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Pr Dm Nancy Rothwell - publications

List of publications

2016

  • PhD, C. O., PhD, B. H., PhD, S. M. A., PhD, S. A., PhD, F. C., Tae, H. C. M. D., ... PhD, D. V. (2016). Efficacy of Alteplase ® in a mouse model of acute ischemic stroke: a retrospective pooled analysis. Stroke. . Publication link: b96c8c5e-b593-4856-9278-d41ca0e4c061
  • Abdulaal, W., Walker, C., Costello, R., Redondo Castro, E., Mufazalov, I. A., Papaemmanouil, A., ... Müller, W. (2016). Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system. European journal of immunology. DOI:10.1002/eji.201546075. Publication link: c1f6e3f5-d2a0-4750-9108-07eb10ca4480 | PubMed:26692072
  • Sobowale, O., Parry-Jones, A., Smith, C. J., Tyrrell, P., Rothwell, N., & Allan, S. (2016). Interleukin-1 in Stroke. From Bench to Bedside. Stroke, 47. DOI:10.1161/STROKEAHA.115.010001. Publication link: 77efd5d7-4513-4a4c-a426-f904884627c0

2015

  • Denes, A., Coutts, G., Lénárt, N., Cruickshank, S. M., Pelegrin, P., Skinner, J., ... Brough, D. (2015). AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3. Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4050-4055. DOI:10.1073/pnas.1419090112. Publication link: c77745b4-3f70-467d-bcac-3c8e9213f5ea | PubMed:25775556
  • Ogungbenro, K., Hulme, S., Rothwell, N., Hopkins, S., Tyrrell, P., & Galea, J. (2015). Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist. Journal of Pharmacokinetics and Pharmacodynamics, 43, 1-12. . Publication link: 952929f8-471d-4b91-abc9-418b504583ea
  • Brough, D., Rothwell, N., & Allan, S. M. (2015). Interleukin-1 as a pharmacological target in acute brain injury.Experimental Physiology, In press. DOI:10.1113/EP085135. Publication link: 8b76901b-e8ff-4fa9-9c35-9d1a7b8df306 | PubMed:26096539
  • Ogungbenro, K., Hulme, S., Rothwell, N., Hopkins, S., Tyrrell, P., & Galea, J. (2015). Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist.Journal of pharmacokinetics and pharmacodynamics. DOI:10.1007/s10928-015-9450-0. Publication link: 0c36d1e0-1cdc-47b5-9a15-c620aa0e9659 | PubMed:26476629
  • Maysami, S., Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., ... Allan, S. M. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. DOI:10.1177/0271678X15606714. Publication link: 4a14af81-beba-4d7e-aa6b-599130fa3a96

2014

  • Girard, S., Murray, K. N., Rothwell, N. J., Metz, G. A. S., & Allan, S. M. (2014). Long-term functional recovery and compensation after cerebral ischemia in rats. Behavioural Brain Research, 270, 18-28. DOI:10.1016/j.bbr.2014.05.008. Publication link: 7aa5d87e-ca7e-4a39-87d8-997b3ed07ec3 | PubMed:24821402
  • England, H., Summersgill, H., Edye, M., Rothwell, N., & Brough, D. (2014). Release of interleukin-1 α or interleukin-1 β depends on mechanism of cell death. Journal of Biological Chemistry, 289(23), 15942-15950. DOI:10.1074/jbc.M114.557561. Publication link: 2d2f381d-ca00-4367-86d2-3d8c723abf21 | PubMed:24790078
  • Rodriguez-Grande, B., Swana, M., Nguyen, L., Englezou, P., Maysami, S., Allan, S. M., ... Pinteaux, E. (2014). The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. Journal of Cerebral Blood Flow and Metabolism, 34(3), 480-488. DOI:10.1038/jcbfm.2013.224. Publication link: 335003e0-c648-4649-91f6-df6e67895ce4 | PubMed:24346689
  • Denes, A., Pradillo, J., Drake, C., Sharp, A., Warn, P., Murray, K. N., ... Allan, S. M. (2014). Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Annals of Neurology, 75(5), 670-683. DOI:10.1002/ana.24146, 10.1002/ana.24146. Publication link: 210c8990-49c0-4fe8-ab5c-58b0dc65c7e5 | PubMed:24644058
  • Singh, N., Hopkins, S. J., Hulme, S., Galea, J. P., Hoadley, M., Vail, A., ... Tyrrell, P. J. (2014). The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: A phase II randomised controlled trial. Journal of Neuroinflammation, 11, [1]. DOI:10.1186/1742-2094-11-1. Publication link: 1d127985-1566-4509-8a2e-aed8de48d009 | PubMed:24383930
  • Giles, J. A., Greenhalgh, A. D., Davies, C. L., Denes, A., Shaw, T., Coutts, G., ... Allan, S. M. (2014). Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.European journal of immunology. DOI:10.1002/eji.201444748. Publication link: b191bacc-9944-4fd8-86e9-87c8e761782a | PubMed:25367678

2013

  • Denes, A., Wilkinson, F., Bigger, B., Chu, M., Rothwell, N. J., & Allan, S. M. (2013). Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice. DMM Disease Models and Mechanisms, 6(4), 1043-1048. DOI:10.1242/dmm.011601. Publication link: fe5c07a7-90cf-46bc-ad29-861bbfd72452 | PubMed:23519030
  • Girard, S., Brough, D., Lopez-Castejon, G., Giles, J., Rothwell, N. J., & Allan, S. M. (2013). Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. GLIA, 61(5), 813-824. DOI:10.1002/glia.22478. Publication link: e88c3626-25b9-4423-9209-a1a8e8944959 | PubMed:23404620
  • Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A. D., Smigova, A., ... Rothwell, N. J. (2013). [18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats. PLoS ONE, 8(2), [e56441]. DOI:10.1371/journal.pone.0056441. Publication link: 6f04c569-e85f-406a-858c-432b98a53fe1 | PubMed:23418569
  • Tyrrell, P., McMahon, C. J., Hopkins, S., Vail, A., King, A. T., Smith, D., ... Tyrrell, P. J. (2013). Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage. Journal of NeuroInterventional Surgery, 5(6), 512-517. DOI:10.1136/neurintsurg-2012-010386. Publication link: 74787425-9722-4669-9d8d-d201a6ed988b | PubMed:22952245
  • Denes, A., Pradillo, J. M., Drake, C., Buggey, H., Rothwell, N. J., & Allan, S. M. (2013). Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice.Frontiers in Neuroscience, 7. DOI:10.3389/fnins.2013.00271. Publication link: a66c9a7d-a8ac-4193-a92e-bc90e420696c | PubMed:24478617

2012

  • Greenhalgh, A. D., Brough, D., Robinson, E. M., Girard, S., Rothwell, N. J., & Allan, S. M. (2012). Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. DMM Disease Models and Mechanisms, 5(6), 823-833. DOI:10.1242/dmm.008557. Publication link: 48009fe1-dcbd-4c54-98a4-91ed4d04439f | PubMed:22679224
  • Leow-Dyke, S., Allen, C., Denes, A., Nilsson, O., Maysami, S., Bowie, A. G., ... Pinteaux, E. (2012). Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. Journal of Neuroinflammation, 9, [230]. DOI:10.1186/1742-2094-9-230. Publication link: 4a9189ff-f135-4933-9b39-4c977dbf43e2 | PubMed:23034047
  • Smith, C. J., Emsley, H. C., Udeh, C. T., Vail, A., Hoadley, M. E., Rothwell, N. J., ... Hopkins, S. J. (2012). Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine, 58(3), 384-389. DOI:10.1016/j.cyto.2012.02.016. Publication link: 05b8908d-f97f-46b1-9b56-6e45877f0aa4 | PubMed:22445501
  • Hopkins, S. J., McMahon, C. J., Singh, N., Galea, J., Hoadley, M., Scarth, S., ... Tyrrell, P. J. (2012). Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection. Journal of Neuroinflammation, 9, [255]. DOI:10.1186/1742-2094-9-255. Publication link: 0969ac89-83b4-4d39-b417-39e797481d8c | PubMed:23176037
  • Denes, A., Drake, C., Stordy, J., Chamberlain, J., McColl, B. W., Gram, H., ... Rothwell, N. J. (2012). Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis.Journal of the American Heart Association, 1(3). DOI:10.1161/JAHA.112.002006. Publication link: 63a7d554-0a9b-4343-91fe-6921d120eca8 | PubMed:23130147
  • Pradillo, J. M., Denes, A., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., ... Allan, S. M. (2012). Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats. Journal of Cerebral Blood Flow and Metabolism, 32(9), 1810-1819. DOI:10.1038/jcbfm.2012.101. Publication link: 78aa70ba-56f1-47ef-bc41-952f8c3dea56 | PubMed:22781338
  • Allen, C., Thornton, P., Denes, A., McColl, B. W., Pierozynski, A., Monestier, M., ... Allan, S. M. (2012). Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. Journal of Immunology, 189(1), 381-392. DOI:10.4049/jimmunol.1200409. Publication link: b9acc387-25cb-46cd-8e56-34b90586e81a | PubMed:22661091

2011

  • Greenhalgh, A. D., Ogungbenro, K., Rothwell, N. J., & Galea, J. P. (2011). Translational pharmacokinetics: Challenges of an emerging approach to drug development in stroke. Expert Opinion on Drug Metabolism and Toxicology, 7(6), 681-695. DOI:10.1517/17425255.2011.570259. Publication link: b6c8b35e-339e-49e2-89ec-a3a24140fb6a | PubMed:21521135
  • Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., ... Boutin, H. (2011). Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [ 18F]-IL1RA and PET imaging in rats. British Journal of Pharmacology, 162(3), 659-672. DOI:10.1111/j.1476-5381.2010.01068.x. Publication link: bd775181-2843-4194-baf5-82fb01857d8f | PubMed:20942812
  • Drake, C., Boutin, H., Jones, M. S., Denes, A., McColl, B. W., Selvarajah, J. R., ... Taylor, S. (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity, 25(6), 1113-1122. DOI:10.1016/j.bbi.2011.02.008. Publication link: f0dcffc5-d229-413f-9543-00048acccd6b | PubMed:21356305
  • Denes, A., McColl, B. W., Leow-Dyke, S. F., Chapman, K. Z., Humphreys, N. E., Grencis, R. K., ... Rothwell, N. J. (2011). Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses. Journal of Cerebral Blood Flow and Metabolism, 31(4), 1036-1050. DOI:10.1038/jcbfm.2010.198. Publication link: fb87ca10-a7aa-47e5-b3e9-b9298dd92f81 | PubMed:21045863
  • Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., ... Tyrrell, P. (2011). Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study. Journal of Cerebral Blood Flow and Metabolism, 31(2), 439-447. DOI:10.1038/jcbfm.2010.103. Publication link: a8266f08-3c99-45d6-8b9b-1c219472c0cd | PubMed:20628399
  • Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., Lopez-Casteon, G., Rothwell, N. J., ... Kell, D. B. (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nature Chemical Biology, 7(12), 902-908. DOI:10.1038/nchembio.689. Publication link: a9a386a1-3e7f-4ba8-9fa8-9ed58056e249 | PubMed:22020553
  • Nguyen, L., Rothwell, N. J., Pinteaux, E., & Boutin, H. (2011). Contribution of interleukin-1 receptor accessory protein b to interleukin-1 actions in neuronal cells. NeuroSignals, 19(4), 222-230. DOI:10.1159/000330803. Publication link: 9c9196d3-a173-4c73-a19e-b3aed8a7a288 | PubMed:21968452
  • Denes, A., Pinteaux, E., Rothwell, N. J., & Allan, S. M. (2011). Interleukin-1 and stroke: Biomarker, harbinger of damage, and therapeutic target. Cerebrovascular Diseases, 32(6), 517-527. DOI:10.1159/000332205. Publication link: 37670d5d-4c19-41d4-93e7-baefed6db103 | PubMed:22104408

2010

2009

2008

  • McColl, B. W., Rothwell, N. J., & Allan, S. M. (2008). Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. Journal of Neuroscience, 28(38), 9451-9462. DOI:10.1523/JNEUROSCI.2674-08.2008. Publication link: 36aa3a6c-cc92-408a-8908-fbb489d315df | PubMed:18799677
  • Tsakiri, N., Kimber, I., Rothwell, N. J., & Pinteaux, E. (2008). Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Molecular and Cellular Neuroscience, 37(1), 110-118. DOI:10.1016/j.mcn.2007.09.001. Publication link: 3f7808a7-4484-42ef-849c-1feaee851001 | PubMed:17933551
  • Clark, S. R., McMahon, C. J., Gueorguieva, I., Rowland, M., Scarth, S., Georgiou, R., ... Rothwell, N. J. (2008). Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. Journal of Cerebral Blood Flow and Metabolism, 28(2), 387-394. DOI:10.1038/sj.jcbfm.9600537. Publication link: 542d72fb-8065-4278-b1c1-4a05fff00aa9
  • Gueorguieva, I., Clark, S. R., McMahon, C. J., Scarth, S., Rothwell, N. J., Tyrell, P. J., ... Tyrrell, P. (2008). Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. British Journal of Clinical Pharmacology, 65(3), 317-325. DOI:10.1111/j.1365-2125.2007.03026.x. Publication link: 4c52426e-836e-4461-b77f-a29501f0f9d3 | PubMed:17875190
  • Parry-Jones, A., Parry-Jones, A. R., Liimatainen, T., Kauppinen, R. A., Gröhn, O. H. J., & Rothwell, N. J. (2008). Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat. Magnetic Resonance in Medicine, 59(6), 1239-1249. DOI:10.1002/mrm.21531. Publication link: 6a72fcea-429e-48f9-b4b6-b58a5e208fdb | PubMed:18421691
  • Tsakiri, N., Kimber, I., Rothwell, N. J., & Pinteaux, E. (2008). Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones. Molecular and Cellular Neuroscience, 38(2), 259-265. DOI:10.1016/j.mcn.2008.02.015. Publication link: 67f3e8b8-3863-4ebf-a922-cbaff498dc0d | PubMed:18434191
  • Wang, P., Rothwell, N. J., Pinteaux, E., & Brough, D. (2008). Neuronal injury induces the release of pro-interleukin-1β from activated microglia in vitro. Brain Research, 1236, 1-7. DOI:10.1016/j.brainres.2008.08.001. Publication link: d6e2d30e-0b4b-4fa0-8c3a-79699eda885c | PubMed:18722361
  • Thornton, P., Pinteaux, E., Allan, S. M., & Rothwell, N. J. (2008). Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Molecular and Cellular Neuroscience, 37(1), 135-142. DOI:10.1016/j.mcn.2007.09.002. Publication link: d486845f-fd0e-4418-8e35-7cd4463b3113 | PubMed:17939964
  • Smith, C. J., Ross, J., Rothwell, N., & Tyrrell, P. (2008). Acute neurodegeneration: cerebral ischaemia and stroke. In Mechanisms of Disease. (Second edition ed., pp. 191-209). New York, US: Cambridge University Press. . Publication link: b0d3c873-4b1a-4531-8996-a5146dfe8dc3
  • Tsakiri, N., Kimber, I., Rothwell, N. J., & Pinteaux, E. (2008). Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones. British Journal of Pharmacology, 153(4), 775-783. DOI:10.1038/sj.bjp.0707610. Publication link: e0f46773-ff45-445f-bcf3-3cfa74237d0f | PubMed:18059318

2007

  • McColl, B. W., Allan, S. M., & Rothwell, N. J. (2007). Systemic inflammation and stroke: Aetiology, pathology and targets for therapy. Biochemical Society Transactions, 35(5), 1163-1165. DOI:10.1042/BST0351163. Publication link: febccf8a-3dfb-4998-b2ce-a3c107cdbf8b | PubMed:17956302
  • Hutchinson, P. J., O'Connell, M. T., Rothwell, N. J., Hopkins, S. J., Nortje, J., Carpenter, K. L. H., ... Pickard, J. D. (2007). Inflammation in human brain injury: Intracerebral concentrations of IL-1α, IL-1β, and their endogenous inhibitor IL-1ra. Journal of Neurotrauma, 24(10), 1545-1557. DOI:10.1089/neu.2007.0295. Publication link: c9a05c8b-e98c-480e-b116-c7e2431e7515
  • Emsley, H. C. A., Smith, C. J., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., ... Hopkins, S. J. (2007). Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurology, 7, [5]. DOI:10.1186/1471-2377-7-5. Publication link: 6b96d271-95f9-4cec-b96b-97ce97aefd39 | PubMed:17328808
  • Brough, D., & Rothwell, N. J. (2007). Caspase-1-dependent processing of pro-interlukin-1β is cytosolic and precedes cell death. Journal of Cell Science, 120(5), 772-781. DOI:10.1242/jcs.03377. Publication link: 62e8f6a8-1ca8-4db6-a3c0-cbf4fad97c82
  • Simi, A., Tsakiri, N., Wang, P., & Rothwell, N. J. (2007). Interleukin-1 and inflammatory neurodegeneration. Biochemical Society Transactions, 35(5), 1122-1126. DOI:10.1042/BST0351122. Publication link: 7b9f9972-e570-4f2a-bb58-a50a1187466e | PubMed:17956293
  • Pinteaux, E., Inoue, W., Schmidt, L., Molina-Holgado, F., Rothwell, N. J., & Luheshi, G. N. (2007). Leptin induces interleukin-1β release from rat microglial cells through a caspase 1 independent mechanism. Journal of Neurochemistry, 102(3), 826-833. DOI:10.1111/j.1471-4159.2007.04559.x. Publication link: ab9f2a12-5f48-4371-88c7-82e6544dadf4 | PubMed:17419800
  • McColl, B. W., Rothwell, N. J., & Allan, S. M. (2007). Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms. Journal of Neuroscience, 27(16), 4403-4412. DOI:10.1523/JNEUROSCI.5376-06.2007. Publication link: a319031f-08bf-4a85-8e39-0964e5e670a2 | PubMed:17442825
  • Miggin, S. M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., ... O'Neill, L. A. J. (2007). NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proceedings of the National Academy of Sciences of the United States of America, 104(9), 3372-3377. DOI:10.1073/pnas.0608100104. Publication link: 2fc821fa-6edd-49db-bda0-becbbc0cc911 | PubMed:17360653
  • Rothwell, N. J., Hutchinson, P., O'Connell, M., Hopkins, S. J., Nortje, J., Carpenter, K., ... Pickard, J. (2007). Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.J Neurotrauma, 24( 10). . Publication link: 157cb91a-0b77-4c52-885c-2f759be1c15e
  • Watson, P. M. D., Humphries, M. J., Relton, J., Rothwell, N. J., Verkhratsky, A., & Gibson, R. M. (2007). Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Molecular and Cellular Neuroscience, 34(2), 147-154. DOI:10.1016/j.mcn.2006.10.007. Publication link: 2850152c-2f4b-424c-a0fb-c0148872cd78 | PubMed:17150373
  • Parry-Jones, A. R., & Rothwell, N. (2007). Brain Temperature and Interleukin-1 in Focal Cerebral Ischaema. University of Manchester.. Publication link: 0a2b2a4b-9954-40fc-a4ef-07917d0b149c
  • Ross, J., Brough, D., Gibson, R. M., Loddick, S. A., & Rothwell, N. J. (2007). A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Neuropharmacology, 53(5), 638-642. DOI:10.1016/j.neuropharm.2007.07.015. Publication link: 03d67478-9444-4f16-bd28-7e2910578ba6 | PubMed:17845807

2006

2005

2004

  • Smith, C. J., Emsley, H. C. A., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., ... Tyrrell, P. (2004). Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurology, 4, [2]. DOI:10.1186/1471-2377-4-2. Publication link: a58545c4-d19c-49cc-a34b-a0f6584c854c | PubMed:14725719
  • Vail, A., Rothwell, N. J., Smith, C., Emsley, H., Gavin, C., Georgiou, R., ... Tyrrell, P. (2004). Correction: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome.BMC Neurol, 4( 1). . Publication link: 37504c08-0b33-4833-a885-4d09af748e8d
  • Gibson, R. M., Rothwell, N. J., & Le Feuvre, R. A. (2004). CNS injury: The role of the cytokine IL-1. Veterinary Journal, 168(3), 230-237. DOI:10.1016/j.tvjl.2003.10.016. Publication link: 129350eb-6e5e-4c08-9474-b7b71366435d | PubMed:15501140

2003

  • Berglöf, E., Andre, R., Renshaw, B. R., Allan, S. M., Lawrence, C. B., Rothwell, N. J., & Pinteaux, E. (2003). IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. Journal of Neuroimmunology, 139(1-2), 36-43. DOI:10.1016/S0165-5728(03)00130-9. Publication link: cb0f279b-7c02-4d28-9428-e89810abbc3a | PubMed:12799018
  • Wheeler, R. D., Brough, D., Le Feuvre, R. A., Takeda, K., Iwakura, Y., Luheshi, G. N., & Rothwell, N. J. (2003). Interleukin-18 induces expression and release of cytokines from murine glial cells: Interactions with interleukin-1β. Journal of Neurochemistry, 85(6), 1412-1420. DOI:10.1046/j.1471-4159.2003.01787.x. Publication link: b953c5ad-3392-4148-beb9-59ca9c1eb32a | PubMed:12787061
  • Molina-Holgado, F., Pinteaux, E., Moore, J. D., Molina-Holgado, E., Guaza, C., Gibson, R. M., & Rothwell, N. J. (2003). Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. Journal of Neuroscience, 23(16), 6470-6474. . Publication link: fbf728e9-00ad-43e6-b2fa-756302b5cd52 | PubMed:12878687
  • Wheeler, R. D., Young, E. A., Rothwell, N. J., Hall, M. D., & Luheshi, G. N. (2003). Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine, 21(4), 161-166. DOI:10.1016/S1043-4666(03)00028-0. Publication link: e5e0469f-acf8-4726-8d8a-ecf59ba19ed8 | PubMed:12788303
  • Andre, R., Wheeler, R. D., Collins, P. D., Luheshi, G. N., Pickering-Brown, S., Kimber, I., ... Pinteaux, E. (2003). Identification of a truncated IL-18Rβ mRNA: A putative regulator of IL-18 expressed in rat brain. Journal of Neuroimmunology, 145(1-2), 40-45. DOI:10.1016/j.jneuroim.2003.09.005. Publication link: 28bacc8b-9c88-4898-9104-f733e1f16c53 | PubMed:14644029
  • Boutin, H., Kimber, I., Rothwell, N. J., & Pinteaux, E. (2003). The Expanding Interleukin-1 Family and Its Receptors: Do Alternative IL-1 Receptor/Signaling Pathways Exist in the Brain?. Molecular Neurobiology, 27(3), 239-248. DOI:10.1385/MN:27:3:239. Publication link: 0be0adcd-4c4a-4971-bf1b-a61cd0dfd1c3 | PubMed:12845150
  • Rothwell, N. (2003). Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential. Brain, Behavior, and Immunity, 17(3), 152-157. DOI:10.1016/S0889-1591(02)00098-3. Publication link: 3682deb1-241f-4117-a958-62b209cdaf07
  • Le Feuvre, R. A., Brough, D., Touzani, O., & Rothwell, N. J. (2003). Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. Journal of Cerebral Blood Flow and Metabolism, 23(3), 381-384. DOI:10.1097/00004647-200303000-00013. Publication link: 2eee4e51-3727-4f98-96f4-dc7b2e549de4 | PubMed:12621313
  • Rothwell, N. J., Andre, R., Wheeler, R., Collins, P., Luheshi, G., Pickering-Brown, S., ... Pinteaux, E. (2003). Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.J Neuroimmunol, 145( 1-2). . Publication link: 39805639-ecee-4010-a5b3-1c6758ff7b5d
  • Emsley, H. C. A., Smith, C. J., Gavin, C. M., Georgiou, R. F., Vail, A., Barberan, E. M., ... Tyrrell, P. (2003). An early and sustained peripheral inflammatory response in acute ischaemic stroke: Relationships with infection and atherosclerosis. Journal of Neuroimmunology, 139(1-2), 93-101. DOI:10.1016/S0165-5728(03)00134-6. Publication link: 68b2a819-1574-43f8-9f6c-2339bfa17953 | PubMed:12799026
  • Wheeler, R. D., Boutin, H., Touzani, O., Luheshi, G. N., Takeda, K., & Rothwell, N. J. (2003). No role for interleukin-18 in acute murine stroke-induced brain injury. Journal of Cerebral Blood Flow and Metabolism, 23(5), 531-535. . Publication link: 6096014c-5ba0-44bd-bb31-fa96f43b241d | PubMed:12771567
  • Brough, D., feuvre, R. L., Wheeler, R. D., Solovyova, N., Hilfiker , S., Rothwell, N., & Verkhratsky, A. (2003). Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.Journal of immunology (Baltimore, Md. : 1950), 170(6). . Publication link: 8013c22c-c5fe-4a32-bff3-e406878e48fc | PubMed:12626557
  • Allan, S. M., & Rothwell, N. J. (2003). Inflammation in central nervous system injury. Philosophical Transactions of the Royal Society B: Biological Sciences, 358(1438), 1669-1677. DOI:10.1098/rstb.2003.1358. Publication link: aeafe0b9-0c9d-435d-bc8f-0ffaf522dc59 | PubMed:14561325
  • Mulcahy, N. J., Ross, J., Rothwell, N. J., & Loddick, S. A. (2003). Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. British Journal of Pharmacology, 140(3), 471-476. DOI:10.1038/sj.bjp.0705462. Publication link: b073a258-9269-4477-b9ad-3cf9286e8970
  • Ross, F. M., Allan, S. M., Rothwell, N. J., & Verkhratsky, A. (2003). A dual role for interleukin-1 in LTP in mouse hippocampal slices. Journal of Neuroimmunology, 144(1-2), 61-67. DOI:10.1016/j.jneuroim.2003.08.030. Publication link: aaeec687-1231-4ecb-817f-e42609419a39 | PubMed:14597099

2002

2001

2000

  • Craighead, M. W., Boutin, H., Middlehurst, K. M. L., Allan, S. M., Brooks, N., Kimber, I., & Rothwell, N. J. (2000). Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo. Brain Research, 881(2), 139-143. DOI:10.1016/S0006-8993(00)02759-1. Publication link: 1756adad-4280-4da4-9c22-006fb49a687e | PubMed:11036151
  • Wheeler, R. D., Culhane, A. C., Hall, M. D., Pickering-Brown, S., Rothwell, N. J., & Luheshi, G. N. (2000). Detection of the interleukin 18 family in rat brain by RT-PCR. Molecular Brain Research, 77(2), 290-293. DOI:10.1016/S0169-328X(00)00069-3. Publication link: 1f5e580b-2399-4112-b38b-d43cbc86b568
  • Rothwell, N. J., Parker, L., Rushforth, D., & Luheshi, G. (2000). IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.Brain Res Mol Brain Res, 79( 1-2). . Publication link: 363e6e01-b8f6-4f1c-a45a-1ca56641c235
  • Cartmell, T., Poole, S., Turnbull, A. V., Rothwell, N. J., & Luheshi, G. N. (2000). Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. Journal of Physiology, 526(3), 653-661. . Publication link: 901962bb-ebf6-4b6b-a17e-900e5d80ede0
  • Zampronio, A. R., Hoadley, M. E., Luheshi, G., Rothwell, N. J., Petto de Souza, G. E., & Hopkins, S. J. (2000). Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages. European cytokine network, 11(4), 589-596. . Publication link: 8c512a81-9295-435f-ab20-5084661246fb
  • Allan, S. M., Parker, L. C., Collins, B., Davies, R., Luheshi, G. N., & Rothwell, N. J. (2000). Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5580-5585. DOI:10.1073/pnas.090464197. Publication link: 81c2d849-b62e-4f74-a157-c8f5ffeb79f2 | PubMed:10779559
  • Allan, S. M., & Rothwell, N. J. (2000). Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors. Journal of Cerebral Blood Flow and Metabolism, 20(10), 1409-1413. . Publication link: 68b14f38-163c-46f1-bcdb-ad156fc233b8 | PubMed:11043903
  • Rothwell, N. J., & Luheshi, G. N. (2000). Interleukin 1 in the brain: Biology, pathology and therapeutic target. Trends in Neurosciences, 23(12), 618-625. DOI:10.1016/S0166-2236(00)01661-1. Publication link: 5ef0be21-9947-4657-98da-2189e7868846
  • Molina-Holgado, F., Toulmond, S., & Rothwell, N. J. (2000). Involvement of interleukin-1 in glial responses to lipopolysaccharide: Endogenous versus exogenous interleukin-1 actions. Journal of Neuroimmunology, 111(1-2), 1-9. DOI:10.1016/S0165-5728(00)00344-1. Publication link: d5fcba9d-c5ba-45e6-80c9-ebf133172491
  • Rothwell, N. J. (2000). Show them how it's really done.Nature, 405( 6787). . Publication link: dece3a43-ebb5-401d-868b-f8a1249179c9

1999

  • Rothwell, N. J., Artis, D., Humphreys, N., Bancroft, A., Potten, C., & Grencis, R. (1999). Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.J Exp Med, 190( 7). . Publication link: fc6e6197-b665-4652-8931-b264bf6bc35d
  • Rothwell, N. J. (1999). Cytokines "Killers in the Brain". Journal of physiology, Paris, 514.1. . Publication link: cdefc4e8-5cf6-48be-b6e9-350cb0ab8429
  • Touzani, O., Boutin, H., Chuquet, J., & Rothwell, N. (1999). Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. Journal of Neuroimmunology, 100(1-2), 203-215. DOI:10.1016/S0165-5728(99)00202-7. Publication link: b50ca412-1680-4b4a-8f07-1eeb20d23454 | PubMed:10695731
  • Davies, C. A., Rothwell, N. J., Loddick, S., Toulmond, S., Stroemer, R., & Hunt, J. (1999). The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat.J Cereb Blood Flow Metab, 19( 1). . Publication link: c4ba411d-e734-40b9-a032-86e2058a0995
  • Rothwell, N. J., & Loddick, S. (1999). Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1.Proc Natl Acad Sci U S A, 96( 17). . Publication link: 358ad653-2bc7-45b2-8fd1-aae3bf95ea91
  • Lawrence, C. B., Turnbull, A. V., & Rothwell, N. J. (1999). Hypothalamic control of feeding. Current Opinion in Neurobiology, 9(6), 778-783. . Publication link: 1576f5c0-d1e3-4e0b-bd85-df24d9d654c5 | PubMed:10607641
  • Luheshi, G. N., Gardner, J. D., Rushforth, D. A., Loudon, A. S., & Rothwell, N. J. (1999). Leptin actions on food intake and body temperature are mediated by IL-1. Proceedings of the National Academy of Sciences of the United States of America, 96(12), 7047-7052. DOI:10.1073/pnas.96.12.7047. Publication link: 14396b36-2c93-4b48-a61c-870684603768 | PubMed:10359836
  • Lenczowski, M. J. P., Bluthé, R. M., Roth, J., Rees, G. S., Rushforth, D. A., Van Dam, A. M., ... Luheshi, G. N. (1999). Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. AJP: Regulatory, Integrative and Comparative Physiology, 276(3), R652-R658. . Publication link: 5b83704c-73e7-424e-8afb-265c768d7664
  • Cartmell, T., Luheshi, G. N., & Rothwell, N. J. (1999). Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. Journal of Physiology, 518(2), 585-594. DOI:10.1111/j.1469-7793.1999.0585p.x. Publication link: 7d79c420-9a6f-40fd-a353-8899b543fc3a
  • Rothwell, N. J. (1999). Annual review prize lecture cytokines - killers in the brain?. Journal of Physiology, 514, 1. . Publication link: 7ceb8c1f-9255-4826-894c-9d4b3cdf0a1e
  • Rothwell, N. J., Pearson, V., & Toulmond, S. (1999). Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death.Glia, 25( 4). . Publication link: af1fdbee-26a7-4c7d-b4a6-1c96936743d2
  • Grundy, R. I., Rothwell, N. J., & Allan, S. M. (1999). Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat. Brain Research, 830(1), 32-37. DOI:10.1016/S0006-8993(99)01377-3. Publication link: a662db73-2aa6-4594-ae0c-c3624b9eb271 | PubMed:10350557

1998

  • Rothwell, N. J., Lawrence, C., & Allan, S. (1998). Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat.Eur J Neurosci, 10( 3). . Publication link: 9c4a66df-70f2-4ff5-a249-7b4dbe0bd15e
  • Davies, C. A., Loddick, S. A., Stroemer, R. P., Hunt, J., & Rothwell, N. J. (1998). An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat. Experimental Neurology, 154(1), 199-212. DOI:10.1006/exnr.1998.6891. Publication link: 72bdb904-a873-48a1-915d-105be1f85a8e
  • Huitinga, I., Bauer, J., Strijbos, P. J. L. M., Rothwell, N. J., Dijkstra, C. D., & Tilders, F. J. H. (1998). Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Clinical and Experimental Immunology, 111(1), 198-204. DOI:10.1046/j.1365-2249.1998.00490.x. Publication link: 6f103af7-5f79-4daa-986d-81b7a18d3238
  • Gardner, J. D., Rothwell, N. J., & Luheshi, G. N. (1998). Leptin affects food intake via CRF-receptor-mediated pathways. Nature Neuroscience, 1(2), 103. . Publication link: 6b320dfb-e6b1-4aaa-adad-3c1bf1f76d00
  • Roe, S. Y., McGowan, E. M., & Rothwell, N. J. (1998). Evidence for the involvement of corticotrophin-releasing hormone in the pathogenesis of traumatic brain injury. European Journal of Neuroscience, 10(2), 553-559. DOI:10.1046/j.1460-9568.1998.00064.x. Publication link: 694ce3ea-f89d-4f53-a8b4-ef8a0e856ee9
  • Cartmell, T., Poole, S., Rothwell, N. J., & Luheshi, G. N. (1998). Relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat. Annals of the New York Academy of Sciences, 856, 252-255. . Publication link: 426c8beb-23e1-440c-8690-18c872696964
  • Loddick, S. A., Turnbull, A. V., & Rothwell, N. J. (1998). Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism, 18(2), 176-179. . Publication link: 56b93404-317c-4556-8bed-43e1e928d0a0
  • Culhane, A. C., Hall, M. D., Rothwell, N. J., & Luheshi, G. N. (1998). Cloning of rat brain interleukin-18 cDNA. Molecular Psychiatry, 3(4), 362-366. . Publication link: b622e594-6ea3-440b-891c-013894e37627
  • Ochu, E. E., Rothwell, N. J., & Waters, C. M. (1998). Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. Journal of Neurochemistry, 70(6), 2637-2640. DOI:10.1046/j.1471-4159.1998.70062637.x. Publication link: cf6ea046-9cbc-491c-9230-0ff91a1beaaa
  • Rothwell, N. J., Allan, S., & Lawrence, C. (1998). Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.Mol Psychiatry, 3( 2). . Publication link: cc69a42a-df96-4070-a4d1-ffe8a1143324
  • Rothwell, N. J., & Stroemer, R. (1998). Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.J Cereb Blood Flow Metab, 18( 8). . Publication link: d222e370-2d39-4d7a-aca9-d26066e56fea
  • Rothwell, N. J., Anforth, H., Bluthe, R., Bristow, A., Hopkins, S., Lenczowski, M., ... Wollman, E. (1998). Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta.Eur Cytokine Netw, 9( 3). . Publication link: e613bfd9-c497-4cb1-8ef8-2eef63e3f624

1997

  • Rothwell, N. J. (1997). Cytokines and acute neurodegeneration. Molecular Psychiatry, 2(2), 120-121. . Publication link: b2b67434-57db-49e3-b57f-3104ee6f2d0c
  • Rothwell, N. J., Luheshi, G., Stefferl, A., Turnbull, A., Dascombe, M., Brouwer, S., & Hopkins, S. (1997). Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat.Am J Physiol, 272( 3 Pt 2). . Publication link: b3c9eed3-549f-4905-8b86-1521cddd0c79
  • Rothwell, N. J., Loddick, S. A., & Stroemer, P. (1997). Interleukins and cerebral ischaemia.International review of neurobiology, 40, 281-298. . Publication link: c9820522-849f-4aa8-a24e-5cf04d16d7e9
  • Roe, S. Y., & Rothwell, N. J. (1997). Whole body metabolic responses to brain trauma in the rat. Journal of Neurotrauma, 14(6), 399-408. . Publication link: c8c0e614-e684-4539-8c9c-803d3bd6c1ee
  • Roe, S. Y., Cooper, A. L., Morris, I. D., & Rothwell, N. J. (1997). Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat. Metabolism, 46(4), 359-365. DOI:10.1016/S0026-0495(97)90047-0. Publication link: cde8ef7e-af6c-447e-ac88-80c8bd5f13d5
  • Rothwell, N. J. (1997). A role for brown adipose tissue in diet-induced thermogenesis. Obesity Research, 5(6), 650-656. . Publication link: a9e19a3a-3422-4e9e-a792-acafea7c13d7
  • Miller, A. J., Luheshi, G. N., Rothwell, N. J., & Hopkins, S. J. (1997). Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response. AJP: Regulatory, Integrative and Comparative Physiology, 272(3), R857-R861. . Publication link: 766f01a7-cc25-4a90-8f29-852cbfeeae16
  • Stroemer, R. P., & Rothwell, N. J. (1997). Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism, 17(6), 597-604. . Publication link: 7e116478-be65-45e3-b7d8-88a66f4984f6
  • Benkovic, S. A., McGowan, E. M., Rothwell, N. J., Hutton, M., Morgan, D. G., & Gordon, M. N. (1997). Regional and cellular localization of presenilin-2 RNA in rat and human brain. Experimental Neurology, 145(2 I), 555-564. DOI:10.1006/exnr.1997.6487. Publication link: 55994b33-8c94-49d3-9964-d9dbb5710a52
  • Rothwell, N., Allan, S., & Toulmond, S. (1997). The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications. Journal of Clinical Investigation, 100(11), 2648-2652. . Publication link: 49768ed9-9d63-43d0-9c37-ea4c494a0043 | PubMed:9389726
  • Loddick, S. A., Wong, M. L., Bongiorno, P. B., Gold, P. W., Licinio, J., & Rothwell, N. J. (1997). Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochemical and Biophysical Research Communications, 234(1), 211-215. DOI:10.1006/bbrc.1997.6436. Publication link: 475888f0-fdfa-4d3d-9429-ea878100192b
  • Roe, S. Y., Cooper, A. L., Morris, I. D., Hopkins, S. J., & Rothwell, N. J. (1997). Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat. European cytokine network, 8(1), 45-49. . Publication link: 1902650f-efad-4a2d-9c42-80f4d6a19fa1
  • Rothwell, N. J. (1997). Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines.Br J Pharmacol, 121( 5). . Publication link: 2957a33b-6d19-4ff0-80a1-4a0f960f4a2d

1996

  • Rothwell, N. J., Sudlow, A., Carey, F., & Forder, R. (1996). The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNF alpha release from human peripheral blood mononuclear cells.Br J Pharmacol, 117( 7). . Publication link: 0718eb58-f742-4a7b-8d6c-a2f642149efe
  • Rothwell, N. J., Sudlow, A., Carey, F., & Forder, R. (1996). Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1 beta-stimulated hypothalamic CRH release in rats.Am J Physiol, 270( 1 Pt 2). . Publication link: 30e074e9-e4e6-4f1b-b15d-530cee4b5117
  • Loddick, S. A., & Rothwell, N. J. (1996). Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. Journal of Cerebral Blood Flow and Metabolism, 16(5), 932-940. . Publication link: 4ca75948-4de6-4e74-bbda-450edd34c372
  • Roe, S., Cooper, A. L., Morris, I. D., & Rothwell, N. J. (1996). Mechanisms of cachexia induced by T-cell leukemia in the rat. Metabolism, 45(5), 645-651. DOI:10.1016/S0026-0495(96)90037-2. Publication link: a6c529fe-2021-45a5-aa97-5d7d42135e76
  • Loddick, S. A., MacKenzie, A., & Rothwell, N. J. (1996). An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. NeuroReport, 7(9), 1465-1468. . Publication link: 6567e65d-7070-4fea-b062-0aa9fca0a5ff
  • Rothwell, N. J., Luheshi, G., & Toulmond, S. (1996). Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology. Pharmacology and Therapeutics, 69(2), 85-95. DOI:10.1016/0163-7258(95)02033-0. Publication link: 70f8545f-eb91-4777-87eb-6761fe82083d
  • Rothwell, N. J., & Luheshi, G. (1996). Brain TNF: damage limitation or damaged reputation?. Nat Med, 2( 7). . Publication link: c18207e4-0479-4e79-b9e2-589d0df0ceb0
  • Luheshi, G., Miller, A. J., Brouwer, S., Dascombe, M. J., Rothwell, N. J., & Hopkins, S. J. (1996). Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat. AJP: Endocrinology and Metabolism, 270(1), E91-E95. . Publication link: b9e46964-8417-4919-af96-2e5a996435f3 | PubMed:8772479
  • Rothwell, N. J., Stefferl, A., Hopkins, S., & Luheshi, G. (1996). The role of TNF-alpha in fever: opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat.Br J Pharmacol, 118( 8). . Publication link: f5b1da10-135d-4252-a3d5-3c932fd60145

1995

  • Rothwell, N. J., & Strijbos, P. J. L. M. (1995). Cytokines in neurodegeneration and repair. International Journal of Developmental Neuroscience, 13(3-4), 179-185. . Publication link: cd5eccad-ddf1-4b9f-aa79-0e548d821ce9
  • Rothwell, N. J., & Strijbos, P. (1995). Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.J Neurosci, 15( 5 Pt 1). . Publication link: b1b8d69d-b3de-46d9-93a4-570f5dd6582f
  • Hopkins, S. J., & Rothwell, N. J. (1995). Cytokines and the nervous system I: expression and recognition. Trends in Neurosciences, 18(2), 83-88. . Publication link: 4866430c-40bb-41b1-8412-6bae4a5394cb
  • Strijbos, P. J. L. M., Zamani, M. R., Rothwell, N. J., Arbuthnott, G., & Harkiss, G. (1995). Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus. Neuroscience Letters, 197(3), 215-218. . Publication link: 378d4ab7-5018-4cca-9e56-069eab3e87c0
  • Wong, M. L., Loddick, S. A., Bongiorno, P. B., Gold, P. W., Rothwell, N. J., & Licinio, J. (1995). Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. NeuroReport, 6(13), 1785-1788. . Publication link: 3ec1ed89-ea09-4005-9550-93b8a60da3cd
  • Toulmond, S., & Rothwell, N. J. (1995). Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Research, 671(2), 261-266. DOI:10.1016/0006-8993(94)01343-G. Publication link: 7319fb7a-29b9-4fde-ad5e-c4499c146dec
  • Rothwell, N. J., & Hopkins, S. J. (1995). Cytokines and the nervous system II: actions and mechanisms of action. Trends in Neurosciences, 18(3), 130-136. . Publication link: 970509af-9c13-43c7-9240-81fd6dd0b655
  • Coelho, M. M., Luheshi, G., Hopkins, S. J., Pela, I. R., & Rothwell, N. J. (1995). Multiple mechanisms mediate antipyretic action of glucocorticoids. AJP: Regulatory, Integrative and Comparative Physiology, 269(3), R527-R535. . Publication link: aedf4b4d-94f6-4106-9d2a-a14f336cabb9

1994

  • Rothwell, N. J., & Luheshi, G. (1994). Pharmacology of interleukin-1 actions in the brain.Advances in Pharmacology, 25, 1-20. . Publication link: b3083c02-dc8f-48cd-82ce-4fe31d1d5691
  • Turnbull, A. V., Dow, R. C., Hopkins, S. J., White, A., Fink, G., & Rothwell, N. J. (1994). Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat. Psychoneuroendocrinology, 19(2), 165-178. . Publication link: d622eb74-2066-463a-9dc0-f305c46e5dc7
  • Rothwell, N. J. (1994). CNS regulation of thermogenesis. Critical Reviews in Neurobiology, 8(1-2), 1-10. . Publication link: eab8cc87-e6b0-46e0-b2b8-88f694ba69ad
  • Rothwell, N. J., Cartana, J., Segues, T., Yebras, M., & Stock, M. J. (1994). Anabolic effects of clenbuterol after long-term treatment and withdrawal in t the rat. Metabolism: clinical and experimental, 43. . Publication link: 210d156a-9cce-4d00-b521-135b65c3e3d6
  • Strijbos, P. J. L. M., Relton, J. K., & Rothwell, N. J. (1994). Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain. Brain Research, 656(2), 405-408. . Publication link: 3ff900bb-3968-49d2-b3f6-460a191404a3
  • Cooper, A. L., Brouwer, S., Turnbull, A. V., Luheshi, G. N., Hopkins, S. J., Kunkel, S. L., & Rothwell, N. J. (1994). Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat. The American journal of physiology, 267(6), R1431-R1436. . Publication link: 801fe0bd-a61a-4883-98cd-27c0d3cdc784
  • Flower, R. J., & Rothwell, N. J. (1994). Lipocortin-1: Cellular mechanisms and clinical relevance. Trends in Pharmacological Sciences, 15(3), 71-76. DOI:10.1016/0165-6147(94)90281-X. Publication link: 9e84ea66-1ab6-4289-9510-e37f40ae9425

1993

  • Rothwell, N. J. (1993). Cytokines and thermogenesis. International Journal of Obesity, 17(3), S98-S101. . Publication link: 0760786f-d388-4293-a3dd-77fdcdf42542
  • Strijbos, P. J. L. M., Horan, M. A., Carey, F., & Rothwell, N. J. (1993). Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1). AJP: Endocrinology and Metabolism, 265(2), E289-E297. . Publication link: 17e2311b-0c7b-4de2-a15f-e2ddac63b44f
  • Rothwell, N. J., Martineau, L., Little, R., & Fisher, M. (1993). Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat.Burns, 19( 1). . Publication link: 3118e23f-90c7-47d9-a481-32b5999d7f2e
  • Rothwell, N. J., & Relton, J. K. (1993). Involvement of cytokines in acute neurodegeneration in the CNS. Neuroscience and Biobehavioral Reviews, 17(2), 217-227. . Publication link: 2e7544b3-8328-4162-8287-9dc4560b7324
  • Rothwell, N. J., & Relton, J. K. (1993). Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage.Cerebrovascular and brain metabolism reviews, 5(3), 178-198. . Publication link: 68d31c94-cb4f-4809-8df7-67ca3160fee2
  • Relton, J. K., Strijbos, P. J. L. M., Cooper, A. L., & Rothwell, N. J. (1993). Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat. Brain Research Bulletin, 32(3), 223-226. . Publication link: 7bbe102b-df5e-42d1-975e-c8df0e273632
  • Turnbull, A. V., Kirkman, E., Rothwell, N. J., & Little, R. A. (1993). The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat. Journal of Physiology, 468, 529-541. . Publication link: 6d606248-c555-4408-8059-8ca6b9b9fc3f
  • Rothwell, N. J., Derijk, R. H., Strijbos, P. J., van, R. N., & Berkenbosch, F. (1993). Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats. Am.J.Physiol, 265. . Publication link: a7066c2d-30b7-496b-aecd-e085e3a7c19a
  • Rothwell, N. J., Coelho, M., & Pelá, I. (1993). Dexamethasone inhibits the pyrogenic activity of prostaglandin F2 alpha, but not prostaglandin E2.Eur J Pharmacol, 238(2-3), 391-394. . Publication link: 889621bb-95ec-4559-a360-a0e80c9de380
  • Rothwell, N. J., Luheshi, G., Hopkins, S., Lefeuvre, R., Dascombe, M., & Ghiara, P. (1993). Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat.Am J Physiol, 265( 4 Pt 1). . Publication link: d224b492-2910-4f44-867e-9f3e72872f7c
  • Rothwell, N. J., Busbridge, N., & Dascombe, M. (1993). Chronic effects of interleukin-1 beta on fever, oxygen consumption and food intake in the rat.Horm Metab Res, 25( 4). . Publication link: cf46273f-e3be-475f-b646-90387fdf4a73
  • Rothwell, N. J., & Cooper, A. (1993). Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation.Prostaglandins Leukot Essent Fatty Acids, 49( 2). . Publication link: ca58990d-96e8-4a09-9dd5-dee80fa0c41c

1992

  • Rothwell, N. J., Choo, J., Horan, M., & Little, R. (1992). Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.Am J Physiol, 263( 1 Pt 1). . Publication link: bdc5b10c-b70d-452e-a091-11eef0639ff6
  • Rothwell, N. J., Royston, M. C., & Roberts, G. W. (1992). Alzheimer"s disease: pathology to potential treatments?. Trends Pharmacol.Sci., 13. . Publication link: d06fe81b-791d-47aa-98ed-f6864d5ec087
  • Rothwell, N. J., Martineau, L., Horan, M., & Little, R. (1992). Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men.Clin Sci (Lond), 83( 5). . Publication link: c90b2bfa-9db8-4da0-93c0-6612c59f0e0f
  • Rothwell, N. J., & Le Feuvre, R. A. (1992). Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. International Journal of Obesity, 16(3), S67-S71. . Publication link: 67e6c9cc-3f72-4b90-b598-7fc031c9b6de | PubMed:1338325
  • Rothwell, N. J., Cooper, A., Horan, M., & Little, R. (1992). Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade.J Appl Physiol, 72( 6). . Publication link: 9029ab55-1251-4b02-a07e-0522b84b7ef7
  • Black, M. D., Carey, F., Crossman, A. R., Relton, J. K., & Rothwell, N. J. (1992). Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat. Brain Research, 585(1-2), 135-140. . Publication link: a5f5689d-8b4a-4793-806a-5fd5159895ad
  • Le Feuvre, R., Serra, F., LeFeuvre, R. A., Slater, D., Palou, A., & Rothwell, N. J. (1992). Thermogenic actions of tryptophan in the rat are mediated independently of 5-HT. Brain Research, 578(1-2), 327-334. DOI:10.1016/0006-8993(92)90265-B. Publication link: 5466d675-39b1-4e04-be83-b86d7756847a | PubMed:1511284
  • Relton, J. K., & Rothwell, N. J. (1992). Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Research Bulletin, 29(2), 243-246. . Publication link: 52a71241-003d-44e9-a1eb-bb13ca134197
  • Kent, S., Bluthe, R. M., Dantzer, R., Hardwick, A. J., Kelley, K. W., Rothwell, N. J., & Vannice, J. L. (1992). Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proceedings of the National Academy of Sciences of the United States of America, 89(19), 9117-9120. . Publication link: 38e80f58-99a0-4a93-a764-2582d8a8634e
  • Rothwell, N. J., & Flower, R. (1992). Lipocortin-1 exhibits novel actions, providing clinical opportunities. Trends in Pharmacological Sciences, 13(2), 45-46. DOI:10.1016/0165-6147(92)90019-3. Publication link: 1194343f-87cf-455c-a9e6-c46cc35209c0
  • Rothwell, N. J. (1992). Eicosanoids, thermogenesis and thermoregulation. Prostaglandins, Leukotrienes & Essential Fatty Acids , 46(1), 1-7. . Publication link: 21ea6bd1-1b5b-4063-8753-17d03add1aa1
  • Strijbos, P. J., Hardwick, A. J., Relton, J. K., Carey, F., & Rothwell, N. J. (1992). Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF. AJP: Endocrinology and Metabolism, 263(4), E632-E636. . Publication link: 25050d2e-ce83-4bb7-9d1a-f102f13dd72c
  • Rothwell, N. J., Martineau, L., Horan, M. A., & Little, R. A. (1992). Muscling in on salbutamol. Lancet, 340. . Publication link: 17302d3f-22bf-462f-91e6-fb645b79f5fe

1991

  • Le Feuvre, R. A., Woods, A. J., Stock, M. J., & Rothwell, N. J. (1991). Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats. Brain Research, 547(1), 110-114. . Publication link: a784a235-509e-4d4b-987f-6f08c3e9e2e0 | PubMed:1860063
  • Rothwell, N. J., Hardwick, A., LeFeuvre, R. A., Crosby, S. R., White, A., & Le Feuvre, R. (1991). Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products. Brain Research, 541(1), 89-92. DOI:10.1016/0006-8993(91)91078-F. Publication link: a95dc995-380d-4a33-b908-04727bfc3ee6 | PubMed:2029628
  • Hopkins, S. J., & Rothwell, N. J. (1991). Further functions of IL-6. Immunology Today, 12(5), 170. . Publication link: 9b112da1-6493-4978-a751-3811d988a104
  • Strijbos, P. J. L. M., Tilders, F. J. H., Carey, F., Forder, R., & Rothwell, N. J. (1991). Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment. Brain Research, 553(2), 249-260. . Publication link: 804db733-6ddb-4472-b9c7-41f1869df5e5
  • Choo, J. J., Emery, P. W., & Rothwell, N. J. (1991). Dose-dependent effects of an anabolic steroid, nandrolone phenylpropionate (Durabolin), on body composition and muscle protein metabolism in female rats. Annals of Nutrition and Metabolism, 35(3), 141-147. . Publication link: 16d7ef56-6323-4b36-9704-e1b2b65ea0f4
  • Cooper, A. L., & Rothwell, N. J. (1991). Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats. AJP: Endocrinology and Metabolism, 261(6), E698-E705. . Publication link: 24fcf5d6-a882-4a92-8cbc-578988bb526c
  • Rothwell, N. J. (1991). The endocrine significance of cytokines. Journal of Endocrinology, 128(2), 171-173. . Publication link: 243c4505-0872-4250-8847-349845104e34
  • Le Feuvre, R. A., Aisenthal, L., & Rothwell, N. J. (1991). Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain Research, 555(2), 245-250. . Publication link: 22bfbae3-8a77-4524-856b-ed2d73f53fc6 | PubMed:1933336
  • Relton, J. K., Strijbos, P. J. L. M., O'Shaughnessy, C. T., Carey, F., Forder, R. A., Tilders, F. J. H., & Rothwell, N. J. (1991). Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. Journal of Experimental Medicine, 174(2), 305-310. . Publication link: e02074d1-4622-42bc-b6cb-192ada5f31c2
  • Rothwell, N. J. (1991). Functions and mechanisms of interleukin 1 in the brain. Trends in Pharmacological Sciences, 12(C), 430-436. . Publication link: ff60da55-01d4-4156-ae03-c515d18686c3
  • Rothwell, N. J., Little, R. A., & Rose, J. G. (1991). Brown adipose tissue activity and oxygen consumption after scald injury in the rat. Circulatory Shock, 33(1), 33-36. . Publication link: db2aae51-9290-4662-bb2f-eb26e4c58348
  • Rothwell, N. J., Busbridge, N. J., Lefeuvre, R. A., Hardwick, A. J., Gauldie, J., Hopkins, S. J., & Le Feuvre, R. (1991). Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Canadian Journal of Physiology and Pharmacology, 69(10), 1465-1469. . Publication link: c01cf3b4-01d7-46eb-bfa7-ddd2690dd7cd | PubMed:1777846

1990

  • Choo, J. J., Horan, M. A., Little, R. A., Rothwell, N. J., & Wareham, A. (1990). Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture. Circulatory Shock, 32(2), 165-171. . Publication link: b90418ea-01a3-4852-bd4c-9fa7480b9859
  • Rothwell, N. J., Hardwick, A. J., & Lindley, I. (1990). Central actions of interleukin-8 in the rat are independent of prostaglandins. Hormone and Metabolic Research, 22(11), 595-596. . Publication link: cb696dc0-8d5d-4533-a799-552ce0fa1ef5
  • Rothwell, N. J. (1990). Central activation of thermogenesis by prostaglandins: Dependence on CRF. Hormone and Metabolic Research, 22(12), 616-618. . Publication link: e82d518e-7008-46f7-bdbb-9fa9a4154c32
  • Rothwell, N. J. (1990). Central effects of CRF on metabolism and energy balance. Neuroscience and Biobehavioral Reviews, 14(3), 263-271. . Publication link: 2e658444-14a3-4623-88ff-6dd4a9e4b471
  • Rothwell, N. J., Arnold, J., Choo, J., & Little, R. (1990). Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues.Circ Shock, 31( 4). . Publication link: 6bb53a12-4517-4ad3-ae45-c4a22d6b29de
  • Rothwell, N. J., Busbridge, N., Carnie, J., Dascombe, M., & Johnston, J. (1990). Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats.International journal of obesity, 14(9). . Publication link: 67059970-f7d6-4706-9d68-7c67dd7a718d | PubMed:2228412
  • Carey, F., Forder, R., Edge, M. D., Greene, A. R., Horan, M. A., Strijbos, P. J. L. M., & Rothwell, N. J. (1990). Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats. AJP: Regulatory, Integrative and Comparative Physiology, 259(2), R266-R269. . Publication link: 82931840-8d77-488a-a66b-549ea98c420e
  • Rothwell, N. J., Choo, J., Horan, M., & Little, R. (1990). Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat.Metabolism, 39( 6). . Publication link: 83ea7362-7797-4b80-9e5a-74ee0d5d2498
  • O'Shaughnessy, C. T., Rothwell, N. J., & Shrewsbury-Gee, J. (1990). Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat. Canadian Journal of Physiology and Pharmacology, 68(10), 1334-1337. . Publication link: a06e2267-f2cb-42c0-98c7-e5d11fd35097
  • Rothwell, N. J. (1990). Mechanisms of the pyrogenic actions of cytokines.European cytokine network, 1(4), 211-213. . Publication link: af24b028-ee78-40fb-aaca-dcc46e042dfc
  • Rothwell, N. J. (1990). Neuroendocrine mechanisms in the thermogenic responses to diet, infection, and trauma. Advances in Experimental Medicine and Biology, 274, 371-380. . Publication link: af812e78-7990-41f6-9455-fc7ba85a6ba0

1989

  • Le Feuvre, R. A., Rothwell, N. J., & White, A. (1989). A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat. Hormone and Metabolic Research, 21(9), 525-526. . Publication link: a016e4c0-47db-4f67-be57-486f5462a4ad | PubMed:2583676
  • Rothwell, N. J., Dascombe, M., Hardwick, A., & Lefeuvre, R. (1989). Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.Int J Obes, 13( 3). . Publication link: 9b233df4-6abb-4bb7-a6b8-61bd709ef38e
  • Cooper, A. L., Fitzgeorge, R. B., Baskerville, A., Little, R. A., & Rothwell, N. J. (1989). Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the Guinea pig. Life Sciences, 45(9), 843-847. . Publication link: 9d989c80-f043-498b-85a3-5d39906befaa
  • Rothwell, N. J. (1989). CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat.Am J Physiol, 256( 1 Pt 1). . Publication link: 9d85ba4b-5839-4455-ac7b-9a11a1e880f1
  • feuvre, R. L., Rothwell, N., & White, A. (1989). A comparison of the thermogenic effects of CRF, Sauvagine and urotensin 1 in the rat. Hormone and Metabolic Research, 21(9), 525-526. . Publication link: 96633f82-12d3-4498-898d-be273d9a9ddf
  • Rothwell, N. J. (1989). Central control of brown adipose tissue.Proceedings of the Nutrition Society, 48(2), 197-206. . Publication link: 62fb2d71-08c5-4b2b-a9d9-7a03bfa3876e
  • Rothwell, N. J., Dascombe, M., Sagay, B., & Stock, M. (1989). Pyrogenic and thermogenic effects of interleukin 1 beta in the rat.Am J Physiol, 256( 1 Pt 1). . Publication link: 14466993-15b1-464d-81cc-75b9655b52ed
  • Rothwell, N. J., Busbridge, N., Dascombe, M., Tilders, F., van, O. J., & Linton, E. (1989). Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms.Biochemical and Biophysical Research Communications, 162( 2). . Publication link: 2b25254e-8074-42a1-9bf0-eb245788d3a0
  • Horan, M. A., Little, R. A., Rothwell, N. J., & Strijbos, P. J. L. M. (1989). Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat. Canadian Journal of Physiology and Pharmacology, 67(9), 1011-1014. . Publication link: 35f1019f-39e5-4c6b-b0d7-88b1294bab4e
  • Bianchi, A., Bruce, J., Cooper, A. L., Childs, C., Kohli, M., Morris, I. D., ... Rothwell, N. J. (1989). Increased brown adipose tissue activity in children with malignant disease. Hormone and Metabolic Research, 21(11), 640-641. . Publication link: 3a31793c-b62a-416a-8afd-0ebf07a8c367
  • Arnold, J., Little, R. A., & Rothwell, N. J. (1989). Energy balance and brown adipose tissue thermogenesis during chronic endotoxemia in rats. Journal of Applied Physiology, 66(4), 1970-1975. . Publication link: 553fdff5-bdf4-4151-9288-dcf584eae436
  • Cooper, A. L., Dascombe, M. J., Rothwell, N. J., & Vale, M. J. (1989). Effects of malaria on O2 consumption and brown adipose tissue activity in mice. Journal of Applied Physiology, 67(3), 1020-1023. . Publication link: 541d37c8-2bac-4b78-8053-029245906366 | PubMed:2676949
  • O'Shaughnessy, C. T., Rothwell, N. J., & Shrewsbury-Gee, J. (1989). Effect of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat. Canadian Journal of Physiology and Pharmacology, 67(10), 1345-1350. . Publication link: cb6b32c6-2c40-41cb-8e2e-a40646b0f8e7
  • McCarthy, H. D., O'Shaughnessy, C. T., & Rothwell, N. J. (1989). Endogenous mediators of cerebral ischaemia-induced hypermetabolism in the rat.British Journal of Pharmacology, 98, 838. . Publication link: cd7bb107-94df-47df-9713-5a68c06f65b7
  • Rothwell, N. J., & Stock, M. J. (1989). Surgical removal of brown fat results in rapid and complete compensation by other depots. AJP: Regulatory, Integrative and Comparative Physiology, 257(2), 26/2. . Publication link: fb61dd89-f99c-4656-b27d-491d040e8708
  • Hardwick, A. J., Linton, E. A., & Rothwell, N. J. (1989). Thermogenic effects of the antiglucocorticoid RU-486 in the rat: Involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology, 124(4), 1684-1688. . Publication link: e4f00ba6-ac11-41f8-9d10-44f4437777ea
  • Rothwell, N. J., Choo, J., Horan, M., & Little, R. (1989). Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol.Biosci Rep, 9( 5). . Publication link: eeb06393-a71b-46cb-a5e0-134d1fada809

1988

  • Horton, R. W., Lefeuvre, R. A., Rothwell, N. J., Stock, M. J., & Le Feuvre, R. (1988). Opposing effects of activation of central GABAA and GABAB receptors on brown fat thermogenesis in the rat. Neuropharmacology, 27(4), 363-366. DOI:10.1016/0028-3908(88)90144-X. Publication link: fa26a136-e5c1-4ee2-b642-37c3e1c705ee | PubMed:2843778
  • Horton, R., Rothwell, N. J., & Stock, M. J. (1988). Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat. General Pharmacology, 19(3), 403-405. . Publication link: c37bf88b-6286-40fc-bbdd-dac317db4d07
  • Holt, S., Rothwell, N. J., Stock, M. J., & York, D. A. (1988). Effect of hypophysectomy on energy balance and brown fat activity in obese Zucker rats. AJP: Endocrinology and Metabolism, 254(2), 17/2. . Publication link: 49f1bcf9-d710-475a-8912-43edd31c2b85
  • Rothwell, N. J. (1988). Central effects of TNF alpha on thermogenesis and fever in the rat.Biosci Rep, 8( 4). . Publication link: 3a9596fc-dea4-4064-a718-5d21af61189a
  • Jepson, M. M., Millward, D. J., Rothwell, N. J., & Stock, M. J. (1988). Involvement of sympathetic nervous system and brown fat in endotoxin-induced fever in rats. AJP: Endocrinology and Metabolism, 255(5), 18/5. . Publication link: 34cab667-faa2-48a0-a506-a8ceea17c3e1
  • Rothwell, N. J., & Stock, M. J. (1988). Increased body-weight gain and body protein in castrated and adrenalectomized rats treated with clenbuterol. British Journal of Nutrition, 60(2), 355-360. . Publication link: 270d6d0d-3c11-4895-aa6d-a1935cf07ae9
  • Rothwell, N. J., Stock, M. J., & Tedstone, A. E. (1988). Thermogenic effects of dihydrocodeine in the rat. Canadian Journal of Physiology and Pharmacology, 66(1), 61-65. . Publication link: 0e84cc00-715a-4fcf-ac55-ee24c450f02d
  • Rothwell, N. J., & Stock, M. J. (1988). Brown adipose tissue: Does it play a role in the development of obesity?. Diabetes/Metabolism Reviews, 4(6), 595-601. . Publication link: 725b62b3-3c01-47cb-adc0-d21195606837
  • Rothwell, N. J., & Stock, M. J. (1988). Influence of adrenalectomy on age-related changes in energy balance, thermogenesis and brown fat activity in the rat. Comparative Biochemistry and Physiology -- Part A: Physiology, 89(2), 265-269. . Publication link: 83233dd1-490f-4628-ba5c-8d9954d196a6
  • Rothwell, N. J., & Stock, M. (1988). Insulin and thermogenesis.Int J Obes, 12( 2). . Publication link: 80e7f216-b084-4894-9b97-daabb4956dd5
  • Rothwell, N. J., & Stock, M. J. (1988). The cafeteria diet as a tool for studies of thermogenesis.Journal of Nutrition, 118(8), 925-928. . Publication link: 67b87623-82dc-4277-91be-122d189b0a43
  • Griffiths, E. C., Rothwell, N. J., & Stock, M. J. (1988). Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat. Experientia, 44(1), 40-42. DOI:10.1007/BF01960238. Publication link: a1fab3c1-d8fc-4f05-896d-c31da2bff53f
  • Horan, M. A., Little, R. A., Rothwell, N. J., & Stock, M. J. (1988). Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence. Experimental Gerontology, 23(6), 455-461. . Publication link: ab27a3bb-d435-405a-ae22-750a9c45421e

1987

  • Rothwell, N. J., & Stock, M. J. (1987). Influence of carbohydrate and fat intake on diet-induced thermogenesis and brown fat activity in rats fed low protein diets. J.Nutr., 117. . Publication link: abd5035f-548b-416f-ba8a-b5b5dae702da
  • Rothwell, N. J., Stock, M. J., & Sudera, D. K. (1987). Changes in tissue blood flow and beta-receptor density of skeletal muscle in rats treated with the beta2-adrenoceptor agonist clenbuterol. British Journal of Pharmacology, 90. . Publication link: 9c6fb170-0a4b-4c49-a9d8-f65b5d2d9f6a
  • Rothwell, N. J., & Stock, M. J. (1987). Effect of environmental temperature on energy balance and thermogenesis in rats fed normal or low protein diets. Journal of Nutrition, 117(5), 833-837. . Publication link: 96e54c21-c2c5-4160-9436-46cdce9fe962
  • Rothwell, N. J., & Stock, M. J. (1987). Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride. Metabolism, 36(2), 128-130. . Publication link: 79b92f6f-51d7-4f25-8460-f11b954bcb00
  • Le Feuvre, R., Lefeuvre, R. A., Rothwell, N. J., & Stock, M. J. (1987). Activation of brown fat thermogenesis in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology, 26(8), 1217-1221. DOI:10.1016/0028-3908(87)90272-3. Publication link: 60fa86e3-7013-41ae-87b4-837768836783 | PubMed:3498913
  • Rothwell, N. J., & Stock, M. J. (1987). Effect of a selective beta 2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats. Biosci.Rep., 7. . Publication link: 12f5d01e-3ff4-49fd-bac6-b5e987ca52f5
  • Jepson, M. M., Cox, M., Bates, P. C., Rothwell, N. J., Stock, M. J., Cady, E. B., & Millward, D. J. (1987). Regional blood flow and skeletal muscle energy status in endotoxemic rats. AJP: Endocrinology and Metabolism, 252(5), 15/5. . Publication link: 4e8af027-ff60-4250-b692-1f6a7d8e3dbb
  • Coombes, R. C., Rothwell, N. J., Shah, P., & Stock, M. J. (1987). Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat. Bioscience Reports, 7(10), 791-799. DOI:10.1007/BF01116752. Publication link: f961e860-cc53-4113-8b92-d216943b6684
  • Rothwell, N. J., & Stock, M. J. (1987). Influence of clenbuterol on energy balance, thermogenesis and body composition in lean and genetically obese Zucker rats. International Journal of Obesity, 11(6), 641-647. . Publication link: d309746b-7439-4bd3-89a6-640862210743
  • Rothwell, N. J., & Stock, M. J. (1987). Effect of diet and fenfluramine on thermogenesis in the rat: Possible involvement of serotonergic mechanisms. International Journal of Obesity, 11(4), 319-324. . Publication link: db808b93-98f4-4a01-b1ac-6dd966be2bd0
  • Rothwell, N. J., Stock, M. J., & Tedstone, A. E. (1987). Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Molecular and Cellular Endocrinology, 51(3), 253-257. . Publication link: b63d150c-0bde-42e1-8991-c69a85e0ed96

1986

  • Rothwell, N. J., & Stock, M. J. (1986). Whither brown fat?. Bioscience Reports, 6(1), 3-18. . Publication link: fa45e7e3-507e-4f47-8d4b-7a7b4aa4aaf4
  • Addae, J. I., Rothwell, N. J., Stock, M. J., & Stone, T. W. (1986). Activation of thermogenesis of brown fat in rats by Baclofen. Neuropharmacology, 25(6), 627-631. . Publication link: f858d7bc-e865-490b-83cf-5a86a4086398
  • Rothwell, N. J., & Stock, M. J. (1986). Spontaneous and experimental variations in body weight, food intake and metabolic rate in captive dormice (Glis glis). Comparative Biochemistry and Physiology -- Part A: Physiology, 84(1), 141-147. . Publication link: e1c347b8-7d81-4858-ae8c-68571764d0ad
  • Rothwell, N. J., & Stock, M. J. (1986). Influence of environmental temperature on energy balance, diet-induced thermogenesis and brown fat activity in "cafeteria"-fed rats. Br.J.Nutr., 56. . Publication link: 99964b2a-d978-4a1f-ad9c-e2bad77d6a77
  • Stock, M. J., & Rothwell, N. J. (1986). The role of brown fat in diet-induced thermogenesis.International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 56(2), 205-210. . Publication link: a0b321c6-a392-4a61-81cb-0ffc2c878e8d
  • Rothwell, N. J., Stock, M. J., & Sudera, D. K. (1986). Thermogenic responses to adrenoceptor agonists and brown fat adrenoceptors in overfed rats. European Journal of Pharmacology, 125(3), 313-323. . Publication link: 5899abcb-5156-419a-ae26-f0882993bf4e
  • Stock, M. J., & Rothwell, N. J. (1986). Brown adipose tissue and the response to overfeeding. Biochemical Society Transactions, 14(2), 239-240. . Publication link: 5af3681b-eac8-44f4-8387-bbbdf66bb9f7
  • Marchington, D., Rothwell, N. J., Stock, M. J., & York, D. A. (1986). Thermogenesis and sympathetic activity in BAT of overfed rats after adrenalectomy. AJP: Endocrinology and Metabolism, 250(4), 13/4. . Publication link: 3579305c-d99c-4c01-84d4-dc23b9ebd7c5
  • Rothwell, N. J., & Stock, M. J. (1986). Body weight and brown fat activity in hyperphagic cafeteria-fed female rats and their offspring. Biology of the Neonate, 49(5), 284-291. . Publication link: 28680ef6-1d20-402c-81f6-14720bc01ca0
  • Rothwell, N. J., & Stock, M. J. (1986). Energy balance and brown fat activity in adrenalectomized male, female, and castrated male rats. Metabolism, 35(7), 657-660. . Publication link: 024a0bc6-fdf5-4e0f-8d77-54d8ca5f430b

1985

  • Rothwell, N. J., Stock, M. J., & Warwick, B. P. (1985). Energy balance and brown fat activity in rats fed cafeteria diets or high-fat, semisynthetic diets at several levels of intake. Metabolism, 34(5), 474-480. . Publication link: 186023fa-80f9-4e9e-ae25-1d90ad4df845
  • Loudon, A., Rothwell, N., & Stock, M. (1985). Brown fat, thermogenesis and physiological birth in a marsupial. Comparative Biochemistry and Physiology -- Part A: Physiology, 81(4), 815-819. . Publication link: 53eb60f9-636f-45e8-9be2-27b2f537187a | PubMed:2863071
  • Rothwell, N. J., Andrews, P. L., & Stock, M. J. (1985). Influence of subdiaphragmatic vagotomy and brown fat sympathectomy on thermogenesis in rats. Am.J.Physiol, 249. . Publication link: 5989b15e-bdc9-4df9-8e6d-bf5e717ef87f
  • Rothwell, N. J., & Stock, M. J. (1985). Is diet-induced thermogenesis an experimental artefact?. British Journal of Nutrition, 53(1), 191-192. . Publication link: 58ecd2bb-2706-4bfb-9b56-3b4ad76869cb
  • Rothwell, N. J., Addae, J. I., Stock, M. J., & Stone, T. W. (1985). Baclofen is a potent activator of brown fat metabolism. Journal of Pharmacy and Pharmacology, 37(12), 926-927. . Publication link: 61b4049f-a8f8-4888-8d0d-d59c3c8086cd
  • Andrews, P. L. R., Rothwell, N. J., & Stock, M. J. (1985). Effects of subdiaphragmatic vagotomy on energy balance and thermogenesis in the rat. Journal of Physiology, 362, 1-12. . Publication link: 61f9834c-84d5-45b4-b4be-7e53e2df85e9
  • Rothwell, N. J., & Stock, M. J. (1985). Acute and chronic effects of ACTH on thermogenesis and brown adipose tissue in the rat. Comparative Biochemistry and Physiology -- Part A: Physiology, 81(1), 99-102. . Publication link: 79437ada-5be6-451a-8f92-e01f35e27ec9
  • Rothwell, N. J., & Stock, M. J. (1985). Thermogenic capacity and brown adipose tissue activity in the common marmoset. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, 81(3), 683-686. . Publication link: a6b0478a-442c-44dc-9fd3-f71c6d01c44f
  • Rothwell, N. J., & Stock, M. J. (1985). Thermogenesis and BAT activity in hypophysectomized rats with and without corticotropin replacement. Am.J.Physiol, 249. . Publication link: acc93af4-67fe-4471-8f9d-521db0f4121a
  • Stock, M. J., & Rothwell, N. J. (1985). Factors influencing brown fat and the capacity for diet-induced thermogenesis. International Journal of Obesity, 9(2), 9-15. . Publication link: 933be5af-61fe-49bc-b670-36c54c08fe40
  • Rothwell, N. J., & Stock, M. J. (1985). Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice. Bioscience Reports, 5(9), 755-760. . Publication link: bc767baa-b071-450d-823f-c54941b8bd4e
  • Rothwell, N. J., Stock, M. J., & Sudera, D. K. (1985). Changes in adrenoreceptor density in brown adipose tissue from hyperthyroid rats. European Journal of Pharmacology, 114(2), 227-229. . Publication link: c44d1c79-0f98-4755-bcd4-c1646ece8739
  • Rothwell, N. J., Stock, M. J., & Warwick, B. P. (1985). Involvement of insulin in the acute thermogenic responses to food and nonmetabolizable substances. Metabolism, 34(1), 43-47. . Publication link: dd082fb3-6816-4f3a-a63c-80e415b3d746
  • Rothwell, N. J., Stock, M. J., & Sudera, D. K. (1985). Beta-adrenoreceptors in rat brown adipose tissue: proportions of beta 1- and beta 2-subtypes.The American journal of physiology, 248(4), E397-402. . Publication link: e51be81b-cb04-4f9f-bcaa-1bea23b4fd35
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1985). Hormonal and metabolic responses to fasting and refeeding. International Journal of Obesity, 9(2), 49-54. . Publication link: f4cad8df-4e97-4169-8ada-c6bd7c620322

1984

  • Wyllie, M. G., Fletcher, A., Rothwell, N. J., & Stock, M. J. (1984). Thermogenic properties of ciclazindol and mazindol in rodents. International Journal of Obesity, 8(1), 85-92. . Publication link: b53036f4-bd31-4611-9ddb-b0b59526ae79
  • Rothwell, N. J., & Stock, M. J. (1984). Influence of alcohol and sucrose consumption on energy balance and brown fat activity in the rat. Metabolism, 33(8), 768-771. . Publication link: d0b2c505-9fd4-438c-85d5-eb3ad74b6bd0
  • Rothwell, N. J., Stock, M. J., & York, D. A. (1984). Effects of adrenalectomy on energy balance, diet-induced thermogenesis and brown adipose tissue in adult cafeteria-fed rats. Comparative Biochemistry and Physiology -- Part A: Physiology, 78(3), 565-569. . Publication link: f23939ab-ac21-4810-bb7a-0a1b60edbc0d
  • Rothwell, N. J., & Stock, M. J. (1984). The development of obesity in animals: The role of dietary factors. Clinics in Endocrinology and Metabolism, 13(3), 437-449. . Publication link: f9525f62-15a9-4576-aa6f-31b1a7607ddb
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1984). Brown fat activity in fasted and refed rats. Bioscience Reports, 4(4), 351-357. . Publication link: f8876547-ee4b-4fd2-8f5c-bd1d1d4dae90
  • Rothwell, N. J., Stock, M. J., & Wyllie, M. G. (1984). Effects of histamine antagonists on noradrenaline-stimulated blood flow and oxygen consumption of brown adipose tissue in the rat. Pflügers Archiv European Journal of Physiology, 402(3), 325-329. DOI:10.1007/BF00585518. Publication link: 550cf51f-ba3e-49a3-b11f-efdad6fddb5b
  • Rothwell, N. J., Jamieson, L., Stribling, D., & Stock, M. J. (1984). Effect of noradrenaline on oxygen consumption and tissue blood flow in young pigs. Can.J.Physiol Pharmacol., 62. . Publication link: 0a449681-37b6-46b0-8ed5-49bd8ae5e405
  • Rothwell, N. J., & Stock, M. J. (1984). Sympathetic and adrenocorticoid influences on diet-induced thermogenesis and brown fat activity in the rat. Comparative Biochemistry and Physiology -- Part A: Physiology, 79(4), 575-579. . Publication link: 197986e4-363e-4203-99ae-e104529f7555
  • Bryant, K. R., Rothwell, N. J., & Stock, M. J. (1984). Influence of sodium intake on thermogenesis and brown adipose tissue in the rat. International Journal of Obesity, 8(3), 221-231. . Publication link: 215396df-1ce6-4a09-9ca8-f476b873e7c2
  • Bryant, K. R., Rothwell, N. J., & Stock, M. J. (1984). Acute influences on the two GDP-binding sites in brown-adipose-tissue mitochondria. Bioscience Reports, 4(6), 523-533. . Publication link: 810aebd6-43b7-40ca-a003-3034ecf6b8d4
  • Rothwell, N. J., & Stock, M. J. (1984). Energy balance, thermogenesis and brown adipose tissue activity in tube-fed rats. Journal of Nutrition, 114(10), 1965-1970. . Publication link: 8c83f27b-8fe1-429f-a012-1c44a0c5a5f0
  • Rothwell, N. J., & Stock, M. J. (1984). Effects of denervating brown adipose tissue on the responses to cold, hyperphagia and noradrenaline treatment in the rat. Journal of Physiology, 355, 457-463. . Publication link: 97f2bdcf-bb79-4896-af40-06bef3d2092b
  • Rothwell, N. J., Emery, P. W., Stock, M. J., & Winter, P. D. (1984). Chronic effects of beta 2-adrenergic agonists on body composition and protein synthesis in the rat. Biosci.Rep., 4. . Publication link: 9921c21d-f5d4-42f0-9c4d-b90c8875a464
  • Rothwell, N. J., & Stock, M. J. (1984). Tissue blood flow in control and cold-adapted hyperthyroid rats. Canadian Journal of Physiology and Pharmacology, 62(8), 928-933. . Publication link: aeeb7808-1fd2-4d38-a953-9557d7330818

1983

  • Rothwell, N. J., Saville, M. E., Stock, M. J., & Wyllie, M. G. (1983). Influence of thyroid hormone on diet-induced thermogenesis in the rat. Hormone and Metabolic Research, 15(8), 394-398. . Publication link: 8a524c2e-0219-4d01-87a7-5fbc8eaf0d9c
  • Rothwell, N. J., Stock, M. J., & Thexton, A. J. (1983). Decerebration activates thermogenesis in the rat. Journal of Physiology, 342, 15-22. . Publication link: 8836753a-55f0-46ca-937b-fc94c7ee20c0
  • Rothwell, N. J., & Stock, M. J. (1983). Effects of age on diet-induced thermogenesis and brown adipose tissue metabolism in the rat. International Journal of Obesity, 7(6), 583-589. . Publication link: 9badc839-7e91-42c4-b0b3-2428d2a3d56d
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1983). Role of insulin in thermogenic responses to refeeding in 3-day-fasted rats. Am.J.Physiol, 245. . Publication link: a553455e-4432-4783-9c1e-fa1a1e050755
  • Rothwell, N. J., Bryant, K. R., Stock, M. J., & Wyllie, M. G. (1983). Parasympathethic effects on diet-induced thermogenesis. Eur.J.Pharmacol., 95. . Publication link: 5958a2d3-fc87-434b-8595-72cab3b30020
  • Rothwell, N. J., Stock, M. J., & Wyllie, M. G. (1983). Influence of chronic administration of ciclazindol on energy balance and brown adipose tissue in adult 'cafeteria'-fed rats. Journal of Autonomic Pharmacology, 3(2), 73-78. . Publication link: 7081ab9d-9ba8-43a7-919e-1c39851e283c
  • Emery, P. W., Rothwell, N. J., & Stock, M. J. (1983). Protein synthesis in liver, skeletal muscle, and brown adipose tissue of rats fed a protein-deficient diet. Bioscience Reports, 3(6), 569-575. DOI:10.1007/BF01120702. Publication link: 143d4832-c9af-4307-957f-1d8ff768483b
  • Stock, M. J., & Rothwell, N. J. (1983). Role of brown adipose tissue thermogenesis in overfeeding: A review. Journal of the Royal Society of Medicine, 76(1), 71-73. . Publication link: 003ddb59-c065-4295-92da-1b13dcb4917d
  • Everard, D. M., Rothwell, N. J., Stock, M. J., & Wilson, C. A. (1983). Physical changes associated with the onset of precocious puberty in rats after treatment with PMSG.Journal of Reproduction and Fertility, 69(1), 201-206. . Publication link: 00fdfd62-7c3a-4153-9770-60d76b519859
  • Rothwell, N. J., Stock, M. J., & Trayhurn, P. (1983). Reduced lipogenesis in cafeteria-fed rats exhibiting diet-induced thermogenesis. Bioscience Reports, 3(3), 217-224. DOI:10.1007/BF01122453. Publication link: 06f2b283-d9a3-482a-840f-8560414e4b07
  • Bryant, K. R., Rothwell, N. J., Stock, M. J., & Stribling, D. (1983). Identification of two mitochondrial GDP-binding sites in rat brown adipose tissue. Bioscience Reports, 3(7), 589-598. DOI:10.1007/BF01172869. Publication link: 1e099ca1-ec05-464b-b2b9-c9849fb8c16f
  • Rothwell, N. J., Stock, M. J., & Tyzbir, R. S. (1983). Mechanisms of thermogenesis induced by low protein diets. Metabolism, 32(3), 257-261. . Publication link: 276a33a3-e7ec-4b33-a527-a517f703f5ba
  • Rothwell, N. J., & Stock, M. J. (1983). Acute effects of fat and carbohydrate on metabolic rate in normal, cold-acclimated and lean and obese (fa/fa) Zucker rats. Metabolism, 32(4), 371-376. . Publication link: 41973f8a-a7b4-46ec-a29c-4efa76739757
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1983). Metabolic responses to fasting and refeeding in lean and genetically obese rats. Am.J.Physiol, 244. . Publication link: 4416fcd6-f0bc-4937-8b7c-585fd7b8c332
  • Rothwell, N. J., & Stock, M. J. (1983). Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour. Clinical Science, 64(1), 19-23. . Publication link: ba1d0668-1f72-41ac-95e4-2d559782a300
  • Rothwell, N. J., Stock, M. J., & Warwick, B. P. (1983). The effect of high fat and high carbohydrate cafeteria diets on diet-induced thermogenesis in the rat. International Journal of Obesity, 7(3), 263-270. . Publication link: c9f19257-9104-4644-8e41-f5d2b14b34c5
  • Rothwell, N. J., Stock, M. J., Warwick, B. P., & Winter, P. D. O. B. (1983). Diurnal variations in circulating hormone levels and brown adipose tissue activity in "cafeteria"-fed rats. Comparative Biochemistry and Physiology -- Part A: Physiology, 75(3), 461-465. . Publication link: dc0b13c1-fde5-489d-bcaa-24933fcd474b
  • Rothwell, N. J., & Stock, M. J. (1983). Diet-induced thermogenesis. Adv.Nutr.Res., 5. . Publication link: e474d4de-ebb6-45d9-89b1-8ca61fdbe8c6
  • Marchington, D., Rothwell, N. J., Stock, M. J., & York, D. A. (1983). Energy balance, diet-induced thermogenesis and brown adipose tissue in lean and obese (fa/fa) Zucker rats after adrenalectomy.Journal of Nutrition, 113(7), 1395-1402. . Publication link: e7777aad-bed4-4fe1-979f-7532eb07c27d

1982

  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1982). Effects of feeding a 'cafeteria' diet on energy balance and diet induced thermogenesis in four strains of rat. Journal of Nutrition, 112(8), 1515-1524. . Publication link: 870dee26-6709-4f47-aa0f-55a0d17b48d9
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1982). Factors influencing the acute effect of food on oxygen consumption in the rat. International Journal of Obesity, 6(1), 53-59. . Publication link: 7714c519-128d-40dc-8917-2b7431b20028
  • Rothwell, N. J., & Stock, M. J. (1982). Effect of chronic food restriction on energy balance, thermogenic capacity, and brown-adipose-tissue activity in the rat. Bioscience Reports, 2(8), 543-549. DOI:10.1007/BF01314214. Publication link: 7304c007-9a54-438e-82e4-8ef4a3df22a8
  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1982). Sympathetic and thyroid influences on metabolic rate in fed, fasted, and refed rats. Am.J.Physiol, 243. . Publication link: 73812661-4b67-4833-8a83-70be61cd9f22
  • Rothwell, N. J., Stock, M. J., & Wyllie, M. G. (1982). Dopaminergic mechanisms in diet-induced thermogenesis and brown adipose tissue metabolism. European Journal of Pharmacology, 77(1), 45-48. . Publication link: 83b362ca-91dc-4f81-a533-7621eb2353fc
  • Rothwell, N. J., & Stock, M. J. (1982). Effects of early overnutrition and undernutrition in rats on the metabolic responses to overnutrition in later life. Journal of Nutrition, 112(3), 426-435. . Publication link: 24bab456-3616-4360-9ee8-624c0dd99c40
  • Brooks, S. L., Rothwell, N. J., & Stock, M. J. (1982). Effects of diet and acute noradrenaline treatment on brown adipose tissue development and mitochondrial purine-nucleotide binding. Quarterly Journal of Experimental Physiology, 67(2), 259-268. . Publication link: 0af9f4e4-f1bd-4fd2-ba3d-7118499aef76
  • Rothwell, N. J., & Stock, M. J. (1982). Energy expenditure of 'cafeteria'-fed rats determined from measurements of energy balance and indirect calorimetry. Journal of Physiology, 328, 371-377. . Publication link: 16105f0d-bd2b-498c-bef9-6ce93d286908
  • Rothwell, N. J., Saville, M. E., Stock, M. J., & Wyllie, M. G. (1982). Catecholamine and thyroid hormone influence on brown fat Na+, K+-ATPase activity and thermogenesis in the rat. Hormone and Metabolic Research, 14(5), 261-265. . Publication link: 1070ab99-f0df-404b-aa0a-f846865f88fa
  • Rothwell, N. J., Stock, M. J., & Tyzbir, R. S. (1982). Energy balance and mitochondrial function in liver and brown fat of rats fed 'cafeteria' diets of varying protein content. Journal of Nutrition, 112(9), 1663-1672. . Publication link: 47259fdd-06ce-40f0-96b7-54b1b728d0c7
  • Stock, M. J., & Rothwell, N. J. (1982). Evidence for diet-induced thermogenesis in hyperphagic cafeteria-fed rats.Proceedings of the Nutrition Society, 41(2), 133-135. . Publication link: 46f3afc7-5b69-4d99-a109-554d06ba5fda
  • Rothwell, N. J., & Stock, M. J. (1982). Effects of feeding a palatable "cafeteria' diet on energy balance in young and adult lean (+/?) Zucker rats.British Journal of Nutrition, 47(3), 461-471. . Publication link: 57e9a088-bd13-4f0c-a8d2-5497f0148776
  • Young, J. B., Saville, E., Rothwell, N. J., Stock, M. J., & Landsberg, L. (1982). Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. Journal of Clinical Investigation, 69(5), 1061-1071. . Publication link: f2cda749-81a3-4f54-8cc9-ce2e6f26dcd2
  • Rothwell, N. J., Stephens, D. N., & Stock, M. J. (1982). Changes in metabolic rate and brown adipose tissue composition during nutritional rehabilitation of postnatally undernourished rats. Biology of the Neonate, 42(1-2), 93-99. . Publication link: dd82539d-6704-4761-98df-17d12ad03661
  • Rothwell, N. J., Stock, M. J., & Stribling, D. (1982). Diet-induced thermogenesis. Pharmacol.Ther., 17. . Publication link: c0a2af23-1b92-452b-8912-99c2c61ab3d1

1981

  • Rothwell, N. J., Saville, M. E., & Stock, M. J. (1981). Acute effects of food, 2-deoxy-d-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats. Pflügers Archiv European Journal of Physiology, 392(2), 172-177. DOI:10.1007/BF00581268. Publication link: cfd1d3a5-c2a4-412f-a87f-5662b8a44afa
  • Rothwell, N. J., & Stock, M. J. (1981). Regulation of energy balance. Annu.Rev.Nutr., 1. . Publication link: d69d91f3-2b9c-440c-82a1-996fbc3e1e86
  • Stock, M. J., & Rothwell, N. J. (1981). Sympathetic control of brown adipose tissue in the regulation of body weight. Biochemical Society Transactions, 9(6), 525-527. . Publication link: c07575dc-a455-4fdb-a7f3-c50dfe5b2dd4
  • Rothwell, N. J., Stock, M. J., & Wyllie, M. G. (1981). Na+, K+-ATPase activity and noradrenaline turnover in brown adipose tissue of rats exhibiting diet-induced thermogenesis. Biochemical Pharmacology, 30(12), 1709-1712. . Publication link: c07948b9-cf93-47a0-a150-31659d5bbeaf
  • Brooks, S. L., Neville, A. M., Rothwell, N. J., Stock, M. J., & Wilson, S. (1981). Sympathetic activation of brown-adipose-tissue thermogenesis in cachexia. Bioscience Reports, 1(6), 509-517. DOI:10.1007/BF01121584. Publication link: c28d15d0-38ac-49f2-86b7-2809aabb84fd
  • Rothwell, N. J., & Stock, M. J. (1981). Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesis. Pflügers Archiv European Journal of Physiology, 389(3), 237-242. DOI:10.1007/BF00584784. Publication link: f97f003a-059d-4eb1-95a1-55981c86773c
  • Perkins, M. N., Rothwell, N. J., Stock, M. J., & Stone, T. W. (1981). Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature, 289(5796), 401-402. . Publication link: 183bd5ac-75af-4d4e-806f-ddc555b2e7ed
  • Rothwell, N. J., & Stock, M. J. (1981). A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats. Metabolism, 30(7), 673-678. . Publication link: 5a391761-a22e-4077-8417-6648ec9490a7
  • Rothwell, N. J., Stock, M. J., & Wyllie, M. G. (1981). Sympathetic mechanisms in diet-induced thermogenesis: Modification by ciclazindol and anorectic drugs. British Journal of Pharmacology, 74(3), 539-546. . Publication link: 9adb834b-76f6-4590-9966-aace56339c1c

1980

  • Rothwell, N. J., & Stock, M. J. (1980). Thermogenesis induced by cafeteria feeding in young growing rats.Proceedings of the Nutrition Society, 39(2), 45. . Publication link: c98c3896-d301-4365-8340-2d1beb941db8
  • Brooks, S. L., Rothwell, N. J., Stock, M. J., Goodbody, A. E., & Trayhurn, P. (1980). Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature, 286(5770), 274-276. DOI:10.1038/286274a0. Publication link: d5769c7c-8e93-4d7e-9de7-1add2eb6c92d
  • Gurr, M. I., Mawson, R., Rothwell, N. J., & Stock, M. J. (1980). Effects of manipulating dietary protein and energy intake on energy balance and thermogenesis in the pig. Journal of Nutrition, 110(3), 532-542. . Publication link: b845bbf5-2670-45a1-be4a-0f6e2678de2c
  • Rothwell, N. J., & Stock, M. J. (1980). Intra-strain differences in the response to overfeeding in the rat.Proceedings of the Nutrition Society, 39(1), 20. . Publication link: bce880fe-e66f-4e2a-a693-82baa72b9efa

1979

  • Gurr, M. I., Mawson, R., Rothwell, N. J., & Stock, M. J. (1979). Weight maintenance and dietary-induced thermogenesis in the weanling pig [proceedings ]. Journal of Physiology, 291, 60. . Publication link: 75d9f2c3-3928-4b47-9e9b-97df740b31a6
  • Rothwell, N. J., & Stock, M. J. (1979). Regulation of energy balance in two models of reversible obesity in the rat. Journal of Comparative and Physiological Psychology, 93(6), 1024-1034. . Publication link: 4788810c-4060-4e4b-bdb2-a64976f5cdb0
  • Rothwell, N. J., & Stock, M. J. (1979). A role for brown adipose tissue in diet-induced thermogenesis. Nature, 281(5726), 31-35. . Publication link: 2873ed2e-1007-4985-aebe-95504cdaaac3
  • Gurr, M. I., Rothwell, N. J., & Stock, M. J. (1979). Effects of tube-feeding iso-energetic amounts of various dietary lipids on energy balance in the rat.Proceedings of the Nutrition Society, 38(1), 6. . Publication link: 2d08fc11-5f27-4928-b026-e46c1def7d4f
  • Rothwell, N. J., & Stock, M. J. (1979). Combined effects of cafeteria and tube-feeding on energy balance in the rat.Proceedings of the Nutrition Society, 38(1), 5. . Publication link: f4a8bc8f-4671-4d4e-916d-e261bd67686d
  • Rothwell, N. J., & Stock, M. J. (1979). Effects of continuous and discontinuous periods of cafeteria feeding on body weight, resting oxygen consumption and noradrenaline sensitivity in the rat [proceedings]. Journal of physiology, Paris, 291. . Publication link: d6c64aee-8a5a-42c9-8232-6bb116b94120
  • Rothwell, N. J., & Stock, M. J. (1979). In vivo determination of body composition by tritium dilution in the rat. British Journal of Nutrition, 41(3), 625-628. . Publication link: d03db642-0560-4d4e-86e6-0d56ae6344c3

1978

  • Rothwell, N. J., & Stock, M. J. (1978). Mechanisms of weight gain and loss in reversible obesity in the rat [proceedings]. Journal of Physiology, 276. . Publication link: 3357ef5c-356d-4f12-9c51-935001774ff8
  • Rothwell, N. J., & Stock, M. J. (1978). A paradox in the control of energy intake in the rat. Nature, 273(5658), 146-147. . Publication link: 7717f42f-2f47-40d6-8dcf-d17829874f58

1976

  • Macdonald, I. A., Rothwell, N. J., & Stock, M. J. (1976). Lipolytic and lipogenic activities of adipose tissue during spontaneous fat depletion and repletion [proceedings]. Proceedings of the Nutrition Society, 35(3). . Publication link: f9f34d2a-cedd-4d7b-a2cb-e10ef881288c