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Professor Arthur Weston (BSc, MSc, PhD, DSc, FMedSci) - research

Research Details

For the past 25 years, my research contributions to pharmacology have comprised four interconnected strands, virtually all of which are related to the pharmacology of blood vessels in health and disease :-

1. Potassium channel opener drugs
2. Pharmacology of potassium ions and of endothelium-derived hyperpolarizing factor
3. Intravascular K+ clouds
4. The extracellular Ca2+-sensing receptors CaR and GPRC6A

My Top 20 original research publications are
1. Hamilton, T.C., Weir, S.W. and Weston, A.H. (1986). Br. J. Pharmacol., 88, 103-111.
2. Bray, K.M., Newgreen, D.T., Small, R.C., Southerton, J.S., Taylor, S.G. and Weston, A.H. (1987). Br. J. Pharmacol., 91, 421-429.
3. Chen, G., Suzuki, H. & Weston, A.H. (1988). Br. J. Pharmacol., 95, 1165-1174.
4. Noack, Th., Deitmer, P., Edwards, G. & Weston, A.H. (1992). Br. J. Pharmacol., 106, 717-726.
5. Noack, Th., Edwards, G., Deitmer, P. & Weston, A.H. (1992). Br. J. Pharmacol., 107, 945-955.
6. Edwards, G., Niederste-Hollenberg, A., Schneider, J., Noack, Th. & Weston, A.H. (1994). Br. J. Pharmacol. 113, 1538-1547.
7. Edwards, G., Dora, K.A., Gardener, M., Garland, C.J. & Weston, A.H. (1998). Nature, 396, 269-272.
8. Edwards, G., Félétou, M., Gardener, M.J., Thollon, C., Vanhoutte, P.M. & Weston, A.H. (1999). Br. J. Pharmacol., 128, 1788-1794.
9. Edwards, G., Thollon, C., Gardener, M.J., Félétou, M., Vilaine, J-P., Vanhoutte, P.M. & Weston, A.H. (2000). Br. J. Pharmacol., 129, 1145-1154.
10. Edwards, G., Gardener, M.J., Félétou, M., Brady, G., Vanhoutte, P.M. & Weston, A.H. (1999) Br. J. Pharmacol., 128, 1064-1070.
11. Edwards, G., Félétou, M., Gardener, M. J. Glen, C.D., Richards, G.R., Vanhoutte, P.M. & Weston, A.H. (2001) Br. J. Pharmacol. 133, 1145-1153.
12. Weston, A. H., Richards, G.R., Burnham, M.P., Félétou, M., Vanhoutte, P.M. & Edwards, G. (2002) Br. J. Pharmacol., 136, 918-926.
13. Burnham, M.P., Bychkov, R., Félétou, M., Richards, G.R., Vanhoutte, P.M., Weston, A.H. & Edwards, G. (2002) Br. J. Pharmacol., 135, 1133-1143.
14. Gardener, M.J., Johnson, I.T., Burnham, M.P., Edwards, G., Heagerty, A.M. & Weston, A.H. (2004) Br. J. Pharmacol., 142, 192-202.
15. Weston, A.H., Félétou, M., Vanhoutte, P.M., Falck, J.R., Campbell, W.B. & Edwards, G. (2005) Br. J. Pharmacol., 145, 775-784.

16. Weston, A.H., Absi, M., Ward, D.T., Ohanian, J., Dodd, R.H., Dauban, P., Petrel, C., Ruat, M. & Edwards, G. (2005) Circ. Res., 97, 391-398.
17. Gönczi, M., Szentandrássy, N., Johnson, I.T., Heagerty, A.M. & Weston, A.H. (2006) Br. J. Pharmacol., 147, 496-505.
18. Harno, E., Edwards, G., Geraghty, A.R., Ward, D.T., Dodd, R.H., Dauban, P., Faure, H., Ruat, M. & Weston, A.H. (2008) Cell Calcium. 44, 210-219.
19. Weston, A.H., Absi, M., Harno, E., Geraghty, A.R., Ward, D.T., Ruat, M., Dodd, R.H., Dauban, P. & Edwards, G. (2008) Br. J Pharmacol., 154, 652-662.
20. Weston, A.H., Porter, E. L., Harno, E. & Edwards, G. (2010) Br. J. Pharmacol., 160, 836-843.

In addition, I have co-authored many reviews. Of these, the two most recent ones, namely
Edwards, G; Félétou, M; Weston, AH (2010) Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflügers Arch. 459, 863-87

Weston, AH, Geraghty AM, Egner I and Edwards G (2011) The vascular extracellular calcium-sensing receptor: an update. Acta Physiol Scand (In press)

have given me particular pleasure.