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Professor Karl Herholz (MD, FRCP) - publications

List of publications


  • Kobylecki, C., Langheinrich, T., Hinz, R., Vardy, E., Brown, G., Martino, M., Haense, C., Richardson, A., Gerhard, A., Anton-Rodriguez, J., Snowden, J., Neary, D., Pontecorvo, M. & Herholz, K (2015). 18F-Florbetapir PET in Patients with Frontotemporal Dementia and Alzheimer Disease. J Nucl Med, 56(3), 386-91. eScholarID:263571 | DOI:10.2967/jnumed.114.147454 jnumed.114.147454 [pii]
  • Kobylecki, C., Gerhard, A. & Herholz, K (2015). Positron emission tomography in neurodegenerative disorders - evolving techniques and new tracers. In Saba, L. (Ed.), Imaging in neurodegenerative disorders. (pp. 135-150). Oxford: Oxford University Press. eScholarID:263572
  • Su, Z., Roncaroli, F., Durrenberger, P., Coope, D., Karabatsou, K., Hinz, R., Thompson, G., Turkheimer, F., Janczar, K., Du Plessis, D., Brodbelt, A., Jackson, A., Gerhard, A. & Herholz, K (2015). The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: An 11C-(R)PK11195 PET Imaging and Neuropathology Study. J Nucl Med, 56(4), 512-7. eScholarID:263570 | DOI:10.2967/jnumed.114.151621 jnumed.114.151621 [pii]


  • Caroli, A., Prestia, A., Wade, S., Chen, K., Ayutyanont, N., Landau, S., Madison, C., Haense, C., Herholz, K., Reiman, E., Jagust, W., Frisoni, G. & . (2014). Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI. Alzheimer Dis Assoc Disord, eScholarID:246255 | PMID:25437302 | DOI:10.1097/WAD.0000000000000071
  • Carter, S., Embleton, K., Anton-Rodriguez, J., Burns, A., Ralph, M. & Herholz, K (2014). Regional Neuronal Network Failure and Cognition in Late-Onset Sporadic Alzheimer Disease. American Journal of Neuroradiology, 35(6 suppl), S18-S30. eScholarID:229795 | DOI:10.3174/ajnr.A3895
  • Herholz, K (2014). Gliomas. In Dierckx, R., Otte, A., De Vries, E., Van Waarde, A. & Leenders, K. (Ed.), PET and SPECT in Neurology. (pp. 863-880). Heidelberg: Springer. eScholarID:229794
  • Herholz, K (2014). Guidance for reading FDG PET scans in dementia patients. Q J Nucl Med Mol Imaging, 58(4), 332-43. eScholarID:246254 | PMID:25391316
  • Herholz, K., Evans, R., Anton-Rodriguez, J., Hinz, R. & Matthews, J (2014). The effect of 18F-florbetapir dose reduction on region-based classification of cortical amyloid deposition. European Journal of Nuclear Medicine and Molecular Imaging, doi:10.1007/s00259-014-2842-3, 1-6. eScholarID:229797 | DOI:10.1007/s00259-014-2842-3
  • Kerklaan, B., Berckel, B., Herholz, K., Dols, A., Flier, W., Scheltens, P. & Pijnenburg, Y (2014). The Added Value of 18-Fluorodeoxyglucose-Positron Emission Tomography in the Diagnosis of the Behavioral Variant of Frontotemporal Dementia. Am J Alzheimers Dis Other Demen, doi:10.1177/1533317514524811, eScholarID:229796 | DOI:10.1177/1533317514524811
  • O'Brien, J., Firbank, M., Davison, C., Barnett, N., Bamford, C., Donaldson, C., Olsen, K., Herholz, K., Williams, D. & Lloyd, J (2014). 18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias. J Nucl Med, 55(12), 1959-65. eScholarID:246253 | PMID:25453043 | DOI:10.2967/jnumed.114.143347


  • Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A., Smigova, A., Cawthorne, C., Julyan, P., Wilkinson, S., Banister, S., Brown, G., Herholz, K., Kassiou, M. & Rothwell, N (2013). [(18)F]DPA-714: Direct Comparison with [(11)C]PK11195 in a Model of Cerebral Ischemia in Rats. PLoS One, 8(2), 13. eScholarID:202436
  • Edison, P., Carter, S., Rinne, J., Gelosa, G., Herholz, K., Nordberg, A., Brooks, D. & Hinz, R (2013). Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET. Neuroimage, 70, 423-33. eScholarID:202435 | DOI:10.1016/j.neuroimage.2012.12.014 S1053-8119(12)01191-3 [pii]
  • Frisoni, G., Bocchetta, M., Chetelat, G., Rabinovici, G., de Leon, M., Kaye, J., Reiman, E., Scheltens, P., Barkhof, F., Black, S., Brooks, D., Carrillo, M., Fox, N., Herholz, K., Nordberg, A., Jack, J., Jagust, W., Johnson, K., Rowe, C., Sperling, R., Thies, W., Wahlund, L., Weiner, M., Pasqualetti, P. & Decarli, C (2013). Imaging markers for Alzheimer disease: Which vs how. Neurology, 81(5), 487-500. eScholarID:214659 | DOI:81/5/487 [pii] 10.1212/WNL.0b013e31829d86e8
  • Herholz, K., Boecker, H., Nemeth, I. & Dunn, G (2013). FDG PET in dementia multicenter studies and clinical trials. Clinical and Translational Imaging, 1(4), 261-270. eScholarID:214658 | DOI:10.1007/s40336-013-0018-y
  • Herholz, S., Herholz, R. & Herholz, K (2013). Non-pharmacological interventions and neuroplasticity in early stage Alzheimer's disease. Expert Rev Neurother, 13(11), 1235-45. eScholarID:214660 | DOI:10.1586/14737175.2013.845086
  • Nordberg, A., Carter, S., Rinne, J., Drzezga, A., Brooks, D., Vandenberghe, R., Perani, D., Forsberg, A., Långström, B., Scheinin, N., Karrasch, M., Någren, K., Grimmer, T., Miederer, I., Edison, P., Okello, A., Laere, K., Nelissen, N., Vandenbulcke, M., Garibotto, V., Almkvist, O., Kalbe, E., Hinz, R. & Herholz, K (2013). A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 40(1), 104-114. eScholarID:185076 | DOI:10.1007/s00259-012-2237-2
  • Prestia, A., Caroli, A., Herholz, K., Reiman, E., Chen, K., Jagust, W. & Frisoni, G (2013). Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series. Alzheimers Dement, eScholarID:202438 | DOI:S1552-5260(12)02527-7 [pii] 10.1016/j.jalz.2012.09.016
  • Su, Z., Herholz, K., Gerhard, A., Roncaroli, F., Du Plessis, D., Jackson, A., Turkheimer, F. & Hinz, R (2013). [C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches. Eur J Nucl Med Mol Imaging, 29, 29. eScholarID:202437
  • Yeh, H., Tian, M., Hinz, R., Young, D., Shavrin, A., Mukhapadhyay, U., Flores, L., Balatoni, J., Soghomonyan, S., Jeong, H., Pal, A., Uthamanthil, R., Jackson, J., Nishii, R., Mizuma, H., Onoe, H., Kagawa, S., Higashi, T., Fukumitsu, N., Alauddin, M., Tong, W., Herholz, K. & Gelovani, J (2013). Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with (18)F-FAHA. Neuroimage, 64, 630-9. eScholarID:185077 | DOI:10.1016/j.neuroimage.2012.09.019 S1053-8119(12)00929-9 [pii]
  • Yeh, H., Young, D., Gelovani, J., Robinson, A., Davidson, Y., Herholz, K. & Mann, D (2013). Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington’s disease. Brain Research, 1504, 16-24. eScholarID:202439 | DOI:


  • Bohnen, N., Djang, D., Herholz, K., Anzai, Y. & Minoshima, S (2012). Effectiveness and Safety of 18F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature. J Nucl Med, 53(1), 59-71. eScholarID:153916 | DOI:jnumed.111.096578 [pii] 10.2967/jnumed.111.096578
  • Caroli, A., Prestia, A., Chen, K., Ayutyanont, N., Landau, S., Madison, C., Haense, C., Herholz, K., Nobili, F., Reiman, E., Jagust, W. & Frisoni, G (2012). Summary Metrics to Assess Alzheimer Disease-Related Hypometabolic Pattern with 18F-FDG PET: Head-to-Head Comparison. J Nucl Med, 53(4), 592-600. eScholarID:168607 | DOI:jnumed.111.094946 [pii] 10.2967/jnumed.111.094946
  • Carter, S., Caine, D., Burns, A., Herholz, K. & Lambon Ralph, M (2012). Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. Int J Geriatr Psychiatry, 27(4), 423-32. eScholarID:168617 | DOI:10.1002/gps.2738
  • Djang, D., Janssen, M., Bohnen, N., Booij, J., Henderson, T., Herholz, K., Minoshima, S., Rowe, C., Sabri, O., Seibyl, J., Van Berckel, B. & Wanner, M (2012). SNM Practice Guideline for Dopamine Transporter Imaging with 123I-Ioflupane SPECT 1.0. J Nucl Med, 53(1), 154-63. eScholarID:153913 | DOI:jnumed.111.100784 [pii] 10.2967/jnumed.111.100784
  • Haense, C., Kalbe, E., Herholz, K., Hohmann, C., Neumaier, B., Krais, R. & Heiss, W (2012). Cholinergic system function and cognition in mild cognitive impairment. Neurobiol Aging, 33(5), 867-877. eScholarID:168609 | DOI:S0197-4580(10)00363-5 [pii] 10.1016/j.neurobiolaging.2010.08.015
  • Herholz, K., Langen, K., Schiepers, C. & Mountz, J (2012). Brain Tumors. Seminars in Nuclear Medicine, 42(6), 375-389. eScholarID:168605 | DOI:10.1053/j.semnuclmed.2012.06.001
  • Herholz, K (2012). Imaging cerebral amyloid plaques: clinical perspective. Lancet Neurol, 11(8), 652-3. eScholarID:168616 | DOI:S1474-4422(12)70158-8 [pii] 10.1016/S1474-4422(12)70158-8
  • Herholz, K (2012). Use of FDG PET as an imaging biomarker in clinical trials in Alzheimer's disease. Biomarkers in Medicine, 6(4), 431-439. eScholarID:168611 | DOI:10.2217/bmm.12.51
  • Marcone, A., Garibotto, V., Moresco, R., Florea, I., Panzacchi, A., Carpinelli, A., Virta, J., Tettamanti, M., Borroni, B., Padovani, A., Bertoldo, A., Herholz, K., Rinne, J., Cappa, S. & Perani, D (2012). [11C]-MP4A PET Cholinergic Measurements in Amnestic Mild Cognitive Impairment, Probable Alzheimer's Disease, and Dementia with Lewy Bodies: A Bayesian Method and Voxel-Based Analysis. J Alzheimers Dis, eScholarID:168606 | DOI:M15528N3T6006287 [pii] 10.3233/JAD-2012-111748
  • Miller, P., Coope, D., Thompson, G., Jackson, A. & Herholz, K (2012). Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registration. Neuroimage, 60(4), 2309-15. eScholarID:168608 | DOI:S1053-8119(12)00210-8 [pii] 10.1016/j.neuroimage.2012.02.033
  • Nordberg, A., Carter, S., Rinne, J., Drzezga, A., Brooks, D., Vandenberghe, R., Perani, D., Forsberg, A., Langstrom, B., Scheinin, N., Karrasch, M., Nagren, K., Grimmer, T., Miederer, I., Edison, P., Okello, A., Van Laere, K., Nelissen, N., Vandenbulcke, M., Garibotto, V., Almkvist, O., Kalbe, E., Hinz, R. & Herholz, K (2012). A European multicentre PET study of fibrillar amyloid in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 40(1), 104-114. eScholarID:173007 | DOI:10.1007/s00259-012-2237-2
  • Teipel, S., Sperling, R., Skudlarski, P., Jack Jr, C., Hampel, H., Fellgiebel, A. & Herholz, K (2012). MRI- and PET- Based Imaging Markers for the Diagnosis of Alzheimer’s Disease. In Hampel, H. & Carrillo, M. (Ed.), Alzheimer’s Disease – Modernizing Concept, Biological Diagnosis and Therapy. (pp. 80-114). Basel: Karger. eScholarID:168610


  • Carter, S., Caine, D., Burns, A., Herholz, K. & Lambon Ralph, M (2011). Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. Int J Geriatr Psychiatry, eScholarID:153912 | DOI:10.1002/gps.2738
  • Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., Rothwell, N. & Boutin, H (2011). Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [(1)F]-IL1RA and PET imaging in rats. Br J Pharmacol, 162(3), 659-72. eScholarID:153915 | DOI:10.1111/j.1476-5381.2010.01068.x
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., Proctor, S., Russell, J., Hopkins, S., Tyrrell, P., Rothwell, N. & Allan, S (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun, 25(6), 1113-22. eScholarID:128095 | DOI:S0889-1591(11)00058-4 [pii] 10.1016/j.bbi.2011.02.008
  • Herholz, K (2011). Amyloid PET: Its diagnostic potential compared to FDG. Medicine Nucleaire, 35, 322-326. eScholarID:128096 | DOI:10.1016/j.mednuc.2011.02.007
  • Herholz, K. & Ebmeier, K (2011). Clinical amyloid imaging in Alzheimer’s disease. Lancet Neurology, 10, 667-670. eScholarID:128097 | DOI:10.1016/S1474-4422(11)70123-5
  • Herholz, K (2011). Molecular imaging in Alzheimer's Disease. European Neurological Review, 6(1), 16-20. eScholarID:128098 | DOI:10.1016/j.jalz.2010.05.515
  • Herholz, K (2011). Perfusion SPECT and FDG-PET. Int Psychogeriatr, 1-7. eScholarID:153911 | DOI:S1041610211000937 [pii] 10.1017/S1041610211000937
  • Herholz, K., Westwood, S., Haense, C. & Dunn, G (2011). Evaluation of a Calibrated 18F-FDG PET Score as a Biomarker for Progression in Alzheimer Disease and Mild Cognitive Impairment. Journal of nuclear medicine, 52(8), 1218. eScholarID:134134 | PMID:21764801 | DOI:10.2967/jnumed.111.090902
  • Kalbe, E., Onur, O., Minnerop, M., Reimann, J., Althaus, A., Ahmadzadehfar, H., Dodel, R., Strach, K., Clemen, C., Herholz, K., Haense, C., Fink, G. & Schroder, R (2011). Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study. J Neurol, 258(3), 515-8. eScholarID:153914 | DOI:10.1007/s00415-010-5774-2
  • Markiewicz, P., Matthews, J., Declerck, J. & Herholz, K (2011). Robustness of correlations between PCA of FDG-PET scans and biological variables in healthy and demented subjects. Neuroimage, 56(2), 782-7. eScholarID:128100 | DOI:S1053-8119(10)00800-1 [pii] 10.1016/j.neuroimage.2010.05.066
  • Markiewicz, P., Matthews, J., Declerck, J. & Herholz, K (2011). Verification of predicted robustness and accuracy of multivariate analysis. Neuroimage, 56(3), 1382-5. eScholarID:128099 | DOI:S1053-8119(11)00192-3 [pii] 10.1016/j.neuroimage.2011.02.036
  • Merhof, D., Markiewicz, P., Platsch, G., Declerck, J., Weih, M., Kornhuber, J., Kuwert, T., Matthews, J. & Herholz, K (2011). Optimized data preprocessing for multivariate analysis applied to (99m)Tc-ECD SPECT data sets of Alzheimer's patients and asymptomatic controls. J Cereb Blood Flow Metab, 31(1), 371-83. eScholarID:107300 | DOI:10.1038/jcbfm.2010.112


  • Hampel, H., R. Frank, K. Broich, S. Teipel, R. G. Katz, J. Hardy, K. Herholz, A. L. Bokde, F. Jessen, Y. G. Hoessler, W. R. Sanhai, H. Zetterberg, J. Woodcock and K. Blennow. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. Nature Reviews Drug Discovery, 9, 560-574. eScholarID:84161 | DOI:10.1038/nrd3115
  • Galldiks N, Kracht LW, Berthold F, Miletic H, Klein JC, Herholz KG, Jacobs AH, Heiss WD. (2010). [11C]-L-Methionine Positron Emission Tomography in the Management of Children and Young Adults with Brain Tumours. Journal of Neuro-Oncology, 96(2), 231-239. eScholarID:1d19616 | DOI:10.1007/s11060-009-9953-x
  • Haense, C., Kalbe, E., Herholz, K., Hohmann, C., Neumaier, B., Krais, R. & Heiss, W (2010). Cholinergic system function and cognition in mild cognitive impairment. Neurobiol Aging, eScholarID:107297 | DOI:10.1016/j.neurobiolaging.2010.08.015
  • Herholz, K (2010). Cerebral glucose metabolism in preclinical and prodromal Alzheimer's disease. Expert Rev Neurother, 10(11), 1667-73. eScholarID:107296 | DOI:10.1586/ern.10.136
  • Kalbe, E., Onur, O., Minnerop, M., Reimann, J., Althaus, A., Ahmadzadehfar, H., Dodel, R., Strach, K., Clemen, C., Herholz, K., Haense, C., Fink, G. & Schroder, R (2010). Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study. J Neurol, eScholarID:107298 | DOI:10.1007/s00415-010-5774-2
  • Terriere, E., Dempsey, M., Herrmann, L., Tierney, K., Lonie, J., O'Carroll, R., Pimlott, S., Wyper, D., Herholz, K. & Ebmeier, K (2010). 5-(123)I-A-85380 binding to the alpha4beta2-nicotinic receptor in mild cognitive impairment. Neurobiol Aging, 31(11), 1885-93. eScholarID:107295 | DOI:S0197-4580(08)00365-5 [pii] 10.1016/j.neurobiolaging.2008.10.008
  • Tolboom, N., van der Flier, W., Boverhoff, J., Yaqub, M., Wattjes, M., Raijmakers, P., Barkhof, F., Scheltens, P., Herholz, K., Lammertsma, A. & van Berckel, B (2010). Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images. J Neurol Neurosurg Psychiatry, 81(8), 882-4. eScholarID:107299 | DOI:jnnp.2009.194779 [pii] 10.1136/jnnp.2009.194779


  • Herholz, K. (2009). Functional imaging with FDG-PET in mild cognitive impairment. Imaging the Aging Brain. In Jagust, W., D'Esposito, M (Ed.), Imaging the Aging Brain. (pp. 183-190). Oxford: Oxford University Press. eScholarID:84157
  • Ullrich, R. T., L. Kracht, A. Brunn, K. Herholz, P. Frommolt, H. Miletic, M. Deckert, W. D. Heiss and A. H. Jacobs. (2009). Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma. Journal of Nuclear Medicine, 50(12), 1962-1968. eScholarID:84172 | DOI:10.2967/jnumed.109.065904
  • Salmon, E, Kerrouche, N, Perani, D, Lekeu, F, Holthoff, V, Beuthien-Baumann, B, Sorbi, S, Lemaire, C, Collette, F, Herholz, KG. (2009). On the multivariate nature of brain metabolic impairment in Alzheimer's disease. Neurobiology of Aging, 30(2), 186-197. eScholarID:1d17584 | DOI:10.1016/j.neurobiolaging.2007.06.010
  • Haense, C., K. Herholz, W. J. Jagust and W. D. Heiss. (2009). Performance of FDG PET for Detection of Alzheimer’s Disease in Two Independent Multicenter Samples (NEST-DD and ADNI). Dementia and Geriatric Cognitive Disorders, 28, 259-266. eScholarID:84158 | DOI:10.1159/000241879
  • Markiewicz, P. J., J. C. Matthews, J. Declerck and K. Herholz. (2009). Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease. NeuroImage, 46(2), 472-485. eScholarID:84166 | DOI:10.1016/j.neuroimage.2009.01.020


  • Terrière, E, Dempsey, M, Herrmann, L, Tierney, K, Lonie, J, O'Carroll, R, Pimlott, S, Wyper, D, Herholz, KG, Ebmeier, K. (2008). 5-(123)I-A-85380 binding to the alpha4beta2-nicotinic receptor in mild cognitive impairment. Neurobiol Aging, eScholarID:1d19523 | DOI:10.1016/j.neurobiolaging.2008.10.008
  • Salmon E, Perani D, Collette F, Feyers D, Kalbe E, Holthoff V, Sorbi S, Herholz KG. (2008). A comparison of unawareness in frontotemporal dementia and Alzheimer's disease. J Neurol Neurosurg Psychiatry, 79( 2), 176-9. eScholarID:1d17583
  • Herholz KG. (2008). Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease. Eur J Nucl Med Mol Imaging, 35 Suppl 1, S25-9. eScholarID:1d17581
  • Haense CC, Buerger K, Kalbe E, Drzezga A, Teipel S, Markiewicz P, Herholz KG, Heiss W, Hampel H. (2008). CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. Eur J Neurol, 15( 11), eScholarID:1d19521 | DOI:10.1111/j.1468-1331.2008.02274.x
  • Klein J, Herholz KG, Wienhard K, Heiss W. (2008). Cortical flattening applied to high-resolution 18F-FDG PET. J Nucl Med, 49( 1), 44-9. eScholarID:1d17582
  • Herholz KG, Weisenbach S, Kalbe E. (2008). Deficits of the cholinergic system in early AD. Neuropsychologia, 46( 6), 1642-7. eScholarID:1d17580
  • Garibotto, V, Borroni, B, Kalbe, E, Herholz, KG, Salmon, E, Holtoff, V, Sorbi, S, Cappa, S, Padovani, A, Fazio, F, Perani, D. (2008). Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology, 71( 17), eScholarID:1d19520 | DOI:10.1212/01.wnl.0000327670.62378.c0
  • Mosconi, L, Tsui, W, Herholz, KG, Pupi, A, Drzezga, A, Lucignani, G, Reiman, E, Holthoff, V, Kalbe, E, Sorbi, S, Diehl-Schmid, J, Perneczky, R, Clerici, F, Caselli, R, Beuthien-Baumann, B, Kurz, A, Minoshima, S, de Leon, M. (2008). Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med, 49( 3), 390-8. eScholarID:1d17579 | DOI:10.2967/jnumed.107.045385


  • Coope DJ, Herholz KG, Price PM. (2007). Brain tumours: planning and monitoring therapy with PET. In: Cancer Imaging, Hayat M (ed). Elsevier Science. eScholarID:3d1091
  • Coope DJ, Cizek J, Eggers C, Vollmar S, Heiss W, Herholz KG. (2007). Evaluation of Primary Brain Tumors Using <sup>11<\sup>C-Methionine PET with Reference to a Normal Methionine Uptake Map. Journal of Nuclear Medicine, 48(12), eScholarID:1d16835
  • Eggers C, Szelies B, Bauer B, Wienhard K, Schröder H, Herholz KG, Heiss W. (2007). Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. Eur J Neurol, 14( 6), 690-3. eScholarID:1d17585
  • Vollmar S, Hampl JA, Kracht L, Herholz KG. (2007). Integration of Functional Data (PET) into Brain Surgery Planning and Neuronavigation. Advances in Medical Engineering. Springer. eScholarID:3d951
  • Herholz KG, Coope DJ, Jackson A. (2007). Metabolic and molecular imaging in neuro-oncology. Lancet Neurology, 6(8), 711-24. eScholarID:1d16060
  • Herholz KG, Carter S, Jones M. (2007). Positron emission tomography imaging in dementia. Br J Radiol, 80 Spec No 2, S160-7. eScholarID:1d17578
  • Herting, B, Beuthien-Baumann, B, Pöttrich, K, Donix, M, Triemer, A, Lampe, J, von Kummer, R, Herholz, KG, Reichmann, H, Holthoff, V. (2007). Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes. Mov Disord, 22( 4), 490-7. eScholarID:1d17587 | DOI:10.1002/mds.21237
  • Rueger, M, Kracht, L, Hilker, R, Thiel, A, Sobesky, J, Winkeler, A, Thomas, A, Heneka, M, Graf, R, Herholz, KG, Heiss, W, Jacobs, A. (2007). Role of in vivo imaging of the central nervous system for developing novel drugs. Q J Nucl Med Mol Imaging, 51( 2), 164-81. eScholarID:1d17586


  • Kerrouche N, Herholz KG, Mielke R, Holthoff V, Baron J. (2006). 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis. J Cereb Blood Flow Metab, 26( 9), 1213-21. eScholarID:1d14195
  • Kracht LW, Herholz KG, Vollmar S, Jacobs AH. (2006). Brain Tumors: Astrocytoma, Oligodendroglioma, and Glioblastoma Images with PET and SPECT. Molecular Anatomic Imaging: PET-CT and SPECT-CT Integrated Modality Imaging Lippincott, eScholarID:1d33052
  • Heiss W, Herholz KG. (2006). Brain receptor imaging. J Nucl Med, 47( 2), 302-12. eScholarID:1d14193 | DOI:10.4061/2010/548913
  • Herholz KG. (2006). Cognitive dysfunction and emotional-behavioural changes in MS: the potential of positron emission tomography. J Neurol Sci, 245( 1-2), 9-13. eScholarID:1d14194
  • Eggers C, Herholz KG, Kalbe E, Heiss W. (2006). Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neurosci Lett, 408( 1), 46-50. eScholarID:1d14191
  • Salmon, E, Kerrouche, N, Herholz, KG, Perani, D, Holthoff, V, Beuthien-Baumann, B, Degueldre, C, Lemaire, C, Luxen, A, Baron, J, Collette, F, Garraux, G. (2006). Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementia. Neuroimage, 30( 3), 871-8. eScholarID:1d14197 | DOI:10.1016/j.neuroimage.2005.10.016
  • Coope DJ, Vollmar S, Eggers C, Herholz KG, Heiss WD. (2006). Development of a normal 11C-methionine PET uptake map: a novel approach to the evaluation of brain tumors using PET. Presented at Seventh Congress of the European Association for Neuro-Oncology. Vienna, Austria. eScholarID:2d2046 | DOI:10.1215/15228517-2006-019
  • Masdeu, J, Irimia, P, Asenbaum, S, Bogousslavsky, J, Brainin, M, Chabriat, H, Herholz, KG, Markus, H, Martínez-Vila, E, Niederkorn, K, Schellinger, P, Seitz, R, NULL. (2006). EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force. Eur J Neurol, 13( 12), eScholarID:1d21256 | DOI:10.1111/j.1468-1331.2006.01507.x
  • Thiel A, Habedank B, Herholz KG, Kessler J, Winhuisen L, Haupt W, Heiss W. (2006). From the left to the right: How the brain compensates progressive loss of language function. Brain Lang, 98( 1), 57-65. eScholarID:1d14199
  • Salmon, E, Perani, D, Herholz, KG, Marique, P, Kalbe, E, Holthoff, V, Delbeuck, X, Beuthien-Baumann, B, Pelati, O, Lespagnard, S, Collette, F, Garraux, G. (2006). Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Hum Brain Mapp, 27( 7), 588-97. eScholarID:1d14198 | DOI:10.1002/hbm.20203
  • Peters, F, Perani, D, Herholz, KG, Holthoff, V, Beuthien-Baumann, B, Sorbi, S, Pupi, A, Degueldre, C, Lemaire, C, Collette, F, Salmon, E. (2006). Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dement Geriatr Cogn Disord, 21( 5-6), 373-9. eScholarID:1d14196 | DOI:10.1159/000091898
  • Herholz KG. (2006). Positron emission tomography (PET) ligands and metabolic brain imaging. Neurodegenerative Diseases. Henry Stewart Talks. eScholarID:3d963
  • Herholz KG, Morris CM, Perani D. (2006). The dementias: early diagnosis and evaluation. Taylor & Francis. eScholarID:4d156
  • Galldiks N, Kracht L, Burghaus L, Thomas A, Jacobs A, Heiss W, Herholz KG. (2006). Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas. Eur J Nucl Med Mol Imaging, 33( 5), 516-24. eScholarID:1d14192


  • Jacobs, A, Thomas, A, Kracht, L, Li, H, Dittmar, C, Garlip, G, Galldiks, N, Klein, J, Sobesky, J, Hilker, R, Vollmar, S, Herholz, KG, Wienhard, K, Heiss, W. (2005). 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors. J Nucl Med, 46( 12), 1948-58. eScholarID:1d14190
  • Herholz KG. (2005). Action of cholinesterase inhibitors in patients' brains. Journal of Neurology, Neurosurgery and Psychiatry, 76 (3), eScholarID:1d10870
  • Kalbe E, Salmon E, Perani D, Holthoff V, Sorbi S, Elsner A, Weisenbach S, Brand M, Lenz O, Kessler J, Luedecke S, Ortelli P, Herholz, KG. (2005). Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment. Dementia & Geriatric Cognitive Disorders, 19, 349-356. eScholarID:1d10912 | DOI:10.1159/000084704
  • Herholz KG, Weisenbach S, Kalbe E, Diederich N, Heiss W. (2005). Cerebral acetylcholine esterase activity in mild cognitive impairment. Neuroreport, 16( 13), 1431-4. eScholarID:1d14185
  • Salmon E, Lespagnard S, Marique P, Peeters F, Herholz, KG, Perani D, Holthoff V, Kalbe E, Anchisi D, Adam S, Collette F, Garraux G. (2005). Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. Journal of Neurology Epub, eScholarID:1d10913
  • Sobesky J, Thiel A, Ghaemi M, Hilker R, Jacobs A, Rudolf J, Herholz KG, Heiss W D. (2005). Crossed cerebellar diaschisis in acute human stroke: A PET study of serial changes and response to supratentorial reperfusion. Journal of Cerebral Blood Flow and Metabolism Epub, eScholarID:1d10968
  • Hilker R, Thomas A, Klein J, Weisenbach S, Kalbe E, Burghaus L, Jacobs A, Herholz KG, Heiss W. (2005). Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology, 65( 11), 1716-22. eScholarID:1d14189
  • Hilker R, Portman A T, Voges J, Staal M J, Burghaus L, van Laar T, Koulousakis A, Maguire R P, Pruim J, Herholz, KG, Sturm V, Heiss W D, Leenders K L. (2005). Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry, eScholarID:1d10911
  • Thiel A, Habedank B, Winhuisen L, Herholz KG, Kessler J, Haupt W F, Heiss W D. (2005). Essential language function of the right hemisphere in brain tumor patients. Annals of Neurology, 57(1), 128-131. eScholarID:1d10908 | DOI:10.1002/ana.20342
  • Herholz KG, Habedank B, Wallesch C W, Forstl. (2005). Funktionelle bildgebende Diagnostik. Demenzen, 134-139. eScholarID:1d10974
  • Anchisi, D, Borroni, B, Franceschi, M, Kerrouche, N, Kalbe, E, Beuthien-Beumann, B, Cappa, S, Lenz, O, Ludecke, S, Marcone, A, Mielke, R, Ortelli, P, Padovani, A, Pelati, O, Pupi, A, Scarpini, E, Weisenbach, S, Herholz, KG, Salmon, E, Holthoff, V, Sorbi, S, Fazio, F, Perani, D. (2005). Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Arch Neurol, 62( 11), 1728-33. eScholarID:1d14184 | DOI:10.1001/archneur.62.11.1728
  • Jacobs A H, Kracht L W, Grossman A, Roger M A, Thomas A V, Thiel A, Herholz KG. (2005). Imaging in Neurooncology. NeuroRx, 2, 333-347. eScholarID:1d10972 | DOI:10.1602/neurorx.2.2.333
  • Mosconi L, Pupi A, Herholz KG, Prohovnik I, Nacmias B, De Cristofaro M T R, Fayyaz M, Bracco L, Sorbi S. (2005). Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. Journal of Neurology, Neurosurgery and Psychiatry, 76 (1), 15-23. eScholarID:1d10910
  • Thiel A, Haupt W F, Habedank B, Winhuisen L, Herholz KG, Kessler J. (2005). Neuroimaging guided rTMS of left inferior frontal gyrus interferes with repetition priming. Neuroimage, 25 (3), 815-823. eScholarID:1d10909
  • Hilker F, Schweitzer K, Coburger S, Ghaemi M, Weisenbach S, Jacobs AH, Rudolf J, Herholz KG, Heiss WD. (2005). Nonlinear Progression of Parkinson Disease as Determined by Serial Positron Emission Tomographic Imaging of Striatal Fluorodopa F 18 Activity. Archives of Neurology, 62 (3), 378-382. eScholarID:1d10905
  • Lange C, Kracht L, Herholz KG, Sachsse U, Irle E. (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research (Neuroimaging Section) Epub, eScholarID:1d10975
  • Holthoff VA, Beuthien-Baumann B, Kalbe E, Ludecke S, Lenz O, Zundorf G, Spirling S, Schierz K, Winiecki P, Sorbi S, Herholz, KG. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry, 57 (4), 412-421. eScholarID:1d10907
  • Cizek J, Herholz KG, Schrader R. (2005). Robust non-linear registration of 3D medical images with one-to-one deformations. Neuroimage, eScholarID:1d10969


  • Mosconi L, Sorbi S, Nacmias B, De Cristofaro M T, Fayyaz M, Bracco L, Herholz KG, Pupi A. (2004). Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study. Psychiatry Research: Neuroimaging, 130(2), eScholarID:1d10983
  • Kracht L W, Miletic H, Busch S, Jacobs A H, Voges J, Hoevels M, Lucht H, Herholz KG, Heiss W D. (2004). Brain Tumor Extent with [11C]-L-methionine Positron Emission Tomography: Local Comparison with Stereotactic Histopatholoy. Clinical Cancer Research, 10, 7163-7170. eScholarID:1d10967 | DOI:10.1158/1078-0432.CCR-04-0262
  • Mosconi L, Nacmias B, Sorbi S, De Cristofaro M T, Fayazz M, Tedde A, Bracco L, Herholz KG, Pupi A. (2004). Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 75(3), eScholarID:1d10977
  • Holthoff V A, Beuthien-Baumann B, Zundorf G, Triemer A, Lundecke S, Winiecki P, Koch R, Fuchtner F, Herholz KG. (2004). Changes in Brain Metabolism Associated with Remission in Unipolar Major Deprssion. Acta Psychiatr.Scand, 110(3), 184-194. eScholarID:1d10980
  • Kracht L W, Miletic H, Busch S, Jacobs A H, Voges J, Hoevels M, Klein J C, Herholz KG, Heiss W D. (2004). Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clinical Cancer Research, 10, 7163-7170. eScholarID:1d26691 | DOI:10.1158/1078-0432.CCR-04-0262
  • Cizek J, Herholz KG, Vollmar S, Schrader R, Klein J, Heiss W D. (2004). Fast and robust registraion of PET and MR images of human brain. Neuroimage, 22(1), 434-442. eScholarID:1d10979
  • Mosconi L, Pupi A, De Cristofaro M T, Fayyaz M, Sorbi S, Herholz KG. (2004). Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease. The journal of Nuclear Medicine, 45(3), 382-392. eScholarID:1d10976
  • Herholz KG, Weisenbach S, Zundorf G, Lenz O, Schrader H, Bauer B, Kalbe E, Heiss W D. (2004). In-vivo Study of Acetylcholine Esterase in Basal Forebrain, Amygdala, and Cortex in Mild to Moderate Alzheimer disease. Neuroimage, 21(1), 136-143. eScholarID:1d10988 | DOI:10.1016/j.neuroimage.2003.09.042
  • Mosconi L, Perani D, Sorbi S, Herholz, KG, Nacmias B, Holthoff V, Salmon E, Baron J C, De Cristofaro M T, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A. (2004). MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET. Neurology, 63(12), 2332-2340. eScholarID:1d10966
  • Herholz, KG, Zundorf G, Bauer B, Weisenbach S, Heiss W D, Silman I, Soreq H, Anglister L, Michaelson D M, Fisher A. (2004). Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional parametric imaging. Cholinergic Mechanisms, eScholarID:1d10981
  • Heiss WD, Habedank B, Klein J C, Herholz KG, Wienhard K, Lenox M, Nutt R. (2004). Metabolic Rates in Small Brain Nuclei Determined by High-Resolution PET. Journal of Nuclear Medicine, 45(11), 1811-1815. eScholarID:1d10965
  • Herholz KG, Herscovitch P, Heiss W D. (2004). NeuroPET. Berlin/Heidelberg/NY: Springer. eScholarID:4d134
  • Galldiks N, Burghaus L, Vollmar S, Cizek J, Impekoven P, Thomas A, Jacobs A H, Herholz KG. (2004). Novel Neuroimaging Findings in a Patient with Cerebral Whipple's Disease: A magnetic Resonance Imaging and Positron Emission Tomography Study. Journal of Neuroimaging, 14(4), 372-376. eScholarID:1d10978
  • Herholz KG, Heiss W D. (2004). PET in clinical neurology. Molecular Imaging & Biology, 6(4), eScholarID:1d10984
  • Hilker R, Voges J, Weisenbach S, Kalbe E, Burghaus L, Ghaemi M, Lehrke R, Koulousakis A, Herholz, KG, Sturm V, Heiss W D. (2004). Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease. Journal of Cerebral Blood Flow & Metabolism, 24, 7. eScholarID:17d214
  • Hartmann P, Herholz KG, Salzberger B, Petereit H F. (2004). Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma. Ann. Hematol, 83(4), eScholarID:1d10982
  • Vollmar S, Cizek J, Sue M, Klein J, Herholz KG, Jacobs A, Kremer K, Macho V. (2004). VINCI -"Volume imaging in Neurological Research, Co-Registration and ROIs included". Forschung and wissenschaftliches Rechnen 2003. eScholarID:3d839


  • Thiel A, Hilker R, Kessler J, Habedank B, Herholz KG, Heiss W D. (2003). Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study. J. Neural Transm, 110(11), eScholarID:1d10989
  • Zundorf G, Kerrouche N, Herholz KG, Baron J C. (2003). An efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging. Hum.Brain Mapp, 18(1), eScholarID:1d11003
  • Mosconi L, Sorbi S, Nacmias B, De Cristofaro M RT R, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz, KG, Pupi A. (2003). Brain metabolic differences between sporadic and familial Alzheimer's disease. Neurology, 61(8), eScholarID:1d10991
  • Scheidhauer K, Herholz KG, Ebmeier K P. (2003). Comparing HMPAO-SPECT and FDG-PET in Alzheimer's Disease. SPECT in dementia. Basel. eScholarID:3d466
  • Hilker R, Voges J, Ghaemia M, Lehrke R, Rudolf J, Koulousakis A, Herholz, KG, Wienhard K, Sturm V, Heiss W D. (2003). Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Mov Disord, 18(1), eScholarID:1d11001
  • Heiss W D, Thiel A, Kessler J, Herholz KG. (2003). Disturbance and recovery of language function: correlates in PET activation studies. Neuroimage, 20(1), eScholarID:1d10990
  • Heiss W D, Thiel A, Winhuisen L, Muhlberger B, Kessler J, Herholz KG. (2003). Functional imaging in the assessment of capability for recovery after stroke. Journal of Rehabilitation Medicine, 35(Suppl), 27-33. eScholarID:1d10997
  • Jacobs A H, Voges J, Kracht L W, Dittmar C, Winkeler A, Thomas A, Wienhard K, Herholz KG, Heiss W D. (2003). Imaging in gene therapy of patients with glioma. J. Neurooncol, 65(3), eScholarID:1d10985
  • Fesl G, Moriggl B, Schmid U D, Naidich T P, Herholz KG, Yousry T A. (2003). Inferior central sulcus: variations of anatomy and function on the example of the motor tongue area. Neuroimage, 20(1), eScholarID:1d10992
  • Kracht L W, Friese M, Herholz KG, Schroeder R, Bauer B, Jacobs A, Heiss W D. (2003). Methyl-[(11)C]- l-methionine uptake as measured by positron emission tomography correlates in microvessel density in patients with glioma. Eur.J Nucl Med Mol.Imaging, 30(6), eScholarID:1d11000
  • Herholz KG, Kracht L, Heiss W D. (2003). Monitoring of the Effect of Chemotherapy in a Mixed Glioma by C-11-methionine PET. Journal of Neuroimaging, 13(3), eScholarID:1d11002
  • Herholz KG. (2003). PET studies in dementia. Annals of Nuclear Medicine, 17(2), 79-89. eScholarID:1d10999
  • Jacobs A H, Li H, Winkeler A, Hilker R, Knoess C, Ruger A, Galldiks N, Schaller B, Sobesky J, Kracht L, Monfared P, Klein M, Vollmar S, Bauer B, Wagner R, Graf R, Wienhard K, Herholz, KG, Heiss W D. (2003). PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol.Imaging, 30, eScholarID:1d10998
  • Salmon E, Garraux G, Delbeuck X, Collette F, Kalbe E, Zuendorf G, Perani D, Fazio F, Herholz KG. (2003). Predominant ventromedial frontopolar metabolic impairment in frontoemporal dementia. Neuroimage, 20(1), eScholarID:1d10993
  • Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz KG, Klein J C, Klosterkitter J. (2003). The Nucleus Accumbens: A Target for Deep Brain Stimulation in Obsessive-Compulsive-and Anxiety-Disorders. Journal of Chemical Neuroanatomy, 26(4), eScholarID:1d10996
  • Ebmeier K P, Darcourt J, Dougall N J, Glasbus M F, Herholz, KG, Koulibaly P M, Migneco O, Nobili F, Pupi A, Robert P, Rodriguez G, Scheidhauer K, Ebmeier K P. (2003). Voxel-based approaches in clinical imaging. SPECT in dementia. Basel. eScholarID:3d840


  • Herholz KG, Kessler J, Ehlen P, Kalbe E, Strotmann T, Markowitsch H J, Senda M, Kimura Y, Herscovitch P. (2002). Brain regions involved in learning face-name associations and the effects of age, performance, and learning phase. Brain imaging using SPECT. San Diego, CA: Academic Press. eScholarID:3d467
  • Hilker R, Voges J, Thiel A, Ghaemi M, Herholz KG, Sturm V, Heiss W D. (2002). Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on-and off-conditions with FDG-PET. Journal of Neural transmission, 10, eScholarID:1d11021
  • Huber M, Herholz KG, Habedank B, Thiel A, Muller-Kuppers M, Ebel H, Subic-Wrana C, Kohle K, Heiss W D. (2002). Differente Muster regionaler Hirnaktivitat nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen. Eine Positronen-Emissions-Tomographische (PET) Studie mit 150-H2O und emotionaler Stimulierung durch autobiographische Erinnerung. Psychother. Psychosom. Med Psychol, 51(11), eScholarID:1d11020
  • Herholz KG, Schopphoff H, Schmidt M, Mielke R, Eschner W, Scheidhauer K, Schicha H, Heiss W D, Ebmeier K P. (2002). Direct comparison of spatially normalized PET and SPECT scans in Alzheimer disease. Journal of Nuclear Medicine, 43(1), eScholarID:1d11024
  • Herholz, KG, Salmon E, Perani D, Baron J C, Holthoff V, Frolich L, Ito K, Mielke R, Kalbe E, Zundorf G, Delbeuck X, Pelati O, Anchisi D, Fazio F, Kerrouche N, Calautti C, Beuthien-Baumann B, Menzel C, Schroder J, Kato T, Arahata Y, Henze M, Heiss W D. (2002). Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET. Neuroimage, 17, 302-316. eScholarID:1d11023 | DOI:10.1006/nimg.2002.1208
  • Szelies B, Sobesky J, Pawlik G, Mielke R, Bauer B, Herholz KG, Heiss W D. (2002). Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [11C]-flumazenil PET. Eur.J Neurol, 9(2), eScholarID:1d11022
  • Jacobs A , Winkler A, Dittmar C, Gossman A, Deckert M, Kracht L, Thiel A, Garlip G, Hilker R, Sobesky J, Vollmar S, Kummer C, Graf R, Voges J, Wienhard K, Herholz, KG, Heiss W D. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas. Technol. Cancer Res Treat, 1(3), eScholarID:1d11008
  • Zundorf G, Herholz, KG, Lercher M, Wienhard K, Bauer B, Weisenbach S, Heiss W D, Senda M, Kimura Y, Herscovitch P. (2002). PET functional parametric images of acetylcholine esterase activity without blood sampling. Brain imaging using PET. San Diego, CA: Academic Press. eScholarID:3d611
  • Heiss W D, Thiel A, Kessler J, Herholz KG. (2002). Sprachaktivierung im PET bei isch,mischen Insulten und Hirntumoren. Zentralblatt fur Neurochirurgie, 63(4), eScholarID:1d32753
  • Hilker R, Klein C, Hedrich K, Ozelius L J, Vieregge P, Herholz KG, Pramstaller P P, Heiss W D. (2002). The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans. Neurosi.Lett, 323(1), eScholarID:1d32785


  • Herholz KG, Perani D, Fazekas F, Markus H, Baumgartner R W, Baron J C. (2001). A survey of neuroimaging research in European neurological departments. Eur.J Neurol, 8(2), eScholarID:1d11025
  • Huber M, Siol T, Herholz KG, Lenz O, Kohle K, Heiss W D. (2001). Activation of Thalamo-Cortical Systems in Post-Traumatic Flashbacks: A Positron Emission Tomography Study. Traumatology, 7(4), eScholarID:1d11026
  • Jauss M, Herholz KG, Kracht L, Pantel J, Hartmann T, Jensen M, Essig M, Schroder. (2001). Frontotemporal dementia: Clinical, neuroimaging and molecular biological findings in 6 patients. European Archives of Psychiatry & Clinical Neuroscience, 251, eScholarID:1d11027
  • Ghaemi M, Rudolf J, Hilker R, Herholz KG. (2001). Increased pineal Fdopa uptake is related to severity of Parkinson's disease - a PET study. J. Pineal Res, 30 (4), eScholarID:1d11095
  • Herholz KG, Ehlen P, Kessler J, Strotmann T, Kalbe E, Markowitsch H J. (2001). Learning face-name associations and the effect of age and performance:a PET activation study. Neuropsychologia, 39, eScholarID:1d11098
  • Herholz KG, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss W D. (2001). PET measurement of cerebral acetylcholine esterase activity without blood sampling. European Journal of Nuclear Medicine, 28, eScholarID:1d11097
  • Thiel A, Herholz KG, Koyuncu A, Ghaemi M, Kracht L W, Habedank B, Heiss W D. (2001). Plasticity of language networks in patients with brain tumors. A positron emission tomography activation study. Annals of Neurology, 50, eScholarID:1d11028
  • Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius L J, Lenz O, Vieregge P, Herholz, KG, Heiss W D, Pramstaller P P. (2001). Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Annals of Neurology, 49, 367-76. eScholarID:1d11096 | DOI:10.1002/ana.74


  • Bartenstein, P, Grünwald, F, Kuwert, T, Tatsch, K, Sabri, O, Benkert, O, Fahlbusch, R, Gründer, G, Herholz, KG, Weiller, C. (2000). Clinical applications of single photon emission tomography in neurology. 2. Dementia, psychoses, inflammation, skull and brain injuries. Nuklearmedizin, 39( 8), 218-32. eScholarID:1d14182
  • Bartenstein P, Grunwald F, Kuwert T, Tatsch K, Sabri O, Benkert O, Fahlbusch R, Grunder G, Herholz, KG, Weiller C. (2000). Clinical applications of single photon emission tomography in neuromedicine. 1. Neuro-oncology, epilepsy, movement disorders, cerebrovascular disease. Nuklearmedizin, 39(7), 180-95. eScholarID:1d14183
  • Thiel A, Pietrzyk U, Sturm V, Herholz KG, Hovels M, Schroder R. (2000). Enhanced accuracy in differential diagnosis of radiation necrosis by positron emission tomography-magnetic resonance imaging coregistration: technical case report. Neurosurgery, 46 (1), eScholarID:1d11099
  • Kessler J, Mielke R, Grond M, Herholz KG, Heiss W D. (2000). Frontal lobe tasks do not reflect frontal lobe function in patients with probable Alzheimer's disease. Journal of Neuroscience, 1, eScholarID:1d11101
  • Herholz KG, Heiss W D. (2000). Functional imaging correlates of recovery after stroke in humans. Journal of Cerebral Blood Flow & Metabolism, 20, eScholarID:1d11100
  • Herholz KG, Bauer B, Wienhard K, Kracht L, Mielke R, Lenz O, Strotmann T, Heiss W D. (2000). In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. J Neural Transm, 12, eScholarID:1d11174
  • Muzik O, Da Silva E A, Juhasz C, Chugani D C, Shah J, Nagy F, Canady A, von Stockhausen H M, Herholz, KG, Gates J, Frost M, Ritter F, Watson C, Chugani H T. (2000). Intracranial EEG vs. flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology, 54, eScholarID:1d11175