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Prof Nicholas Turner - publications

List of publications

2014

  • O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C. and Turner, N. J. A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines. Angewandte Chemie (International Edition). 2014 February; 53(9): 2447-2456. eScholarID:222855 | DOI:10.1002/anie.201309208

2013

  • M. Kalim Akhtar, Nicholas J. Turner, and Patrik R. Jones. Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities. Proceedings of the National Academy of Sciences. 2013; 110(1): 87-92. eScholarID:191976
  • O'Reilly, Elaine, Mark Corbett, Shahed Hussain, Paul P. Kelly, Dominique Richardson, S. L. Flitsch, and Nicholas J. Turner. Substrate Promiscuity of Cytochrome P450 RhF. The Royal Society of Chemistry; Catalysis Science & Technology (2013). 2013 April; eScholarID:191977 | DOI:10.1039/c3cy00091e
  • V. Köhler, Y. M. Wilson, M. Dürrenberger, D. Ghislieri, E. Churakova, T. Quinto, L. Knörr, D. Häussinger, F. Hollmann, N. J. Turner & T. R. Ward. Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes. Nature Chemistry. 2013; 5(2): 93-99. eScholarID:213338 | DOI:10.1038/nchem.1498

2012

  • Nicholas J. Turner. Biocatalysis. Catal. Sci. Technol. 2012 June; 2: 1523-1523. eScholarID:185139 | DOI:10.1039/C2CY90030K
  • Simon C. Willies, Jemma L. White, Nicholas J. Turner. Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine. Tetrahedron. 2012 September; 68(37): 7564-7567. eScholarID:185134 | DOI:10.1016/j.tet.2012.06.062
  • 31. Dr. Ian Rowles, Dr. Kirk J. Malone, Dr. Laura L. Etchells, Dr. Simon C. Willies, Prof. Nicholas J. Turner. Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine A. Chem.Cat.Chem. 2012 September; 4(9): 1259-1261. eScholarID:185128 | DOI:10.1002/cctc.201200202
  • 32. Rajesh Kumar, Jim Cawley, Michael Karmilowicz, Carlos A. Martinez, Nathan Wymer, Bo Yuan, Franck Escalettes, Nicholas J. Turner, Johann H. Sattler, Katharina Tauber, Francesco G. Mutti, Wolfgang Kroutil. Oxidation of Alcohols. Practical Methods for Biocatalysis and Biotransformations 2. 2012 May; eScholarID:185129 | DOI:10.1002/9781119943426.ch6
  • 35. Prof. Dr. Karlheinz Drauz Ph.D, Prof. Dr. Harald Gröger, Dr. Oliver May PhD and Nicholas J Turner. Oxidation of CN Bonds. Enzyme Catalysis in Organic Synthesis, Third Edition. 2012 April; eScholarID:185138 | DOI:10.1002/9783527639861.ch35
  • 36. Simon Willies, Matthew D. Truppo, Christopher K. Savile, Jacob M. Janey, Jeffrey C. Moore, Gjalt W. Huisman, Gregory J. Hughes, Francesco G. Mutti, Christine S. Fuchs, Wolfgang Kroutil, Jennifer Hopwood, Matthew D. Truppo, Richard Lloyd, Nicholas J. Turner, Eun Young Hong, Minho Cha, Hyungdon Yun, Byung-Gee Kim and S. Stella, Anju Chadha. Reductive Amination. Practical Methods for Biocatalysis and Biotransformations 2. 2012 May; eScholarID:185137 | DOI:10.1002/9781119943426.ch2
  • Elaine O’Reilly, Suzanne J Aitken, Gideon Grogan, Paul P Kelly, Nicholas J Turner, and Sabine L Flitsch. Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous. Beilstein J Org Chem. 2012 April; 8: 496-500. eScholarID:185133 | DOI:10.3762/bjoc.8.56
  • 34. John Whittall, Peter W. Sutton, Valentin Köhler, Bas Groenendaal, Kevin R. Bailey, Anass Znabet, James Raferty, Madeleine Helliwell, Nicholas J. Turner, Kristian Geitner, Uwe T. Bornscheuer, Gonzalo de Gonzalo, Vicente Gotor, Shuvendu Das, John P. N. Rosazza, Aashrita Rajagopalan, Francesco G. Mutti and Wolfgang Kroutil. Selective Oxidation. Practical Methods for Biocatalysis and Biotransformations 2. 2012 May; eScholarID:185135 | DOI:10.1002/9781119943426.ch7

2011

  • Dunsmore C, Malone K, Bailey K, Wear M, Florance H, Shirran S, Barran P, Page A, Walkinshaw M, Turner N. Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans. Chembiochem. 2011; 12(5): 802-810. eScholarID:150586 | DOI:10.1002/cbic.201000413
  • Fessner W, Turner N, Wang M. Biocatalysis - A Gateway to Industrial Biotechnology. Advanced Synthesis & Catalysis. 2011; 353(13): 2189-2190. eScholarID:150591 | DOI:10.1002/adsc.201100679
  • Foulkes J, Malone K, Coker V, Turner N, Lloyd J. Engineering a Biometallic Whole Cell Catalyst for Enantioselective Deracemization Reactions. Acs Catalysis. 2011; 1(11): 1589-1594. eScholarID:150592 | DOI:10.1021/cs200400t
  • Hopwood J, Truppo M, Turner N, Lloyd R. A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases. Chemical Communications. 2011; 47(2): 773-775. eScholarID:150587 | DOI:10.1039/c0cc02919j
  • Ioannou A, Cini E, Timofte R, Flitsch S, Turner N, Linclau B. Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase. Chemical Communications. 2011; 47(40): 11228-11230. eScholarID:150595 | DOI:10.1039/c1cc13956h
  • O'Neill M, Hauer B, Schneider N, Turner N. Enzyme-Catalyzed Enantioselective Hydrolysis of Dihydrouracils as a Route to Enantiomerically Pure beta-Amino Acids. Acs Catalysis. 2011; 1(9): 1014-1016. eScholarID:150594 | DOI:10.1021/cs2002252
  • O'Reilly E, Koehler V, Flitsch S, Turner N. Cytochromes P450 as useful biocatalysts: addressing the limitations. Chemical Communications. 2011; 47(9): 2490-2501. eScholarID:150588 | DOI:10.1039/c0cc03165h
  • Rannes J, Ioannou A, Willies S, Grogan G, Behrens C, Flitsch S, Turner N. Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution. Journal of the American Chemical Society. 2011; 133(22): 8436-8439. eScholarID:150596 | DOI:10.1021/ja2018477
  • Robin A, Koehler V, Jones A, Ali A, Kelly P, O'Reilly E, Turner N, Flitsch S. Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope. Beilstein Journal of Organic Chemistry. 2011; 7: 1494-1498. eScholarID:150590 | DOI:10.3762/bjoc.7.173
  • Turner N. Ammonia lyases and aminomutases as biocatalysts for the synthesis of alpha-amino and beta-amino acids. Current Opinion in Chemical Biology. 2011; 15(2): 234-240. eScholarID:150593 | DOI:10.1016/j.cbpa.2010.11.009
  • Turner N. Enantioselective Oxidation of C-O and C-N Bonds Using Oxidases. Chemical Reviews. 2011; 111(7): 4073-4087. eScholarID:150589 | DOI:10.1021/cr200111v
  • Walker R, Thomson G, Malone K, Nowicki M, Brown E, Blake D, Turner N, Walkinshaw M, Grant K, Mottram J. High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase. Plos Neglected Tropical Diseases. 2011; 5(4): eScholarID:150597 | DOI:10.1371/journal.pntd.0001033

2010

  • 12. Anass Znabet, Marloes M. Polak, Elwin Janssen, Frans J. J. de Kanter, Nicholas J. Turner, Romano V. A. Orru and Eelco Ruijter. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. Chem. Commun. 2010 September; 46: 7918-7920. eScholarID:185148 | DOI:10.1039/C0CC02823A
  • Nicholas J. Turner. Deracemisation methods. Current Opinion in Chemical Biology. 2010 April; 14(2): 115-121. eScholarID:185144 | DOI:10.1016/j.cbpa.2009.11.027
  • 14. Anass Znabet, Dr. Eelco Ruijter, Dr. Valentin Köhler, Dr. Madeleine Helliwell, Prof. Dr. Nicholas J. Turner, Prof. Dr. Romano V. A. Orru. Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions. Angewandte Chemie. 2010 July; 122(31): 5417-5420. eScholarID:185150 | DOI:10.1002/ange.201001592

2008

  • Atkin K, Reiss R, Turner N, Brzozowski A, Grogan G. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 2008 March; 64: 182-185. eScholarID:1f494 | DOI:10.1107/s174430910800345x
  • Atkin K, Reiss R, Koehler V, Bailey K, Hart S, Turkenburg J, Turner N, Brzozowski A, Grogan G. The Structure of Monoamine Oxidase from Aspergillus niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution. Journal of Molecular Biology. 2008 December; 384(5): 1218-1231. eScholarID:1f495 | DOI:10.1016/j.jmb.2008.09.090
  • Escalettes F, Turner N. Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases. Chembiochem. 2008 April; 9(6): 857-860. eScholarID:1f364 | DOI:10.1002/cbic.200700689
  • Nowicki M, Tulloch L, Worralll L, McNae I, Hannaert V, Michels P, Fothergill-Gilmore L, Walkinshaw M, Turner N. Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorganic & Medicinal Chemistry. 2008 May; 16(9): 5050-5061. eScholarID:1f168 | DOI:10.1016/j.bmc.2008.03.045
  • Truppo M, Escalettes F, Turner N. Rapid determination of both the activity and enantioselectivity of ketoreductases. Angewandte Chemie-International Edition. 2008; 47(14): 2639-2641. eScholarID:1f59 | DOI:10.1002/anie.200705046

2007

  • Bailey K, Ellis A, Reiss R, Snape T, Turner N. A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (+/-)-crispine A. Chemical Communications. 2007; (35): 3640-3642. eScholarID:1f767 | DOI:10.1039/b710456a
  • Eve T, Wells A, Turner N. Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst. Chemical Communications. 2007; (15): 1530-1531. eScholarID:1f701 | DOI:10.1039/b617537f

2004

  • TURNER NJ; ROFF, GEOFFREY J.; LLOYD, RICHARD C A Versatile Chemo-Enzymatic Route to Enantiomerically Pure beta-Branched alpha-Amino Acids. Journal of the American Chemical Society. 2004 March; 126(13): 4098-4099. eScholarID:1a10690 | DOI:10.1021/ja049499d

2003

  • TURNER NJ; CARR, REUBEN; ALEXEEVA, MARINA; ENRIGHT, ALEXIS; . Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity. Angewandte Chemie, International Edition. 2003 October; 42(39): 4807-4810. eScholarID:1a10687 | DOI:10.1002/anie.200352100
  • TURNER NJ; HUMPHREY, CARA E.; EASSON, MORAG A. M.; FLITSCH, SABINE L.; . Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy. Journal of the American Chemical Society. 2003 October; 125(46): 13952-13953. eScholarID:1a10688 | DOI:10.1021/ja037922x

2002