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Professor Dame Nancy Rothwell (BSc, PhD, DSc, FMedSci, FRS) - publications

List of publications

2014

  • Singh, N., Hopkins, S., Hulme, S., Galea, J., Hoadley, M., Vail, A., Hutchinson, P., Grainger, S., Rothwell, N., King, A. & Tyrrell, P (2014). The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation, 11(1), 1. eScholarID:216890 | PMID:24383930 | DOI:10.1186/1742-2094-11-1

2013

  • Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A., Smigova, A., Cawthorne, C., Julyan, P., Wilkinson, S., Banister, S., Brown, G., Herholz, K., Kassiou, M. & Rothwell, N (2013). [(18)F]DPA-714: Direct Comparison with [(11)C]PK11195 in a Model of Cerebral Ischemia in Rats. PLoS One, 8(2), e56441. eScholarID:189648 | PMID:23418569 | DOI:10.1371/journal.pone.0056441
  • Denes, A., Wilkinson, F., Bigger, B., Chu, M., Rothwell, N. & Allan, S (2013). Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice. Dis Model Mech, eScholarID:194747 | PMID:23519030 | DOI:10.1242/dmm.011601
  • Dhungana, H., Malm, T., Denes, A., Valonen, P., Wojciechowski, S., Magga, J., Savchenko, E., Humphreys, N., Grencis, R., Rothwell, N. & Koistinaho, J (2013). Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection. Aging Cell, eScholarID:203300 | PMID:23725345 | DOI:10.1111/acel.12106
  • Girard, S., Brough, D., Lopez-Castejon, G., Giles, J., Rothwell, N. & Allan, S (2013). Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia, eScholarID:189647 | PMID:23404620 | DOI:10.1002/glia.22478

2012

  • Allen, C., Thornton, P., Denes, A., McColl, B., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. & Allan, S (2012). Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA. J Immunol, 189(1), 381-92. eScholarID:165343 | PMID:22661091 | DOI:10.4049/jimmunol.1200409
  • Cantrill, C., Skinner, R., Rothwell, N. & Penny, J (2012). An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model. Brain Res, eScholarID:169096 | PMID:22940232 | DOI:10.1016/j.brainres.2012.08.031
  • Denes, A., Drake, C., Stordy, J., Chamberlain, J., McColl, B., Gram, H., Crossman, D., Francis, S., Allan, S. & Rothwell, N (2012). Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis. J Am Heart Assoc, 1(3), e002006. eScholarID:182945 | PMID:23130147 | DOI:10.1161/JAHA.112.002006
  • Greenhalgh, A., Brough, D., Robinson, E., Girard, S., Rothwell, N. & Allan, S (2012). Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. Dis Model Mech, eScholarID:165342 | PMID:22679224 | DOI:10.1242/dmm.008557
  • Hopkins, S., McMahon, C., Singh, N., Galea, J., Hoadley, M., Scarth, S., Patel, H., Vail, A., Hulme, S., Rothwell, N., King, A. & Tyrrell, P (2012). Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection. J Neuroinflammation, 9(1), 255. eScholarID:182946 | PMID:23176037 | DOI:10.1186/1742-2094-9-255
  • Leow-Dyke, S., Allen, C., Denes, A., Nilsson, O., Maysami, S., Bowie, A., Rothwell, N. & Pinteaux, E (2012). Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J Neuroinflammation, 9, 230. eScholarID:184725 | PMID:23034047 | DOI:10.1186/1742-2094-9-230
  • McMahon, C., Hopkins, S., Vail, A., King, A., Smith, D., Illingworth, K., Clark, S., Rothwell, N. & Tyrrell, P (2012). Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage. J Neurointerv Surg, eScholarID:169100 | PMID:22952245 | DOI:10.1136/neurintsurg-2012-010386
  • Pradillo, J., Denes, A., Greenhalgh, A., Boutin, H., Drake, C., McColl, B., Barton, E., Proctor, S., Russell, J., Rothwell, N. & Allan, S (2012). Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats. J Cereb Blood Flow Metab, eScholarID:165344 | PMID:22781338 | DOI:10.1038/jcbfm.2012.101
  • Smith, C., Emsley, H., Udeh, C., Vail, A., Hoadley, M., Rothwell, N., Tyrrell, P. & Hopkins, S (2012). Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine, 58(3), 384-9. eScholarID:165345 | PMID:22445501 | DOI:10.1016/j.cyto.2012.02.016

2011

  • Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., Rothwell, N. & Boutin, H (2011). Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats. Br J Pharmacol, 162(3), 659-72. eScholarID:126179 | PMID:20942812 | DOI:10.1111/j.1476-5381.2010.01068.x
  • Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., Rothwell, N. & Boutin, H (2011). Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats. Br J Pharmacol, 162(3), 659-72. eScholarID:169102 | PMID:20942812 | DOI:10.1111/j.1476-5381.2010.01068.x
  • Denes, A., McColl, B., Leow-Dyke, S., Chapman, K., Humphreys, N., Grencis, R., Allan, S. & Rothwell, N (2011). Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses. Journal of Cerebral Blood Flow & Metabolism, 31(4), 1036. eScholarID:126181 | PMID:21045863 | DOI:10.1038/jcbfm.2010.198
  • Denes, A., Pinteaux, E., Rothwell, N. & Allan, S (2011). Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc Dis, 32(6), 517-27. eScholarID:159455 | PMID:22104408 | DOI:10.1159/000332205
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., Proctor, S., Russell, J., Hopkins, S., Tyrrell, P., Rothwell, N. & Allan, S (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun, eScholarID:126182 | PMID:21356305 | DOI:10.1016/j.bbi.2011.02.008
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., Proctor, S., Russell, J., Hopkins, S., Tyrrell, P., Rothwell, N. & Allan, S (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun, 25(6), 1113-22. eScholarID:169101 | PMID:21356305 | DOI:10.1016/j.bbi.2011.02.008
  • Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S., Rothwell, N. & Tyrrell, P (2011). Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study. J Cereb Blood Flow Metab, 31(2), 439-47. eScholarID:126180 | PMID:20628399 | DOI:10.1038/jcbfm.2010.103
  • Greenhalgh, A., Ogungbenro, K., Rothwell, N. & Galea, J (2011). Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke. Expert Opin Drug Metab Toxicol, 7(6), 681-95. eScholarID:126183 | PMID:21521135 | DOI:10.1517/17425255.2011.570259
  • Nguyen, L., Rothwell, N., Pinteaux, E. & Boutin, H (2011). Contribution of interleukin-1 receptor accessory protein B to interleukin-1 actions in neuronal cells. Neurosignals, 19(4), 222-30. eScholarID:159452 | PMID:21968452 | DOI:10.1159/000330803
  • Selvarajah, J., Smith, C., Hulme, S., Georgiou, R., Sherrington, C., Staniland, J., Illingworth, K., Jury, F., Payton, A., Ollier, W., Vail, A., Rothwell, N., Hopkins, S. & Tyrrell, P (2011). Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study. Int J Stroke, 6(3), 187-94. eScholarID:126184 | PMID:21557802 | DOI:10.1111/j.1747-4949.2010.00561.x
  • Small, B., McColl, B., Allmendinger, R., Pahle, J., López-Castejón, G., Rothwell, N., Knowles, J., Mendes, P., Brough, D. & Kell, D (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nat Chem Biol, 7(12), 902-8. eScholarID:159453 | PMID:22020553 | DOI:10.1038/nchembio.689

2010

  • Dénes A, Humphreys N, Lane TE, Grencis R, Rothwell N. (2010). Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice. Journal of Neuroscience, 30(30), 10086-10095. eScholarID:97971 | DOI:10.1523/JNEUROSCI.1227-10.2010
  • Thornton P, McColl BW, Cooper L, Rothwell NJ, Allan SM. (2010). Interleukin-1 Drives Cerebrovascular Inflammation via MAP Kinase-Independent Pathways. Curr Neurovasc Res, 7(4), 330-340. eScholarID:97965 | DOI:10.2174/156720210793180800
  • Denes, A., Thornton, P., Rothwell, N. & Allan, S (2010). Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav Immun, 24(5), 708-23. eScholarID:126185 | PMID:19770034 | DOI:10.1016/j.bbi.2009.09.010
  • Greenhalgh, A., Galea, J., Dénes, A., Tyrrell, P. & Rothwell, N (2010). Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection. British journal of pharmacology, 160(1), 153. eScholarID:97975 | PMID:20412072 | DOI:10.1111/j.1476-5381.2010.00684.x
  • McColl, B., Rose, N., Robson, F., Rothwell, N. & Lawrence, C (2010). Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke. J Cereb Blood Flow Metab, 30(2), 267-72. eScholarID:76669 | PMID:19826431 | DOI:10.1038/jcbfm.2009.217
  • Prenant, C., Cawthorne, C., Fairclough, M., Rothwell, N. & Boutin, H (2010). Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist. Appl Radiat Isot, 68(9), 1721-7. eScholarID:97976 | PMID:20435481 | DOI:10.1016/j.apradiso.2010.04.007
  • Thornton, P., McColl, B., Greenhalgh, A., Denes, A., Allan, S. & Rothwell, N (2010). Platelet interleukin-1{alpha} drives cerebrovascular inflammation. Blood, eScholarID:78635 | PMID:20200351 | DOI:10.1182/blood-2009-11-252643

2009

  • Brough D, Pelegrin P, Rothwell NJ. (2009). Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc. European journal of immunology, 39(2), 352-8. eScholarID:1c8177 | PMID:19130485 | DOI:10.1002/eji.200838843
  • Luheshi NM, Rothwell NJ, Brough D. (2009). The Dynamics and Mechanisms of Interleukin-1α and β Nuclear Import. Traffic, 10(1), 16-25. eScholarID:1c8176 | PMID:18939951 | DOI:10.1111/j.1600-0854.2008.00840.x
  • Chapman, K., Dale, V., Dénes, A., Bennett, G., Rothwell, N., Allan, S. & McColl, B (2009). A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab, 29(11), 1764-8. eScholarID:76672 | PMID:19654587 | DOI:10.1038/jcbfm.2009.113
  • Denes, A., Thornton, P., Rothwell, N. & Allan, S (2009). Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation. Brain Behav Immun, eScholarID:76670 | PMID:19770034 | DOI:10.1016/j.bbi.2009.09.010
  • Luheshi, N., Rothwell, N. & Brough, D (2009). Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy. Br J Pharmacol, 157(8), 1318-29. eScholarID:76671 | PMID:19681864 | DOI:10.1111/j.1476-5381.2009.00331.x
  • Skinner, R., Gibson, R., Rothwell, N., Pinteaux, E. & Penny, J (2009). Transport of interleukin-1 across cerebromicrovascular endothelial cells. Br J Pharmacol, 156(7), 1115-23. eScholarID:76673 | PMID:19298391 | DOI:10.1111/j.1476-5381.2008.00129.x

2008

  • Parry-Jones AR, Liimatainen T, Kauppinen RA, Gröhn OH, Rothwell NJ. (2008). Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 59(6), 1239-49. eScholarID:1c8173 | PMID:18421691 | DOI:10.1002/mrm.21531
  • Clark S, McMahon C, Gueorguieva I, Rowland M, Scarth S, Georgiou R, Tyrrell PJ, Hopkins SJ, Rothwell NJ. (2008). Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. J Cereb Blood Flow Metab, 28( 2), eScholarID:1d16878
  • Tsakiri N, Kimber I, Rothwell NJ, Pinteaux E. (2008). Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones. British Journal of Pharmacology, 153, 775-783. eScholarID:1c7099 | PMID:18059318 | DOI:10.1038/sj.bjp.0707610
  • Thornton P, Pinteaux E, Allan SM, Rothwell NJ. (2008). Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Molecular Cellular Neuroscience, 37, 135-142. eScholarID:1c7077 | PMID:17939964 | DOI:10.1016/j.mcn.2007.09.002
  • Tsakiri N, Kimber I, Rothwell NJ, Pinteaux E. (2008). Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Molecular Cellular Neuroscience, 37, 110-118. eScholarID:1c7096 | PMID:17933551 | DOI:10.1016/j.mcn.2007.09.001
  • Wang P, Rothwell NJ, Pinteaux E, Brough D. (2008). Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro. Brain research, 1236, 1-7. eScholarID:1c8174 | PMID:18722361 | DOI:10.1016/j.brainres.2008.08.001
  • Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrrell PJ, Hopkins SJ, Rowland M. (2008). Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol, 65(3), eScholarID:1d16890
  • Selvarajah JR, Scott M, Stivaros S, Hulme S, Georgiou R, Rothwell NJ, Tyrrell PJ, Jackson A-. (2008). Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke. European Radiology, 19(4), 1011. eScholarID:1d18692 | DOI:10.1007/s00330-008-1202-8
  • McColl BW, Rothwell NJ, Allan SM. (2008). Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice. Journal of Neuroscience, 28(38), 9451-62. eScholarID:1c8178 | PMID:18799677 | DOI:10.1523/JNEUROSCI.2674-08.2008
  • McColl BW, Allan SM, Rothwell NJ. (2008). Systemic infection, inflammation and acute ischemic stroke. Neuroscience, eScholarID:1c8175 | PMID:18789376 | DOI:10.1016/j.neuroscience.2008.08.019

2007

  • Ross J, Brough D, Gibson RM, Loddick SA, Rothwell NJ. (2007). A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Neuropharmacology, 53(5), 638-42. eScholarID:1c7094 | PMID:17845807 | DOI:10.1016/j.neuropharm.2007.07.015
  • Brough D, Rothwell NJ. (2007). Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. The Journal of Cell Science, 120, 772-781. eScholarID:1c6261 | DOI:10.1242/jcs.03377
  • Emsley HC, Smith CJ, Gavin CM, Georgiou RF, Vail A, Barberan EM, Illingworth K, Scarth S, Wickramasinghe V, Hoadley ME, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2007). Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC neurology, 7, 5. eScholarID:1c6526 | PMID:17328808 | DOI:10.1186/1471-2377-7-5
  • Emsley, HCA, Smith, CJ, Gavin, CCM, Georgiou, R, Vail, A, Barberan, EM, Illingworth, K, Scarth, S, Wickramasinghe, V, Hoadley, M, Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2007). Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol, 7, eScholarID:1d16882 | DOI:10.1186/1471-2377-7-5
  • Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD. (2007). Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. Journal of neurotrauma, 24(10), 1545-57. eScholarID:1c7098 | PMID:17970618 | DOI:10.1089/neu.2007.0295
  • Hutchinson, P, O'Connell, M, Rothwell, NJ, Hopkins, SJ, Nortje, J, Carpenter, K, Timofeev, I, Al-Rawi, P, Menon, D, Pickard, J. (2007). Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma, 24( 10), eScholarID:1d16888
  • Watson PM, Humphries MJ, Relton J, Rothwell NJ, Verkhratsky A, Gibson RM. (2007). Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Molecular and cellular neurosciences, 34(2), 147-54. eScholarID:1c6527 | PMID:17150373 | DOI:10.1016/j.mcn.2006.10.007
  • Simi A, Tsakiri N, Wang P, Rothwell NJ. (2007). Interleukin-1 and inflammatory neurodegeneration. Biochemical Society transactions, 35(Pt 5), 1122-6. eScholarID:1c7097 | PMID:17956293 | DOI:10.1042/BST0351122
  • Clark SR, McMahon CJ, Gueorguieva I, Rowland M, Scarth S, Georgiou R, Tyrrell PJ, Hopkins SJ, Rothwell NJ. (2007). Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. eScholarID:1c7093 | PMID:17684519 | DOI:10.1038/sj.jcbfm.9600537
  • Pinteaux E, Inoue W, Schmidt L, Molina-Holgado F, Rothwell NJ, Luheshi GN. (2007). Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism. Journal of Neurochemistry, 102, 826-833. eScholarID:1c6513 | PMID:17419800 | DOI:10.1111/j.1471-4159.2007.04559.x
  • Miggin SM, Pålsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA. (2007). NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proceedings of the National Academy of Sciences of the United States of America, 104(9), 3372-7. eScholarID:1c6514 | PMID:17360653 | DOI:10.1073/pnas.0608100104
  • Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrell PJ, Hopkins SJ, Rowland M. (2007). Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. eScholarID:1c7095 | PMID:17875190 | DOI:10.1111/j.1365-2125.2007.03026.x
  • McColl BW, Allan SM, Rothwell NJ. (2007). Systemic inflammation and stroke: aetiology, pathology and targets for therapy. Biochemical Society transactions, 35(Pt 5), 1163-5. eScholarID:1c7078 | PMID:17956302 | DOI:10.1042/BST0351163
  • McColl BW, Rothwell NJ, Allan SM. (2007). Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(16), 4403-12. eScholarID:1c6537 | PMID:17442825 | DOI:10.1523/JNEUROSCI.5376-06.2007

2006

  • Andre R, Moggs JG, Kimber I, Rothwell NJ, Pinteaux E. (2006). Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia, 53(5), 477-83. eScholarID:1c5628 | PMID:16358337 | DOI:10.1002/glia.20302
  • Thornton P, Pinteaux E, Gibson RM, Allan SM, Rothwell NJ. (2006). Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release. Journal of Neurochemistry, 98, 258-66. eScholarID:1c5617 | PMID:16805812 | DOI:10.1111/j.1471-4159.2006.03872.x
  • Patel HC, Ross FM, Heenan LE, Davies RE, Rothwell NJ, Allan SM. (2006). Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. Journal of neuroscience research, 83(3), 385-91. eScholarID:1c5620 | PMID:16358339 | DOI:10.1002/jnr.20735
  • Pinteaux E, Rothwell NJ, Boutin H. (2006). Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia. Glia, 53(5), 551-6. eScholarID:1c5627 | PMID:16374779 | DOI:10.1002/glia.20308
  • Pinteaux E, Rothwell NJ, Boutin H. (2006). Neuroprotective actions of endogenous interleukin-1 receptor antagonist(IL-1ra) are mediated by glia. Glia, 53 (5), eScholarID:1d33139
  • Lucas SM, Rothwell NJ, Gibson RM. (2006). The role of inflammation in CNS injury and disease. British journal of pharmacology, 147 Suppl 1, S232-40. eScholarID:1c5626 | PMID:16402109 | DOI:10.1038/sj.bjp.0706400
  • Smith CJ, Emsley HCA, Vail A, Georgiou R, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2006). Variability of the systemic acute phase response after ischemic stroke. J Neuro Sci, 251(1-2), eScholarID:1d27470 | DOI:10.1016/j.jns.2006.09.011

2005

  • Emsley C A, Smith CJ, Georgiou R, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ. (2005). A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. Journal of Neurol. Neurosurg. Psychiatry, 76, eScholarID:1d11508 | DOI:10.1136/jnnp.2004.054882
  • Bano D, Young KW, Guerin CJ, LeFeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P. (2005). Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell, 120(2), 275-85. eScholarID:1c4614 | PMID:15680332 | DOI:10.1016/j.cell.2004.11.049
  • Emsley HC, Smith CJ, Georgiou RF, Vail A, Tyrrell PJ, Barberan EM, Rothwell NJ, Hopkins SJ. (2005). Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke; a journal of cerebral circulation, 36(2), 228-9; author reply 228-9. eScholarID:1c4615 | PMID:15625287 | DOI:10.1161/01.STR.0000155197.88944.ac
  • Emsley, HCA, Smith, CJ, Georgiou, R, Vail, A, Tyrrell, PJ, Barberan, EM, Rothwell, NJ, Hopkins, SJ, Audebert, H, Haberl, RL. (2005). Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke, 36( 2), eScholarID:17d511
  • Andre R, Pinteaux E, Kimber I, Rothwell NJ. (2005). Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways. Neuroreport, 16(2), 153-7. eScholarID:1c4609 | PMID:15671867 | DOI:10.1097/00001756-200502080-00017
  • Allan S, Tyrrell PJ, Rothwell NJ. (2005). Interleukin-1 and neuronal injury. Nat Rev Immunol, 5( 8), eScholarID:1d31190
  • Allan SM, Tyrrell PJ, Rothwell NJ. (2005). Interleukin-1 and neuronal injury. Nature reviews. Immunology, 5(8), 629-40. eScholarID:1c4608 | PMID:16034365 | DOI:10.1038/nri1664
  • Emsley HCA, Craig Smith, Georgiou R, Vail A, Barberan EM, Rothwell NJ, Tyrrell PJ. (2005). Interleukin-6 and acute ischaemic stroke. Acta Neurologica Scandinavica (+suppl), 112, eScholarID:17d424
  • Emsley HC, Smith CJ, Georgiu RF, Vail A, Barberan EM, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2005). Interleukin-6 and acute ischaemic stroke. Acta neurologica Scandinavica, 112(4), 273-4; author reply 275. eScholarID:1c4612 | PMID:16146500 | DOI:10.1111/j.1600-0404.2005.00479.x
  • Emsley H, Smith CJ, Georgiu R, Vail A, Barberan EM, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2005). Interleukin-6 and acute ischaemic stroke. Acta Neurol Scand, 112( 4), eScholarID:17d504
  • Molina-Holgado F, Pinteaux E, Heenan L, Moore JD, Rothwell NJ, Gibson RM. (2005). Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling. Molecular and cellular neurosciences, 28(1), 189-94. eScholarID:1c4610 | PMID:15607953 | DOI:10.1016/j.mcn.2004.09.004
  • Andre R, Lerouet D, Kimber I, Pinteaux E, Rothwell NJ. (2005). Regulation of expression of the novel IL-1 receptor family members in the mouse brain. Journal of neurochemistry, 95(2), 324-30. eScholarID:1c4607 | PMID:16086690 | DOI:10.1111/j.1471-4159.2005.03364.x
  • Wang P, Meinhardt B, Andre R, Renshaw BR, Kimber I, Rothwell NJ, Pinteaux E. (2005). The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses. Cytokine, 29(6), 245-50. eScholarID:1c4613 | PMID:15749024

2004

  • Gibson RM, Rothwell NJ, Le Feuvre RA. (2004). CNS injury: the role of the cytokine IL-1. Veterinary journal (London, England : 1997), 168(3), 230-7. eScholarID:1c4611 | PMID:15501140 | DOI:10.1016/j.tvjl.2003.10.016
  • Smith, C, Emsley, H, Gavin, C, Georgiou, R, Vail, A, Barberan, E, Del Zoppo, G, Hallenbeck, J, Rothwell, NJ, Hopkins, S, Tyrrell, P. (2004). Correction: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol, 4( 1), eScholarID:1d29083
  • Smith, CJ, Emsley, HCA, Gavin, C, Georgiou, R, Vail, A, Barberan, EM, Del Zoppo, G, Hallenbeck, J, Rothwell, NJ, Hopkins, SJ, Tyrrell, PJ. (2004). Peak Plasma Interleukin-6 and Other Periperhal Markers of Inflammation in tne first week of Ischaemic Stroke Correlate with Brain Infarct Volume, Stroke Severity and Long-term Outcome. BMC Neurology, Jan 15; 4:2, eScholarID:1d7414 | DOI:10.1186/1471-2377-4-2
  • Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, Barberan EM, Del Zoppo GJ, Hallenbeck JM, Rothwell NJ, Hopkins SJ, Tyrrell PJ. (2004). Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurology, 4(1), 2. eScholarID:1c2892

2003

  • Ross F, Allan S, Rothwell NJ, Verkhratsky A. (2003). A dual role for interleukin-1 in LTP in mouse hippocampal slices. J Neuroimmunol, 144( 1-2), 61-7. eScholarID:1d28997
  • Verkhratsky A, Rothwell NJ, Ross FM, Allan SM. (2003). A dual role for interleukin-1 in LTP in mouse hippocampal slices. Journal of neuroimmunology, 144(1-2), 61-67. eScholarID:1c83 | PMID:14597099 | DOI:10.1016/j.jneuroim.2003.08.030
  • Rothwell N.J., Emsley H.C., Smith C.J., Barberan E.M., Tyrrell P.J., Gavin C.M., Hopkins S.J., Vail A., Georgiou R.F., Hallenbeck J.M., Del Zoppo G.J. (2003). An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. Journal of neuroimmunology, 139(1-2), 93-101. eScholarID:1c316 | DOI:10.1016/S0165-5728(03)00134-6
  • Emsley, HCA, Smith, CJ, Gavin,C.M., Georgiou, R, Vail, A, Barberan,E.M., Hallenbeck,J.M., del Zoppo,G.J., Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2003). An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. Journal of Neuroimmunology, 139, 1-2, 93-101. eScholarID:1d5582 | DOI:10.1016/S0165-5728(03)00134-6
  • Brough D, Le Feuvre RA, Wheeler RD, Solovyova N, Hilfiker S, Rothwell NJ, Verkhratsky A. (2003). Ca(2+) Stores and Ca(2+) Entry Differentially Contribute to the Release of IL-1beta and IL-1alpha from Murine Macrophages. Journal of immunology (Baltimore, Md. : 1950), 170(6), 3029-3036. eScholarID:1c315
  • Brough D, Le Feuvre R, Wheeler R, Solovyova N, Hilfiker S, Rothwell NJ, Verkhratsky A. (2003). Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J Immunol, 170( 6), 3029-36. eScholarID:1d28929
  • Mulcahy N, Ross J, Rothwell NJ, Loddick S. (2003). Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br J Pharmacol, 140( 3), 471-6. eScholarID:1d28998
  • Mulcahy NJ, Ross J, Rothwell NJ, Loddick SA. (2003). Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. British journal of pharmacology, 140, 471-476. eScholarID:1c2378 | DOI:10.1038/sj.bjp.0705462
  • Molina-Holgado F, Pinteaux E, Moore JD, Molina-Holgado E, Guaza C, Gibson RM, Rothwell NJ. (2003). Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurones and glia. Journal of Neuroscience, 23, 6470-6474. eScholarID:1c2376
  • Molina-Holgado F, Pinteaux E, Moore J, Molina-Holgado E, Guaza C, Gibson R, Rothwell NJ. (2003). Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J Neurosci, 23( 16), 6470-4. eScholarID:1d28928
  • Berglof E, Andre R, Renshaw BR, Allan SM, Lawrence CB, Rothwell NJ, Pinteaux E. (2003). IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. Journal of neuroimmunology, 139(1-2), 36-43. eScholarID:1c314 | DOI:10.1016/S0165-5728(03)00130-9
  • Berglöf E, Andre R, Renshaw B, Allan S, Lawrence C, Rothwell NJ, Pinteaux E. (2003). IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. J Neuroimmunol, 139(1-2), 36-43. eScholarID:1d28557 | DOI:10.1016/S0165-5728(03)00130-9
  • Andre R, Wheeler RD, Collins PD, Luheshi GN, Pickering-Brown S, Kimber I, Rothwell NJ, Pinteaux E. (2003). Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. Journal of neuroimmunology, 145(1-2), 40-5. eScholarID:1c4666 | PMID:14644029 | DOI:10.1016/j.jneuroim.2003.09.005
  • Andre R, Wheeler R, Collins P, Luheshi G, Pickering-Brown S, Kimber I, Rothwell NJ, Pinteaux E. (2003). Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. J Neuroimmunol, 145( 1-2), 40-5. eScholarID:1d28927
  • Allan S, Rothwell NJ. (2003). Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci, 358( 1438), 1669-77. eScholarID:1d28575
  • Allan SM, Rothwell NJ. (2003). Inflammation in central nervous system injury. Philosophical Transactions of the Royal Society (London), 358(1438), 1669-1677. eScholarID:1c84 | PMID:14561325 | DOI:10.1098/rstb.2003.1358
  • Rothwell NJ. (2003). Interleukin-1 and neuronal injury: mechanisms, modification and therapeutic potential. Brain, Bahaviour and Immunity, 17, 152-157. eScholarID:1c2379 | DOI:10.1016/S0889-1591(02)00098-3
  • Rothwell NJ. (2003). Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav Immun, 17( 3), 152-7. eScholarID:1d29722
  • Wheeler R, Brough D, Le Feuvre R, Takeda K, Iwakura Y, Luheshi G, Rothwell NJ. (2003). Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta. J Neurochem, 85( 6), 1412-20. eScholarID:1d28582
  • Wheeler RD, Brough D, Le Feuvre RA, Takeda K, Iwakura Y, Luheshi GN, Rothwell NJ. (2003). Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1beta. Journal of neurochemistry, 85(6), 1412-1420. eScholarID:1c322 | DOI:10.1046/j.1471-4159.2003.01787.x
  • Wheeler R, Boutin H, Touzani O, Luheshi G, Takeda K, Rothwell NJ. (2003). No role for interleukin-18 in acute murine stroke-induced brain injury. J Cereb Blood Flow Metab, 23( 5), 531-5. eScholarID:1d29005
  • Wheeler RD, Boutin H, Touzani O, Luheshi GN, Takeda K, Rothwell NJ. (2003). No role for interleukin-18 in acute murine stroke-induced brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23(5), 531-5. eScholarID:1c4665 | PMID:12771567
  • Le Feuvre RA, Brough D, Touzani O, Rothwell NJ. (2003). Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23(3), 381-4. eScholarID:1c79 | PMID:12621313
  • Le Feuvre R, Brough D, Touzani O, Rothwell NJ. (2003). Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. J Cereb Blood Flow Metab, 23( 3), 381-4. eScholarID:1d29006
  • Boutin H, Kimber I, Rothwell NJ, Pinteaux E. (2003). The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol Neurobiol, 27( 3), 239-48. eScholarID:1d28544
  • Boutin H, Kimber I, Rothwell NJ, Pinteaux E. (2003). The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signalling pathways exist in the brain? Molecular neurobiology, 27, 239-248. eScholarID:1c2377 | DOI:10.1385/MN:27:3:239
  • Wheeler R, Young E, Rothwell NJ, Hall M, Luheshi G. (2003). Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine, 21( 4), 161-6. eScholarID:1d28558
  • Wheeler RD, Young EA, Rothwell NJ, Hall MD, Luheshi GN. (2003). Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine, 21(4), 161-6. eScholarID:1c4669 | PMID:12788303 | DOI:10.1016/S1043-4666(03)00028-0

2002

  • Pinteaux E., Parker L.C., Rothwell N.J., Luheshi G.N. (2002). Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. Journal of neurochemistry, 83, 754-763. eScholarID:1c541 | DOI:10.1046/j.1471-4159.2002.01184.x
  • Pinteaux E, Parker L, Rothwell NJ, Luheshi G. (2002). Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J Neurochem, 83( 4), 754-63. eScholarID:1d29084
  • Le Feuvre R, Brough D, Rothwell N. (2002). Extracellular ATP and P2X7 receptors in neurodegeneration. European journal of pharmacology, 447(2-3), 261-9. eScholarID:1c80 | PMID:12151017 | DOI:10.1016/S0014-2999(02)01848-4
  • Parker L.C., Luheshi G.N., Rothwell N.J., Pinteaux E. (2002). IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice. British journal of pharmacology, 136, 312-320. eScholarID:1c538 | DOI:10.1038/sj.bjp.0704715
  • Parker L, Luheshi G, Rothwell NJ, Pinteaux E. (2002). IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice. Br J Pharmacol, 136( 2), 312-20. eScholarID:1d28438
  • Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G, Rothwell N. (2002). Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. Journal of Neuroscience, 22(1), 38-43. eScholarID:1c81 | PMID:11756486
  • Moore J.D., Rothwell N.J., Gibson R.M. (2002). Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent. British journal of pharmacology, 135, 1069-1077. eScholarID:1c318 | DOI:10.1038/sj.bjp.0704538
  • Moore J, Rothwell NJ, Gibson R. (2002). Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent. Br J Pharmacol, 135( 4), 1069-77. eScholarID:1d28439
  • Ellacott K.L., Lawrence C.B., Rothwell N.J., Luckman S.M. (2002). PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology, 143, 368-374. eScholarID:1c482 | DOI:10.1210/en.143.2.368
  • Ellacott K, Lawrence C, Rothwell NJ, Luckman S. (2002). PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology, 143( 2), 368-74. eScholarID:1d28930
  • Le Feuvre R.A., Brough D., Iwakura Y., Takeda K., Rothwell N.J. (2002). Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. Journal of Biological Chemistry, 277, 3210-3218. eScholarID:1c317 | DOI:10.1074/jbc.M104388200
  • Le Feuvre R, Brough D, Iwakura Y, Takeda K, Rothwell NJ. (2002). Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem, 277( 5), 3210-8. eScholarID:1d28565
  • Brough D., Le Feuvre R.A., Iwakura Y., Rothwell N.J. (2002). Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Molecular and cellular neurosciences, 19, 272-280. eScholarID:1c446 | DOI:10.1006/mcne.2001.1054
  • Brough D, Le Feuvre R, Iwakura Y, Rothwell NJ. (2002). Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol Cell Neurosci, 19( 2), 272-80. eScholarID:1d29724
  • Molina-Holgado F., Molina-Holgado E., Guaza C., Rothwell N.J. (2002). Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. Journal of neuroscience research, 67, 829-836. eScholarID:1c533 | DOI:10.1002/jnr.10165
  • Molina-Holgado F, Molina-Holgado E, Guaza C, Rothwell NJ. (2002). Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. J Neurosci Res, 67( 6), 829-36. eScholarID:1d29085
  • Grundy R.I., Rothwell N.J., Allan S.M. (2002). Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum. Brain research, 926, 142-148. eScholarID:1c490 | DOI:10.1016/S0006-8993(01)03325-X
  • Grundy R, Rothwell NJ, Allan S. (2002). Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum. Brain Res, 926( 1-2), 142-8. eScholarID:1d29120
  • Oakden E, Chiswick M, Rothwell N, Loddick S. (2002). The influence of litter size on brain damage caused by hypoxic-ischemic injury in the neonatal rat. Pediatric research, 52(5), 692-6. eScholarID:1c4682 | PMID:12409515 | DOI:10.1203/00006450-200211000-00014

2001

  • Molina-Holgado F., Grencis R., Rothwell N.J. (2001). Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines. Glia, 33, 97-106. eScholarID:1c532 | DOI:10.1002/1098-1136(200102)33:2<97::AID-GLIA1009>3.0.CO;2- N
  • Molina-Holgado F, Grencis R, Rothwell NJ. (2001). Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines. Glia, 33( 2), 97-106. eScholarID:1d28584
  • Lawrence C, Rothwell NJ. (2001). Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. J Neuroendocrinol, 13( 6), 490-5. eScholarID:1d29726
  • Lawrence CB, Rothwell NJ. (2001). Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. Journal of neuroendocrinology, 13(6), 490-5. eScholarID:1c4681 | PMID:11412335 | DOI:10.1046/j.1365-2826.2001.00660.x
  • Allan S.M., Rothwell N.J. (2001). Cytokines and acute neurodegeneration. Nature reviews. Neuroscience, 2, 734-744. eScholarID:1c431 | DOI:10.1038/35094583
  • Allan SS.M, Rothwell NJ. (2001). Cytokines and acute neurodegeneration. Nat Rev Neurosci, eScholarID:1d33059
  • Allan S, Rothwell NJ. (2001). Cytokines and acute neurodegeneration. Nat Rev Neurosci, 2( 10), 734-44. eScholarID:1d28545
  • Craighead M.W., Middlehurst K.M., LeFeuvre R., Kimber I., Rothwell N.J. (2001). Oxidised adenosine 5"-triphosphate, a P2X(7) antagonist, is toxic to rat cerebellar granule neurones in vitro. Neuroscience letters, 311, 77-80. eScholarID:1c475 | DOI:10.1016/S0304-3940(01)02110-3
  • Craighead M, Middlehurst K, LeFeuvre R, Kimber I, Rothwell NJ. (2001). Oxidised adenosine 5'-triphosphate, a P2X(7) antagonist, is toxic to rat cerebellar granule neurones in vitro. Neurosci Lett, 311( 2), 77-80. eScholarID:1d28546
  • Boutin H., LeFeuvre R.A., Horai R., Asano M., Iwakura Y., Rothwell N.J. (2001). Role of IL-1alpha and IL-1beta in ischemic brain damage. Journal of Neuroscience, 21, 5528-5534. eScholarID:1c442
  • Boutin H, LeFeuvre R, Horai R, Asano M, Iwakura Y, Rothwell NJ. (2001). Role of IL-1alpha and IL-1beta in ischemic brain damage. J Neurosci, 21( 15), 5528-34. eScholarID:1d28936
  • Cartmell T., Luheshi G.N., Hopkins S.J., Rothwell N.J., Poole S. (2001). Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat. Journal of physiology, Paris, 531, 171-180. eScholarID:1c459
  • Cartmell T, Luheshi GG, Hopkins SJ, Rothwell NJ, Poole S. (2001). Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat. J Physiol, 531( Pt 1), 171-80. eScholarID:1d7832
  • Allan S.M., Harrison D.C., Read S., Collins B., Parsons A.A., Philpott K., Rothwell N.J. (2001). Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1. Brain research. Molecular brain research, 93, 180-189. eScholarID:1c432
  • Allan S, Harrison D, Read S, Collins B, Parsons A, Philpott K, Rothwell NJ. (2001). Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1. Brain Res Mol Brain Res, 93( 2), 180-9. eScholarID:1d28566
  • Rothwell NJ. (2001). Thermogenesis: where are we and where are we going? Report of a workshop held in London 21st April 2001, convened by Professor Mike Stock. Int J Obes Relat Metab Disord, 25( 9), 1272-4. eScholarID:1d28926

2000

  • Cartmell T., Poole S., Turnbull A.V., Rothwell N.J., Luheshi G.N. (2000). Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. Journal of physiology, Paris, 526 Pt 3, 653. eScholarID:1c458
  • Cartmell T, Poole S, Turnbull A, Rothwell NJ, Luheshi G. (2000). Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J Physiol, 526 Pt 3, 653-61. eScholarID:1d28585
  • Allan S.M., Parker L.C., Collins B., Davies R., Luheshi G.N., Rothwell N.J. (2000). Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc.Natl.Acad.Sci.U.S.A, 97, 5580. eScholarID:1c429
  • Allan S, Parker L, Collins B, Davies R, Luheshi G, Rothwell NJ. (2000). Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc Natl Acad Sci U S A, 97( 10), 5580-5. eScholarID:1d29008
  • Allan S.M., Rothwell N.J. (2000). Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 20, 1409. eScholarID:1c430
  • Allan S, Rothwell NJ. (2000). Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors. J Cereb Blood Flow Metab, 20( 10), 1409-13. eScholarID:1d28440
  • Wheeler R.D., Culhane A.C., Hall M.D., Pickering-Brown S., Rothwell N.J., Luheshi G.N. (2000). Detection of the interleukin 18 family in rat brain by RT-PCR. Brain research. Molecular brain research, 77, 290. eScholarID:1c683
  • Wheeler R, Culhane A, Hall M, Pickering-Brown S, Rothwell NJ, Luheshi G. (2000). Detection of the interleukin 18 family in rat brain by RT-PCR. Brain Res Mol Brain Res, 77( 2), 290-3. eScholarID:1d28938
  • Parker L.C., Rushforth D.A., Rothwell N.J., Luheshi G.N. (2000). IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat. Brain research. Molecular brain research, 79, 156. eScholarID:1c537
  • Parker L, Rushforth D, Rothwell NJ, Luheshi G. (2000). IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat. Brain Res Mol Brain Res, 79( 1-2), 156-8. eScholarID:1d28441
  • Craighead M.W., Boutin H., Middlehurst K.M., Allan S.M., Brooks N., Kimber I., Rothwell N.J. (2000). Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo. Brain research, 881, 139. eScholarID:1c474
  • Craighead M, Boutin H, Middlehurst K, Allan S, Brooks N, Kimber I, Rothwell NJ. (2000). Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo. Brain Res, 881( 2), 139-43. eScholarID:1d29188
  • Zampronio A.R., Hoadley M.E., Luheshi G., Rothwell N.J., De Souza G.E., Hopkins S.J. (2000). Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages. Eur.Cytokine Netw, 11, 589. eScholarID:1c687
  • Zampronio A, Hoadley M, Luheshi GG, Rothwell NJ, de Souza G, Hopkins SJ. (2000). Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages. Eur Cytokine Netw, 11( 4), 589-96. eScholarID:1d16905
  • Rothwell NJ, Luheshi G. (2000). Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci, 23( 12), 618-25. eScholarID:1d28937
  • Rothwell N.J., Luheshi G.N. (2000). Interleukin-1 in the brain: biology, pathology and therapeutic target. Trends in neurosciences, 23, 618. eScholarID:1c660
  • Molina-Holgado F., Toulmond S., Rothwell N.J. (2000). Involvement of interleukin-1 in glial responses to lipopolysaccharide: endogenous versus exogenous interleukin-1 actions. Journal of neuroimmunology, 111, 1. eScholarID:1c531
  • Molina-Holgado F, Toulmond S, Rothwell NJ. (2000). Involvement of interleukin-1 in glial responses to lipopolysaccharide: endogenous versus exogenous interleukin-1 actions. J Neuroimmunol, 111( 1-2), 1-9. eScholarID:1d29187
  • Rothwell N.J. (2000). Show them how it"s really done. Nature, 405, 621. eScholarID:1c661
  • Rothwell NJ. (2000). Show them how it's really done. Nature, 405( 6787), eScholarID:1d29007

1999

  • Rothwell NJ. (1999). Annual review prize lecture cytokines - killers in the brain? J Physiol, 514 ( Pt 1), 3-17. eScholarID:1d29723
  • Rothwell N.J. (1999). Annual review prize lecture. Cytokines - killers in the brain? Journal of physiology, Paris, 514 (Pt 1), 3. eScholarID:1c658
  • Cartmell T., Luheshi G.N., Rothwell N.J. (1999). Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. Journal of physiology, Paris, 518 ( Pt 2), 585. eScholarID:1c457
  • Cartmell T, Luheshi G, Rothwell NJ. (1999). Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol, 518 ( Pt 2), 585-94. eScholarID:1d28948
  • Lenczowski M.J., Bluthe R.M., Roth J., Rees G.S., Rushforth D.A., van Dam A.M., Tilders F.J., Dantzer R., Rothwell N.J., Luheshi G.N. (1999). Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. Am.J.Physiol, 276, R652. eScholarID:1c513
  • Rothwell N.J. (1999). Cytokines "Killers in the Brain". Journal of physiology, Paris, 514.1, 3. eScholarID:1c659
  • Grundy R.I., Rothwell N.J., Allan S.M. (1999). Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat. Brain research, 830, 32. eScholarID:1c489
  • Grundy R, Rothwell NJ, Allan S. (1999). Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat. Brain Res, 830( 1), 32-7. eScholarID:1d28939
  • Pearson V.L., Rothwell N.J., Toulmond S. (1999). Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia, 25, 311. eScholarID:1c539
  • Pearson V, Rothwell NJ, Toulmond S. (1999). Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia, 25( 4), 311-23. eScholarID:1d29010
  • Lawrence C.B., Turnbull A.V., Rothwell N.J. (1999). Hypothalamic control of feeding. Curr.Opin.Neurobiol, 9, 778. eScholarID:1c508
  • Lawrence C, Turnbull A, Rothwell NJ. (1999). Hypothalamic control of feeding. Curr Opin Neurobiol, 9( 6), 778-83. eScholarID:1d28547
  • Luheshi G.N., Gardner J.D., Rushforth D.A., Loudon A.S., Rothwell N.J. (1999). Leptin actions on food intake and body temperature are mediated by IL-1. Proc.Natl.Acad.Sci.U.S.A, 96, 7047. eScholarID:1c522
  • Luheshi G, Gardner J, Rushforth D, Loudon A, Rothwell NJ. (1999). Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A, 96( 12), 7047-52. eScholarID:1d29009
  • Loddick S.A., Rothwell N.J. (1999). Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1. Proc.Natl.Acad.Sci.U.S.A, 96, 9449. eScholarID:1c518
  • Loddick S, Rothwell NJ. (1999). Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1. Proc Natl Acad Sci U S A, 96( 17), 9449-51. eScholarID:1d28568
  • Davies C.A., Loddick S.A., Toulmond S., Stroemer R.P., Hunt J., Rothwell N.J. (1999). The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19, 87. eScholarID:1c480
  • Davies CA, Loddick S, Toulmond S, Stroemer R, Hunt J, Rothwell NJ. (1999). The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab, 19( 1), 87-98. eScholarID:1d28586
  • Artis D., Humphreys N.E., Bancroft A.J., Rothwell N.J., Potten C.S., Grencis R.K. (1999). Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J.Exp.Med, 190, 953. eScholarID:1c438
  • Artis D, Humphreys N, Bancroft A, Rothwell NJ, Potten C, Grencis R. (1999). Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med, 190( 7), 953-62. eScholarID:1d28567

1998

  • Davies C.A., Loddick S.A., Stroemer R.P., Hunt J., Rothwell N.J. (1998). An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat. Exp.Neurol, 154, 199. eScholarID:1c479
  • Davies CA, Loddick S, Stroemer R, Hunt J, Rothwell NJ. (1998). An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat. Exp Neurol, 154( 1), 199-212. eScholarID:1d28583
  • Anforth H.R., Bluthe R.M., Bristow A., Hopkins S., Lenczowski M.J., Luheshi G., Lundkvist J., Michaud B., Mistry Y., van Dam A.M., Zhen C., Dantzer R., Poole S., Rothwell N.J., Tilders F.J., Wollman E.E. (1998). Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta. Eur.Cytokine Netw, 9, 279. eScholarID:1c435
  • Anforth, H, Bluthe, R, Bristow, A, Hopkins, S, Lenczowski, M, Luheshi, G, Lundkvist, J, Michaud, B, Mistry, Y, Van Dam, A, Zhen, C, Dantzer, R, Poole, S, Rothwell, NJ, Tilders, F, Wollman, E. (1998). Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta. Eur Cytokine Netw, 9( 3), 279-88. eScholarID:1d28442
  • Ochu E.E., Rothwell N.J., Waters C.M. (1998). Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. Journal of neurochemistry, 70, 2637. eScholarID:1c536
  • Ochu E, Rothwell NJ, Waters C. (1998). Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J Neurochem, 70( 6), 2637-40. eScholarID:1d29727
  • Loddick S.A., Turnbull A.V., Rothwell N.J. (1998). Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 18, 176. eScholarID:1c517
  • Loddick S, Turnbull A, Rothwell NJ. (1998). Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab, 18( 2), 176-9. eScholarID:1d29728
  • Culhane A.C., Hall M.D., Rothwell N.J., Luheshi G.N. (1998). Cloning of rat brain interleukin-18 cDNA. Mol.Psychiatry, 3, 362. eScholarID:1c476
  • Culhane A, Hall M, Rothwell NJ, Luheshi G. (1998). Cloning of rat brain interleukin-18 cDNA. Mol Psychiatry, 3( 4), 362-6. eScholarID:1d29190
  • Huitinga I., Bauer J., Strijbos P.J., Rothwell N.J., Dijkstra C.D., Tilders F.J. (1998). Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Clin.Exp.Immunol, 111, 198. eScholarID:1c502
  • Roe S.Y., McGowan E.M., Rothwell N.J. (1998). Evidence for the involvement of corticotrophin-releasing hormone in the pathogenesis of traumatic brain injury. Eur.J.Neurosci, 10, 553. eScholarID:1c549
  • Roe S, McGowan E, Rothwell NJ. (1998). Evidence for the involvement of corticotrophin-releasing hormone in the pathogenesis of traumatic brain injury. Eur J Neurosci, 10( 2), 553-9. eScholarID:1d28443
  • Stroemer R.P., Rothwell N.J. (1998). Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 18, 833. eScholarID:1c678
  • Stroemer R, Rothwell NJ. (1998). Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat. J Cereb Blood Flow Metab, 18( 8), 833-9. eScholarID:1d28450
  • Allan S.M., Lawrence C.B., Rothwell N.J. (1998). Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes. Mol.Psychiatry, 3, 178. eScholarID:1c428
  • Allan S, Lawrence C, Rothwell NJ. (1998). Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes. Mol Psychiatry, 3( 2), 178-82. eScholarID:1d28587
  • Lawrence C.B., Allan S.M., Rothwell N.J. (1998). Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur.J.Neurosci, 10, 1188. eScholarID:1c507
  • Lawrence C, Allan S, Rothwell NJ. (1998). Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur J Neurosci, 10( 3), 1188-95. eScholarID:1d29189
  • Gardner J.D., Rothwell N.J., Luheshi G.N. (1998). Leptin affects food intake via CRF-receptor-mediated pathways. Nat.Neurosci, 1, 103. eScholarID:1c487
  • Cartmell T., Poole S., Rothwell N.J., Luheshi G.N. (1998). Relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat. Ann.N.Y.Acad.Sci, 856, 252. eScholarID:1c456
  • Cartmell T, Poole S, Rothwell NJ, Luheshi G. (1998). Relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat. Ann N Y Acad Sci, 856, 252-5. eScholarID:1d29725

1997

  • Rothwell N.J., Stock M.J. (1997). A role for brown adipose tissue in diet-induced thermogenesis. Obes.Res, 5, 650. eScholarID:1c654
  • Stroemer R.P., Rothwell N.J. (1997). Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 17, 597. eScholarID:1c677
  • Stroemer R, Rothwell NJ. (1997). Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat. J Cereb Blood Flow Metab, 17( 6), 597-604. eScholarID:1d28949
  • Rothwell N.J. (1997). Cytokines and acute neurodegeneration. Mol.Psychiatry, 2, 120. eScholarID:1c655
  • Rothwell NJ. (1997). Cytokines and acute neurodegeneration. Mol Psychiatry, 2( 2), 120-1. eScholarID:1d29082
  • Loddick S.A., Wong M.L., Bongiorno P.B., Gold P.W., Licinio J., Rothwell N.J. (1997). Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochemical and biophysical research communications, 234, 211. eScholarID:1c516
  • Loddick S, Wong M, Bongiorno P, Gold P, Licinio J, Rothwell NJ. (1997). Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem Biophys Res Commun, 234( 1), 211-5. eScholarID:1d28569
  • Luheshi G.N., Stefferl A., Turnbull A.V., Dascombe M.J., Brouwer S., Hopkins S.J., Rothwell N.J. (1997). Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat. Am.J.Physiol, 272, R862. eScholarID:1c521
  • Luheshi G, Stefferl A, Turnbull A, Dascombe M, Brouwer S, Hopkins S, Rothwell NJ. (1997). Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat. Am J Physiol, 272( 3 Pt 2), R862-8. eScholarID:1d29729
  • Rothwell N.J., Loddick S.A., Stroemer P. (1997). Interleukins and cerebral ischaemia. Int.Rev.Neurobiol, 40, 281. eScholarID:1c656
  • Rothwell NJ, Loddick S, Stroemer P. (1997). Interleukins and cerebral ischaemia. Int Rev Neurobiol, 40, 281-98. eScholarID:1d29730
  • Roe S.Y., Cooper A.L., Morris I.D., Hopkins S.J., Rothwell N.J. (1997). Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat. Eur.Cytokine Netw, 8, 45. eScholarID:1c546
  • Roe S, Cooper A, Morris I, Hopkins S, Rothwell NJ. (1997). Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat. Eur Cytokine Netw, 8( 1), 45-9. eScholarID:1d28595
  • Roe S.Y., Cooper A.L., Morris I.D., Rothwell N.J. (1997). Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat. Metabolism: clinical and experimental, 46, 359. eScholarID:1c547
  • Roe S, Cooper A, Morris I, Rothwell NJ. (1997). Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat. Metabolism, 46( 4), 359-65. eScholarID:1d28576
  • Miller A.J., Luheshi G.N., Rothwell N.J., Hopkins S.J. (1997). Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response. Am.J.Physiol, 272, R857. eScholarID:1c530
  • Miller A, Luheshi G, Rothwell NJ, Hopkins S. (1997). Local cytokine induction by LPS in the rat air pouch and its relationship to the febrile response. Am J Physiol, 272( 3 Pt 2), R857-61. eScholarID:1d28941
  • Benkovic S.A., McGowan E.M., Rothwell N.J., Hutton M., Morgan D.G., Gordon M.N. (1997). Regional and cellular localization of presenilin-2 RNA in rat and human brain. Exp.Neurol, 145, 555. eScholarID:1c439
  • Rothwell N.J. (1997). Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines. British journal of pharmacology, 121, 841. eScholarID:1c657
  • Rothwell NJ. (1997). Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines. Br J Pharmacol, 121( 5), 841-7. eScholarID:1d28940
  • Rothwell NJ, Allan S, Toulmond S. (1997). The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J Clin Invest, 100( 11), 2648-52. eScholarID:1d28574
  • Roe S.Y., Rothwell N.J. (1997). Whole body metabolic responses to brain trauma in the rat. J.Neurotrauma, 14, 399. eScholarID:1c548
  • Roe S, Rothwell NJ. (1997). Whole body metabolic responses to brain trauma in the rat. J Neurotrauma, 14( 6), 399-408. eScholarID:1d28950

1996

  • Loddick S.A., MacKenzie A., Rothwell N.J. (1996). An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. Neuroreport, 7, 1465. eScholarID:1c514
  • Loddick S, MacKenzie A, Rothwell NJ. (1996). An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. Neuroreport, 7( 9), 1465-8. eScholarID:1d29192
  • Rothwell N.J., Luheshi G.N. (1996). Brain TNF: damage limitation or damaged reputation? Nat.Med, 2, 746. eScholarID:1c652
  • Rothwell NJ, Luheshi G. (1996). Brain TNF: damage limitation or damaged reputation? Nat Med, 2( 7), 746-7. eScholarID:1d28452
  • Rothwell N.J., Luheshi G., Toulmond S. (1996). Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology. Pharmacol.Ther, 69, 85. eScholarID:1c653
  • Rothwell NJ, Luheshi G, Toulmond S. (1996). Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology. Pharmacol Ther, 69( 2), 85-95. eScholarID:1d29019
  • Luheshi G., Miller A.J., Brouwer S., Dascombe M.J., Rothwell N.J., Hopkins S.J. (1996). Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat. Am.J.Physiol, 270, E91. eScholarID:1c520
  • Luheshi G, Miller A, Brouwer S, Dascombe M, Rothwell NJ, Hopkins S. (1996). Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat. Am J Physiol, 270( 1 Pt 1), E91-5. eScholarID:1d28596
  • Sudlow A.W., Carey F., Forder R., Rothwell N.J. (1996). Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1 beta-stimulated hypothalamic CRH release in rats. Am.J.Physiol, 270, R54. eScholarID:1c679
  • Sudlow A, Carey F, Forder R, Rothwell NJ. (1996). Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1 beta-stimulated hypothalamic CRH release in rats. Am J Physiol, 270( 1 Pt 2), R54-60. eScholarID:1d28577
  • Roe S., Cooper A.L., Morris I.D., Rothwell N.J. (1996). Mechanisms of cachexia induced by T-cell leukemia in the rat. Metabolism: clinical and experimental, 45, 645. eScholarID:1c545
  • Roe S, Cooper A, Morris I, Rothwell NJ. (1996). Mechanisms of cachexia induced by T-cell leukemia in the rat. Metabolism, 45( 5), 645-51. eScholarID:1d29018
  • Loddick S.A., Rothwell N.J. (1996). Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 16, 932. eScholarID:1c515
  • Loddick S, Rothwell NJ. (1996). Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab, 16( 5), 932-40. eScholarID:1d28451
  • Stefferl A., Hopkins S.J., Rothwell N.J., Luheshi G.N. (1996). The role of TNF-alpha in fever: opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat. British journal of pharmacology, 118, 1919. eScholarID:1c664
  • Stefferl A, Hopkins S, Rothwell NJ, Luheshi G. (1996). The role of TNF-alpha in fever: opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat. Br J Pharmacol, 118( 8), 1919-24. eScholarID:1d29191
  • Sudlow A.W., Carey F., Forder R., Rothwell N.J. (1996). The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNF alpha release from human peripheral blood mononuclear cells. British journal of pharmacology, 117, 1449. eScholarID:1c680
  • Sudlow A, Carey F, Forder R, Rothwell NJ. (1996). The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNF alpha release from human peripheral blood mononuclear cells. Br J Pharmacol, 117( 7), 1449-56. eScholarID:1d28942

1995

  • Rothwell N.J., Hopkins S.J. (1995). Cytokines and the nervous system II: Actions and mechanisms of action. Trends in neurosciences, 18, 130. eScholarID:1c650
  • Rothwell NJ, Hopkins S. (1995). Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci, 18( 3), 130-6. eScholarID:1d28952
  • Hopkins S.J., Rothwell N.J. (1995). Cytokines and the nervous system. I: Expression and recognition. Trends in neurosciences, 18, 83. eScholarID:1c497
  • Hopkins S, Rothwell NJ. (1995). Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci, 18( 2), 83-8. eScholarID:1d29020
  • Rothwell N.J., Strijbos P.J. (1995). Cytokines in neurodegeneration and repair. Int.J.Dev.Neurosci, 13, 179. eScholarID:1c651
  • Rothwell NJ, Strijbos P. (1995). Cytokines in neurodegeneration and repair. Int J Dev Neurosci, 13( 3-4), 179-85. eScholarID:1d28578
  • Wong M.L., Loddick S.A., Bongiorno P.B., Gold P.W., Rothwell N.J., Licinio J. (1995). Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Neuroreport, 6, 1785. eScholarID:1c684
  • Strijbos P.J., Rothwell N.J. (1995). Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. Journal of Neuroscience, 15, 3468. eScholarID:1c675
  • Strijbos P, Rothwell NJ. (1995). Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J Neurosci, 15( 5 Pt 1), 3468-74. eScholarID:1d28951
  • Toulmond S., Rothwell N.J. (1995). Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain research, 671, 261. eScholarID:1c321
  • Toulmond S, Rothwell NJ. (1995). Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res, 671( 2), 261-6. eScholarID:1d28579
  • Coelho M.M., Luheshi G., Hopkins S.J., Pela I.R., Rothwell N.J. (1995). Multiple mechanisms mediate antipyretic action of glucocorticoids. Am.J.Physiol, 269, R527. eScholarID:1c466
  • Strijbos P.J., Zamani M.R., Rothwell N.J., Arbuthnott G., Harkiss G. (1995). Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus. Neuroscience letters, 197, 215. eScholarID:1c676

1994

  • Cartana J., Segues T., Yebras M., Rothwell N.J., Stock M.J. (1994). Anabolic effects of clenbuterol after long-term treatment and withdrawal in t the rat. Metabolism: clinical and experimental, 43, 1086. eScholarID:1c455
  • Rothwell N.J. (1994). CNS regulation of thermogenesis. Crit Rev.Neurobiol, 8, 1. eScholarID:1c649
  • Rothwell NJ. (1994). CNS regulation of thermogenesis. Crit Rev Neurobiol, 8( 1-2), 1-10. eScholarID:1d29198
  • Strijbos P.J., Relton J.K., Rothwell N.J. (1994). Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain. Brain research, 656, 405. eScholarID:1c674
  • Strijbos P, Relton J, Rothwell NJ. (1994). Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain. Brain Res, 656( 2), 405-8. eScholarID:1d29021
  • Flower R.J., Rothwell N.J. (1994). Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol.Sci, 15, 71. eScholarID:1c486
  • Turnbull A.V., Dow R.C., Hopkins S.J., White A., Fink G., Rothwell N.J. (1994). Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat. Psychoneuroendocrinology, 19, 165. eScholarID:1c682
  • Rothwell N.J., Luheshi G. (1994). Pharmacology of interleukin-1 actions in the brain. Adv.Pharmacol, 25, eScholarID:1c320
  • Rothwell NJ, Luheshi G. (1994). Pharmacology of interleukin-1 actions in the brain. Adv Pharmacol, 25, 1-20. eScholarID:1d28943
  • Cooper A.L., Brouwer S., Turnbull A.V., Luheshi G.N., Hopkins S.J., Kunkel S.L., Rothwell N.J. (1994). Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat. Am.J.Physiol, 267, R1431. eScholarID:1c473
  • Cooper A, Brouwer S, Turnbull A, Luheshi G, Hopkins S, Kunkel S, Rothwell NJ. (1994). Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat. Am J Physiol, 267( 6 Pt 2), R1431-6. eScholarID:1d28597

1993

  • Busbridge N.J., Dascombe M.J., Rothwell N.J. (1993). Chronic effects of interleukin-1 beta on fever, oxygen consumption and food intake in the rat. Horm.Metab Res, 25, 222. eScholarID:1c453
  • Busbridge N, Dascombe M, Rothwell NJ. (1993). Chronic effects of interleukin-1 beta on fever, oxygen consumption and food intake in the rat. Horm Metab Res, 25( 4), 222-7. eScholarID:1d28953
  • Martineau L., Little R.A., Rothwell N.J., Fisher M.I. (1993). Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat. Burns, 19, 26. eScholarID:1c528
  • Martineau L, Little R, Rothwell NJ, Fisher M. (1993). Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat. Burns, 19( 1), 26-34. eScholarID:1d28580
  • Rothwell N.J. (1993). Cytokines and thermogenesis. Int.J.Obes.Relat Metab Disord, 17 Suppl 3, S98. eScholarID:1c646
  • Rothwell NJ. (1993). Cytokines and thermogenesis. Int J Obes Relat Metab Disord, 17 Suppl 3, S98-101; discussion 115. eScholarID:1d28454
  • Coelho M.M., Pela I.R., Rothwell N.J. (1993). Dexamethasone inhibits the pyrogenic activity of prostaglandin F2 alpha, but not prostaglandin E2. Eur.J.Pharmacol, 238, 391. eScholarID:1c465
  • Coelho M, Pelá I, Rothwell NJ. (1993). Dexamethasone inhibits the pyrogenic activity of prostaglandin F2 alpha, but not prostaglandin E2. Eur J Pharmacol, 238(2-3), 391-394. eScholarID:1d29732
  • Relton J.K., Strijbos P.J., Cooper A.L., Rothwell N.J. (1993). Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat. Brain Res.Bull, 32, 223. eScholarID:1c544
  • Relton J, Strijbos P, Cooper A, Rothwell NJ. (1993). Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat. Brain Res Bull, 32( 3), 223-6. eScholarID:1d28960
  • Derijk R.H., Strijbos P.J., van Rooijen N., Rothwell N.J., Berkenbosch F. (1993). Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats. Am.J.Physiol, 265, R1179. eScholarID:1c481
  • Strijbos P.J., Horan M.A., Carey F., Rothwell N.J. (1993). Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1). Am.J.Physiol, 265, E289. eScholarID:1c673
  • Strijbos P, Horan M, Carey F, Rothwell NJ. (1993). Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1). Am J Physiol, 265( 2 Pt 1), E289-97. eScholarID:1d29731
  • Luheshi G., Hopkins S.J., LeFeuvre R.A., Dascombe M.J., Ghiara P., Rothwell N.J. (1993). Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat. Am.J.Physiol, 265, E585. eScholarID:1c519
  • Luheshi G, Hopkins S, Lefeuvre R, Dascombe M, Ghiara P, Rothwell NJ. (1993). Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat. Am J Physiol, 265( 4 Pt 1), E585-91. eScholarID:1d29199
  • Cooper A.L., Rothwell N.J. (1993). Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation. Prostaglandins Leukot.Essent.Fatty Acids, 49, 615. eScholarID:1c472
  • Cooper A, Rothwell NJ. (1993). Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation. Prostaglandins Leukot Essent Fatty Acids, 49( 2), 615-26. eScholarID:1d28598
  • Rothwell N.J., Relton J.K. (1993). Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci.Biobehav.Rev, 17, 217. eScholarID:1c647
  • Rothwell NJ, Relton J. (1993). Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci Biobehav Rev, 17( 2), 217-27. eScholarID:1d28581
  • Rothwell N.J., Relton J.K. (1993). Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage. Cerebrovasc.Brain Metab Rev, 5, 178. eScholarID:1c648
  • Rothwell NJ, Relton J. (1993). Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage. Cerebrovasc Brain Metab Rev, 5( 3), 178-98. eScholarID:1d29733
  • Turnbull A.V., Kirkman E., Rothwell N.J., Little R.A. (1993). The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat. Journal of physiology, Paris, 468, 529. eScholarID:1c681
  • Turnbull A, Kirkman E, Rothwell NJ, Little R. (1993). The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat. J Physiol, 468, 529-41. eScholarID:1d28944

1992

  • Royston M.C., Rothwell N.J., Roberts G.W. (1992). Alzheimer"s disease: pathology to potential treatments? Trends Pharmacol.Sci, 13, 131. eScholarID:1c662
  • Choo J.J., Horan M.A., Little R.A., Rothwell N.J. (1992). Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation. Am.J.Physiol, 263, E50. eScholarID:1c464
  • Choo J, Horan M, Little R, Rothwell NJ. (1992). Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation. Am J Physiol, 263( 1 Pt 1), E50-6. eScholarID:1d29200
  • Kent S., Bluthe R.M., Dantzer R., Hardwick A.J., Kelley K.W., Rothwell N.J., Vannice J.L. (1992). Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc.Natl.Acad.Sci.U.S.A, 89, 9117. eScholarID:1c506
  • Rothwell N.J. (1992). Eicosanoids, thermogenesis and thermoregulation. Prostaglandins Leukot.Essent.Fatty Acids, 46, 1. eScholarID:1c643
  • Rothwell NJ. (1992). Eicosanoids, thermogenesis and thermoregulation. Prostaglandins Leukot Essent Fatty Acids, 46( 1), 1-7. eScholarID:1d29201
  • Strijbos P.J., Hardwick A.J., Relton J.K., Carey F., Rothwell N.J. (1992). Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF. Am.J.Physiol, 263, E632. eScholarID:1c672
  • Strijbos P, Hardwick A, Relton J, Carey F, Rothwell NJ. (1992). Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF. Am J Physiol, 263( 4 Pt 1), E632-6. eScholarID:1d28599
  • Relton J.K., Rothwell N.J. (1992). Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain research bulletin, 29, 243. eScholarID:1c543
  • Relton J, Rothwell NJ. (1992). Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull, 29( 2), 243-6. eScholarID:1d29735
  • Rothwell N.J., Flower R. (1992). Lipocortin-1 exhibits novel actions, providing clinical opportunities. Trends Pharmacol.Sci, 13, 45. eScholarID:1c644
  • Rothwell NJ, Flower R. (1992). Lipocortin-1 exhibits novel actions, providing clinical opportunities. Trends Pharmacol Sci, 13( 2), 45-6. eScholarID:1d29022
  • Black M.D., Carey F., Crossman A.R., Relton J.K., Rothwell N.J. (1992). Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat. Brain research, 585, 135. eScholarID:1c441
  • Black M, Carey F, Crossman AA.R, Relton J, Rothwell NJ. (1992). Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat. Brain Res, 585( 1-2), 135-40. eScholarID:1d28455
  • Cooper A.L., Horan M.A., Little R.A., Rothwell N.J. (1992). Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade. J.Appl.Physiol, 72, 2322. eScholarID:1c471
  • Cooper A, Horan M, Little R, Rothwell NJ. (1992). Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade. J Appl Physiol, 72( 6), 2322-8. eScholarID:1d28456
  • Martineau L., Horan M.A., Rothwell N.J., Little R.A. (1992). Muscling in on salbutamol. Lancet, 340, 1094. eScholarID:1c526
  • Martineau L., Horan M.A., Rothwell N.J., Little R.A. (1992). Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin.Sci.(Lond), 83, 615. eScholarID:1c527
  • Martineau L, Horan M, Rothwell NJ, Little R. (1992). Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin Sci (Lond), 83( 5), 615-21. eScholarID:1d29734
  • Rothwell N.J., Le Feuvre R.A. (1992). Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. Int.J.Obes.Relat Metab Disord, 16 Suppl 3, S67. eScholarID:1c645
  • Rothwell NJ, Le Feuvre R. (1992). Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. Int J Obes Relat Metab Disord, 16 Suppl 3, S67-71. eScholarID:1d28945
  • Serra F., LeFeuvre R.A., Slater D., Palou A., Rothwell N.J. (1992). Thermogenic actions of tryptophan in the rat are mediated independently of 5-HT. Brain research, 578, 327. eScholarID:1c663

1991

  • Rothwell N.J., Little R.A., Rose J.G. (1991). Brown adipose tissue activity and oxygen consumption after scald injury in the rat. Circ.Shock, 33, 33. eScholarID:1c638
  • Rothwell NJ, Little R, Rose J. (1991). Brown adipose tissue activity and oxygen consumption after scald injury in the rat. Circ Shock, 33( 1), 33-6. eScholarID:1d29029
  • Rothwell N.J., Hardwick A., LeFeuvre R.A., Crosby S.R., White A. (1991). Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products. Brain research, 541, 89. eScholarID:1c639
  • Choo J.J., Emery P.W., Rothwell N.J. (1991). Dose-dependent effects of an anabolic steroid, nandrolone phenylpropionate (Durabolin), on body composition and muscle protein metabolism in female rats. Ann.Nutr.Metab, 35, 141. eScholarID:1c463
  • Le Feuvre R.A., Woods A.J., Stock M.J., Rothwell N.J. (1991). Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats. Brain research, 547, 110. eScholarID:1c510
  • Le Feuvre R, Woods A, Stock M, Rothwell NJ. (1991). Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats. Brain Res, 547( 1), 110-4. eScholarID:1d28588
  • Rothwell N.J. (1991). Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol.Sci, 12, 430. eScholarID:1c640
  • Rothwell NJ. (1991). Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol Sci, 12( 11), 430-6. eScholarID:1d28437
  • Hopkins S.J., Rothwell N.J. (1991). Further functions of IL-6. Immunol.Today, 12, 170. eScholarID:1c496
  • Rothwell N.J., Busbridge N.J., LeFeuvre R.A., Hardwick A.J., Gauldie J., Hopkins S.J. (1991). Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Can.J.Physiol Pharmacol, 69, 1465. eScholarID:1c641
  • Rothwell NJ, Busbridge N, Lefeuvre R, Hardwick A, Gauldie J, Hopkins S. (1991). Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Can J Physiol Pharmacol, 69( 10), 1465-9. eScholarID:1d29023
  • Le Feuvre R.A., Aisenthal L., Rothwell N.J. (1991). Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain research, 555, 245. eScholarID:1c511
  • Le Feuvre R, Aisenthal L, Rothwell NJ. (1991). Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain Res, 555( 2), 245-50. eScholarID:1d28946
  • Relton J.K., Strijbos P.J., O"Shaughnessy C.T., Carey F., Forder R.A., Tilders F.J., Rothwell N.J. (1991). Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. J.Exp.Med, 174, 305. eScholarID:1c542
  • Relton J, Strijbos P, O'Shaughnessy C, Carey F, Forder R, Tilders F, Rothwell NJ. (1991). Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. J Exp Med, 174( 2), 305-10. eScholarID:1d28961
  • Strijbos P.J., Tilders F.J., Carey F., Forder R., Rothwell N.J. (1991). Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment. Brain research, 553, 249. eScholarID:1c671
  • Strijbos P, Tilders F, Carey F, Forder R, Rothwell NJ. (1991). Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment. Brain Res, 553( 2), 249-60. eScholarID:1d28962
  • Cooper A.L., Rothwell N.J. (1991). Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats. Am.J.Physiol, 261, E698. eScholarID:1c470
  • Cooper A, Rothwell NJ. (1991). Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats. Am J Physiol, 261( 6 Pt 1), E698-705. eScholarID:1d28600
  • Rothwell N.J. (1991). The endocrine significance of cytokines. J.Endocrinol, 128, 171. eScholarID:1c642
  • Rothwell NJ. (1991). The endocrine significance of cytokines. J Endocrinol, 128( 2), 171-3. eScholarID:1d28606

1990

  • Busbridge N.J., Carnie J.A., Dascombe M.J., Johnston J.A., Rothwell N.J. (1990). Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats. Int.J.Obes, 14, 809. eScholarID:1c452
  • Busbridge N, Carnie J, Dascombe M, Johnston J, Rothwell NJ. (1990). Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats. Int J Obes, 14( 9), 809-14. eScholarID:1d28458
  • Choo J.J., Horan M.A., Little R.A., Rothwell N.J., Wareham A. (1990). Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture. Circ.Shock, 32, 165. eScholarID:1c461
  • Choo J, Horan M, Little R, Rothwell NJ, Wareham A. (1990). Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture. Circ Shock, 32( 2), 165-71. eScholarID:1d29203
  • Rothwell N.J., Hardwick A.J., Lindley I. (1990). Central actions of interleukin-8 in the rat are independent of prostaglandins. Horm.Metab Res, 22, 595. eScholarID:1c633
  • Rothwell NJ, Hardwick A, Lindley I. (1990). Central actions of interleukin-8 in the rat are independent of prostaglandins. Horm Metab Res, 22( 11), 595-6. eScholarID:1d29030
  • Rothwell N.J. (1990). Central activation of thermogenesis by prostaglandins: dependence on CRF. Horm.Metab Res, 22, 616. eScholarID:1c634
  • Rothwell NJ. (1990). Central activation of thermogenesis by prostaglandins: dependence on CRF. Horm Metab Res, 22( 12), 616-8. eScholarID:1d28947
  • Rothwell N.J. (1990). Central effects of CRF on metabolism and energy balance. Neurosci.Biobehav.Rev, 14, 263. eScholarID:1c635
  • Rothwell NJ. (1990). Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev, 14( 3), 263-71. eScholarID:1d28607
  • Arnold J., Choo J.J., Little R.A., Rothwell N.J. (1990). Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues. Circ.Shock, 31, 387. eScholarID:1c437
  • Arnold J, Choo J, Little R, Rothwell NJ. (1990). Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues. Circ Shock, 31( 4), 387-94. eScholarID:1d29736
  • Choo J.J., Horan M.A., Little R.A., Rothwell N.J. (1990). Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat. Metabolism: clinical and experimental, 39, 647. eScholarID:1c462
  • Choo J, Horan M, Little R, Rothwell NJ. (1990). Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat. Metabolism, 39( 6), 647-50. eScholarID:1d28954
  • Carey F., Forder R., Edge M.D., Greene A.R., Horan M.A., Strijbos P.J., Rothwell N.J. (1990). Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats. Am.J.Physiol, 259, R266. eScholarID:1c454
  • Rothwell N.J. (1990). Mechanisms of the pyrogenic actions of cytokines. Eur.Cytokine Netw, 1, 211. eScholarID:1c636
  • Rothwell NJ. (1990). Mechanisms of the pyrogenic actions of cytokines. Eur Cytokine Netw, 1( 4), 211-3. eScholarID:1d29202
  • Rothwell N.J. (1990). Neuroendocrine mechanisms in the thermogenic responses to diet, infection, and trauma. Adv.Exp.Med.Biol, 274, 371. eScholarID:1c637
  • Rothwell NJ. (1990). Neuroendocrine mechanisms in the thermogenic responses to diet, infection, and trauma. Adv Exp Med Biol, 274, 371-80. eScholarID:1d29737
  • O"Shaughnessy C.T., Rothwell N.J., Shrewsbury-Gee J. (1990). Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat. Can.J.Physiol Pharmacol, 68, 1334. eScholarID:1c535
  • O'Shaughnessy C, Rothwell NJ, Shrewsbury-Gee J. (1990). Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat. Can J Physiol Pharmacol, 68( 10), 1334-7. eScholarID:1d28457

1989

  • Le Feuvre R.A., Rothwell N.J., White A. (1989). A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat. Horm.Metab Res, 21, 525. eScholarID:1c509
  • Le Feuvre R, Rothwell NJ, White A. (1989). A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat. Horm Metab Res, 21( 9), 525-6. eScholarID:1d29739
  • Cooper A.L., Fitzgeorge R.B., Baskerville A., Little R.A., Rothwell N.J. (1989). Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig. Life sciences, 45, 843. eScholarID:1c468
  • Cooper A, Fitzgeorge R, Baskerville A, Little R, Rothwell NJ. (1989). Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig. Life Sci, 45( 9), 843-7. eScholarID:1d28609
  • Rothwell N.J. (1989). CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat. Am.J.Physiol, 256, E111. eScholarID:1c631
  • Rothwell NJ. (1989). CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat. Am J Physiol, 256( 1 Pt 1), E111-5. eScholarID:1d28460
  • Busbridge N.J., Dascombe M.J., Tilders F.J., van Oers J.W., Linton E.A., Rothwell N.J. (1989). Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms. Biochem.Biophys.Res.Commun, 162, 591. eScholarID:1c451
  • Busbridge N, Dascombe M, Tilders F, van Oers J, Linton E, Rothwell NJ. (1989). Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms. Biochem Biophys Res Commun, 162( 2), 591-6. eScholarID:1d28608
  • Rothwell N.J. (1989). Central control of brown adipose tissue. Proc.Nutr.Soc, 48, 197. eScholarID:1c630
  • Rothwell NJ. (1989). Central control of brown adipose tissue. Proc Nutr Soc, 48( 2), 197-206. eScholarID:1d29740
  • Horan M.A., Little R.A., Rothwell N.J., Strijbos P.J. (1989). Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat. Can.J.Physiol Pharmacol, 67, 1011. eScholarID:1c499
  • O"Shaughnessy C.T., Rothwell N.J., Shrewsbury-Gee J. (1989). Effects of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat. Can.J.Physiol Pharmacol, 67, 1345. eScholarID:1c534
  • O'Shaughnessy C, Rothwell NJ, Shrewsbury-Gee J. (1989). Effects of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat. Can J Physiol Pharmacol, 67( 10), 1345-50. eScholarID:1d28964
  • Cooper A.L., Dascombe M.J., Rothwell N.J., Vale M.J. (1989). Effects of malaria on O2 consumption and brown adipose tissue activity in mice. J.Appl.Physiol, 67, 1020. eScholarID:1c469
  • Cooper A, Dascombe M, Rothwell NJ, Vale M. (1989). Effects of malaria on O2 consumption and brown adipose tissue activity in mice. J Appl Physiol, 67( 3), 1020-3. eScholarID:1d28591
  • McCarthy H.D., O"Shaughnessy C.T., Rothwell N.J. (1989). Endogenous mediators of cerebral ischaemia-induced hypermetabolism in the rat. British journal of pharmacology, 98 Suppl, 838P. eScholarID:1c529
  • McCarthy H, O'Shaughnessy C, Rothwell NJ. (1989). Endogenous mediators of cerebral ischaemia-induced hypermetabolism in the rat. Br J Pharmacol, 98 Suppl, eScholarID:1d29738
  • Arnold J., Little R.A., Rothwell N.J. (1989). Energy balance and brown adipose tissue thermogenesis during chronic endotoxemia in rats. J.Appl.Physiol, 66, 1970. eScholarID:1c436
  • Arnold J, Little R, Rothwell NJ. (1989). Energy balance and brown adipose tissue thermogenesis during chronic endotoxemia in rats. J Appl Physiol, 66( 4), 1970-5. eScholarID:1d29204
  • Dascombe M.J., Hardwick A., LeFeuvre R.A., Rothwell N.J. (1989). Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats. Int.J.Obes, 13, 367. eScholarID:1c477
  • Dascombe M, Hardwick A, Lefeuvre R, Rothwell NJ. (1989). Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats. Int J Obes, 13( 3), 367-73. eScholarID:1d28459
  • Bianchi A., Bruce J., Cooper A.L., Childs C., Kohli M., Morris I.D., Morris-Jones P., Rothwell N.J. (1989). Increased brown adipose tissue activity in children with malignant disease. Horm.Metab Res, 21, 640. eScholarID:1c440
  • Bianchi A, Bruce J, Cooper A, Childs C, Kohli M, Morris I, Morris-Jones P, Rothwell NJ. (1989). Increased brown adipose tissue activity in children with malignant disease. Horm Metab Res, 21( 11), 640-1. eScholarID:1d28589
  • Choo J.J., Horan M.A., Little R.A., Rothwell N.J. (1989). Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol. Biosci.Rep, 9, 615. eScholarID:1c460
  • Choo J, Horan M, Little R, Rothwell NJ. (1989). Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol. Biosci Rep, 9( 5), 615-21. eScholarID:1d28963
  • Dascombe M.J., Rothwell N.J., Sagay B.O., Stock M.J. (1989). Pyrogenic and thermogenic effects of interleukin 1 beta in the rat. Am.J.Physiol, 256, E7. eScholarID:1c478
  • Dascombe M, Rothwell NJ, Sagay B, Stock M. (1989). Pyrogenic and thermogenic effects of interleukin 1 beta in the rat. Am J Physiol, 256( 1 Pt 1), E7-11. eScholarID:1d29212
  • Rothwell N.J., Stock M.J. (1989). Surgical removal of brown fat results in rapid and complete compensation by other depots. Am.J.Physiol, 257, R253. eScholarID:1c632
  • Hardwick A.J., Linton E.A., Rothwell N.J. (1989). Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology, 124, 1684. eScholarID:1c494
  • Hardwick A, Linton E, Rothwell NJ. (1989). Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology, 124( 4), 1684-8. eScholarID:1d28955

1988

  • Rothwell N.J., Stock M.J. (1988). Brown adipose tissue: does it play a role in the development of obesity? Diabetes Metab Rev, 4, 595. eScholarID:1c623
  • Rothwell NJ, Stock M. (1988). Brown adipose tissue: does it play a role in the development of obesity? Diabetes Metab Rev, 4( 6), 595-601. eScholarID:1d29031
  • Rothwell N.J. (1988). Central effects of TNF alpha on thermogenesis and fever in the rat. Biosci.Rep, 8, 345. eScholarID:1c624
  • Rothwell NJ. (1988). Central effects of TNF alpha on thermogenesis and fever in the rat. Biosci Rep, 8( 4), 345-52. eScholarID:1d28956
  • Horan M.A., Little R.A., Rothwell N.J., Stock M.J. (1988). Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence. Exp.Gerontol, 23, 455. eScholarID:1c498
  • Horan M, Little R, Rothwell NJ, Stock M. (1988). Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence. Exp Gerontol, 23( 6), 455-61. eScholarID:1d28593
  • Horton R., Rothwell N.J., Stock M.J. (1988). Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat. Gen.Pharmacol, 19, 403. eScholarID:1c500
  • Holt S., Rothwell N.J., Stock M.J., York D.A. (1988). Effect of hypophysectomy on energy balance and brown fat activity in obese Zucker rats. Am.J.Physiol, 254, E162. eScholarID:1c495
  • Rothwell N.J., Stock M.J. (1988). Increased body-weight gain and body protein in castrated and adrenalectomized rats treated with clenbuterol. Br.J.Nutr, 60, 355. eScholarID:1c625
  • Rothwell N.J., Stock M.J. (1988). Influence of adrenalectomy on age-related changes in energy balance, thermogenesis and brown fat activity in the rat. Comp Biochem.Physiol A, 89, 265. eScholarID:1c626
  • Rothwell N.J., Stock M.J. (1988). Insulin and thermogenesis. Int.J.Obes, 12, 93. eScholarID:1c627
  • Rothwell NJ, Stock M. (1988). Insulin and thermogenesis. Int J Obes, 12( 2), 93-102. eScholarID:1d28592
  • Jepson M.M., Millward D.J., Rothwell N.J., Stock M.J. (1988). Involvement of sympathetic nervous system and brown fat in endotoxin-induced fever in rats. Am.J.Physiol, 255, E617. eScholarID:1c505
  • Horton R.W., LeFeuvre R.A., Rothwell N.J., Stock M.J. (1988). Opposing effects of activation of central GABAA and GABAB receptors on brown fat thermogenesis in the rat. Neuropharmacology, 27, 363. eScholarID:1c501
  • Rothwell N.J., Stock M.J. (1988). The cafeteria diet as a tool for studies of thermogenesis. J.Nutr, 118, 925. eScholarID:1c628
  • Rothwell NJ, Stock M. (1988). The cafeteria diet as a tool for studies of thermogenesis. J Nutr, 118( 8), 925-8. eScholarID:1d29032
  • Rothwell N.J., Stock M.J., Tedstone A.E. (1988). Thermogenic effects of dihydrocodeine in the rat. Can.J.Physiol Pharmacol, 66, 61. eScholarID:1c629
  • Griffiths E.C., Rothwell N.J., Stock M.J. (1988). Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat. Experientia, 44, 40. eScholarID:1c488
  • Griffiths E, Rothwell NJ, Stock M. (1988). Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat. Experientia, 44( 1), 40-2. eScholarID:1d28970

1987

  • LeFeuvre R.A., Rothwell N.J., Stock M.J. (1987). Activation of brown fat thermogenesis in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology, 26, 1217. eScholarID:1c512
  • Coombes R.C., Rothwell N.J., Shah P., Stock M.J. (1987). Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat. Biosci.Rep, 7, 791. eScholarID:1c467
  • Rothwell N.J., Stock M.J., Sudera D.K. (1987). Changes in tissue blood flow and beta-receptor density of skeletal muscle in rats treated with the beta2-adrenoceptor agonist clenbuterol. British journal of pharmacology, 90, 601. eScholarID:1c615
  • Rothwell N.J., Stock M.J. (1987). Effect of a selective beta 2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats. Biosci.Rep, 7, 933. eScholarID:1c616
  • Rothwell N.J., Stock M.J. (1987). Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms. Int.J.Obes, 11, 319. eScholarID:1c617
  • Rothwell N.J., Stock M.J. (1987). Effect of environmental temperature on energy balance and thermogenesis in rats fed normal or low protein diets. J.Nutr, 117, 833. eScholarID:1c618
  • Rothwell N.J., Stock M.J., Tedstone A.E. (1987). Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Mol.Cell Endocrinol, 51, 253. eScholarID:1c619
  • Rothwell N.J., Stock M.J. (1987). Influence of carbohydrate and fat intake on diet-induced thermogenesis and brown fat activity in rats fed low protein diets. J.Nutr, 117, 1721. eScholarID:1c620
  • Rothwell N.J., Stock M.J. (1987). Influence of clenbuterol on energy balance, thermogenesis and body composition in lean and genetically obese Zucker rats. Int.J.Obes, 11, 641. eScholarID:1c621
  • Jepson M.M., Cox M., Bates P.C., Rothwell N.J., Stock M.J., Cady E.B., Millward D.J. (1987). Regional blood flow and skeletal muscle energy status in endotoxemic rats. Am.J.Physiol, 252, E581. eScholarID:1c504
  • Rothwell N.J., Stock M.J. (1987). Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride. Metabolism: clinical and experimental, 36, 128. eScholarID:1c622

1986

  • Addae J.I., Rothwell N.J., Stock M.J., Stone T.W. (1986). Activation of thermogenesis of brown fat in rats by baclofen. Neuropharmacology, 25, 627. eScholarID:1c313
  • Rothwell N.J., Stock M.J. (1986). Body weight and brown fat activity in hyperphagic cafeteria-fed female rats and their offspring. Biol.Neonate, 49, 284. eScholarID:1c609
  • Stock M.J., Rothwell N.J. (1986). Brown adipose tissue and the response to overfeeding. Biochem.Soc.Trans, 14, 239. eScholarID:1c669
  • Rothwell N.J., Stock M.J. (1986). Energy balance and brown fat activity in adrenalectomized male, female, and castrated male rats. Metabolism: clinical and experimental, 35, 657. eScholarID:1c610
  • Rothwell N.J., Stock M.J. (1986). Influence of environmental temperature on energy balance, diet-induced thermogenesis and brown fat activity in "cafeteria"-fed rats. Br.J.Nutr, 56, 123. eScholarID:1c611
  • Rothwell N.J., Stock M.J. (1986). Spontaneous and experimental variations in body weight, food intake and metabolic rate in captive dormice (Glis glis). Comp Biochem.Physiol A, 84, 141. eScholarID:1c612
  • Stock M.J., Rothwell N.J. (1986). The role of brown fat in diet-induced thermogenesis. Int.J.Vitam.Nutr.Res, 56, 205. eScholarID:1c670
  • Marchington D., Rothwell N.J., Stock M.J., York D.A. (1986). Thermogenesis and sympathetic activity in BAT of overfed rats after adrenalectomy. Am.J.Physiol, 250, E362. eScholarID:1c525
  • Rothwell N.J., Stock M.J., Sudera D.K. (1986). Thermogenic responses to adrenoceptor agonists and brown fat adrenoceptors in overfed rats. Eur.J.Pharmacol, 125, 313. eScholarID:1c613
  • Rothwell N.J., Stock M.J. (1986). Whither brown fat? Biosci.Rep, 6, 3. eScholarID:1c614

1985

  • Rothwell N.J., Stock M.J. (1985). Acute and chronic effects of ACTH on thermogenesis and brown adipose tissue in the rat. Comp Biochem.Physiol A, 81, 99. eScholarID:1c598
  • Rothwell N.J., Addae J.I., Stock M.J., Stone T.W. (1985). Baclofen is a potent activator of brown fat metabolism. J.Pharm.Pharmacol, 37, 926. eScholarID:1c599
  • Rothwell N.J., Stock M.J., Sudera D.K. (1985). Beta-adrenoreceptors in rat brown adipose tissue: proportions of beta 1- and beta 2-subtypes. Am.J.Physiol, 248, E397. eScholarID:1c600
  • Rothwell N.J., Stock M.J., Sudera D.K. (1985). Changes in adrenoreceptor density in brown adipose tissue from hyperthyroid rats. Eur.J.Pharmacol, 114, 227. eScholarID:1c601
  • Andrews P.L., Rothwell N.J., Stock M.J. (1985). Effects of subdiaphragmatic vagotomy on energy balance and thermogenesis in the rat. Journal of physiology, Paris, 362, 1. eScholarID:1c433
  • Rothwell N.J., Stock M.J., Warwick B.P. (1985). Energy balance and brown fat activity in rats fed cafeteria diets or high-fat, semisynthetic diets at several levels of intake. Metabolism: clinical and experimental, 34, 474. eScholarID:1c602
  • Stock M.J., Rothwell N.J. (1985). Factors influencing brown fat and the capacity for diet-induced thermogenesis. Int.J.Obes, 9 Suppl 2, 9. eScholarID:1c668
  • Rothwell N.J., Saville M.E., Stock M.J. (1985). Hormonal and metabolic responses to fasting and refeeding. Int.J.Obes, 9 Suppl 2, 49. eScholarID:1c603
  • Andrews P.L., Rothwell N.J., Stock M.J. (1985). Influence of subdiaphragmatic vagotomy and brown fat sympathectomy on thermogenesis in rats. Am.J.Physiol, 249, E239. eScholarID:1c434
  • Rothwell N.J., Stock M.J., Warwick B.P. (1985). Involvement of insulin in the acute thermogenic responses to food and nonmetabolizable substances. Metabolism: clinical and experimental, 34, 43. eScholarID:1c604
  • Rothwell N.J., Stock M.J. (1985). Is diet-induced thermogenesis an experimental artefact? Br.J.Nutr, 53, 191. eScholarID:1c605
  • Rothwell N.J., Stock M.J. (1985). Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice. Biosci.Rep, 5, 755. eScholarID:1c606
  • Rothwell N.J., Stock M.J. (1985). Thermogenesis and BAT activity in hypophysectomized rats with and without corticotropin replacement. Am.J.Physiol, 249, E333. eScholarID:1c607
  • Rothwell N.J., Stock M.J. (1985). Thermogenic capacity and brown adipose tissue activity in the common marmoset. Comp Biochem.Physiol A, 81, 683. eScholarID:1c608

1984

  • Bryant K.R., Rothwell N.J., Stock M.J. (1984). Acute influences on the two GDP-binding sites in brown-adipose-tissue mitochondria. Biosci.Rep, 4, 523. eScholarID:1c449
  • Rothwell N.J., Saville M.E., Stock M.J. (1984). Brown fat activity in fasted and refed rats. Biosci.Rep, 4, 351. eScholarID:1c589
  • Emery P.W., Rothwell N.J., Stock M.J., Winter P.D. (1984). Chronic effects of beta 2-adrenergic agonists on body composition and protein synthesis in the rat. Biosci.Rep, 4, 83. eScholarID:1c484
  • Jamieson L., Stribling D., Rothwell N.J., Stock M.J. (1984). Effect of noradrenaline on oxygen consumption and tissue blood flow in young pigs. Can.J.Physiol Pharmacol, 62, 136. eScholarID:1c503
  • Rothwell N.J., Stock M.J., York D.A. (1984). Effects of adrenalectomy on energy balance, diet-induced thermogenesis and brown adipose tissue in adult cafeteria-fed rats. Comp Biochem.Physiol A, 78, 565. eScholarID:1c590
  • Rothwell N.J., Stock M.J. (1984). Effects of denervating brown adipose tissue on the responses to cold, hyperphagia and noradrenaline treatment in the rat. Journal of physiology, Paris, 355, 457. eScholarID:1c591
  • Rothwell N.J., Stock M.J., Wyllie M.G. (1984). Effects of histamine antagonists on noradrenaline-stimulated blood flow and oxygen consumption of brown adipose tissue in the rat. Pflugers Archiv : European journal of physiology, 402, 325. eScholarID:1c592
  • Rothwell N.J., Stock M.J. (1984). Energy balance, thermogenesis and brown adipose tissue activity in tube-fed rats. J.Nutr, 114, 1965. eScholarID:1c593
  • Rothwell N.J., Stock M.J. (1984). Influence of alcohol and sucrose consumption on energy balance and brown fat activity in the rat. Metabolism: clinical and experimental, 33, 768. eScholarID:1c594
  • Bryant K.R., Rothwell N.J., Stock M.J. (1984). Influence of sodium intake on thermogenesis and brown adipose tissue in the rat. Int.J.Obes, 8, 221. eScholarID:1c450
  • Rothwell N.J., Stock M.J. (1984). Sympathetic and adrenocorticoid influences on diet-induced thermogenesis and brown fat activity in the rat. Comp Biochem.Physiol A, 79, 575. eScholarID:1c595
  • Rothwell N.J., Stock M.J. (1984). The development of obesity in animals: the role of dietary factors. Clin.Endocrinol.Metab, 13, 437. eScholarID:1c596
  • Wyllie M.G., Fletcher A., Rothwell N.J., Stock M.J. (1984). Thermogenic properties of ciclazindol and mazindol in rodents. Int.J.Obes, 8 Suppl 1, 85. eScholarID:1c685
  • Rothwell N.J., Stock M.J. (1984). Tissue blood flow in control and cold-adapted hyperthyroid rats. Can.J.Physiol Pharmacol, 62, 928. eScholarID:1c597

1983

  • Rothwell N.J., Stock M.J. (1983). Acute effects of fat and carbohydrate on metabolic rate in normal, cold-acclimated and lean and obese (fa/fa) Zucker rats. Metabolism: clinical and experimental, 32, 371. eScholarID:1c577
  • Rothwell N.J., Stock M.J., Thexton A.J. (1983). Decerebration activates thermogenesis in the rat. Journal of physiology, Paris, 342, 15. eScholarID:1c578
  • Rothwell N.J., Stock M.J. (1983). Diet-induced thermogenesis. Adv.Nutr.Res, 5, 201. eScholarID:1c579
  • Rothwell N.J., Stock M.J., Warwick B.P., Winter P.D. (1983). Diurnal variations in circulating hormone levels and brown adipose tissue activity in "cafeteria"-fed rats. Comp Biochem.Physiol A, 75, 461. eScholarID:1c580
  • Rothwell N.J., Stock M.J. (1983). Effects of age on diet-induced thermogenesis and brown adipose tissue metabolism in the rat. Int.J.Obes, 7, 583. eScholarID:1c581
  • Marchington D., Rothwell N.J., Stock M.J., York D.A. (1983). Energy balance, diet-induced thermogenesis and brown adipose tissue in lean and obese (fa/fa) Zucker rats after adrenalectomy. J.Nutr, 113, 1395. eScholarID:1c524
  • Bryant K.R., Rothwell N.J., Stock M.J., Stribling D. (1983). Identification of two mitochondrial GDP-binding sites in rat brown adipose tissue. Biosci.Rep, 3, 589. eScholarID:1c447
  • Rothwell N.J., Stock M.J., Wyllie M.G. (1983). Influence of chronic administration of ciclazindol on energy balance and brown adipose tissue in adult "cafeteria"-fed rats. J.Auton.Pharmacol, 3, 73. eScholarID:1c582
  • Rothwell N.J., Saville M.E., Stock M.J., Wyllie M.G. (1983). Influence of thyroid hormone on diet-induced thermogenesis in the rat. Horm.Metab Res, 15, 394. eScholarID:1c319
  • Rothwell N.J., Stock M.J. (1983). Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour. Clin.Sci.(Lond), 64, 19. eScholarID:1c583
  • Rothwell N.J., Stock M.J., Tyzbir R.S. (1983). Mechanisms of thermogenesis induced by low protein diets. Metabolism: clinical and experimental, 32, 257. eScholarID:1c584
  • Rothwell N.J., Saville M.E., Stock M.J. (1983). Metabolic responses to fasting and refeeding in lean and genetically obese rats. Am.J.Physiol, 244, R615. eScholarID:1c585
  • Bryant K.R., Rothwell N.J., Stock M.J., Wyllie M.G. (1983). Parasympathethic effects on diet-induced thermogenesis. Eur.J.Pharmacol, 95, 291. eScholarID:1c448
  • Everard D.M., Rothwell N.J., Stock M.J., Wilson C.A. (1983). Physical changes associated with the onset of precocious puberty in rats after treatment with PMSG. J.Reprod.Fertil, 69, 201. eScholarID:1c485
  • Emery P.W., Rothwell N.J., Stock M.J. (1983). Protein synthesis in liver, skeletal muscle, and brown adipose tissue of rats fed a protein-deficient diet. Biosci.Rep, 3, 569. eScholarID:1c483
  • Rothwell N.J., Stock M.J., Trayhurn P. (1983). Reduced lipogenesis in cafeteria-fed rats exhibiting diet-induced thermogenesis. Biosci.Rep, 3, 217. eScholarID:1c586
  • Stock M.J., Rothwell N.J. (1983). Role of brown adipose tissue thermogenesis in overfeeding: a review. J.R.Soc.Med, 76, 71. eScholarID:1c667
  • Rothwell N.J., Saville M.E., Stock M.J. (1983). Role of insulin in thermogenic responses to refeeding in 3-day-fasted rats. Am.J.Physiol, 245, E160. eScholarID:1c587
  • Rothwell N.J., Stock M.J., Warwick B.P. (1983). The effect of high fat and high carbohydrate cafeteria diets on diet-induced thermogenesis in the rat. Int.J.Obes, 7, 263. eScholarID:1c588

1982

  • Rothwell N.J., Saville M.E., Stock M.J., Wyllie M.G. (1982). Catecholamine and thyroid hormone influence on brown fat Na+, K+-ATPase activity and thermogenesis in the rat. Horm.Metab Res, 14, 261. eScholarID:1c565
  • Rothwell N.J., Stephens D.N., Stock M.J. (1982). Changes in metabolic rate and brown adipose tissue composition during nutritional rehabilitation of postnatally undernourished rats. Biol.Neonate, 42, 93. eScholarID:1c566
  • Rothwell N.J., Stock M.J., Stribling D. (1982). Diet-induced thermogenesis. Pharmacol.Ther, 17, 251. eScholarID:1c567
  • Rothwell N.J., Stock M.J., Wyllie M.G. (1982). Dopaminergic mechanisms in diet-induced thermogenesis and brown adipose tissue metabolism. Eur.J.Pharmacol, 77, 45. eScholarID:1c568
  • Rothwell N.J., Stock M.J. (1982). Effect of chronic food restriction on energy balance, thermogenic capacity, and brown-adipose-tissue activity in the rat. Biosci.Rep, 2, 543. eScholarID:1c569
  • Young J.B., Saville E., Rothwell N.J., Stock M.J., Landsberg L. (1982). Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. J.Clin.Invest, 69, 1061. eScholarID:1c686
  • Brooks S.L., Rothwell N.J., Stock M.J. (1982). Effects of diet and acute noradrenaline treatment on brown adipose tissue development and mitochondrial purine-nucleotide binding. Q.J.Exp.Physiol, 67, 259. eScholarID:1c445
  • Rothwell N.J., Stock M.J. (1982). Effects of early overnutrition and undernutrition in rats on the metabolic responses to overnutrition in later life. J.Nutr, 112, 426. eScholarID:1c570
  • Rothwell N.J., Saville M.E., Stock M.J. (1982). Effects of feeding a "cafeteria" diet on energy balance and diet-induced thermogenesis in four strains of rat. J.Nutr, 112, 1515. eScholarID:1c571
  • Rothwell N.J., Stock M.J. (1982). Effects of feeding a palatable "cafeteria" diet on energy balance in young and adult lean (+/?) Zucker rats. Br.J.Nutr, 47, 461. eScholarID:1c572
  • Rothwell N.J., Stock M.J., Tyzbir R.S. (1982). Energy balance and mitochondrial function in liver and brown fat of rats fed "cafeteria" diets of varying protein content. J.Nutr, 112, 1663. eScholarID:1c573
  • Rothwell N.J., Stock M.J. (1982). Energy expenditure of "cafeteria"-fed rats determined from measurements of energy balance and indirect calorimetry. Journal of physiology, Paris, 328, 371. eScholarID:1c574
  • Stock M.J., Rothwell N.J. (1982). Evidence for diet-induced thermogenesis in hyperphagic cafeteria-fed rats. Proc.Nutr.Soc, 41, 133. eScholarID:1c666
  • Rothwell N.J., Saville M.E., Stock M.J. (1982). Factors influencing the acute effect of food on oxygen consumption in the rat. Int.J.Obes, 6, 53. eScholarID:1c575
  • Rothwell N.J., Saville M.E., Stock M.J. (1982). Sympathetic and thyroid influences on metabolic rate in fed, fasted, and refed rats. Am.J.Physiol, 243, R339. eScholarID:1c576

1981

  • Rothwell N.J., Stock M.J. (1981). A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats. Metabolism: clinical and experimental, 30, 673. eScholarID:1c559
  • Perkins M.N., Rothwell N.J., Stock M.J., Stone T.W. (1981). Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature, 289, 401. eScholarID:1c540
  • Rothwell N.J., Saville M.E., Stock M.J. (1981). Acute effects of food, 2-deoxy-D-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats. Pflugers Archiv : European journal of physiology, 392, 172. eScholarID:1c560
  • Rothwell N.J., Stock M.J. (1981). Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesis. Pflugers Archiv : European journal of physiology, 389, 237. eScholarID:1c561
  • Rothwell N.J., Stock M.J., Wyllie M.G. (1981). Na+, K+-ATPase activity and noradrenaline turnover in brown adipose tissue of rats exhibiting diet-induced thermogenesis. Biochem.Pharmacol, 30, 1709. eScholarID:1c562
  • Rothwell N.J., Stock M.J. (1981). Regulation of energy balance. Annu.Rev.Nutr, 1, 235. eScholarID:1c563
  • Brooks S.L., Neville A.M., Rothwell N.J., Stock M.J., Wilson S. (1981). Sympathetic activation of brown-adipose-tissue thermogenesis in cachexia. Biosci.Rep, 1, 509. eScholarID:1c444
  • Stock M.J., Rothwell N.J. (1981). Sympathetic control of brown adipose tissue in the regulation of body weight. Biochem.Soc.Trans, 9, 525. eScholarID:1c665
  • Rothwell N.J., Stock M.J., Wyllie M.G. (1981). Sympathetic mechanisms in diet-induced thermogenesis: modification by ciclazindol and anorectic drugs. British journal of pharmacology, 74, 539. eScholarID:1c564

1980

  • Gurr M.I., Mawson R., Rothwell N.J., Stock M.J. (1980). Effects of manipulating dietary protein and energy intake on energy balance and thermogenesis in the pig. J.Nutr, 110, 532. eScholarID:1c493
  • Brooks S.L., Rothwell N.J., Stock M.J., Goodbody A.E., Trayhurn P. (1980). Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature, 286, 274. eScholarID:1c443
  • Rothwell N.J., Stock M.J. (1980). Intra-strain differences in the response to overfeeding in the rat. Proc.Nutr.Soc, 39, 20A. eScholarID:1c557
  • Rothwell N.J., Stock M.J. (1980). Thermogenesis induced by cafeteria feeding in young growing rats. Proc.Nutr.Soc, 39, 45A. eScholarID:1c558

1979

  • Rothwell N.J., Stock M.J. (1979). A role for brown adipose tissue in diet-induced thermogenesis. Nature, 281, 31. eScholarID:1c552
  • Rothwell N.J., Stock M.J. (1979). Combined effects of cafeteria and tube-feeding on energy balance in the rat. Proc.Nutr.Soc, 38, 5A. eScholarID:1c553
  • Rothwell N.J., Stock M.J. (1979). Effects of continuous and discontinuous periods of cafeteria feeding on body weight, resting oxygen consumption and noradrenaline sensitivity in the rat [proceedings]. Journal of physiology, Paris, 291, 59P. eScholarID:1c554
  • Gurr M.I., Rothwell N.J., Stock M.J. (1979). Effects of tube-feeding iso-energetic amounts of various dietary lipids on energy balance in the rat. Proc.Nutr.Soc, 38, 6A. eScholarID:1c491
  • Rothwell N.J., Stock M.J. (1979). In vivo determination of body composition by tritium dilution in the rat. Br.J.Nutr, 41, 625. eScholarID:1c555
  • Rothwell N.J., Stock M.J. (1979). Regulation of energy balance in two models of reversible obesity in the rat. J.Comp Physiol Psychol, 93, 1024. eScholarID:1c556
  • Gurr M.I., Mawson R., Rothwell N.J., Stock M.J. (1979). Weight maintenance and dietary-induced thermogenesis in the weanling pig [proceedings ]. Journal of physiology, Paris, 291, 60P. eScholarID:1c492

1978

  • Rothwell N.J., Stock M.J. (1978). A paradox in the control of energy intake in the rat. Nature, 273, 146. eScholarID:1c550
  • Rothwell N.J., Stock M.J. (1978). Mechanisms of weight gain and loss in reversible obesity in the rat [proceedings]. Journal of physiology, Paris, 276, 60P. eScholarID:1c551

1976

  • Macdonald I.A., Rothwell N.J., Stock M.J. (1976). Lipolytic and lipogenic activities of adipose tissue during spontaneous fat depletion and repletion [proceedings]. Proc.Nutr.Soc, 35, 129A. eScholarID:1c523