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Prof Nicholas Turner - publications

List of publications


  • Westley, C., Xu, Y., Thilaganathan, B., Carnell, A. J., Turner, N., & Goodacre, R. (2017). Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method. Analytical Chemistry. . Publication link: 867d6dc8-5bc4-4d8a-9ba2-32eb55c569ac
  • Klenk, J. M., Nebel, B., Porter, J., Kulig, J. K., Hussain, S., Richter, S. M., ... Flitsch, S. (2017). The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac. Biotechnology Journal. DOI: 10.1002/biot.201600520. Publication link: 35baed66-c5dc-46d7-954e-4cc7eb039aef
  • Galman, J., Slabu, I., Weise, N., Iglesias, C., Lloyd, R. C., Parmeggiani, F., & Turner, N. (2017). Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Green Chemistry. DOI: 10.1039/C6GC02102F . Publication link: 4d2d6eff-5d51-4b15-a463-08e0141612d5
  • Weise, N., Ahmed, S., Parmeggiani, F., & Turner, N. (2017). Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts. Advanced Synthesis & Catalysis. DOI: 10.1002/adsc.201600894. Publication link: 4df63b31-0419-45de-a701-9efae1ed431e
  • Slabu, I., Galman, J., Iglesias, C., Weise, N., Lloyd, R. C., & Turner, N. (2017). n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones. Catalysis Today. DOI: 10.1016/j.cattod.2017.01.025. Publication link: 167dc811-c1dd-41fd-b260-d35cf203664d
  • Hepworth, L., France, S., Hussain, S., Both, P., Turner, N., & Flitsch, S. (2017). De Novo Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines.ACS Catalysis. DOI: 10.1021/acscatal.7b00513. Publication link: cef58957-157d-4c91-89a5-9d0361d63b8f
  • Flitsch, S., France, S., Hepworth, L., & Turner, N. (2017). Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways. ACS Catalysis, 710-724. DOI: 10.1021/acscatal.6b02979. Publication link: b8c3c36b-885f-4c7c-9bcd-01db0f414eab
  • Yan, C., Parmeggiani, F., Jones, E. A., Claude, E., Hussain, S., Turner, N., ... Barran, P. (2017). Real-time screening of biocatalysts in live bacterial colonies. Journal of the American Chemical Society. DOI: 10.1021/jacs.6b12165. Publication link: f2d9785e-a873-4ddc-94f9-9bec46885ab2


  • Turner, N., Mas Roselló, J., Staniland, S., & Clayden, J. (2016). Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation. Tetrahedron, 72(34), 5172-5177. DOI: 10.1016/j.tet.2016.01.037. Publication link: 88fcbaf2-b8f6-4843-8d3a-f827f31bd9ed
  • Westley, C., Xu, Y., Carnell, A. J., Turner, N., & Goodacre, R. (2016). A novel label-free SERS approach for high-throughput screening of biocatalysts. Analytical Chemistry, 88(11). DOI: 10.1021/acs.analchem.6b00813. Publication link: 98f47394-a645-4a62-b12f-62a03630f20b
  • France, S., Hussain, S., Hill, A., Hepworth, L., Howard, R. M., Mulholland, K. R., ... Turner, N. (2016). One Pot Cascade Synthesis of Mono- and Di-Substituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA) and Imine Reductase (IRED) Biocatalysts. ACS Catalysis, 3753-3759. DOI: 10.1021/acscatal.6b00855. Publication link: 8695b7d0-8839-4dc3-9d7b-897a4c6bb919
  • Rowles, I., Groenendaal, B., Binay, B., Malone, K. J., Willies, S. C., & Turner, N. J. (2016). Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids. Tetrahedron, 72(46), 7343-7347. DOI: 10.1016/j.tet.2016.06.026. Publication link: 8399726f-2338-450e-a9e6-281e91dac819
  • Turner, N., Wells, A., Wong, J. W., Michels, P. C., Fandrick, K., Finch, G. L., ... Watson, T. J. (2016). Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form. Organic Process Research & Development, 20(3), 3298-3306. DOI: 10.1021/acs.oprd.5b00369. Publication link: 7cfb2cbd-58ad-45db-98af-cf0f9de127ca
  • Weise, N., Ahmed, S., Parmeggiani, F., Siirola, E., Pushpanath, A., Schell, U., & Turner, N. (2016). Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source. Catalysis Science and Technology, 6(12), 4086-4089. DOI: 10.1039/C6CY00855K . Publication link: 7bb344b8-296d-437d-9ee4-651af165b91e
  • Ahmed, S., Parmeggiani, F., Weise, N., Flitsch, S., & Turner, N. (2016). Synthesis of Enantiomerically Pure Ring-Substituted l-Pyridylalanines by Biocatalytic Hydroamination. Organic letters. DOI: 10.1021/acs.orglett.6b02559. Publication link: 6f84b5eb-8379-46ed-b4f9-b121513066e0
  • Weissenborn, M. J., Notonier, S., Lang, S. L., Otte, K. B., Herter, S., Turner, N., ... Hauer, B. (2016). Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s. Chemical Communications, 52(36), 6158-6161. DOI: 10.1039/c6cc01749e. Publication link: 6c5f5f49-3827-4914-88dc-8960a00a5d55
  • Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S., & Turner, N. J. (2016). Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor. Organic and Biomolecular Chemistry, 14(34), 8064-8067. DOI: 10.1039/c6ob01382a. Publication link: 4859971f-9ac3-4e76-888a-4febb950a15f
  • Heath, R. S., Pontini, M., Hussain, S., & Turner, N. J. (2016). Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles. ChemCatChem, 8(1), 117-120. DOI: 10.1002/cctc.201500822. Publication link: 28eb7225-15c1-435c-8d70-093d2549c5c3
  • Staniland, S., Adams, R., Mcdouall, J., Maffucci, I., Contini, A., Grainger, D., ... Clayden, J. (2016). Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts. Angewandte Chemie, 55(36), 10755-10759. DOI: 10.1002/anie.201605486. Publication link: 151df7dd-819a-4e74-abb0-96157fa53428
  • Yan, C., Schmidberger, J., Parmeggiani, F., Hussain, S., Turner, N., Flitsch, S., & Barran, P. (2016). Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry. Analyst. DOI: 10.1039/C6AN00617E . Publication link: 1a35a71a-03f9-4cc3-96c4-c43174fac140
  • Turner, N., & Green, A. (2016). Biocatalytic retrosynthesis:: Redesigning synthetic routes to high-value chemicals. Perspectives in Science. DOI: 10.1016/j.pisc.2016.04.106. Publication link: 1ae81c10-4930-4e00-ac68-ba924dcea8fe
  • Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., ... Turner, N. J. (2016). SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.Biochemical Society Transactions, 44(3), 675-7. DOI: 10.1042/BST20160009. Publication link: 230b6a5b-8b99-4c32-9285-03bc1b0e20b1 | PubMed:27284023
  • Both, P., Kelly, P., Mutti, F., Turner, N., & Flitsch, S. (2016). Whole-cell biocatalysts for stereoselective C-H amination reactions. Angewandte Chemie (International Edition). DOI: 10.1002/anie.201510028. Publication link: 253cbabd-0a5c-4a7f-962b-a89f1d26dad9
  • Willies, S., Galman, J., Slabu, I., & Turner, N. (2016). A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases. Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences. DOI: 10.1098/rsta.2015.0084 . Publication link: 20791fdf-9f72-4c05-9190-8e681494b344
  • Feuvre, R. L., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., ... Turner, N. J. (2016). SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production. Synthetic and Systems Biotechnology. DOI: 10.1016/j.synbio.2016.07.001. Publication link: 0ad51c53-08d0-4c69-b469-c9975abca512
  • Markošová, K., Dolejš, I., Stloukal, R., Rios-Solis, L., Rosenberg, M., Micheletti, M., ... Rebroš, M. (2016). Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels. Journal of Molecular Catalysis - B Enzymatic, 129, 69-74. DOI: 10.1016/j.molcatb.2016.04.009. Publication link: 00e3af88-b8c2-49a0-a3af-ee9a4e503c5b
  • Turner, N., de Graaff, C., Oppelaar, B., Péruch, O., Vande Velde, C. M. L., Bechi, B., ... Orru, R. V. A. (2016). Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer. Advanced Synthesis and Catalysis, 358(10), 1555-1560. DOI: 10.1002/adsc.201600038. Publication link: b6f7429b-3b12-4d1c-aa9d-1fd49ae5d788
  • Parmeggiani, F., Ahmed, S., Thompson, M., Weise, N., Galman, J., Gahloth, D., ... Dunstan, M. (2016). Single-Biocatalyst Synthesis of Enantiopure D-Arylalanines Exploiting an Engineered D-Amino Acid Dehydrogenase. Advanced Synthesis & Catalysis. DOI: 10.1002/adsc.201600682. Publication link: b10d0687-e41c-470f-b7da-15d763bdf07c
  • Slabu, I., Galman, J. L., Weise, N. J., Lloyd, R. C., & Turner, N. J. (2016). Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines. ChemCatChem, 8(6), 1038-1042. DOI: 10.1002/cctc.201600075. Publication link: a674294c-9069-4d9b-8a68-39b14254b22d
  • Turner, N., Fisk, H., Westley, C., & Goodacre, R. (2016). Achieving optimal SERS through enhanced experimental design. Journal of Raman Spectroscopy, 47(1), 59-66. DOI: 10.1002/jrs.4855, 10.1002/jrs.4855. Publication link: a8d571cb-0bca-47b4-a668-37a75b0cb80e
  • Eichler, A., Gricman, Ł., Herter, S., Kelly, P., Turner, N., Pleiss, J., & Flitsch, S. (2016). Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling. CHEMBIOCHEM, 17(5), 426-432. DOI: 10.1002/cbic.201500536. Publication link: ae0be331-2d8e-4427-b0be-722a9b586353
  • Turner, N., Parmeggiani, F., Ahmed, S., & Weise, N. (2016). Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes. Tetrahedron, 72(46), 7256-7262. DOI: 10.1016/j.tet.2015.12.063. Publication link: a4062533-02b0-4a3d-9b3b-55f09ddace7d
  • Westley, C., Xu, Y., Carnell, A. J., Turner, N., & Goodacre, R. (2016). Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts. Analytical Chemistry, 88(11), 5898-5903. DOI: 10.1021/acs.analchem.6b00813. Publication link: d4b9c3fe-c9dd-4885-ba74-858091a87a66
  • Grogan, G., & Turner, N. (2016). InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines. Chemistry - A European Journal, 22(6), 1900-1907. DOI: 10.1002/chem.201503954. Publication link: fe9b1306-fee9-4c5e-b088-a47d42578339


  • Turner, N., Özgün, G., Karagüler, N. G., & Turunen, O. (2015). Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum. Journal of Molecular Catalysis B: Enzymatic, 122, 212-217. DOI: 10.1016/j.molcatb.2015.09.014. Publication link: 022efb6b-7ee5-43b2-bf16-f1d472c193c8
  • Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., ... Turner, N. (2015). An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines. ChemCatChem (Online). DOI: 10.1002/cctc.201402797. Publication link: 087c4f6b-008d-4fbe-99ea-af83be4f286c
  • Weise, N., Parmeggiani, F., Ahmed, S., Turner, N., & Lovelock, S. (2015). Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process. Angewandte Chemie (International Edition), 54(15). DOI: 10.1002/anie.201410670. Publication link: 203fc5b9-8319-4279-89b1-e3e791667d29
  • Ahmed, S., Parmeggiani, F., Weise, N., Flitsch, S., & Turner, N. (2015). Chemoenzymatic Synthesis of Optically Pure L- and D-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation. ACS Catalysis, 5, 5410-5413. DOI: 10.1021/acscatal.5b01132. Publication link: 2a759a8f-a42e-4307-9ccc-a472e6aea938
  • Turner, N., Herter, S., McKenna, S. M., Frazer, A., Leimkühler, S., & Carnell, A. J. (2015). Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis. ChemCatChem, 7(15), 2313-2317. DOI: 10.1002/cctc.201500218. Publication link: 2cbf08b6-3300-4f94-b11a-71eba62b51dc
  • Knaus, T., Mutti, F., Humphreys, L. D., Turner, N., & Scrutton, N. (2015). Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes. Organic & Biomolecular Chemistry, 13(1), 223-233. DOI: 10.1039/c4ob02282c. Publication link: 40b65ced-f13e-48bc-8c23-0ea416427d64
  • Weise, N., Parmeggiani, F., Ahmed, S., & Turner, N. (2015). The Bacterial Ammonia Lyase EncP: A Tunable Biocatalyst for the Synthesis of Unnatural Amino Acids. Journal of the American Chemical Society, 137(40), 12977-12983. DOI: 10.1021/jacs.5b07326. Publication link: 88633ab9-bcf8-4e57-a74e-e7cc5c78d7b5
  • Man, H., Wells, E., Hussain, S., Leipold, F., Hart, S., Turkenburg, J. P., ... Grogan, G. (2015). Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline. Chembiochem, 16(7), 1052-1059. DOI: 10.1002/cbic.201402625. Publication link: 5f83a996-d387-477c-a7ed-09a0a44366be
  • Mutti, F. G., Knaus, T., Scrutton, N. S., Breuer, M., & Turner, N. (2015). Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.Science, (349), 1525-1529. DOI: 10.1126/science.aac9283. Publication link: 6ecbb7fb-12e0-401e-87fe-06994467b6b6
  • Turner, N., & Köhler, V. (2015). Artificial concurrent catalytic processes involving enzymes. Chemical Communications, 51(3), 450-464. DOI: 10.1039/c4cc07277d. Publication link: 6759d8d1-e01b-455a-8689-77fca4f792cf
  • de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., Van Lint, M. J., Janssen, E., ... Ruijter, E. (2015). Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction. Angewandte Chemie - International Edition, 54(47), 14133-14136. DOI: 10.1002/anie.201507041. Publication link: cd896b35-2d98-4842-85ce-e2a2f41ab82d
  • Toftgaard Pedersen, A., Birmingham, W., Rehn, G., Charnock, S. J., Turner, N., & Woodley, J. M. (2015). Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols. Organic Process Research and Development, 19(11), 1580-1589. DOI: 10.1021/acs.oprd.5b00278. Publication link: d7a24dfd-c7e6-487d-be4a-545d1b269cf9
  • Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C., & Turner, N. (2015). Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions. Beilstein Journal of Organic Chemistry, 11, 1713-1720. DOI: 10.3762/bjoc.11.186. Publication link: e883004e-71a8-42a1-925b-1187ace5dd4e
  • Faber, K., Fessner, W. D., & Turner, N. (2015). Engineering biocatalysts for synthesis including cascade processes. Advanced Synthesis and Catalysis, 357(8), 1565-1566. DOI: 10.1002/adsc.201500450. Publication link: bc197694-b59a-454e-9d5b-b714f6d67cef
  • McKenna, S., Leimkühler, S., Herter, S., Turner, N., & Carnell, A. J. (2015). Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem. Green Chemistry, 17(6), 3271-3275. DOI: 10.1039/c5gc00707k. Publication link: fc4288cd-bc1c-4482-823c-86ac7bdd0b7c


  • Schrittwieser, J., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., ... Kroutil, W. (2014). Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion. Angewandte Chemie - International Edition, 53(14), 3731-3734. DOI: 10.1002/anie.201400027. Publication link: bbccfac0-179e-4676-9d97-ad0783d4ebf4
  • Lovelock, S. L., Lloyd, R. C., & Turner, N. (2014). Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway. Angewandte Chemie - International Edition, 126(18), 4652-4656. DOI: 10.1002/anie.201311061. Publication link: e4252f44-2dfa-4853-821e-71ee9e8f8edc
  • Humphrey, C., Ahmed, M., Ghanem, A., & Turner, N. (2014). Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions. In M. Todd (Ed.), Separation Of Enantiomers : Synthetic Methods. (pp. 123-160). DOI: 10.1002/9783527650880.ch4. Publication link: d314b080-9c34-4ee4-960d-7ec57b1b6762
  • Staniland, S., Yuan, B., Giménez-Agulló, N., Marcelli, T., Willies, S. C., Grainger, D. M., ... Clayden, J. (2014). Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers. Chemistry: A European Journal, 20(41), 13084-13088. DOI: 10.1002/chem.201404509. Publication link: d74f164c-616e-4238-b962-76ea485b5d57
  • Turner, N., O'Reilly, E., & Iglesias, C. (2014). Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines. ChemCatChem, 6(4), 992-995. DOI: 10.1002/cctc.201300990. Publication link: d6ca6f96-773a-4869-b9ef-378ddf4dbe62
  • Green, A., Turner, N., & O'Reilly, E. (2014). Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor Which Displaces Equilibria and Enables High-Throughput Screening. Angewandte Chemie (International Edition), 53(40), 10714-10717. DOI: 10.1002/anie.201406571. Publication link: cf1bd4ef-5761-4a29-a1fc-b82cdee5971a
  • Heap, L., Green, A., Brown, D., van Dongen, B. E., & Turner, N. (2014). Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification. Catalysis Science and Technology, 4(8), 2251-2259. DOI: 10.1039/c4cy00046c. Publication link: ce4a666f-061f-4925-9550-fb791cbc1fe4
  • Heath, R., Pontini, M., Turner, N., & Bechi, B. (2014). Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity. ChemCatChem, 6(4), 996-1002. DOI: 10.1002/cctc.201301008. Publication link: 5a9b497e-4e53-416f-85ae-cc0a74ddc7de
  • Schrittwieser, J., Groenendaal, B., Willies, S. C., Ghislieri, D., Rowles, I., Resch, V., ... Kroutil, W. (2014). Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants. Catalysis Science and Technology, 4(10), 3657-3664. DOI: 10.1039/c4cy00642a. Publication link: 7ccda2b4-4e19-4695-92d9-339f0c69de88
  • O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C., & Turner, N. J. (2014). A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines. Angewandte Chemie - International Edition, 53(9), 2447-2450. DOI: 10.1002/anie.201309208. Publication link: 813d57d8-c5bc-40a9-8646-178337c14bbe
  • Turner, N. (2014). A Reduction of C N to CH-NH Using Enzymes and Microorganisms. In P. Knochel , & G. A. Molander (Eds.), Comprehensive Organic Synthesis: Second Edition. (second ed., Vol. 8, pp. 328-338). DOI: 10.1016/B978-0-08-097742-3.00810-7. Publication link: 87cd59a1-a535-46c4-a0ee-6c2ea6cae55e
  • Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J., & Carnell, A. J. (2014). Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis. Green Chemistry, 16, 4524-4529. [C4GC01321B]. DOI: 10.1039/C4GC01321B. Publication link: 9720ee56-69e7-4500-b83d-3a0df6c5ea6b
  • Turner, N., Whittall, J., & Ward, T. R. (2014). Foreword. Topics in Catalysis, 57(5), 283. DOI: 10.1007/s11244-013-0186-z. Publication link: 9e8b3d58-fc29-4031-ab38-1949befea61f
  • Scheller, P. N., Fademrecht, S., Hofelzer, S., Pleiss, J., Leipold, F., Turner, N., ... Hauer, B. (2014). Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases. Chembiochem, 15(15), 2201-2204. DOI: 10.1002/cbic.201402213. Publication link: 2e356a6d-f9d1-4fcd-ab59-85a054628cbe
  • Turner, N., & Lovelock, S. L. (2014). Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity. Bioorganic and Medicinal Chemistry, 22(20), 5555-5557. DOI: 10.1016/j.bmc.2014.06.035. Publication link: 14c0ce9a-5eb7-468a-9f03-e0e3f2ce432b
  • Zajkoska, P., Rosenberg, M., Heath, R., Malone, K., Stloukal, R., Turner, N., & Rebros, M. (2014). Immobilised whole-cell recombinant monoamine oxidase biocatalysis. Applied Microbiology and Biotechnology, 99(3), 1229-1236. DOI: 10.1007/s00253-014-5983-1. Publication link: 17f8ec51-ac38-4524-af7b-476834917138
  • Ghislieri, D., & Turner, N. (2014). Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines. Topics in Catalysis, 57(5), 284-300. DOI: 10.1007/s11244-013-0184-1. Publication link: 21b01459-1ead-4e46-b7f4-6d9d918275cb
  • Turner, N., & Wells, A. (2014). The enzyme spring: Biocatalysis at its best. ChemCatChem, 6(4), 900-901. DOI: 10.1002/cctc.201400104. Publication link: 00451c7b-33d5-4e9b-99ba-21fc581ea88a


  • Kalim Akhtara, M., Turner, N. J., & Jones, P. R. (2013). Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities. Proceedings of the National Academy of Sciences of the United States of America, 110(1), 87-92. DOI: 10.1073/pnas.1216516110. Publication link: 7907bb8c-af36-43bb-9ffb-92d1914e3b9f
  • Ghislieri, D., Green, A., Pontini, M., Willies, S. C., Rowles, I., Frank, A., ... Turner, N. J. (2013). Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products. Journal of the American Chemical Society, 135(29), 10863-9. DOI: 10.1021/ja4051235. Publication link: 61dcbd39-c15b-4ac8-af4b-4e357aa148b3 | PubMed:23808566
  • Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., ... Ward, T. R. (2013). Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes. Nature Chemistry, 5(2), 93-99. DOI: 10.1038/nchem.1498. Publication link: ad73417f-a872-4fea-bcf4-0195ed582c00
  • O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L., & Turner, N. J. (2013). Substrate promiscuity of cytochrome P450 RhF. Catalysis Science and Technology, 3(6), 1490-1492. DOI: 10.1039/c3cy00091e. Publication link: f1ac0a93-1a47-43a3-8ae2-d3727b4c3b25



  • Oneill, M., Hauer, B., Schneider, N., & Turner, N. J. (2011). Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids. Acs Catalysis, 1(9), 1014-1016. DOI: 10.1021/cs2002252. Publication link: b25721c3-8df3-4d06-9e5a-480d3d5ed753
  • Dunsmore, C. J., Malone, K. J., Bailey, K. R., Wear, M. A., Florance, H., Shirran, S., ... Turner, N. J. (2011). Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans. ChemBioChem: a European journal of chemical biology , 12(5), 802-810. DOI: 10.1002/cbic.201000413. Publication link: bca306a8-a5ed-49b8-913a-f30c04623236
  • O'Reilly, E., Köhler, V., Flitsch, S. L., & Turner, N. J. (2011). Cytochromes P450 as useful biocatalysts: Addressing the limitations. Chemical Communications, 47(9), 2490-2501. DOI: 10.1039/c0cc03165h. Publication link: 3eeb65bc-2c17-4c2b-9cee-49021b13453b | PubMed:21264369
  • Turner, N. J. (2011). Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids. Current Opinion in Chemical Biology, 15(2), 234-240. DOI: 10.1016/j.cbpa.2010.11.009. Publication link: 3fa8dcee-aa84-4d45-9423-1bd9d89b9a60
  • Hopwood, J., Truppo, M. D., Turner, N. J., & Lloyd, R. C. (2011). A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases. Chemical Communications, 47(2), 773-775. DOI: 10.1039/c0cc02919j. Publication link: 42fe62fb-483b-4807-aa77-c513addbc826
  • Turner, N. J. (2011). Enantioselective Oxidation of C-O and C-N bonds using oxidases. Chemical Reviews, 111(7), 4073-4087. DOI: 10.1021/cr200111v. Publication link: 485f192e-9322-4b1e-af5f-e3bc538f3e4e
  • Walker, R. G., Thomson, G., Malone, K., Nowicki, M. W., Brown, E., Blake, D. G., ... Mottram, J. C. (2011). High throughput screens yield small molecule inhibitors of leishmania CRK3:CYC6 cyclin-dependent kinase. PLoS Neglected Tropical Diseases, 5(4), [e1033]. DOI: 10.1371/journal.pntd.0001033. Publication link: 2b993ead-c7a1-494f-9414-f73cd535144d
  • Foulkes, J. M., Malone, K. J., Coker, V. S., Turner, N. J., & Lloyd, J. R. (2011). Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions. Acs Catalysis, 1(11), 1589-1594. DOI: 10.1021/cs200400t. Publication link: 37ae69f1-91e8-400c-9143-4f44775d94ee
  • Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., ... Flitsch, S. L. (2011). Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope. Beilstein Journal of Organic Chemistry, 7, 1494-1498. [7]. DOI: 10.3762/bjoc.7.173. Publication link: 681965df-6e4f-4836-ab2e-02b35f3ae536
  • Ioannou, A., Cini, E., Timofte, R. S., Flitsch, S. L., Turner, N. J., & Linclau, B. (2011). Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase. Chemical Communications, 47(40), 11228-11230. DOI: 10.1039/c1cc13956h. Publication link: 868dd3f1-e2f4-436a-a87d-8fae08769c4b
  • Fessner, W. D., Turner, N. J., & Wang, M. X. (2011). Biocatalysis - A gateway to industrial biotechnology. Advanced Synthesis & Catalysis, 353(13), 2189-2190. DOI: 10.1002/adsc.201100679. Publication link: 8d057681-cd06-41ff-a7fa-312597ac1c76
  • Rannes, J. B., Ioannou, A., Willies, S. C., Grogan, G., Behrens, C., Flitsch, S. L., & Turner, N. J. (2011). Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution. Journal of the American Chemical Society, 133(22), 8436-8439. DOI: 10.1021/ja2018477. Publication link: 9772336a-816f-460e-a7a4-a1672b1e1c99 | PubMed:21526835


  • Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., ... Walkinshaw, M. (2010). Selective chemical intervention in the proteome of caenorhabditis elegans. Journal of Proteome Research, 9(11), 6060-6070. DOI: 10.1021/pr100427c. Publication link: d2f2c810-da79-42c5-a4bb-0ecd49e4cc90
  • Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., ... Clayden, J. (2010). Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases. Angewandte Chemie - International Edition, 49(39), 7010-7013. DOI: 10.1002/anie.201002580. Publication link: 9642f1fb-d492-4374-8501-641734b4c354
  • Dunn, R. V., Munro, A. W., Turner, N. J., Rigby, S. E. J., & Scrutton, N. S. (2010). Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases. ChemBioChem: a European journal of chemical biology , 11(9), 1158-1231. DOI: 10.1002/cbic.201000184. Publication link: 9368fcda-ac50-41cb-9d6a-6299ba246466 | PubMed:20480485
  • Turner, N. J. (2010). Deracemisation methods. Current Opinion in Chemical Biology, 14(2), 115-121. DOI: 10.1016/j.cbpa.2009.11.027. Publication link: 9d7a6b5c-8c0e-4cb7-b5cb-29015664a186


  • Robin, A., Roberts, G. A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., ... Flitsch, S. L. (2009). Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme. Chemical Communications, (18), 2478-2480. DOI: 10.1039/b901716j. Publication link: 923a6a43-9395-4772-97a7-bd7f42bdf9c5


  • Truppo, M. D., Escalettes, F., & Turner, N. J. (2008). Rapid determination of both the activity and enantioselectivity of ketoreductases. Angewandte Chemie - International Edition, 47(14), 2639-2641. DOI: 10.1002/anie.200705046. Publication link: 7c82246d-ec68-4814-a09e-8560497b79e7
  • Atkin, K. E., Reiss, R., Turner, N. J., Brzozowski, A. M., & Grogan, G. (2008). Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64(3), 182-185. DOI: 10.1107/S174430910800345X. Publication link: 6d59ebb3-f51b-4c7e-b146-17933f030d2a
  • Escalettes, F., & Turner, N. J. (2008). Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases. ChemBioChem: a European journal of chemical biology , 9(6), 857-860. DOI: 10.1002/cbic.200700689. Publication link: d8054573-3401-41f2-8934-8838321a054d
  • Nowicki, M. W., Tulloch, L. B., Worralll, L., McNae, I. W., Hannaert, V., Michels, P. A. M., ... Turner, N. J. (2008). Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorganic and Medicinal Chemistry, 16(9), 5050-5061. DOI: 10.1016/j.bmc.2008.03.045. Publication link: c5e7bff7-644a-434b-877a-8d9d0fec0a0d


  • Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J., & Turner, N. J. (2007). A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A. Chemical Communications, (35), 3640-3642. DOI: 10.1039/b710456a. Publication link: 2eda7e7b-209b-4935-a6b7-cdbbfb5eea5c



  • Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L., & Ulijn, R. V. (2003). Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy. Journal of the American Chemical Society, 125(46), 13952-13953. DOI: 10.1021/ja037922x. Publication link: dbb8779b-0502-4d50-8599-09fdb5adbceb
  • Carr, R., Alexeeva, M., Enright, A., Eve, T. S. C., Dawson, M. J., & Turner, N. J. (2003). Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity. Angewandte Chemie - International Edition, 42(39), 4807-4810. DOI: 10.1002/anie.200352100. Publication link: 8e30fccf-d923-419e-9007-d5d648695a2f