Dr Stephen Fowler (MD) - research
Asthma phenotyping: We are investigating the factors that are important in determining asthma severity and progression by collecting comprehensive longitudinal data in severe asthma. Asthma phenotypes identified in this way will then be further defined in terms of both novel and established biomarkers, genetic-association studies, and treatment response. This approach will inform future standards for asthma diagnosis, and may lead to the development of targeted therapeutic strategies in specific subgroups.
Breath metabolomics: Characterisation of the metabolomic profile of volatile organic compounds in the exhaled breath of patients with respiratory disease may provide us with novel mechanistic insights, as well as biomarkers potentially suitable for future use in diagnosis and monitoring. We have:
- designed novel breath collections systems (IP in University of Manchester), for use in diagnostics and monitoring of patients with respiratory disease, and also in early detection and characterisation of infection in ventilated patients in ICU.
- developed methods for sample analysis by GC-MS, and subsequent complex data analysis (collaboration with Goodacre group)