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Prof Nicholas Turner - publications

List of publications

2016

  • France, S., Hussain, S., Hill, A., Hepworth, L., Howard, R. M., Mulholland, K. R., ... Turner, N. (2016). One Pot Cascade Synthesis of Mono- and Di-Substituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA) and Imine Reductase (IRED) Biocatalysts. ACS Catalysis, 3753-3759. DOI: 10.1021/acscatal.6b00855. Publication link: 8695b7d0-8839-4dc3-9d7b-897a4c6bb919
  • Westley, C., Xu, Y., Carnell, A. J., Turner, N., & Goodacre, R. (2016). A novel label-free SERS approach for high-throughput screening of biocatalysts. Analytical Chemistry. . Publication link: 98f47394-a645-4a62-b12f-62a03630f20b
  • Slabu, I., Galman, J. L., Weise, N. J., Lloyd, R. C., & Turner, N. J. (2016). Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines. ChemCatChem, 8(6), 1038-1042. DOI: 10.1002/cctc.201600075. Publication link: a674294c-9069-4d9b-8a68-39b14254b22d
  • Weise, N., Ahmed, S. T., Parmeggiani, F., Siirola, E., Pushpanath, A., Schell, U., & Turner, N. (2016). Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source. Catalysis Science and Technology, 6(12), 4086-4089. DOI: 10.1039/C6CY00855K . Publication link: 7bb344b8-296d-437d-9ee4-651af165b91e
  • Weissenborn, M. J., Notonier, S., Lang, S. L., Otte, K. B., Herter, S., Turner, N., ... Hauer, B. (2016). Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s. Chemical Communications, 52(36), 6158-6161. DOI: 10.1039/c6cc01749e. Publication link: 6c5f5f49-3827-4914-88dc-8960a00a5d55
  • Staniland, S., Adams, R., Mcdouall, J., Maffucci, I., Contini, A., Grainger, D., ... Clayden, J. (2016). Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts. Angewandte Chemie. . Publication link: 151df7dd-819a-4e74-abb0-96157fa53428
  • Yan, C., Schmidberger, J., Parmeggiani, F., Hussain, S., Turner, N., Flitsch, S., & Barran, P. (2016). Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry. Analyst. DOI: 10.1039/C6AN00617E . Publication link: 1a35a71a-03f9-4cc3-96c4-c43174fac140
  • Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., ... Turner, N. J. (2016). SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.Biochemical Society Transactions, 44(3), 675-7. DOI: 10.1042/BST20160009. Publication link: 230b6a5b-8b99-4c32-9285-03bc1b0e20b1 | PubMed:27284023
  • Willies, S., Galman, J., Slabu, I., & Turner, N. (2016). A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases. Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences. DOI: 10.1098/rsta.2015.0084 . Publication link: 20791fdf-9f72-4c05-9190-8e681494b344
  • Both, P., Kelly, P., Mutti, F., Turner, N., & Flitsch, S. (2016). Whole-cell biocatalysts for stereoselective C-H amination reactions. Angewandte Chemie (International Edition). . Publication link: 253cbabd-0a5c-4a7f-962b-a89f1d26dad9
  • Heath, R. S., Pontini, M., Hussain, S., & Turner, N. J. (2016). Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles. ChemCatChem, 8(1), 117-120. DOI: 10.1002/cctc.201500822. Publication link: 28eb7225-15c1-435c-8d70-093d2549c5c3
  • Markošová, K., Dolejš, I., Stloukal, R., Rios-Solis, L., Rosenberg, M., Micheletti, M., ... Rebroš, M. (2016). Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels. Journal of Molecular Catalysis - B Enzymatic, 129, 69-74. DOI: 10.1016/j.molcatb.2016.04.009. Publication link: 00e3af88-b8c2-49a0-a3af-ee9a4e503c5b
  • Eichler, A., Gricman, Ł., Herter, S., Kelly, P., Turner, N., Pleiss, J., & Flitsch, S. (2016). Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling. CHEMBIOCHEM, 17(5), 426-432. DOI: 10.1002/cbic.201500536. Publication link: ae0be331-2d8e-4427-b0be-722a9b586353
  • Westley, C., Xu, Y., Carnell, A. J., Turner, N., & Goodacre, R. (2016). Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts. Analytical Chemistry, 88(11), 5898-5903. DOI: 10.1021/acs.analchem.6b00813. Publication link: d4b9c3fe-c9dd-4885-ba74-858091a87a66
  • Grogan, G., & Turner, N. (2016). InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines. Chemistry - A European Journal, 22(6), 1900-1907. DOI: 10.1002/chem.201503954. Publication link: fe9b1306-fee9-4c5e-b088-a47d42578339

2015

  • Flitsch, S., Ahmed, S. T., Parmeggiani, F., Weise, N., & Turner, N. (2015). Chemoenzymatic Synthesis of Optically Pure L- and D-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation. ACS Catalysis, 5, 5410-5413. DOI: 10.1021/acscatal.5b01132. Publication link: 2a759a8f-a42e-4307-9ccc-a472e6aea938
  • Parmeggiani, F., Lovelock, S. L., Weise, N. J., & Turner, S. T. A. A. N. J. (2015). Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process. Angewandte Chemie (International Edition). . Publication link: 203fc5b9-8319-4279-89b1-e3e791667d29
  • Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., ... Turner, N. (2015). An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines. ChemCatChem (Online). . Publication link: 087c4f6b-008d-4fbe-99ea-af83be4f286c
  • Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C., & Turner, N. (2015). Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions. Beilstein Journal of Organic Chemistry, 11, 1713-1720. DOI: DOI 10.1021/acscatal.5b01132. Publication link: e883004e-71a8-42a1-925b-1187ace5dd4e

2014

  • Staniland, S., Yuan, B., Giménez-Agulló, N., Marcelli, T., Willies, S. C., Grainger, D. M., ... Clayden, J. (2014). Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers. Chemistry: A European Journal, 20, 13084-8. . Publication link: d74f164c-616e-4238-b962-76ea485b5d57
  • Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J., & Carnell, A. J. (2014). Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis. Green Chemistry, 16, 4524-4529. [C4GC01321B]. DOI: 10.1039/C4GC01321B. Publication link: 9720ee56-69e7-4500-b83d-3a0df6c5ea6b
  • O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C., & Turner, N. J. (2014). A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines. Angewandte Chemie - International Edition, 53(9), 2447-2450. DOI: 10.1002/anie.201309208. Publication link: 813d57d8-c5bc-40a9-8646-178337c14bbe

2013

  • Kalim Akhtara, M., Turner, N. J., & Jones, P. R. (2013). Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities. Proceedings of the National Academy of Sciences of the United States of America, 110(1), 87-92. DOI: 10.1073/pnas.1216516110. Publication link: 7907bb8c-af36-43bb-9ffb-92d1914e3b9f
  • O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L., & Turner, N. J. (2013). Substrate promiscuity of cytochrome P450 RhF. Catalysis Science and Technology, 3(6), 1490-1492. DOI: 10.1039/c3cy00091e. Publication link: f1ac0a93-1a47-43a3-8ae2-d3727b4c3b25
  • Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., ... Ward, T. R. (2013). Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes. Nature Chemistry, 5(2), 93-99. DOI: 10.1038/nchem.1498. Publication link: ad73417f-a872-4fea-bcf4-0195ed582c00

2012

2011

  • Oneill, M., Hauer, B., Schneider, N., & Turner, N. J. (2011). Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids. Acs Catalysis, 1(9), 1014-1016. DOI: 10.1021/cs2002252. Publication link: b25721c3-8df3-4d06-9e5a-480d3d5ed753
  • Dunsmore, C. J., Malone, K. J., Bailey, K. R., Wear, M. A., Florance, H., Shirran, S., ... Turner, N. J. (2011). Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans. ChemBioChem: a European journal of chemical biology , 12(5), 802-810. DOI: 10.1002/cbic.201000413. Publication link: bca306a8-a5ed-49b8-913a-f30c04623236
  • Foulkes, J. M., Malone, K. J., Coker, V. S., Turner, N. J., & Lloyd, J. R. (2011). Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions. Acs Catalysis, 1(11), 1589-1594. DOI: 10.1021/cs200400t. Publication link: 37ae69f1-91e8-400c-9143-4f44775d94ee
  • O'Reilly, E., Köhler, V., Flitsch, S. L., & Turner, N. J. (2011). Cytochromes P450 as useful biocatalysts: Addressing the limitations. Chemical Communications, 47(9), 2490-2501. DOI: 10.1039/c0cc03165h. Publication link: 3eeb65bc-2c17-4c2b-9cee-49021b13453b | PubMed:21264369
  • Turner, N. J. (2011). Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids. Current Opinion in Chemical Biology, 15(2), 234-240. DOI: 10.1016/j.cbpa.2010.11.009. Publication link: 3fa8dcee-aa84-4d45-9423-1bd9d89b9a60
  • Turner, N. J. (2011). Enantioselective Oxidation of C-O and C-N bonds using oxidases. Chemical Reviews, 111(7), 4073-4087. DOI: 10.1021/cr200111v. Publication link: 485f192e-9322-4b1e-af5f-e3bc538f3e4e
  • Hopwood, J., Truppo, M. D., Turner, N. J., & Lloyd, R. C. (2011). A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases. Chemical Communications, 47(2), 773-775. DOI: 10.1039/c0cc02919j. Publication link: 42fe62fb-483b-4807-aa77-c513addbc826
  • Walker, R. G., Thomson, G., Malone, K., Nowicki, M. W., Brown, E., Blake, D. G., ... Mottram, J. C. (2011). High throughput screens yield small molecule inhibitors of leishmania CRK3:CYC6 cyclin-dependent kinase. PLoS Neglected Tropical Diseases, 5(4), [e1033]. DOI: 10.1371/journal.pntd.0001033. Publication link: 2b993ead-c7a1-494f-9414-f73cd535144d
  • Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., ... Flitsch, S. L. (2011). Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope. Beilstein Journal of Organic Chemistry, 7, 1494-1498. [7]. DOI: 10.3762/bjoc.7.173. Publication link: 681965df-6e4f-4836-ab2e-02b35f3ae536
  • Fessner, W. D., Turner, N. J., & Wang, M. X. (2011). Biocatalysis - A gateway to industrial biotechnology. Advanced Synthesis & Catalysis, 353(13), 2189-2190. DOI: 10.1002/adsc.201100679. Publication link: 8d057681-cd06-41ff-a7fa-312597ac1c76
  • Ioannou, A., Cini, E., Timofte, R. S., Flitsch, S. L., Turner, N. J., & Linclau, B. (2011). Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase. Chemical Communications, 47(40), 11228-11230. DOI: 10.1039/c1cc13956h. Publication link: 868dd3f1-e2f4-436a-a87d-8fae08769c4b
  • Rannes, J. B., Ioannou, A., Willies, S. C., Grogan, G., Behrens, C., Flitsch, S. L., & Turner, N. J. (2011). Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution. Journal of the American Chemical Society, 133(22), 8436-8439. DOI: 10.1021/ja2018477. Publication link: 9772336a-816f-460e-a7a4-a1672b1e1c99 | PubMed:21526835

2010

  • Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., ... Walkinshaw, M. (2010). Selective chemical intervention in the proteome of caenorhabditis elegans. Journal of Proteome Research, 9(11), 6060-6070. DOI: 10.1021/pr100427c. Publication link: d2f2c810-da79-42c5-a4bb-0ecd49e4cc90
  • Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., ... Clayden, J. (2010). Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases. Angewandte Chemie - International Edition, 49(39), 7010-7013. DOI: 10.1002/anie.201002580. Publication link: 9642f1fb-d492-4374-8501-641734b4c354
  • Dunn, R. V., Munro, A. W., Turner, N. J., Rigby, S. E. J., & Scrutton, N. S. (2010). Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases. ChemBioChem: a European journal of chemical biology , 11(9), 1158-1231. DOI: 10.1002/cbic.201000184. Publication link: 9368fcda-ac50-41cb-9d6a-6299ba246466 | PubMed:20480485
  • Turner, N. J. (2010). Deracemisation methods. Current Opinion in Chemical Biology, 14(2), 115-121. DOI: 10.1016/j.cbpa.2009.11.027. Publication link: 9d7a6b5c-8c0e-4cb7-b5cb-29015664a186

2009

  • Robin, A., Roberts, G. A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., ... Flitsch, S. L. (2009). Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme. Chemical Communications, (18), 2478-2480. DOI: 10.1039/b901716j. Publication link: 923a6a43-9395-4772-97a7-bd7f42bdf9c5

2008

  • Truppo, M. D., Escalettes, F., & Turner, N. J. (2008). Rapid determination of both the activity and enantioselectivity of ketoreductases. Angewandte Chemie - International Edition, 47(14), 2639-2641. DOI: 10.1002/anie.200705046. Publication link: 7c82246d-ec68-4814-a09e-8560497b79e7
  • Atkin, K. E., Reiss, R., Turner, N. J., Brzozowski, A. M., & Grogan, G. (2008). Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64(3), 182-185. DOI: 10.1107/S174430910800345X. Publication link: 6d59ebb3-f51b-4c7e-b146-17933f030d2a
  • Escalettes, F., & Turner, N. J. (2008). Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases. ChemBioChem: a European journal of chemical biology , 9(6), 857-860. DOI: 10.1002/cbic.200700689. Publication link: d8054573-3401-41f2-8934-8838321a054d
  • Nowicki, M. W., Tulloch, L. B., Worralll, L., McNae, I. W., Hannaert, V., Michels, P. A. M., ... Turner, N. J. (2008). Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorganic and Medicinal Chemistry, 16(9), 5050-5061. DOI: 10.1016/j.bmc.2008.03.045. Publication link: c5e7bff7-644a-434b-877a-8d9d0fec0a0d

2007

  • Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J., & Turner, N. J. (2007). A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A. Chemical Communications, (35), 3640-3642. DOI: 10.1039/b710456a. Publication link: 2eda7e7b-209b-4935-a6b7-cdbbfb5eea5c

2004

2003

  • Carr, R., Alexeeva, M., Enright, A., Eve, T. S. C., Dawson, M. J., & Turner, N. J. (2003). Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity. Angewandte Chemie - International Edition, 42(39), 4807-4810. DOI: 10.1002/anie.200352100. Publication link: 8e30fccf-d923-419e-9007-d5d648695a2f
  • Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L., & Ulijn, R. V. (2003). Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy. Journal of the American Chemical Society, 125(46), 13952-13953. DOI: 10.1021/ja037922x. Publication link: dbb8779b-0502-4d50-8599-09fdb5adbceb

2002