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Dr Stephen Fowler (MD FRCP) - publications

List of publications


  • Kane, B., Fowler, S. J., & Niven, R. (2015). Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.Chronic Respiratory Disease, 12(1). 10.1177/1479972314562210. Publication link: 997cf268-5030-47e2-bba1-a9dc16be2f55 | DOI:10.1177/1479972314562210 | PubMed:25492977
  • Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., ... Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.The European respiratory journal, 46(5). 10.1183/13993003.00780-2015. Publication link: c2dde770-a03b-4994-b5d2-41ab3e0f7d71 | DOI:10.1183/13993003.00780-2015 | PubMed:26405287
  • Spyridoulias, A., Lillie, S., Vyas, A., & Fowler, S. J. (2015). Detecting laryngopharyngeal reflux in patients with upper airways symptoms: Symptoms, signs or salivary pepsin?. Respiratory medicine, 109(8). 10.1016/j.rmed.2015.05.019. Publication link: aff83ba5-5db9-4dbd-bc6b-09dd744b6aa4 | DOI:10.1016/j.rmed.2015.05.019 | PubMed:26044812
  • Welsh, E. J., Evans, D. J., Fowler, S. J., & Spencer, S. (2015). Interventions for bronchiectasis: an overview of Cochrane systematic reviews.The Cochrane database of systematic reviews, 7. 10.1002/14651858.CD010337.pub2. Publication link: 3141d9d5-0a8c-4996-b51c-d3daeceec8a7 | DOI:10.1002/14651858.CD010337.pub2 | PubMed:26171905
  • Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., ... Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.The European respiratory journal, 46(5). 10.1183/13993003.00779-2015. Publication link: 351ce666-8ebe-483b-9dd4-8e2fd9ab75ab | DOI:10.1183/13993003.00779-2015 | PubMed:26357963
  • Fowler, S. J., Basanta-Sanchez, M., Xu, Y., Goodacre, R., & Dark, P. M. (2015). Surveillance for lower airway pathogens in mechanically ventilated patients by metabolomic analysis of exhaled breath: a case-control study.Thorax, 70(4). 10.1136/thoraxjnl-2014-206273. Publication link: 336bd187-f19e-4d9f-9915-0420c9471f85 | DOI:10.1136/thoraxjnl-2014-206273 | PubMed:25661115
  • Fowler, S. J., Thurston, A., Chesworth, B., Cheng, V., Constantinou, P., Vyas, A., ... Haines, J. (2015). The VCDQ--a Questionnaire for symptom monitoring in vocal cord dysfunction.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(9). 10.1111/cea.12550. Publication link: 595fe1cd-e087-408b-a214-55c40d00d2da | DOI:10.1111/cea.12550 | PubMed:25867098


  • Fowler, S., Rattray, N. J. W., Hamrang, Z., Trivedi, D. K., Goodacre, R., & Fowler, S. J. (2014). Taking your breath away: metabolomics breathes life in to personalized medicine. Trends in Biotechnology. 10.1016/j.tibtech.2014.08.003. Publication link: 63305f06-733c-4057-9a06-9cc0dca8fdce | DOI:10.1016/j.tibtech.2014.08.003
  • Fowler, S. (2014). High blood eosinophils predict sputum eosinophilia in severe asthma. Journal of Allergy and Clinical Immunology.. Publication link: a39d3fb0-a70c-4189-9dc6-303387dce119
  • Hart, A., Sugumar, K., Milan, S. J., Fowler, S. J., & Crossingham, I. (2014). Inhaled hyperosmolar agents for bronchiectasis.The Cochrane database of systematic reviews, 5. 10.1002/14651858.CD002996.pub3. Publication link: 9e870f20-824f-4fd7-99f1-1d2d0627b5da | DOI:10.1002/14651858.CD002996.pub3 | PubMed:24817558
  • Fowler, S. J., Xu, Y., Bayat, A., & Goodacre, R. (2014). Chemometrics models for overcoming high between subject variability: applications in clinical metabolic profiling studies. Metabolomics, 10, 375-385.. Publication link: 8f0e18aa-7924-4528-89ed-a9ab82794b8b


  • Wheelock, C. E., Goss, V. M., Balgoma, D., Nicholas, B., Brandsma, J., Skipp, P. J., ... Djukanović, R. (2013). Application of 'omics technologies to biomarker discovery in inflammatory lung diseases. European Respiratory Journal, 42(3), 802-825. 10.1183/09031936.00078812. Publication link: 65ff6242-c1b9-4401-b331-8164ab47817e | DOI:10.1183/09031936.00078812
  • Fowler, S. J., Ibrahim, B., Marsden, P., Morris, J., Smith, J., & Nilsson, M. (2013). Metabolomic Analysis of Exhaled Breath Condensate by NMR Spectroscopy Discriminates Inflammatory Phenotypes in Asthma. Allergy.. Publication link: df199120-8e94-46b6-b3c4-8320f2350e03


  • Basanta, M., Ibrahim, B., Dockry, R., Douce, D., Morris, M., Singh, D., ... Fowler, S. J. (2012). Exhaled volatile organic compounds for phenotyping chronic obstructive pulmonary disease: a cross-sectional study. Respiratory Research, 13, [72]. 10.1186/1465-9921-13-72. Publication link: c4d55d0d-2e04-4272-af41-578996a8e129 | DOI:10.1186/1465-9921-13-72 | PubMed:22916684
  • Fowler, S., Basanta, M., Ibrahim, B., Douce, D., Morris, M., Woodcock, A., & Fowler, S. J. (2012). Methodology validation, intra-subject reproducibility and stability of exhaled volatile organic compounds. Journal of Breath Research, 6(2), [026002]. 10.1088/1752-7155/6/2/026002. Publication link: c7da87d7-aa3d-46a6-ada2-91d210fde500 | DOI:10.1088/1752-7155/6/2/026002



  • Fowler, S., Basanta, M., Jarvis, R. M., Xu, Y., Blackburn, G., Tal-Singer, R., ... Fowler, S. J. (2010). Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst, 135(2), 315-320. 10.1039/b916374c. Publication link: 7f9a2007-9967-4f26-ad00-bb0aaca2034f | DOI:10.1039/b916374c | PubMed:20098764


  • Custovic, A., Fowler, S. J., Langley, S. J., Truman, N. J., Woodcock, A., Simpson, A., ... Truman, N. J. (2009). Long term effects of allergen sensitisation and exposure in adult asthma: A prospective study.World Allergy Organization Journal, 2(5), 83-90. 10.1097/WOX.0b013e3181a45f96. Publication link: 0646b24a-ea07-491c-a1b6-824e174147da | DOI:10.1097/WOX.0b013e3181a45f96 | PubMed:23283015


  • Fowler, S., Firth, J. (Ed.), & Roberts, P. (Ed.) (2008). Medical Masterclass: Module 7: Cardiology and Respiratory Medicine. (2 ed.) Royal College of Physicians of London.. Publication link: 0783e6c9-e209-4c01-979b-0db130157d40
  • Fowler, S., Firth, J. (Ed.), & Roberts, P. (Ed.) (2008). Multiple Chapters. In Medical Masterclass: Module 7: Cardiology and Respiratory Medicine. (2 ed.). Royal College of Physicians of London.. Publication link: 044d463d-624e-471b-bb56-7e82f33d32fd
  • Fowler, S., & Firth, J. (Ed.) (2008). Respiratory System. In Medical Masterclass: Module 1: Scientific Background to Medicine 1. (2 ed.). Royal College of Physicians of London.. Publication link: 568144f5-2584-4b1e-9115-99d8444602c0


  • Basanta, M., Singh, D., Fowler, S., Wilson, I., Dennis, R., & Thomas, C. L. P. (2007). Increasing analytical space in gas chromatography-differential mobility spectrometry with dispersion field amplitude programming. Journal of Chromatography A, 1173(1-2), 129-138. 10.1016/j.chroma.2007.09.082. Publication link: 75e4a33a-4b99-4357-95ad-2f38e8c36aa8 | DOI:10.1016/j.chroma.2007.09.082


  • Fowler, S., Fowler, S. J., French, J., Screaton, N. J., Foweraker, J., Condliffe, A., ... Bilton, D. (2006). Nontuberculous mycobacteria in bronchiectasis: Prevalence and patient characteristics. European Respiratory Journal, 28(6), 1204-1210. 10.1183/09031936.06.00149805. Publication link: a588f811-dff9-45a7-adc4-36979d4894bf | DOI:10.1183/09031936.06.00149805


  • Currie, G. P., Lee, D. K. C., Dempsey, O. J., Fowler, S. J., Cowan, L. M., & Lipworth, B. J. (2003). A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics. British Journal of Clinical Pharmacology, 55(6), 609-615. 10.1046/j.1365-2125.2003.01813.x. Publication link: 07ae4e68-6d0d-43bb-b8a2-4c623cc0c525 | DOI:10.1046/j.1365-2125.2003.01813.x
  • Fowler, S. J., & Lipworth, B. J. (2003). Relationship of skin-prick reactivity to aeroallergens and hyperresponsiveness to challenges with methacholine and adenosine monophosphate. Allergy: European Journal of Allergy and Clinical Immunology, 58(1), 46-52. 10.1034/j.1398-9995.2003.23779.x. Publication link: 4ec2ad71-baaf-4e97-adeb-d2d5f8861c5e | DOI:10.1034/j.1398-9995.2003.23779.x
  • Orr, L. C., Fowler, S. J., & Lipworth, B. J. (2003). Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma. American Journal of Respiratory Medicine, 2(5), 433-438.. Publication link: 990714c3-bdee-4c89-97b1-afbb68a95896
  • Currie, G. P., Fowler, S. J., & Lipworth, B. J. (2003). Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: A meta-analysis. Annals of Allergy, Asthma and Immunology, 90(2), 194-198.. Publication link: df06c25a-d63f-4e39-b455-0342bffa5af4
  • Currie, G. P., Haggart, K., Lee, D. K. C., Fowler, S. J., Wilson, A. M., Brannan, J. D., ... Lipworth, B. J. (2003). Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. Clinical and Experimental Allergy, 33(6), 783-788. 10.1046/j.1365-2222.2003.01688.x. Publication link: b813fcf1-1f89-423d-afa9-6d2acf0b802c | DOI:10.1046/j.1365-2222.2003.01688.x


  • Currie, G. P., Fowler, S. J., Wilson, A. M., Sims, E. J., Orr, L. C., & Lipworth, B. J. (2002). Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma. Thorax, 57(10), 865-868. 10.1136/thorax.57.10.865. Publication link: 81e0b45e-193c-474d-8665-1da398434b28 | DOI:10.1136/thorax.57.10.865
  • Fowler, S. J., Hall, I. P., Wilson, A. M., Wheatley, A. P., & Lipworth, B. J. (2002). 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. European Journal of Clinical Pharmacology, 58(3), 187-190. 10.1007/s00228-002-0458-1. Publication link: 98dc9c93-426f-4974-a47d-2c11174e91a8 | DOI:10.1007/s00228-002-0458-1
  • Fowler, S. J., Currie, G. P., & Lipworth, B. J. (2002). Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone. Journal of Allergy and Clinical Immunology, 109(6), 929-935. 10.1067/mai.2002.123869. Publication link: 311528a9-539c-47c3-846a-f5877331221d | DOI:10.1067/mai.2002.123869
  • Fowler, S. J., Orr, L. C., Sims, E. J., Wilson, A. M., Currie, G. P., McFarlane, L., & Lipworth, B. J. (2002). Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate. Chest, 122(2), 618-623. 10.1378/chest.122.2.618. Publication link: abb2aa83-7fec-49e4-9c3a-10bbdf870374 | DOI:10.1378/chest.122.2.618
  • Dempsey, O. J., Fowler, S. J., Wilson, A., Kennedy, G., & Lipworth, B. J. (2002). Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma. Chest, 122(1), 151-159. 10.1378/chest.122.1.151. Publication link: e5451bf7-2054-46b0-9cea-20e961430cbf | DOI:10.1378/chest.122.1.151


  • Fowler, S. J., Wilson, A. M., Griffiths, E. A., & Lipworth, B. J. (2001). Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube. Chest, 119(4), 1018-1020. 10.1378/chest.119.4.1018. Publication link: 317b6fa6-87e8-4f18-9fc0-c0cc24b3bbad | DOI:10.1378/chest.119.4.1018
  • Fowler, S. J., Orr, L. C., Wilson, A. M., Sims, E. J., & Lipworth, B. J. (2001). Dose-response for adrenal suppression with hydrofluoroalkane formulations of fluticasone propionate and beclomethasone dipropionate. British Journal of Clinical Pharmacology, 52(1), 93-95. 10.1046/j.0306-5251.2001.BJCP.1399.x. Publication link: 46963717-4803-415e-bc20-3a62c0c912e8 | DOI:10.1046/j.0306-5251.2001.BJCP.1399.x
  • Fowler, S. J., & Lipworth, B. (2001). Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol.Br J Clin Pharmacol, 51( 4).. Publication link: 88b47713-adbf-4905-9e4c-5246aeb6d01b
  • Fowler, S. J., & Lipworth, B. (2001). Salmeterol and inhaled corticosteroids in patients with persistent asthma.JAMA, 286( 24).. Publication link: 4e6bf7fb-6f1b-497a-8f03-3c49065c212c
  • Wilson, A. M., Fowler, S. J., Martin, S. W., White, P. S., Gardiner, Q., & Lipworth, B. J. (2001). Evaluation of the importance of head and probe stabilisation in acoustic rhinometry. Rhinology, 39(2), 93-97.. Publication link: 7c42bf20-7c03-44db-abdc-2d048c8d0696


  • Fowler, S. J., Dempsey, O., Sims, E., & Lipworth, B. (2000). Screening for bronchial hyperresponsiveness using methacholine and adenosine monophosphate. Relationship to asthma severity and beta(2)-receptor genotype.Am J Respir Crit Care Med, 162( 4 Pt 1).. Publication link: 192bc441-cfa7-4b1a-8001-4ae3b2d47bd1