Professor Hugh Piggins (BSc, PhD) - publications

2011

• Hughes AT, Guilding C, Piggins HD. (2011). Neuropeptide signaling differentially affects phase maintenance and rhythm generation in SCN and extra-SCN oscillators. PlosOne, 6(4), e18926. eScholarID:135632
• Piggins HD. (2011). Schizophrenia: Zooming in on a gene. Nature, 471(7339), 2. eScholarID:135636 | DOI:10.1038/471455a
• Piggins HD, Guilding C. (2011). The neural circadian system of mammals. Essays in Biochemistry, 49(1), 17. eScholarID:135633

2010

• Guilding C, Hughes ATL, Piggins HD. (2010). Circadian oscillators in the epithalamus. Neuroscience, 169(4), 10. eScholarID:107926 | DOI:10.1016/j.neuroscience.2010.06.015
• Scott FF, Belle MDC, Delagrange P, Piggins HD. (2010). Electrophysiological effects of melatonin on mouse per1 and non-per1 suprachiasmatic nuclei neurones in vitro. Journal of Neuroendocrinology, 22(11), 1148-1156. eScholarID:107964 | DOI:10.1111/j.1365-2826.2010.02063.x
• Brown TM, Gias C, Hatori M, Keding SR, Semo M, Coffey PJ, Gigg J, Piggins HD, Panda S, Lucas RJ. (2010). Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoSBiology, 8(12), e1000558. eScholarID:107967
• Power A, Hughes ATL, Samuels RE, Piggins HD. (2010). Rhytym-promoting actions of exercise in mice with deficient neuropeptide signaling. Journal of Biological Rhythms, 25(4), 11. eScholarID:107955 | DOI:10.1177/0748730410374446
• Brown TM, Allen AE, Wynne J, Paul DL, Piggins HD, Lucas RJ. (2010). Visual responses in the lateral geniculate evoked by CX36-independent rod pathways. Vision Research, 51, 280-287. eScholarID:107958

2009

• Guilding C, Hughes AT, Brown TM, Namvar S, Piggins HD. (2009). A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus. Molecular Brain, 2(1), 28. eScholarID:77171 | DOI:10.1186/1756-6606-2-28
• Belle MD, Diekman CO, Forger DB, Piggins HD. (2009). Daily electrical silencing in the mammalian circadian clock. Science, 326(5950), 281-284. eScholarID:77170 | DOI:10.1126/science.1169657
• Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL. (2009). Deletion of the secretory vesicle proteins IA-2 and IA-2 beta disrupts circadian rhythms of cardiovascular and physical activity. FASEB Journal, 23(9), 3226-3232. eScholarID:77173 | DOI:10.1096/fj.09-132019
• Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sladek M, Semikhodski AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon ASI. (2009). Setting clock speed in mammalss: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron, 58(1), 11. eScholarID:112619 | DOI:10.1016/j.neuron.2008.01.019
• Brown TM, Piggins HD. (2009). Spatiotemporal heterogeneity in the electrical activity of suprachiasmatic nuclei neurons and their response to photoperiod. Journal of Biological Rhythms, 24(1), 44-54. eScholarID:77174 | DOI:10.1177/0748730408327918

2008

• Brown TM, McLachlan E, Piggins HD. (2008). Angiotensin II regulates the activity of mouse suprachiasmatic nuclei neurons. Neuroscience, 154(2), 839-47. eScholarID:1c8361 | PMID:18479832 | DOI:10.1016/j.neuroscience.2008.03.068
• Hughes AT, Piggins HD. (2008). Behavioral responses of Vipr2-/- mice to light. Journal of biological rhythms, 23(3), 211-9. eScholarID:1c8360 | PMID:18487413 | DOI:10.1177/0748730408316290
• Marston OJ, Williams RH, Canal MM, Samuels RE, Upton N, Piggins HD. (2008). Circadian and dark-pulse activation of orexin/hypocretin neurons. Molecular brain, 1(1), 19. eScholarID:1c8356 | PMID:19055781 | DOI:10.1186/1756-6606-1-19
• Brown TM, Coogan AN, Cutler DJ, Hughes AT, Piggins HD. (2008). Electrophysiological actions of orexins on rat suprachiasmatic neurons in vitro. Neuroscience letters, 448(3), 273-8. eScholarID:1c8357 | PMID:18973790 | DOI:10.1016/j.neulet.2008.10.058
• Hughes AT, Guilding C, Lennox L, Samuels RE, McMahon DG, Piggins HD. (2008). Live imaging of altered period1 expression in the suprachiasmatic nuclei of Vipr2-/- mice. Journal of neurochemistry, 106(4), 1646-57. eScholarID:1c8359 | PMID:18554318 | DOI:10.1111/j.1471-4159.2008.05520.x
• Bechtold DA, Brown TM, Luckman, Piggins HD. (2008). Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling. American Journal of Physiology: Regulatory, Intergrative and Comparative Physiology, 294, R344-R351. eScholarID:44838
• Thompson S, Croft NJ, Sotiriou A, Piggins HD, Crosthwaite SK. (2008). Neurospora crassa heat shock factor 1 Is an essential gene; a second heat shock factor-like gene, hsf2, is required for asexual spore formation. Eukaryotic cell, 7(9), 1573-81. eScholarID:1c8358 | PMID:18586951 | DOI:10.1128/EC.00427-07

2007

• Oldekop JA, Smiseth PT, Piggins HD, Moore AJ. (2007). Adaptive switch from infanticide to parental care: how do beetles time their behaviour? Journal of Evolutionary Biology, 20(5), 1998-2004. eScholarID:1c7366 | DOI:10.1111/j.1420-9101.2007.01364.x
• Piggins H, Meijer J. (2007). Biological clocks and endocrine function in vertebrates and invertebrates. General and Comparative Endocrinology, 152(2-3), 142-143. eScholarID:1c7370 | DOI:10.1016/j.ygcen.2007.05.020
• Guilding C, Piggins HD. (2007). Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain? European Journal of Neuroscience, 25(11), 3195-3216. eScholarID:1c7369 | DOI:10.1111/j.1460-9568.2007.05581.x
• Brown TM, Colwell CS, Waschek JA, Piggins HD. (2007). Disrupted Neuronal Activity Rhythms in the Suprachiasmatic Nuclei of Vasoactive Intestinal Polypeptide-Deficient Mice. Journa of Neurophysiology, 97(3), 2553-2558. eScholarID:1c7367 | DOI:10.1152/jn.01206.2006
• Brown TM, Piggins HD. (2007). Electrophysiology of the suprachiasmatic clock. Progress in Neurobiology, 82(5), 229-255. eScholarID:1c7368 | DOI:10.1016/j.pneurobio.2007.05.002

2006

• Brown TM, Banks JR, Piggins HD. (2006). A novel suction electrode recording technique for monitoring circadian rhythms in single and multiunit discharge from brain slices. Journal of neuroscience methods, 156(1-2), eScholarID:1c6176 | PMID:16581136 | DOI:10.1016/j.jneumeth.2006.02.024
• Canal MM, Piggins HD. (2006). Resetting of the hamster circadian system by dark pulses. American journal of physiology. Regulatory, integrative and comparative physiology, 290(3), R785-792. eScholarID:1c4832 | PMID:16239370
• Piggins HD. (2006). Stabilizing daily clock proteins. The Biochemical journal, 399(1), e1-2. eScholarID:1c6174 | PMID:16956325 | DOI:10.1042/BJ20061211
• Samuels RE, Tavernier RJ, Castillo MR, Bult-Ito A, Piggins HD. (2006). Substance P and neurokinin-1 immunoreactivities in the neural circadian system of the Alaskan northern red-backed vole, Clethrionomys rutilus. Peptides, 27(11), 2976-92. eScholarID:1c6175 | PMID:16930773 | DOI:10.1016/j.peptides.2006.05.028
• Pakhotin P, Harmar AJ, Verkhratsky A, Piggins H. (2006). VIP receptors control excitability of suprachiasmatic nuclei neurones. Pflugers Archiv : European journal of physiology, 452(April), 7-15. eScholarID:1c4836 | PMID:16283205

2005

• Piggins HD, Loudon A. (2005). Circadian biology: clocks within clocks. Current biology : CB, 15(12), R455-7. eScholarID:1c4834 | PMID:15964264
• Coogan AN, Piggins HD. (2005). Dark pulse suppression of P-ERK and c-Fos in the hamster suprachiasmatic nuclei. The European journal of neuroscience, 22(1), 158-68. eScholarID:1c4833 | PMID:16029205
• Piggins HD, Goguen D, Rusak B. (2005). Gastrin-releasing peptide induces c-Fos in the hamster suprachiasmatic nucleus. Neuroscience letters, 384(3), 205-10. eScholarID:1c4835 | PMID:15955628
• Brown TM, Hughes AT, Piggins HD. (2005). Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling. Journal of Neuroscience, 25(48), 11155-64. eScholarID:1c4831 | PMID:16319315 | DOI:10.1523/JNEUROSCI.3821-05.2005

2004

• Hughes AT, Fahey B, Cutler DJ, Coogan AN, Piggins HD. (2004). Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC2 receptor. Journal of Neuroscience, 24(14), 3522-6. eScholarID:1c3409 | PMID:15071099 | DOI:10.1523/JNEUROSCI.5345-03.2004
• Kalló I, Kalamatianos T, Piggins HD, Coen CW. (2004). Ageing and the diurnal expression of mRNAs for vasoactive intestinal peptide and for the VPAC2 and PAC1 receptors in the suprachiasmatic nucleus of male rats. Journal of neuroendocrinology, 16(9), 758-66. eScholarID:1c3406 | PMID:15344914
• Kalamatianos T, Kalló I, Piggins HD, Coen CW. (2004). Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites. The Journal of comparative neurology, 475(1), 19-35. eScholarID:1c3408 | PMID:15176082
• Coogan AN, Piggins HD. (2004). MAP kinases in the mammalian circadian system--key regulators of clock function. Journal of neurochemistry, 90(4), 769-75. eScholarID:1c3407 | PMID:15287881
• Meyer-Spasche A, Piggins HD. (2004). Vasoactive intestinal polypeptide phase-advances the rat suprachiasmatic nuclei circadian pacemaker in vitro via protein kinase A and mitogen-activated protein kinase. Neuroscience letters, 358(2), 91-4. eScholarID:1c3410 | PMID:15026156

2003

• Coogan AN, Piggins HD. (2003). Circadian and photic regulation of phosphorylation of ERK1/2 and Elk-1 in the suprachiasmatic nuclei of the Syrian hamster. Journal of Neuroscience, 23(7), 3085-93. eScholarID:1c1543 | PMID:12684495
• Cutler DJ, Haraura M, Reed HE, Shen S, Sheward WJ, Morrison CF, Marston HM, Harmar AJ, Piggins HD. (2003). The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro. European Journal of Neuroscience, 17(2), 197-204. eScholarID:1c280
• Piggins HD, Cutler DJ. (2003). The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. The Journal of endocrinology, 177(1), 7-15. eScholarID:1c281
• Piggins HD, Cutler DJ. (2003). The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. The Journal of endocrinology, 177(1), 7-15. eScholarID:1c1542 | PMID:12697032

2002

• Reed HE, Cutler DJ, Brown TM, Brown J, Coen CW, Piggins HD. (2002). Effects of vasoactive intestinal polypeptide on neurones of the rat suprachiasmatic nuclei in vitro. Journal of neuroendocrinology, 14(8), 639-46. eScholarID:1c70 | PMID:12153466
• Piggins HD. (2002). Human clock genes. Annals of medicine, 34(5), 394-400. eScholarID:1c1544 | PMID:12452483
• Ajpru S, McArthur AJ, Piggins HD, Sugden D. (2002). Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Brain research. Molecular brain research, 105(1-2), 29-37. eScholarID:1c1545 | PMID:12399105
• Meyer-Spasche A, Reed HE, Piggins HD. (2002). Neurotensin phase-shifts the firing rate rhythm of neurons in the rat suprachiasmatic nuclei in vitro. The European journal of neuroscience, 16(2), 339-44. eScholarID:1c1546 | PMID:12169114
• Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH. (2002). The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell, 109(4), 497-508. eScholarID:1c1547 | PMID:12086606

2001

• Piggins HD, Samuels RE, Coogan AN, Cutler DJ. (2001). Distribution of substance P and neurokinin-1 receptor immunoreactivity in the suprachiasmatic nuclei and intergeniculate leaflet of hamster, mouse, and rat. The Journal of comparative neurology, 438(1), 50-65. eScholarID:1c1548 | PMID:11503152
• Coogan AN, Rawlings N, Luckman SM, Piggins HD. (2001). Effects of neurotensin on discharge rates of rat suprachiasmatic nucleus neurons in vitro. Neuroscience, 103(3), 663-72. eScholarID:1c715 | PMID:11274786
• McGranaghan PA, Piggins HD. (2001). Orexin A-like immunoreactivity in the hypothalamus and thalamus of the Syrian hamster (Mesocricetus auratus) and Siberian hamster (Phodopus sungorus), with special reference to circadian structures. Brain research, 904(2), 234-44. eScholarID:1c1549 | PMID:11406121
• Piggins HD, Marchant EG, Goguen D, Rusak B. (2001). Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms. Neuroscience letters, 305(1), 25-8. eScholarID:1c1550 | PMID:11356299
• Reed HE, Meyer-Spasche A, Cutler DJ, Coen CW, Piggins HD. (2001). Vasoactive intestinal polypeptide (VIP) phase-shifts the rat suprachiasmatic nucleus clock in vitro. The European journal of neuroscience, 13(4), 839-43. eScholarID:1c1551 | PMID:11207820

2000

• McArthur AJ, Coogan AN, Ajpru S, Sugden D, Biello SM, Piggins HD. (2000). Gastrin-releasing peptide phase-shifts suprachiasmatic nuclei neuronal rhythms in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(14), 5496-502. eScholarID:1c1552 | PMID:0010884333

1999

• Sugden D, McArthur AJ, Ajpru S, Duniec K, Piggins HD. (1999). Expression of mt(1) melatonin receptor subtype mRNA in the entrained rat suprachiasmatic nucleus: a quantitative RT-PCR study across the diurnal cycle. Brain research. Molecular brain research, 72(2), 176-82. eScholarID:1c1553 | PMID:0010529476

1998

• Scott G, Piggins HD, Semba K, Rusak B. (1998). Actions of histamine in the suprachiasmatic nucleus of the Syrian hamster. Brain research, 783(1), 1-9. eScholarID:1c1557 | PMID:0009479032
• Cagampang FR, Piggins HD, Sheward WJ, Harmar AJ, Coen CW. (1998). Circadian changes in PACAP type 1 (PAC1) receptor mRNA in the rat suprachiasmatic and supraoptic nuclei. Brain research, 813(1), 218-22. eScholarID:1c1554 | PMID:0009824702
• Cagampang FR, Sheward WJ, Harmar AJ, Piggins HD, Coen CW. (1998). Circadian changes in the expression of vasoactive intestinal peptide 2 receptor mRNA in the rat suprachiasmatic nuclei. Brain research. Molecular brain research, 54(1), 108-12. eScholarID:1c1558 | PMID:0009526060
• Cagampang FR, Antoni FA, Smith SM, Piggins HD, Coen CW. (1998). Circadian changes of type II adenylyl cyclase mRNA in the rat suprachiasmatic nuclei. Brain research, 810(1-2), 279-82. eScholarID:1c1555 | PMID:0009813369
• Cutler DJ, Piggins HD, Selbie LA, Mason R. (1998). Responses to neuropeptide Y in adult hamster suprachiasmatic nucleus neurones in vitro. European journal of pharmacology, 345(2), 155-62. eScholarID:1c1556 | PMID:0009600631

1997

• Stamp JA, Piggins HD, Rusak B, Semba K. (1997). Distribution of ionotropic glutamate receptor subunit immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet of the hamster. Brain research, 756(1-2), 215-24. eScholarID:1c1559 | PMID:0009187335
• Piggins HD, Rusak B. (1997). Effects of microinjections of substance P into the suprachiasmatic nucleus region on hamster wheel-running rhythms. Brain research bulletin, 42(6), 451-5. eScholarID:1c1560 | PMID:0009128920

1996

• Piggins HD, Stamp JA, Burns J, Rusak B, Semba K. (1996). Distribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactivity in the hypothalamus and extended amygdala of the rat. The Journal of comparative neurology, 376(2), 278-94. eScholarID:1c1561 | PMID:0008951643

1995

• Piggins HD, Cutler DJ, Rusak B. (1995). Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons. Brain research bulletin, 37(5), 475-9. eScholarID:1c1563 | PMID:0007543357
• Piggins HD, Antle MC, Rusak B. (1995). Neuropeptides phase shift the mammalian circadian pacemaker. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(8), 5612-22. eScholarID:1c1562 | PMID:0007643205

1994

• Piggins HD, Cutler DJ, Rusak B. (1994). Effects of ionophoretically applied bombesin-like peptides on hamster suprachiasmatic nucleus neurons in vitro. European journal of pharmacology, 271(2-3), 413-9. eScholarID:1c1564 | PMID:0007705441

1993

• Piggins HD, Moody TW, Merali Z. (1993). Effects of neonatal blockade of bombesin (BN) receptors with [D-Phe6, phi Leu13-Cpa14]BN(6-14) on adult behavior and sensitivity to BN. Peptides, 14(4), 845-8. eScholarID:1c1566 | PMID:0008234034
• Piggins HD, Rusak B. (1993). Electrophysiological effects of pressure-ejected bombesin-like peptides on hamster suprachiasmatic nucleus neurons in vitro. Journal of neuroendocrinology, 5(5), 575-81. eScholarID:1c1565 | PMID:0008680427
• Rusak B, Abe H, Mason R, Piggins HD, Ying SW. (1993). Neurophysiological analysis of circadian rhythm entrainment. Journal of biological rhythms, 8 Suppl, S39-45. eScholarID:1c1568 | PMID:0008274762
• Yu GD, Rusak B, Piggins HD. (1993). Regulation of melatonin-sensitivity and firing-rate rhythms of hamster suprachiasmatic nucleus neurons: constant light effects. Brain research, 602(2), 191-9. eScholarID:1c1567 | PMID:0008448665