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Professor Karl Herholz (MD, FRCP) - publications

List of publications



  • Su, Z., Roncaroli, F., Brodbelt, A., Jackson, A., Gerhard, A., Herholz, K., ... Du Plessis, D. (2015). The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: An 11C-(R)PK11195 PET Imaging and Neuropathology Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 512-7. DOI: 10.2967/jnumed.114.151621. Publication link: dec3774b-b00c-4c22-9dbe-66eeafa9df21 | PubMed:25722450
  • Firbank, M. J., Lloyd, J., Williams, D., Barber, R., Colloby, S. J., Barnett, N., ... O'Brien, J. T. (2015). An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy.The British journal of psychiatry : the journal of mental science. DOI: 10.1192/bjp.bp.114.160804. Publication link: a5dd2904-1514-495b-96dd-5fbff61b2149 | PubMed:26045347
  • O'Brien, J. T., & Herholz, K. (2015). Amyloid imaging for dementia in clinical practice.BMC Medicine, 13. DOI: 10.1186/s12916-015-0404-6. Publication link: 12234750-653c-4017-b8ce-f0f712e99e0e | PubMed:26170121
  • Kobylecki, C., Gerhard, A., Herholz, K., & Saba, L. (Ed.) (2015). Positron emission tomography in neurodegenerative disorders - evolving techniques and new tracers. In Imaging in neurodegenerative disorders. (pp. 135-150). Oxford: Oxford University Press. . Publication link: 9405c929-0110-4c12-a67c-454d7a06e0f8
  • Kobylecki, C., Langheinrich, T., Hinz, R., Vardy, E., Brown, G., Martino Casado, E., ... Herholz, K. (2015). 18F-Florbetapir PET in Patients with Frontotemporal Dementia and Alzheimer Disease. Journal of Nuclear Medicine Technology, 56(3), 386-391. DOI: 10.2967/jnumed.114.147454, 10.2967/jnumed.114.147454. Publication link: 8eb7dde6-993c-4534-8421-6552bf7ca3a2 | PubMed:25655625
  • Lista, S., Molinuevo, J. L., Cavedo, E., Rami, L., Amouyel, P., Teipel, S. J., ... Hampel, H. (2015). Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD, 48 Suppl 1. DOI: 10.3233/JAD-150202. Publication link: 8eee1f23-1b36-4f00-9d65-7528877d7091 | PubMed:26402088
  • Li, C., Su, Z., Li, K-L., Gerhard, A., Thompson, G., Zhu, X., ... Jackson, A. (2015). A Comparison of [11C]-(R)PK11195 Tracer Kinetics and MRI-Based Vascularity-Related Parameters in Gliomas. In 2015 Annual Meeting proceedings. (pp. 4671-4671). . Publication link: 8818a5db-ee93-480f-94d9-20481e948568
  • Su, Z., Roncaroli, F., Durrenberger, P. F., Coope, D. J., Karabatsou, K., Hinz, R., ... Herholz, K. (2015). The 18kDa Mitochondrial Translocator Protein (TSPO) in Human Gliomas: A [11C]-(R)PK11195 PET Imaging and Neuropathlogy Study. The Journal of Nuclear Medicine, [JNUMED/2014/151621]. . Publication link: 5fb783da-afde-437b-b05e-6700f71c2df2


  • Cavedo, E., Lista, S., Khachaturian, Z., Aisen, P., Amouyel, P., Herholz, K., ... Hampel, H. (2014). The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.The journal of prevention of Alzheimer's disease, 1(3). DOI: 10.14283/jpad.2014.32. Publication link: 8faa9885-d0a2-44d6-9472-8c4a11c712ee | PubMed:26478889
  • Carter, S. F., Embleton, K. V., Anton-Rodriguez, J. M., Burns, A., Ralph, M. A. L., & Herholz, K. (2014). Regional neuronal network failure and cognition in late-onset sporadic Alzheimer disease. American Journal of Neuroradiology, 35(6 SUPPL.), S18-S30. DOI: 10.3174/ajnr.A3895. Publication link: 9aad61d1-c202-48f7-932f-b1996cb9d93b | PubMed:24578281
  • Herholz, K., Kobylecki, C., Gerhard, A., Langheinrich, T., Vardy, E., Martino Casado, E., ... Hinz, R. (2014). Regional analysis and visual reading of [18F]-florbetapir PET in frontotemporal dementia. In Eur. J. Nucl. Med. Mol. Imaging 41, suppl. 2 (Oct 2014), S618.. DOI: 10.1007/s00259-014-2901-9. Publication link: 9b79cf5a-6fc3-4816-b537-394b9584dd49
  • Herholz, K., Dierckx, R. A. (Ed.), Otte, A. (Ed.), De Vries, E. G. (Ed.), Van Waarde, A. (Ed.), & Leenders, K. L. (Ed.) (2014). Gliomas. In PET and SPECT in Neurology. (pp. 863-880). Heidelberg: Springer Verlag. . Publication link: 445375ff-461e-400e-8d63-cacccfdcb563
  • Kerklaan, B. J., Berckel, B. N., Herholz, K., Dols, A., Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. (2014). The Added Value of 18-Fluorodeoxyglucose-Positron Emission Tomography in the Diagnosis of the Behavioral Variant of Frontotemporal Dementia. Am J Alzheimers Dis Other Demen, doi:10.1177/1533317514524811. DOI: 10.1177/1533317514524811. Publication link: 4fd2a538-e15e-4d50-be68-5bb58e9ce847
  • O'Brien, J. T., Firbank, M. J., Davison, C., Barnett, N., Bamford, C., Donaldson, C., ... Lloyd, J. (2014). 18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(12). DOI: 10.2967/jnumed.114.143347. Publication link: 3cc1976d-66b4-4ebd-8edb-eeff37db9340 | PubMed:25453043
  • Herholz, K. (2014). Guidance for reading FDG PET scans in dementia patients.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology, 58(4). . Publication link: 1f5dcf0a-ce0a-4e30-b3c5-e8f8a34c1ac5 | PubMed:25391316
  • Caroli, A., Prestia, A., Wade, S., Chen, K., Ayutyanont, N., Landau, S. M., ... Frisoni, G. B. (2014). Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI.Alzheimer disease and associated disorders. DOI: 10.1097/WAD.0000000000000071. Publication link: e7e61763-607d-4ffb-b4e1-6cad96a28472 | PubMed:25437302






  • Markiewicz, P. J., Matthews, J. C., Declerck, J., & Herholz, K. (2009). Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease. NeuroImage, 46(2), 472-485. DOI: 10.1016/j.neuroimage.2009.01.020. Publication link: be867afa-f9cc-44f2-a865-6ef54e4046da
  • Ullrich, R. T., Kracht, L., Brunn, A., Herholz, K., Frommolt, P., Miletic, H., ... Jacobs, A. H. (2009). Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma. Journal of Nuclear Medicine, 50(12), 1962-1968. DOI: 10.2967/jnumed.109.065904. Publication link: af23cc42-7569-43f9-b7a8-bbbc63ca7b9f
  • Haense, C., Herholz, K., Jagust, W. J., & Heiss, W. D. (2009). Performance of FDG PET for detection of Alzheimer's disease in two independent multicentre samples (NEST-DD and ADNI). Dementia and Geriatric Cognitive Disorders, 28(3), 259-266. DOI: 10.1159/000241879. Publication link: 29473718-4553-466c-84ef-3eb5c70a7d3e
  • Salmon, E., Kerrouche, N., Perani, D., Lekeu, F., Holthoff, V., Beuthien-Baumann, B., ... Herholz, K. (2009). On the multivariate nature of brain metabolic impairment in Alzheimer's disease. Neurobiology of Aging, 30(2), 186-197. DOI: 10.1016/j.neurobiolaging.2007.06.010. Publication link: 40276566-d7ba-4c5b-aaea-a6252e3e53f8
  • Herholz, K., Jagust, W. (Ed.), & D'Esposito, M. (Ed.) (2009). Functional imaging with FDG-PET in mild cognitive impairment. Imaging the Aging Brain. In Imaging the Aging Brain. (pp. 183-190). Oxford: Oxford University Press. . Publication link: 411f14df-7dab-45a9-ad5a-6fdb67962853



  • Herholz, K. G., Vollmar, S., Hampl, J. A., & Kracht, L. (2007). Integration of Functional Data (PET) into Brain Surgery Planning and Neuronavigation. In Advances in Medical Engineering. Springer Verlag. . Publication link: c802cfad-187c-4854-9c3d-af1e9509e0ed
  • Herholz, K., Carter, S. F., & Jones, M. (2007). Positron emission tomography imaging in dementia. British Journal of Radiology, 80(2), S160-S167. DOI: 10.1259/bjr/97295129. Publication link: bd0a11aa-d055-4570-850c-05d6c5e93807 | PubMed:18445746
  • Herholz, K. G., Price, P. M., & Coope, D. J. (2007). Brain tumours: planning and monitoring therapy with PET. In In: Cancer Imaging, Hayat M (ed).. Elsevier Science. . Publication link: a66edf1d-6eb0-43ec-96a5-83e298f0eecf
  • Eggers, C., Szelies, B., Bauer, B., Wienhard, K., Schröder, H., Herholz, K., & Heiss, W. D. (2007). Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. European Journal of Neurology, 14(6), 690-693. DOI: 10.1111/j.1468-1331.2007.01737.x. Publication link: cc4211d0-c915-422e-89bb-d920a3e1e1fd
  • Rueger, M. A., Kracht, L. W., Hilker, R., Thiel, A., Sobesky, J., Winkeler, A., ... Jacobs, A. H. (2007). Role of in vivo imaging of the central nervous system for developing novel drugs. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 51(2), 164-181. . Publication link: 22e02c32-cba1-459e-940c-71405be27cf2
  • Herting, B., Beuthien-Baumann, B., Pöttrich, K., Donix, M., Triemer, A., Lampe, J. B., ... Holthoff, V. A. (2007). Prefrontal cortex dysfunction and depression in atypical Parkinsonian syndromes. Movement Disorders, 22(4), 490-497. DOI: 10.1002/mds.21237. Publication link: 936a0e79-1bba-434e-9748-ac6c8fec1662
  • Herholz, K., Coope, D., & Jackson, A. (2007). Metabolic and molecular imaging in neuro-oncology. The Lancet Neurology, 6(8), 711-724. DOI: 10.1016/S1474-4422(07)70192-8. Publication link: 65bc7aee-9137-4120-ab17-c6ddceb93c5f | PubMed:17638612


  • Herholz, K. G. (2006). Positron emission tomography (PET) ligands and metabolic brain imaging. In Neurodegenerative Diseases. Henry Stewart Talks. . Publication link: 831d9a57-6675-4514-95fb-cb274392f905
  • Galldiks, N., Kracht, L. W., Burghaus, L., Thomas, A., Jacobs, A. H., Heiss, W. D., & Herholz, K. (2006). Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas. European Journal of Nuclear Medicine and Molecular Imaging, 33(5), 516-524. DOI: 10.1007/s00259-005-0002-5. Publication link: 81ca4391-13b7-4f4d-9502-c79bcfaf8676
  • Salmon, E., Perani, D., Herholz, K., Marique, P., Kalbe, E., Holthoff, V., ... Garraux, G. (2006). Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Human Brain Mapping, 27(7), 588-597. DOI: 10.1002/hbm.20203. Publication link: 81cff936-1915-4204-b1fa-c395a142dc66
  • Kracht, L. W., Herholz, K. G., Vollmar, S., & Jacobs, A. H. (2006). Brain Tumors: Astrocytoma, Oligodendroglioma, and Glioblastoma Images with PET and SPECT. Molecular Anatomic Imaging: PET-CT and SPECT-CT Integrated Modality Imaging Lippincott. . Publication link: 6ecd63e5-1233-4552-9c94-ff1b61c9698a
  • Kerrouche, N., Herholz, K. G., Mielke, R., Holthoff, V., & Baron, J. (2006). 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis.J Cereb Blood Flow Metab, 26( 9). . Publication link: 75ede156-eb84-4604-8185-b7627de6e2c0
  • Peters, F., Perani, D., Herholz, K., Holthoff, V., Beuthien-Baumann, B., Sorbi, S., ... Salmon, E. (2006). Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 21(5-6), 373-379. DOI: 10.1159/000091898. Publication link: 56bfb335-92a7-45bc-9e88-154c6efa3d57
  • Herholz, K. G., Morris, C. M., & Perani, D. (2006). The dementias: early diagnosis and evaluation. Taylor & Francis .. Publication link: 006ee6ba-0d8b-49b8-ac78-43a8015434c3
  • Salmon, E., Kerrouche, N., Herholz, K., Perani, D., Holthoff, V., Beuthien-Baumann, B., ... Garraux, G. (2006). Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementia. NeuroImage, 30(3), 871-878. DOI: 10.1016/j.neuroimage.2005.10.016. Publication link: 1cf3e6d7-4b5a-4208-af86-1358950f7bd3
  • Thiel, A., Habedank, B., Herholz, K., Kessler, J., Winhuisen, L., Haupt, W. F., & Heiss, W. D. (2006). From the left to the right: How the brain compensates progressive loss of language function. Brain and Language, 98(1), 57-65. DOI: 10.1016/j.bandl.2006.01.007. Publication link: 27f08c79-6ec1-4fa7-ad65-6664191b5f5b
  • Masdeu, J. C., Irimia, P., Asenbaum, S., Bogousslavsky, J., Brainin, M., Chabriat, H., ... Seitz, R. J. (2006). EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force. European Journal of Neurology, 13(12), 1271-1283. DOI: 10.1111/j.1468-1331.2006.01507.x. Publication link: 41c8f5b4-4a27-4ef7-ac57-43150bcb63b6
  • Coope, D. J., Herholz, K. G., Vollmar, S., Eggers, C., & Heiss, W. D. (2006). Development of a normal 11C-methionine PET uptake map: a novel approach to the evaluation of brain tumors using PET. 371-371. Poster session presented at Seventh Congress of the European Association for Neuro-Oncology, Vienna, Austria, .DOI: 10.1215/15228517-2006-019. Publication link: e790aba2-e207-4e91-9ae3-4cc635093f85
  • Eggers, C., Herholz, K., Kalbe, E., & Heiss, W. D. (2006). Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neuroscience Letters, 408(1), 46-50. DOI: 10.1016/j.neulet.2006.08.061. Publication link: bb2121c6-5324-400a-95be-e9d130320cae
  • Herholz, K. (2006). Cognitive dysfunction and emotional-behavioural changes in MS: The potential of positron emission tomography. JOURNAL OF THE NEUROLOGICAL SCIENCES, 245(1-2), 9-13. DOI: 10.1016/j.jns.2005.09.012. Publication link: c18c53a4-33b2-4fcf-b2c1-b99dff8c1d71


  • Mosconi, L., Pupi, A., Herholz, K. G., Prohovnik, I., Nacmias, B., De, C. M. T. R., ... Sorbi, S. (2005). Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. Journal of Neurology, Neurosurgery and Psychiatry, 76 (1). . Publication link: 9c2e111d-d203-4240-91ed-182c9fbf09c5
  • Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Ludecke, S., Lenz, O., Zundorf, G., ... KG, . U. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry, 57 (4). . Publication link: 8407afa4-3491-482c-a683-be992823ac54
  • Lange, C., Kracht, L., Herholz, K., Sachsse, U., & Irle, E. (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research - Neuroimaging, 139(2), 115-126. DOI: 10.1016/j.pscychresns.2005.05.003. Publication link: 85bf5616-37c2-4082-93a4-4f044a558aa0
  • Herholz, K. G., Habedank, B., Wallesch, C. W., & Forstl, . U. (2005). Funktionelle bildgebende Diagnostik.Demenzen. . Publication link: 6f9d6f65-e32a-4edb-9937-3e157228b62b
  • Anchisi, D., Borroni, B., Franceschi, M., Kerrouche, N., Kalbe, E., Beuthien-Beumann, B., ... Perani, D. (2005). Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to alzheimer disease. Archives of Neurology, 62(11), 1728-1733. DOI: 10.1001/archneur.62.11.1728. Publication link: 5a984237-7d76-40bc-81d3-78bc59386aca
  • Jacobs, A. H., Thomas, A., Kracht, L. W., Li, H., Dittmar, C., Garlip, G., ... Heiss, W. D. (2005). 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors. Journal of Nuclear Medicine, 46(12), 1948-1958. . Publication link: 31f86196-c0c3-4ff2-8cae-c05678d5593c
  • Cizek, J., Herholz, K. G., & Schrader, R. (2005). Robust non-linear registration of 3D medical images with one-to-one deformations.Neuroimage. . Publication link: 352910dd-0f04-40af-8abe-c069d7b1bed1
  • Thiel, A., Haupt, W. F., Habedank, B., Winhuisen, L., Herholz, K. G., & Kessler, J. (2005). Neuroimaging guided rTMS of left inferior frontal gyrus interferes with repetition priming. Neuroimage, 25 (3). . Publication link: 1c2bae28-9812-4628-b505-8108b3fcfef7
  • Herholz, K. (2005). Action of cholinesterase inhibitors in patients' brains. Journal of Neurology, Neurosurgery and Psychiatry, 76(3), 305. DOI: 10.1136/jnnp.2004.048405. Publication link: 21b6c4bd-184e-4ce9-b586-b1dfef8f7a33
  • Herholz, K., Salmon, E., Lespagnard, S., Marique, P., Peeters, F., KG, . U., ... Garraux, G. (2005). Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. Journal of Neurology Epub. . Publication link: 0bf0d0ab-234f-46a3-b54f-245c8c59c1ab
  • Thiel, A., Habedank, B., Winhuisen, L., Herholz, K., Kessler, J., Haupt, W. F., & Heiss, W. D. (2005). Essential language function of the right hemisphere in brain tumor patients. Annals of Neurology, 57(1), 128-131. DOI: 10.1002/ana.20342. Publication link: 02011497-20fe-4119-a269-d78b0096a420
  • Herholz, K., Hilker, R., Portman, A. T., Voges, J., Staal, M. J., Burghaus, L., ... Leenders, K. L. (2005). Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry. . Publication link: 01271ae0-4911-485b-b85d-f81bd94aff02
  • Kalbe, E., Salmon, E., Perani, D., Holthoff, V., Sorbi, S., Elsner, A., ... Herholz, K. (2005). Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 19(5-6), 349-356. DOI: 10.1159/000084704. Publication link: aa637833-4eba-4ad0-ac6f-5928bbd362ed
  • Hilker, R., Thomas, A. V., Klein, J. C., Weisenbach, S., Kalbe, E., Burghaus, L., ... Heiss, W. D. (2005). Dementia in Parkinson disease: Functional imaging of cholinergic and dopaminergic pathways. Neurology, 65(11), 1716-1722. DOI: 10.1212/01.wnl.0000191154.78131.f6. Publication link: ada162ce-16ca-48d9-b5c0-ddf9ddbdc9ae
  • Jacobs, A. H., Kracht, L. W., Gossmann, A., Rüger, M. A., Thomas, A. V., Thiel, A., & Herholz, K. (2005). Imaging in neurooncology. NeuroRx, 2(2), 333-347. DOI: 10.1602/neurorx.2.2.333. Publication link: ca48be6f-ed40-4aec-a16c-549bfc38fc49
  • Hilker, R., Schweitzer, K., Coburger, S., Ghaemi, M., Weisenbach, S., Jacobs, A. H., ... Heiss, W. D. (2005). Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Archives of Neurology, 62(3), 378-382. DOI: 10.1001/archneur.62.3.378. Publication link: f67a8d83-a689-4e8c-947f-b2c9cd7e7bfd
  • Herholz, K., Weisenbach, S., Kalbe, E., Diederich, N. J., & Heiss, W. D. (2005). Cerebral acetylcholine esterase activity in mild cognitive impairment. NeuroReport, 16(13), 1431-1434. DOI: 10.1097/01.wnr.0000177007.21732.7b. Publication link: f96e20dc-f416-4951-8197-192f8ad5381d
  • Sobesky, J., Thiel, A., Ghaemi, M., Hilker, R. H., Rudolf, J., Jacobs, A. H., ... Heiss, W. D. (2005). Crossed cerebellar diaschisis in acute human stroke: A PET study of serial changes and response to supratentorial reperfusion. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1685-1691. DOI: 10.1038/sj.jcbfm.9600162. Publication link: f435825e-ae8b-49df-9584-70b9e1e964d2


  • Mosconi, L., Pupi, A., De, C. M. T., Fayyaz, M., Herholz, K. G., & Sorbi, S. (2004). Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease.The journal of Nuclear Medicine, 45(3). . Publication link: fac959e4-8320-4104-9ed4-42049a4a08e6
  • Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., ... Pupi, A. (2004). MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET. Neurology, 63(12), 2332-2340. . Publication link: f7603028-c711-4c64-b827-223741e715c1
  • Mosconi, L., Sorbi, S., Nacmias, B., De, C. M. T., Fayyaz, M., Bracco, L., ... Pupi, A. (2004). Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study.Psychiatry Research: Neuroimaging, 130(2). . Publication link: c83f1ff8-c50e-435c-840e-d075fbe17387
  • Mosconi, L., Nacmias, B., Sorbi, S., De, C. M. T., Fayazz, M., Tedde, A., ... Pupi, A. (2004). Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 75(3). . Publication link: cf95036b-cd44-42db-b3bc-8c86341b2eec
  • Holthoff, V. A., Beuthien-Baumann, B., Zundorf, G., Triemer, A., Lundecke, S., Winiecki, P., ... Herholz, K. G. (2004). Changes in Brain Metabolism Associated with Remission in Unipolar Major Deprssion.Acta Psychiatr.Scand., 110(3). . Publication link: b8088239-4813-4471-8da7-7f406fe52734
  • Hilker, R., Voges, J., Weisenbach, S., Kalbe, E., Burghaus, L., Ghaemi, M., ... KG, . U. (2004). Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease.Journal of Cerebral Blood Flow & Metabolism, 24. . Publication link: 18192c75-e44f-4bce-8370-262a32a0d6cd
  • Herholz, K., KG, . U., Zundorf, G., Bauer, B., Weisenbach, S., Heiss, W. D., ... Fisher, A. (2004). Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional parametric imaging.Cholinergic Mechanisms. . Publication link: 16d7d78c-0ab6-47d5-a5ed-1c9bc0ffed0b
  • Herholz, K. G., Herscovitch, P., & Heiss, W. D. (2004). NeuroPET. (NeuroPET). Berlin/Heidelberg/NY: Springer Verlag.. Publication link: 16297345-4992-44ce-9f3b-84f25d01ab96
  • Cizek, J., Herholz, K. G., Vollmar, S., Galldiks, N., Burghaus, L., Impekoven, P., ... Jacobs, A. H. (2004). Novel Neuroimaging Findings in a Patient with Cerebral Whipple's Disease: A magnetic Resonance Imaging and Positron Emission Tomography Study.Journal of Neuroimaging, 14(4). . Publication link: 4491ab9c-e703-43d7-a273-f282a13aeaf4
  • Kracht, L. W., Miletic, H., Busch, S., Jacobs, A. H., Voges, J., Hoevels, M., ... Heiss, W. D. (2004). Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: Local comparison with stereotactic histopathology. Clinical Cancer Research, 10(21), 7163-7170. DOI: 10.1158/1078-0432.CCR-04-0262. Publication link: 47763939-71a4-448f-964e-59b2b65ddcb9
  • Herholz, K. G., & Heiss, W. D. (2004). PET in clinical neurology.Molecular Imaging & Biology, 6(4). . Publication link: 2ae2e5fa-89ca-4f04-886e-1bab8331a157
  • Herholz, K. G., Cizek, J., Vollmar, S., Schrader, R., Klein, J., & Heiss, W. D. (2004). Fast and robust registraion of PET and MR images of human brain.Neuroimage, 22(1). . Publication link: 3856d7d1-8483-436c-ad9e-c6a319a65298
  • Herholz, K., Weisenbach, S., Zündorf, G., Lenz, O., Schröder, H., Bauer, B., ... Heiss, W. D. (2004). In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease. NeuroImage, 21(1), 136-143. DOI: 10.1016/j.neuroimage.2003.09.042. Publication link: 323c13ad-909b-406d-82a0-ee4d00bd2da8
  • Heiss, W. D., Habedank, B., Klein, J. C., Herholz, K., Wienhard, K., Lenox, M., & Nutt, R. (2004). Metabolic rates in small brain nuclei determined by high-resolution PET. Journal of Nuclear Medicine, 45(11), 1811-1815. . Publication link: 73c46b9e-1d0e-4d07-ad3c-7f9a63e4c637
  • Hartmann, P., Herholz, K., Salzberger, B., & Petereit, H. F. (2004). Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma. Annals of Hematology, 83(4), 212-217. DOI: 10.1007/s00277-003-0802-2. Publication link: 7dbe80b8-2b1c-47f5-903c-2e478d376485
  • Herholz, K. G., Vollmar, S., Cizek, J., Sue, M., Klein, J., Jacobs, A., ... Macho, V. (2004). VINCI -"Volume imaging in Neurological Research, Co-Registration and ROIs included". In Forschung and wissenschaftliches Rechnen 2003.. Publication link: 8d22f045-11de-4793-8059-481970c9daa3


  • Kracht, L. W., Friese, M., Herholz, K. G., Schroeder, R., Bauer, B., Jacobs, A., & Heiss, W. D. (2003). Methyl-[(11)C]- l-methionine uptake as measured by positron emission tomography correlates in microvessel density in patients with glioma.Eur.J Nucl Med Mol.Imaging, 30(6). . Publication link: 7791098b-dc07-4bd1-ae8c-11deed43fea3
  • Jacobs, A. H., Voges, J., Kracht, L. W., Dittmar, C., Winkeler, A., Thomas, A., ... Heiss, W. D. (2003). Imaging in gene therapy of patients with glioma. Journal of Neuro-Oncology, 65(3), 291-305. DOI: 10.1023/B:NEON.0000003658.51816.3f. Publication link: 70c6d653-4e2d-4b32-a6be-a426f3e7a176
  • Sturm, V., Lenartz, D., Koulousakis, A., Treuer, H., Herholz, K., Klein, J. C., & Klosterkötter, J. (2003). The nucleus accumbens: A target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. Journal of Chemical Neuroanatomy, 26(4), 293-299. DOI: 10.1016/j.jchemneu.2003.09.003. Publication link: 6d7aad07-a90c-4f64-8095-a8e12f8f7067
  • Thiel, A., Hilker, R., Kessler, J., Habedank, B., Herholz, K. G., & Heiss, W. D. (2003). Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study.Journal of Neural Transmission, 110(11). . Publication link: 5bb2d139-bb48-4974-82fd-da16d402dc48
  • Mosconi, L., Sorbi, S., Nacmias, B., De, C. M. R. T. R., Fayyaz, M., Cellini, E., ... Pupi, A. (2003). Brain metabolic differences between sporadic and familial Alzheimer's disease.Neurology, 61(8). . Publication link: 5151e1fa-779e-472f-aa58-874db9f7a7be
  • Heiss, W. D., Thiel, A., Winhuisen, L., Muhlberger, B., Kessler, J., & Herholz, K. G. (2003). Functional imaging in the assessment of capability for recovery after stroke.Journal of Rehabilitation Medicine, 35(Suppl). . Publication link: 479c9178-aa75-43a3-92dd-8dc21a37dfd1
  • Herholz, K. G., Scheidhauer, K., & Ebmeier, K. P. (2003). Comparing HMPAO-SPECT and FDG-PET in Alzheimer's Disease. In SPECT in dementia. Basel. . Publication link: 499f9e2d-4b1d-4f99-b7e0-64e1a1bb753f
  • Herholz, K., Ebmeier, K. P., Darcourt, J., Dougall, N. J., Glasbus, M. F., KG, . U., ... Scheidhauer, K. (2003). Voxel-based approaches in clinical imaging. In SPECT in dementia. Basel. . Publication link: 4ef35e55-43ad-477c-873f-a49f725c1440
  • Hilker, R., Voges, J., Ghaemi, M., Lehrke, R., Rudolf, J., Koulousakis, A., ... Heiss, W. D. (2003). Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Movement Disorders, 18(1), 41-48. DOI: 10.1002/mds.10297. Publication link: 3cb07c41-d4da-4abd-9b68-fad900c94103
  • Salmon, E., Garraux, G., Delbeuck, X., Collette, F., Kalbe, E., Zuendorf, G., ... Herholz, K. G. (2003). Predominant ventromedial frontopolar metabolic impairment in frontoemporal dementia.Neuroimage, 20(1). . Publication link: 1318bc60-9997-48dd-9dfb-36819739a7ee
  • Fesl, G., Moriggl, B., Schmid, U. D., Naidich, T. P., Herholz, K., & Yousry, T. A. (2003). Inferior central sulcus: Variations of anatomy and function on the example of the motor tongue area. NeuroImage, 20(1), 601-610. DOI: 10.1016/S1053-8119(03)00299-4. Publication link: 255834a7-aa96-4075-804a-1d8cf4195368
  • Jacobs, A. H., Li, H., Winkeler, A., Hilker, R., Knoess, C., Rüger, A., ... Heiss, W. D. (2003). Pet-based molecular imaging in neuroscience. European Journal of Nuclear Medicine and Molecular Imaging, 30(7), 1051-1065. DOI: 10.1007/s00259-003-1202-5. Publication link: 9d657322-a63b-49b0-90ed-c81ce7706040
  • Herholz, K. G., Kracht, L., & Heiss, W. D. (2003). Monitoring of the Effect of Chemotherapy in a Mixed Glioma by C-11-methionine PET. Journal of Neuroimaging, 13(3). . Publication link: c3bc6ef5-85a4-4a93-9f96-ea11a7c388b1
  • Herholz, K. (2003). PET studies in dementia. Annals of Nuclear Medicine, 17(2), 79-89. . Publication link: d780869f-9659-453d-bc4b-f91b6b97b6a5
  • Zundorf, G., Kerrouche, N., Herholz, K. G., & Baron, J. C. (2003). An efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging.Hum.Brain Mapp, 18(1). . Publication link: ca6ef094-f1da-42d2-8b29-1585dfc158ac
  • Heiss, W. D., Thiel, A., Kessler, J., & Herholz, K. (2003). Disturbance and recovery of language function: Correlates in PET activation studies. NeuroImage, 20(1), S42-S49. DOI: 10.1016/j.neuroimage.2003.09.005. Publication link: f9d0bc3a-c9b7-4392-bdc0-35d8dd9a9a42


  • Hilker, R., Klein, C., Hedrich, K., Ozelius, L. J., Vieregge, P., Herholz, K., ... Heiss, W. D. (2002). The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: Evidence for enzymatic parkin function in humans. Neuroscience Letters, 323(1), 50-54. . Publication link: cfbf6b2c-3804-4d95-87fa-f0b55fb1f254
  • Herholz, K. G., Kessler, J., Ehlen, P., Kalbe, E., Strotmann, T., Markowitsch, H. J., ... Herscovitch, P. (2002). Brain regions involved in learning face-name associations and the effects of age, performance, and learning phase. In Brain imaging using SPECT. San Diego, CA: Academic Press. . Publication link: b822245d-c51d-4a57-801d-3c3bd2f7f7ac
  • Jacobs, A. H., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, L., ... Heiss, W. D. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas. Technology in Cancer Research and Treatment, 1(3), 187-204. . Publication link: f9399e70-7765-4425-a313-0d56cbd3a158
  • Szelies, B., Sobesky, J., Pawlik, G., Mielke, R., Bauer, B., Herholz, K., & Heiss, W. D. (2002). Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [11C]-flumazenil PET. European Journal of Neurology, 9(2), 137-142. DOI: 10.1046/j.1468-1331.2002.00338.x. Publication link: fa690353-09f4-44ef-aa71-d74fef1e1608
  • Herholz, K., Schopphoff, H., Schmidt, M., Mielke, R., Eschner, W., Scheidhauer, K., ... Ebmeier, K. (2002). Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. Journal of Nuclear Medicine, 43(1), 21-26. . Publication link: 24a94ace-b8fc-44ba-a37b-9500170695eb
  • Herholz, K., Salmon, E., Perani, D., Baron, J. C., Holthoff, V., Frölich, L., ... Heiss, W. D. (2002). Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. NeuroImage, 17(1), 302-316. DOI: 10.1006/nimg.2002.1208. Publication link: 258d0817-005d-4109-8f2f-988dbfd62646
  • Heiss, W. D., Thiel, A., Kessler, J., & Herholz, K. G. (2002). Sprachaktivierung im PET bei isch,mischen Insulten und Hirntumoren.Zentralblatt fur Neurochirurgie, 63(4). . Publication link: 00e84a9e-d5f6-4097-90bd-8875f34facbf
  • Huber, M., Herholz, K. G., Habedank, B., Thiel, A., Muller-Kuppers, M., Ebel, H., ... Heiss, W. D. (2002). Differente Muster regionaler Hirnaktivitat nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen. Eine Positronen-Emissions-Tomographische (PET) Studie mit 150-H2O und emotionaler Stimulierung durch autobiographische Erinnerung.Psychother. Psychosom. Med Psychol., 51(11). . Publication link: 45ad075b-7e4e-410b-8c41-23dad72d601d
  • Herholz, K., Zundorf, G., KG, . U., Lercher, M., Wienhard, K., Bauer, B., ... Herscovitch, P. (2002). PET functional parametric images of acetylcholine esterase activity without blood sampling. In Brain imaging using PET. San Diego, CA: Academic Press. . Publication link: 48922597-50c7-42e6-b574-d90ba480b758
  • Hilker, R., Voges, J., Thiel, A., Ghaemi, M., Herholz, K. G., Sturm, V., & Heiss, W. D. (2002). Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on-and off-conditions with FDG-PET.Journal of Neural transmission, 10. . Publication link: 5fea023e-c444-4b6b-92df-728a070fbd5c


  • Huber, M., Siol, T., Herholz, K. G., Lenz, O., Kohle, K., & Heiss, W. D. (2001). Activation of Thalamo-Cortical Systems in Post-Traumatic Flashbacks: A Positron Emission Tomography Study.Traumatology, 7(4). . Publication link: 9d118380-014d-4fcd-81f8-ed0d879d1e08
  • Jauss, M., Herholz, K., Kracht, L., Pantel, J., Hartmann, T., Jensen, M., ... Schröder, J. (2001). Frontotemporal dementia: Clinical, neuroimaging, and molecular biological findings in 6 patients. European Archives of Psychiatry and Clinical Neuroscience, 251(5), 225-231. DOI: 10.1007/s004060170031. Publication link: 9ea2b66b-3f6f-4e94-ac40-238ed95a9509
  • Thiel, A., Herholz, K., Koyuncu, A., Ghaemi, M., Kracht, L. W., Habedank, B., & Heiss, W. D. (2001). Plasticity of language networks in patients with brain tumors: A positron emission tomography activation study. Annals of Neurology, 50(5), 620-629. DOI: 10.1002/ana.1253. Publication link: 6ce6cb76-925f-4687-8713-7556830f3112
  • Hilker, R., Klein, C., Ghaemi, M., Kis, B., Strotmann, T., Ozelius, L. J., ... Pramstaller, P. P. (2001). Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Annals of Neurology, 49(3), 367-376. DOI: 10.1002/ana.74. Publication link: 44d23afb-9bfc-45bf-99df-23edf2124b9c
  • Ghaemi, M., Rudolf, J., Hilker, R., & Herholz, K. G. (2001). Increased pineal Fdopa uptake is related to severity of Parkinson's disease - a PET study. Journal of Pineal Research, 30 (4). . Publication link: 4035c048-7151-4700-bc0d-b30e19bc828f
  • Herholz, K., Ehlen, P., Kessler, J., Strotmann, T., Kalbe, E., & Markowitsch, H. J. (2001). Learning face-name associations and the effect of age and performance: A PET activation study. Neuropsychologia, 39(6), 643-650. DOI: 10.1016/S0028-3932(00)00144-5. Publication link: 147b21df-ccbc-48ec-ba6c-b31e2957e26d
  • Perani, D., Fazekas, F., Markus, H., Baumgartner, R. W., Baron, J. C., & Herholz, K. (2001). A survey of neuroimaging research in European neurological departments. European Journal of Neurology, 8(2), 111-117. DOI: 10.1046/j.1468-1331.2001.00206.x. Publication link: d4d855e4-013b-4d03-a5ee-347edea5619c
  • Herholz, K., Lercher, M., Wienhard, K., Bauer, B., Lenz, O., & Heiss, W. D. (2001). PET measurement of cerebral acetylcholine esterase activity without blood sampling. European Journal of Nuclear Medicine, 28(4), 472-477. DOI: 10.1007/s002590100492. Publication link: e2005eeb-8e08-47ae-ba24-2ef27bb533a8


  • Herholz, K., & Heiss, W. D. (2000). Functional imaging correlates of recovery after stroke in humans. Journal of Cerebral Blood Flow and Metabolism, 20(12), 1619-1631. . Publication link: 82a06b73-9ea5-4c73-8e11-5c59fd31cb37
  • Thiel, A., Pietrzyk, U., Sturm, V., Herholz, K., Hövels, M., & Schröder, R. (2000). Enhanced accuracy in differential diagnosis of radiation necrosis by positron emission tomography-magnetic resonance imaging coregistration: Technical case report. Neurosurgery, 46(1), 232-234. . Publication link: 7a3d9331-f9e2-46ea-b73b-886f4f9be9b6
  • Bartenstein, P., Grunwald, F., Kuwert, T., Tatsch, K., Sabri, O., Benkert, O., ... Weiller, C. (2000). Clinical applications of single photon emission tomography in neuromedicine. 1. Neuro-oncology, epilepsy, movement disorders, cerebrovascular disease. Nuklearmedizin, 39(7). . Publication link: 97887ad7-351b-45ff-8a80-8093fbca1e12
  • Herholz, K., Bauer, B., Wienhard, K., Kracht, L., Mielke, R., Lenz, O., ... Heiss, W. D. (2000). In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: Comparison with blood flow and glucose metabolism. Journal of Neural Transmission, 107(12), 1457-1468. DOI: 10.1007/s007020070009. Publication link: 0a2bc067-99a1-46b6-b111-a08684046f5d
  • Muzik, O., Da, S. E. A., Juhasz, C., Chugani, D. C., Shah, J., Nagy, F., ... Chugani, H. T. (2000). Intracranial EEG vs. flumazenil and glucose PET in children with extratemporal lobe epilepsy.Neurology, 54. . Publication link: 45181ea3-3e0a-47ff-b593-88c5a62c7af8
  • Bartenstein, P., Grünwald, F., Kuwert, T., Tatsch, K., Sabri, O., Benkert, O., ... Weiller, C. (2000). Clinical applications of single photon emission tomography in neurology. 2. Dementia, psychoses, inflammation, skull and brain injuries. Nuklearmedizin, 39( 8). . Publication link: c6ba8c74-6362-4df2-bf46-bdfbf9e67895
  • Kessler, J., Mielke, R., Grond, M., Herholz, K. G., & Heiss, W. D. (2000). Frontal lobe tasks do not reflect frontal lobe function in patients with probable Alzheimer's disease.Journal of Neuroscience, 1. . Publication link: f50fb7d2-4fc7-4d23-ac7f-11999e0c5d5f