M., Guerret, S., Zibara, K., ... McGregor, J. L. (2003). Ischemia Induces Early Expression of a New Transcription Factor (6A3-5) in Kidney Vascular Smooth Muscle Cells: Studies in Rat and Human Renal Pathology. American Journal of Pathology, 163(6), 2485-2494. DOI:10.1016/S0002-9440(10)63603-6. Publication link: b581d924-a510-45ef-87be-1caa40aa9323 | PubMed:14633620



  • Tobias, E. S., Hurlstone, A. F. L., MacKenzie, E., Mcfarlane, R., & Black, D. M. (2001). The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene, 20(22), 2844-2853. DOI:10.1038/sj.onc.1204433. Publication link: 39393494-d898-499c-a503-bf0211b721ef
  • Barker, N., Hurlstone, A., Musisi, H., Miles, A., Bienz, M., & Clevers, H. (2001). The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation. EMBO Journal, 20(17), 4935-4943. DOI:10.1093/emboj/20.17.4935. Publication link: 7f52ce7a-535f-408e-a1b0-749dbb6cd218
  • Hughes, K. A., Hurlstone, A. F. L., Tobias, E. S., McFarlane, R., & Black, D. M. (2001). Absence of ST7 mutations in tumor-derived cell lines and tumors. Nature Genetics, 29(4), 380-381. DOI:10.1038/ng783. Publication link: 5c035fea-1a29-43db-959a-51078cbf8e3b


  • Hurlstone, A. F. L., Reid, G., Reeves, J. R., Fraser, J., Strathdee, G., Rahilly, M., ... Black, D. M. (1999). Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene, 18(10), 1881-1890. DOI:10.1038/sj.onc.1202491. Publication link: 435d343d-bffc-4c62-8e38-9ee0ca1173e5


  • Malliri, A., Symons, M., Hennigan, R. F., Hurlstone, A. F. L., Lamb, R. F., Wheeler, T., & Ozanne, B. W. (1998). The transcription factor AP-1 is required for EGF-induced activation of Rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. Journal of Cell Biology, 143(4), 1087-1099. DOI:10.1083/jcb.143.4.1087. Publication link: 358f16da-bf3d-419c-9075-ea477cd0ec1c | PubMed:9817764
  • Hurlstone, A., & Black, D. M. (1998). Prostate cancer: New therapies in the pipeline?. Current Biology, 8(12), R428-R430. . Publication link: 1e2ee171-4736-406c-9961-32b8f700e285 | PubMed:9637916