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Professor Tony Whetton - publications

List of publications


  • Aspinall-O'Dea, M., Pierce, A., Pellicano, F., Williamson, A., Scott, M., Walker, M., Holyoake, T. & Whetton, A (2015). Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. Nat Protoc, 10(1), 149-68. eScholarID:253528 | PMID:25521791 | DOI:10.1038/nprot.2015.007


  • Brown, S., Hutchinson, C., Aspinall-O'Dea, M., Whetton, A., Johnson, S., Rees-Unwin, K. & Burthem, J (2014). Monocyte-derived dendritic cells from chronic myeloid leukaemia have abnormal maturation and cytoskeletal function that is associated with defective localisation and signalling by normal ABL1 protein. Eur J Haematol, 93(2), 96-102. eScholarID:253534 | PMID:24617663 | DOI:10.1111/ejh.12306
  • Gallipoli, P., Cook, A., Rhodes, S., Hopcroft, L., Wheadon, H., Whetton, A., Jørgensen, H., Bhatia, R. & Holyoake, T (2014). JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood, 124(9), 1492-501. eScholarID:253532 | PMID:24957147 | DOI:10.1182/blood-2013-12-545640
  • Jangani, M., Poolman, T., Matthews, L., Yang, N., Farrow, S., Berry, A., Hanley, N., Williamson, A., Whetton, A., Donn, R. & Ray, D (2014). The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and is Regulated in Lung Inflammation and Cancer. J Biol Chem, eScholarID:219361 | PMID:24488492 | DOI:10.1074/jbc.M113.540906
  • Pellicano, F., Scott, M., Helgason, G., Hopcroft, L., Allan, E., Aspinall-O'Dea, M., Copland, M., Pierce, A., Huntly, B., Whetton, A. & Holyoake, T (2014). The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells, 32(9), 2324-37. eScholarID:253536 | PMID:24806995 | DOI:10.1002/stem.1748
  • Schaller-Schönitz, M., Barzan, D., Williamson, A., Griffiths, J., Dallmann, I., Battmer, K., Ganser, A., Whetton, A., Scherr, M. & Eder, M (2014). BCR-ABL affects STAT5A and STAT5B differentially. PLoS One, 9(5), e97243. eScholarID:253531 | PMID:24836440 | DOI:10.1371/journal.pone.0097243
  • Tran, D., Saran, S., Williamson, A., Pierce, A., Dittrich-Breiholz, O., Wiehlmann, L., Koch, A., Whetton, A. & Tamura, T (2014). THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100). Nucleic Acids Res, 42(19), 12249-60. eScholarID:253535 | PMID:25274738 | DOI:10.1093/nar/gku911
  • Wood, S., Pernemalm, M., Crosbie, P. & Whetton, A (2014). The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev, 40(4), 558-66. eScholarID:253533 | PMID:24176790 | DOI:10.1016/j.ctrv.2013.10.001
  • Zhou, C., Walker, M., Williamson, A., Pierce, A., Berzuini, C., Dive, C. & Whetton, A (2014). A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data. Bioinformatics, eScholarID:219324 | PMID:24344193 | DOI:10.1093/bioinformatics/btt722


  • F.Griaud, A.Pierce, M.B.Gonzalez Sanchez, M.Scott, S.A.Abraham, T.L.Holyoake, D.D.H.Tran, T.Tamura, A.D.Whetton. (2013). A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia, 27, 932-940. eScholarID:172990 | DOI:10.1038/leu.2012.283
  • Balabanov, S., Evans, C., Abraham, S., Pellicano, F., Copland, M., Walker, M., Whetton, A. & Holyoake, T (2013). Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients. Proteomics, 13(1), 153-68. eScholarID:219357 | PMID:23184491 | DOI:10.1002/pmic.201200022
  • Blankley, R., Fisher, C., Westwood, M., North, R., Baker, P., Walker, M., Williamson, A., Whetton, A., Lin, W., McCowan, L., Roberts, C., Cooper, G., Unwin, R. & Myers, J (2013). A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia. Mol Cell Proteomics, 12(11), 3148-59. eScholarID:219327 | PMID:23897580 | DOI:10.1074/mcp.M112.026872
  • Evans, C., Griffiths, J., Unwin, R., Whetton, A. & Corfe, B (2013). Application of the MIDAS approach for analysis of lysine acetylation sites. Methods Mol Biol, 981, 25-36. eScholarID:219333 | PMID:23381851 | DOI:10.1007/978-1-62703-305-3_3
  • Pierce, A., Whetton, A., Meyer, S., Ravandi-Kashani, F., Borthakur, G., Coombes, K., Zhang, N. & Kornblau, S (2013). Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility. Proteomics, 13(14), 2216-24. eScholarID:219372 | PMID:23576428 | DOI:10.1002/pmic.201200471
  • Simpson, K., Cawthorne, C., Zhou, C., Hodgkinson, C., Walker, M., Trapani, F., Kadirvel, M., Brown, G., Dawson, M., MacFarlane, M., Williams, K., Whetton, A. & Dive, C (2013). A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis, 4, e613. eScholarID:219325 | PMID:23640455 | DOI:10.1038/cddis.2013.137
  • Takeda, T., Robinson, I., Savoian, M., Griffiths, J., Whetton, A., McMahon, H. & Glover, D (2013). Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis. Open Biol, 3(8), 130081. eScholarID:219340 | PMID:23926047 | DOI:10.1098/rsob.130081
  • Tran, D., Saran, S., Dittrich-Breiholz, O., Williamson, A., Klebba-Färber, S., Koch, A., Kracht, M., Whetton, A. & Tamura, T (2013). Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis, 4, e879. eScholarID:219371 | PMID:24157873 | DOI:10.1038/cddis.2013.409
  • White, D., Unwin, R., Bindels, E., Pierce, A., Teng, H., Muter, J., Greystoke, B., Somerville, T., Griffiths, J., Lovell, S., Somervaille, T., Delwel, R., Whetton, A. & Meyer, S (2013). Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability. PLoS One, 8(6), e66510. eScholarID:219348 | PMID:23776681 | DOI:10.1371/journal.pone.0066510
  • Williamson, A., Pierce, A., Jaworska, E., Zhou, C., Aspinall-O'Dea, M., Lancashire, L., Unwin, R., Abraham, S., Walker, M., Cadecco, S., Spooncer, E., Holyoake, T. & Whetton, A (2013). A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility. Mol Cell Proteomics, 12(11), 3319-29. eScholarID:219331 | PMID:23997015 | DOI:10.1074/mcp.M112.024604
  • Wood, S., Pernemalm, M., Crosbie, P. & Whetton, A (2013). The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev, eScholarID:219364 | PMID:24176790 | DOI:10.1016/j.ctrv.2013.10.001


  • Dung-Fang Lee, Jie Su, Yen-Sin Ang, Xonia Carvajal-Vergara, Sonia Mulero-Navarro, Carlos F. Pereira, Julian Gingold, Hung-Liang Wang, Ruiying Zhao, Ana Sevilla, Henia Darr, Andrew J.K. Williamson, Betty Chang, Xiaohong Niu, Francesca Aguilo, Elsa R. Flores, Yuh-Pyng Sher, Mien-Chie Hung, Anthony D. Whetton, Bruce D. Gelb, Kateri A. Moore, Hans-Willem Snoeck, Avi Ma’ayan, Christoph Schaniel, Ihor R. Lemischka. (2012). Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell, 11(2), 179-194. eScholarID:171558 | DOI:10.1016/j.stem.2012.05.020
  • Griaud, F., Williamson, A., Taylor, S., Potier, D., Spooncer, E., Pierce, A. & Whetton, A (2012). BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response. J Proteomics, 77, 14-26. eScholarID:219337 | PMID:22705319 | DOI:10.1016/j.jprot.2012.06.003
  • Pierce, A., Williamson, A., Jaworska, E., Griffiths, J., Taylor, S., Walker, M., O'Dea, M., Spooncer, E., Unwin, R., Poolman, T., Ray, D. & Whetton, A (2012). Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation. PLoS One, 7(6), e38928. eScholarID:219344 | PMID:22745689 | DOI:10.1371/journal.pone.0038928
  • Potier, D., Griffiths, J., Unwin, R., Walker, M., Carrick, E., Willamson, A. & Whetton, A (2012). An assessment of peptide enrichment methods employing mTRAQ quantification approaches. Anal Chem, 84(13), 5604-10. eScholarID:219334 | PMID:22762262 | DOI:10.1021/ac300584y
  • Smetsers, S., Muter, J., Bristow, C., Patel, L., Chandler, K., Bonney, D., Wynn, R., Whetton, A., Will, A., Rockx, D., Joenje, H., Strathdee, G., Shanks, J., Klopocki, E., Gille, J., Dorsman, J. & Meyer, S (2012). Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma. Fam Cancer, 11(4), 661-5. eScholarID:219345 | PMID:22829014 | DOI:10.1007/s10689-012-9553-3
  • Vaughan, A., Dunn, W., Allwood, J., Wedge, D., Blackhall, F., Whetton, A., Dive, C. & Goodacre, R (2012). Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion. Anal Chem, 84(22), 9848-57. eScholarID:219343 | PMID:23072438 | DOI:10.1021/ac302227c
  • Zhou, C., Simpson, K., Lancashire, L., Walker, M., Dawson, M., Unwin, R., Rembielak, A., Price, P., West, C., Dive, C. & Whetton, A (2012). Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery. J Proteome Res, 11(4), 2103-13. eScholarID:219362 | PMID:22338609 | DOI:10.1021/pr200636x


  • 5. Meyer S, Bristow C, Wappett M, Pepper S, Whetton AD, Hanenberg H, Neitzel H, Wlodarski MW, Ebell W, Tönnies H. (2011). Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood, 117(22), 6047-6050. eScholarID:144123 | DOI:10.1182/blood-2011-03-343897
  • 6. Bonadies N, Foster SD, Chan WI, Kvinlaug BT, Spensberger D, Dawson MA, Spooncer E, Whetton AD, Bannister AJ, Huntly BJ, Göttgens B. (2011). Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One, 6(1), eScholarID:144128
  • 4. Wedge DC, Allwood JW, Dunn WB, Vaughan AA, Simpson K, Brown M, Priest L, Blackhall FH, Whetton AD, Dive C, Goodacre R. (2011). Is serum or plasma more appropriate for inter-subject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal Chem, 83(17), 6689-6697. eScholarID:144117 | DOI:10.1021/ac2012224
  • 1. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. (2011). RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood, 118, 638-649. eScholarID:144112 | DOI:10.1182/blood-2010-09-307330
  • Williamson AJ, Whetton AD. (2011). The requirement for proteomics to unravel stem cell regulatory mechanisms. J Cell Physiol, 226(10), 2478-2483. eScholarID:144116 | DOI:10.1002/jcp.22610


  • Blankley RT, Robinson NJ, Aplin JD, Crocker IP, Gaskell SJ, Whetton AD, Baker PN, Myers JE. (2010). A Gel-Free Quantitative Proteomics Analysis of Factors Released From Hypoxic-Conditioned Placentae. Reproductive Sciences, 17(3), eScholarID:81800
  • Lee CF, Griffiths S, Rodríguez-Suárez E, Pierce A, Unwin RD, Jaworska E, Evans CA, J Gaskell S, Whetton AD. (2010). Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches. Proteomics, 10(18), 3321-3342. eScholarID:96769 | DOI:10.1002/pmic.201000176
  • Williamson, A and Whetton AD. (2010). Development of approaches for systematic analysis of protein networks in stem cells. Advances in Enzyme Regulation, 50(1), 273-284. eScholarID:144165 | DOI:10.1016/j.advenzreg.2009.10.028
  • Dobbin E, Graham C, Freeburn RW, Unwin RD, Griffiths JR, Pierce A, Whetton AD, Wheadon H. (2010). Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), 226-243. eScholarID:96768 | DOI:10.1016/j.scr.2010.08.001
  • Unwin RD, Griffiths JR, Whetton AD. (2010). Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D-nanoLC-MS/MS. Nature Protocols, 5(9), 1574-1582. eScholarID:144161 | DOI:10.1038/nprot.2010.123
  • Mancini, A., Niemann-Seyde, S., Pankow, R., El Bounkari, O., Klebba-Färber, S., Koch, A., Jaworska, E., Spooncer, E., Gruber, A., Whetton, A. & Tamura, T (2010). THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol, 8, 1. eScholarID:81516 | PMID:20051105 | DOI:10.1186/1741-7007-8-1
  • Rees-Unwin, K., Faragher, R., Unwin, R., Adams, J., Brown, P., Buckle, A., Pettitt, A., Hutchinson, C., Johnson, S., Pulford, K., Banham, A., Whetton, A., Lucas, G., Mason, D. & Burthem, J (2010). Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia. Br J Haematol, 148(4), 534-43. eScholarID:81515 | PMID:19961478 | DOI:10.1111/j.1365-2141.2009.07979.x


  • Unwin RD, Griffiths J, Whetton A. (2009). A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc, 4( 6), eScholarID:1d19638 | DOI:10.1038/nprot.2009.57
  • Leverentz MK, Campbell RN, Connolly Y, Whetton A, Reece RJ. (2009). Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner. J Biol Chem, eScholarID:1d20883 | DOI:10.1074/jbc.M109.030361
  • El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths J, Whetton A, Koch A, Tamura T. (2009). Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). FEBS Lett, 583( 1), eScholarID:1d19641 | DOI:10.1016/j.febslet.2008.11.024
  • Woodcock S, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton A, Gorgoulis V, Malliri A. (2009). Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1. Molecular Cell, 33(5), 639-663. eScholarID:1d19640 | DOI:10.1016/j.molcel.2009.02.012
  • Lu, R, Markowetz, F, Unwin, RD, Leek, JT, Airoldi, EM, MacArthur, BD, Lachmann, A, Rovov, R, Ma’yan, A, Boyer, LA, Troyanskaya, OG, Whetton, AD, Lemischka, IR. (2009). Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature, 462(7271), 358-362. eScholarID:134764 | DOI:10.1038/nature08575
  • Carney L, Pierce A, Rijnen M, Gonzalez Sanchez M, Hamzah H, Zhang L, Tamura T, Whetton A. (2009). THOC5 couples M-CSF receptor signaling to transcription factor expression. Cell Signal, 21( 2), eScholarID:1d19643 | DOI:10.1016/j.cellsig.2008.10.018


  • Spooncer, E, Brouard, N, Nilsson, S, Williams, B, Liu, M, Unwin, R, Unwin, RD, Blinco, D, Jaworska, E, Simmons, P, Whetton, A. (2008). Developmental Fate Determination and Marker Discovery in Hematopoietic Stem Cell Biology Using Proteomic Fingerprinting. MCP, 7(3), 573-581. eScholarID:1d16931 | DOI:10.1074/mcp.M700292-MCP200
  • Pierce, A, Unwin, RD, Evans, C, Griffiths, S, Carney, L, Zhang, L, Jaworska, E, Lee, C, Blinco, D, Okoniewski, M, Miller, C, Bitton, D, Spooncer, E, Whetton, A. (2008). Eight-channel iTRAQ Enables Comparison of the Activity of Six Leukemogenic Tyrosine Kinases. MCP, 7(5), 853-863. eScholarID:1d16932 | DOI:10.1074/mcp.M700251-MCP200
  • Krijgsveld J, Whetton A, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). Proteome Biology of Stem Cells: A New Joint HUPO and ISSCR Initiative. Mol Cell Proteomics, 7( 1), eScholarID:1d31843
  • Leech S, Evans C, Shaw L, Wong C, Connolly J, Griffiths J, Whetton A, Corfe B. (2008). Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated - implications for colorectal epithelial homeostasis. Proteomics, 8( 2), eScholarID:1d31807
  • Williamson, A, Smith, D, Blinco, D, Unwin, RD, Pearson, S, Wilson, C, Miller, C, Lancashire, L, Lacaud, G, Kouskoff, V, Whetton, A, Whetton, A. (2008). Quantitative proteomic analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics, 7, 459-72. eScholarID:1d16956 | DOI:10.1074/mcp.M700370-MCP200
  • Pierce, A, Carney, L, Hamza, H, Griffiths, J, Zhang, L, Whetton, B, Gonzalez Sanchez, M, Tamura, T, Sternberg, D, Whetton, A. (2008). THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. Br J Haematol, 141( 5), eScholarID:1d19645 | DOI:10.1111/j.1365-2141.2008.07090.x
  • Whetton A, Williamson A, Krijgsveld J, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). The time is right: proteome biology of stem cells. Cell Stem Cell, 2( 3), eScholarID:1d19644


  • Meyer, S, Fergusson, W, Whetton, A, Moreira-Leite F, Pepper SD, Miller, CCJ, Saunders EK, White, DDJ, Will AM, Eden, OB, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. (2007). Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosome Cancer, 46 (4), 359-372. eScholarID:1d27524 | DOI:10.1002/gcc.20417
  • Mancini, A, El Bounkari, O, Norrenbrock, A, Scherr, M, Schaefer, D, Eder, M, Banham, A, Pulford, K, Lyne, L, Whetton, A, Tamura, T. (2007). FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha. Oncogene, 26( 7), eScholarID:1d20884 | DOI:10.1038/sj.onc.1209853
  • Unwin RD, Whetton A. (2007). How will haematologists use proteomics? Blood Rev, 21( 6), eScholarID:1d16957
  • Griffiths J, Unwin RD, Evans C, Leech S, Corfe B, Whetton A. (2007). The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues. J Am Soc Mass Spectrom, 18( 8), eScholarID:1d16959
  • Burthem J, Rees-Unwin KKS, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton A, Whetton AD. (2007). The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells. Leukemia, eScholarID:1d31663
  • Griffiths S, Burthem J, Unwin RD, Holyoake T, Melo J, Lucas G, Whetton A. (2007). The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia. Mol Biotechnol, 36( 2), eScholarID:1d16961
  • Welman, A., Griffiths, J., Whetton, A. & Dive, C (2007). Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. Protein Sci, 16(12), 2711-5. eScholarID:219375 | PMID:17965192 | DOI:10.1110/ps.072874607


  • McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton A, Irvine A. (2006). A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood, 108( 5), eScholarID:1d20886 | DOI:10.1182/blood-2006-04-016113
  • Pierce A, Lu Y, Hamzah H, Thompson S, Owen-Lynch P, Whetton A, Spooncer E. (2006). Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation. Br J Haematol, 133( 3), 345-52. eScholarID:1d31038
  • Warwood S, Mohammed S, Cristea I, Evans C, Whetton A, Gaskell S. (2006). Guanidination chemistry for qualitative and quantitative proteomics. Rapid Commun Mass Spectrom, 20( 21), 3245-56. eScholarID:1d31078
  • Unwin, RD, Smith, D, Blinco, D, Wilson, C, Miller, C, Evans, C, Jaworska, E, Baldwin, S, Barnes, K, Pierce, A, Spooncer, E, Whetton, A. (2006). Quantitative proteomics reveals post-translational control as a regulatory factor in primary hematopoietic stem cells. Blood, eScholarID:1d12944 | DOI:10.1182/blood-2005-12-4995
  • Unwin RD, Evans CL, Whetton A. (2006). Relative quantification in proteomics: new approaches for biochemistry. Trends in Biochemical Sciences, 31, 473-84. eScholarID:1d13562 | DOI:10.1016/j.tibs.2006.06.003
  • Underhill-Day N, Pierce A, Thompson S, Xenaki D, Whetton A, Owen-Lynch P. (2006). Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance. Br J Haematol, 132( 6), 774-83. eScholarID:1d30366
  • Unwin RD, Whetton A. (2006). Systematic proteome and transcriptome analysis of stem cell populations. Cell Cycle, 5( 15), 1587-91. eScholarID:1d14854
  • Bashamboo A, Taylor A, Samuel K, Panthier J, Whetton A, Forrester L. (2006). The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. J Cell Sci, 119( Pt 15), eScholarID:1d20885 | DOI:10.1242/jcs.03038


  • Chen C, Lorimore SA, Evans CA, Whetton A, Wright EG. (2005). A proteomic analysis of murine bone marrow and its response to ionizing radiation. Proteomics, eScholarID:1d30722
  • Chen C, Boylan M, Evans C, Whetton A, Wright E. (2005). Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to ionizing radiation. J Proteome Res, 4( 4), 1371-80. eScholarID:1d29850
  • Barnes K, McIntosh E, Whetton A, Daley G, Bentley J, Baldwin S. (2005). Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene, 24( 20), 3257-67. eScholarID:1d28909
  • Hamzah H, Pierce A, Stewart W, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton A. (2005). Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P(3)) and lack a PtdIns(3,4,5)P(3) response to cytokines and chemotactic factors; effects reversed by imatinib. Leukemia, 19( 10), 1851-3. eScholarID:1d30714
  • Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton A. (2005). Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: Identification of the Rho pathway as a target of BCR/ABL. J Biol Chem, 280(8), 6316-6326. eScholarID:1d9392 | DOI:10.1074/jbc.M410598200
  • Unwin RD, Griffiths J, Leverentz M, Grallert A, Hagan IM, Whetton A. (2005). Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics, 4( 8), 1134-44. eScholarID:1d11460
  • Unwin RD, Pierce A, Watson R, Sternberg D, Whetton A. (2005). Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics, 4( 7), 924-35. eScholarID:1d11633


  • Xenaki D, Pierce A, Underhill-Day N, Whetton A, Owen-Lynch P. (2004). Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII. Cell Signal, 16( 2), 145-56. eScholarID:1d29037
  • Evans, C, Tonge, R, Blinco, D, Pierce, A, Shaw, J, Lu, Y, Hamzah, H, Gray, A, Downes, C, Gaskell, S, Spooncer, E, Whetton, A. (2004). Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood, 103( 10), 3751-9. eScholarID:1d28781 | DOI:10.1182/blood-2003-09-3294
  • Garwood, K, McLaughlin, T, Garwood, C, Joens, S, Morrison, N, Taylor, C, Carroll, K, Evans, C, Whetton, A, Hart, S, Stead, D, Yin, Z, Brown, A, Hesketh, A, Chater, K, Hansson, L, Mewissen, M, Ghazal, P, Howard, J, Lilley, K, Gaskell, S, Brass, A, Hubbard, S, Oliver, S, Paton, N. (2004). PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics, 5( 1), eScholarID:1d29405
  • Cristea I, Gaskell S, Whetton A. (2004). Proteomics techniques and their application to hematology. Blood, 103( 10), 3624-34. eScholarID:1d29499
  • Whetton A. (2004). Stem cells bank on ATM machine. Nat Med, 10( 11), 1166-8. eScholarID:1d29036
  • Mancini A, Koch A, Whetton A, Tamura T. (2004). The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene, 23( 39), 6581-9. eScholarID:1d28780


  • Lee C, Evans C, Spooncer E, Pierce A, Mottram R, Whetton A. (2003). Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate. Br J Haematol, 122( 6), 985-95. eScholarID:1d28728
  • Bentley, J, Itchayanan, D, Barnes, K, McIntosh, E, Tang, X, Downes, C, Holman, G, Whetton, A, Owen-Lynch, P, Baldwin, S. (2003). Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem, 278( 41), 39337-48. eScholarID:1d29329 | DOI:10.1074/jbc.M305689200
  • Whetton A, Lu Y, Pierce A, Carney L, Spooncer E. (2003). Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood, 102( 8), 2798-802. eScholarID:1d9394 | DOI:10.1182/blood-2002-12-3635
  • Smith D, Burthem J, Whetton A. (2003). Molecular pathogenesis of chronic myeloid leukaemia. Expert Rev Mol Med, 2003, eScholarID:1d29406
  • Cochran DA, Evans CA, Blinco D, Burthem J, Burthem J, Stevenson FK, Gaskell SJ, Whetton A. (2003). Proteomic Analysis of Chronic Lymphocytic Leukemia Subtypes with Mutated or Unmutated Ig VH Genes. Mol Cell Proteomics, 2( 12), 1331-1341. eScholarID:1d29153
  • Unwin RD, Gaskell S, Evans C, Whetton A. (2003). The potential for proteomic definition of stem cell populations. Exp Hematol, 31( 12), 1147-59. eScholarID:1d9393


  • Pierce A, Spooncer E, Ainsworth S, Whetton A. (2002). BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor. Oncogene, 21( 19), eScholarID:1d29160
  • Smith D, Evans C, Pierce A, Gaskell S, Whetton A. (2002). Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation. Mol Cell Proteomics, 1( 11), 876-84. eScholarID:1d28729
  • Evans C, Ariffin S, Pierce A, Whetton A. (2002). Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors. Blood, 100( 9), 3164-74. eScholarID:1d9395 | DOI:10.1182/blood-2001-12-0235
  • Ross A, Lee P, Smith D, Langridge J, Whetton A, Gaskell S. (2002). Identification of proteins from two-dimensional polyacrylamide gels using a novel acid-labile surfactant. Proteomics, 2( 7), 928-36. eScholarID:1d29038


  • Bentley J, Walker I, McIntosh E, Whetton A, Owen-Lynch P, Baldwin S. (2001). Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. Br J Haematol, 112( 1), 212-5. eScholarID:1d28788
  • Pierce A, Smith D, Jakobsen L, Whetton A, Spooncer E. (2001). The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells. Hematol J, 2( 4), 257-64. eScholarID:1d29501


  • Pierce, A, Spooncer, E, Woolley, S, Dive, C, Francis, JM, Miyan, J, Owen-Lynch, PJ, Dexter, TM, and Whetton, AD. (2000). Bcr-Abl tyrosine kinase activity induces a loss of p53 protein that mediates a delay in differentiation. Oncogene, 19(48), 5487-5497. eScholarID:146323
  • Broome CS, Whetton AD and Miyan JA. (2000). Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU-GM. Brit J Haematol, 108(1), 140-150. eScholarID:146276
  • Tang, X, Downes, CP, Whetton, AD and Owen-Lynch, PJ. (2000). Role of Phosphatidylinositol 3 Kinase and specific PKB isoforms in the suppression of apoptosis mediated by the Abelson protein tyrosine kinase. J Biol Chem, 275(17), 13142-13148. eScholarID:146270
  • Buckle A.-M, Mottram R, Pierce, A, Lucas, GS, Russell, N, Miyan, JA, and Whetton, AD. (2000). The effect of the Bcr-Abl protein tyrosine kinase on maturation and proliferation of human primitive hematopoietic cells. Molecular Medicine, 6(10), 892-902. eScholarID:146272
  • Francis JM, Heyworth, CM, Spooncer, E, Pierce A, Dexter, TM and Whetton A. (2000). Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells. Journal of Biological Chemistry, 275(50), 39137-39145. eScholarID:146277


  • Evans, CA, Pierce, A, Winter, SA, Spooncer, E, Heyworth, CM and Whetton AD. (1999). Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development. Blood, 94(5), 1504-1514. eScholarID:146326
  • Whetton AD, and Graham GJ. (1999). Homing and mobilization in the stem cell niche. Trends Cell Biol, 9(6), 233-238. eScholarID:146327
  • Nicholls SE, Lucas G, Graham GJ, Russell NH, Mottram R, Whetton AD, and Buckle AM. (1999). Macrophage-inflammatory protein-1 alpha receptor expression on normal and chronic myeloid leukemia CD34(+) cells. J Immunol, 162(10), 6191-6199. eScholarID:146324


  • Wark.G., Heyworth, C.M., Spooncer, E., Czaplewski, L., Francis, J.M., Dexter, T.M., and A.D. Whetton. (1998). Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha. Oncogene, 16(10), 1319-1324. eScholarID:146328
  • Pierce, A, Heyworth, CM, Nicholls, SN, Spooncer, E, Dexter, TM, Lord, JM, Owen-Lynch, PJ Wark, G, Whetton AD. (1998). An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks Macrophage-Colony Stimulating Factor-stimulated signalling events. J Cell Biol, 140(6), 1511-1518. eScholarID:146333
  • Pierce, A, A.D. Whetton, P.J. Owen-Lynch, J. Tavernier, E. Spooncer, T.M. Dexter, C.M. Heyworth. (1998). Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. J Cell Science, 111(pt 6), 815-823. eScholarID:146334
  • Pearson M.A., O'Farrell A-M, Dexter T.M., Whetton A.D., Owen-Lynch, P.J. and Heyworth C.M. (1998). Investigation of the molecular mechanisms underlying growth factor synergy: The role of MAPK activation in synergy. Growth Factors, 15(4), 293-306. eScholarID:146337
  • Whetton, A.D., Spooncer, E. (1998). Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells. Current Opinions in Cell Biology, 10(6), 721-726. eScholarID:146331
  • Nicholls, S.E., S. Winter, R. Mottram, J.A. Miyan, and A.D. Whetton. (1998). The Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells. Experimental Hematology, 27(4), 663-672. eScholarID:146343
  • Pierce, A., P. J. Owen-Lynch, E. Spooncer. T.M. Dexter, and A.D. Whetton. (1998). p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia. Oncogene, 17(5), 667-672. eScholarID:146340


  • A.M. Afan, C.S. Broome, S.E. Nicholls, A.D. Whetton, and J.A. Miyan. (1997). Bone marrow innervation regulates cellular retention in the murine haemopoietic system. British Journal of Haematology, 98(3), 569-572. eScholarID:146349
  • Chen, Q., Benson, R.S.P., Whetton, A.D., Brant, S.R., Donowitz, M., Montrose, M.H., Dive, C., and Watson, A.J.M. (1997). Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. J Cell Science, 110(pt 3), 379-387. eScholarID:146365


  • Chasty, R, and Whetton, A D and Lucas, G. (1996). A comparison of the effect of bcr\abl breakpoint specific phosphothiorate oligodeoxynucleotides on colony formation by bcr\abl positive and negative , CD34 enriched mononuclear cell populations. Leukaemia Res, 20(5), 391-395. eScholarID:146369


  • Whetton, A.D. and Dexter T.M. (1993). Influence of growth factors and substrates on the differentiation of haemopoietic stem cells. Current Opinions in Cell Biology, 5(6), 1044-1049. eScholarID:146361