F.Griaud, A.Pierce, M.B.Gonzalez Sanchez, M.Scott, S.A.Abraham, T.L.Holyoake, D.D.H.Tran, T.Tamura, A.D.Whetton. (2012). A pathway from leukaemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukaemia, In Press, eScholarID:172990
F.Griaud, A.J.K.Williamson, S.Taylor, D.Potier, E.Spooncer, A.Pierce A.D.Whetton. (2012). BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response. Journal of Proteome Research, epub ahead of print, eScholarID:172989
Dung-Fang Lee, Jie Su, Yen-Sin Ang, Xonia Carvajal-Vergara, Sonia Mulero-Navarro, Carlos F. Pereira, Julian Gingold, Hung-Liang Wang, Ruiying Zhao, Ana Sevilla, Henia Darr, Andrew J.K. Williamson, Betty Chang, Xiaohong Niu, Francesca Aguilo, Elsa R. Flores, Yuh-Pyng Sher, Mien-Chie Hung, Anthony D. Whetton, Bruce D. Gelb, Kateri A. Moore, Hans-Willem Snoeck, Avi Ma’ayan, Christoph Schaniel, Ihor R. Lemischka. (2012). Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell, 11(2), 179-194. eScholarID:171558 | DOI:10.1016/j.stem.2012.05.020
2011
2. Ramachandran S, Tran, DDH, Klebba-Faerber, Kardinal, C, Whetton AD, Tamura, T. (2011). An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA, 17(11), 1957-1966. eScholarID:144114 | DOI:10.1261/rna.2820911
5. Meyer S, Bristow C, Wappett M, Pepper S, Whetton AD, Hanenberg H, Neitzel H, Wlodarski MW, Ebell W, Tönnies H. (2011). Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood, 117(22), 6047-6050. eScholarID:144123 | DOI:10.1182/blood-2011-03-343897
6. Bonadies N, Foster SD, Chan WI, Kvinlaug BT, Spensberger D, Dawson MA, Spooncer E, Whetton AD, Bannister AJ, Huntly BJ, Göttgens B. (2011). Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One, 6(1), eScholarID:144128
4. Wedge DC, Allwood JW, Dunn WB, Vaughan AA, Simpson K, Brown M, Priest L, Blackhall FH, Whetton AD, Dive C, Goodacre R. (2011). Is serum or plasma more appropriate for inter-subject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal Chem, 83(17), 6689-6697. eScholarID:144117 | DOI:10.1021/ac2012224
1. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. (2011). RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood, 118, 638-649. eScholarID:144112 | DOI:10.1182/blood-2010-09-307330
Williamson AJ, Whetton AD. (2011). The requirement for proteomics to unravel stem cell regulatory mechanisms. J Cell Physiol, 226(10), 2478-2483. eScholarID:144116 | DOI:10.1002/jcp.22610
2010
Blankley RT, Robinson NJ, Aplin JD, Crocker IP, Gaskell SJ, Whetton AD, Baker PN, Myers JE. (2010). A Gel-Free Quantitative Proteomics Analysis of Factors Released From Hypoxic-Conditioned Placentae. Reproductive Sciences, 17(3), eScholarID:81800
Lee CF, Griffiths S, Rodríguez-Suárez E, Pierce A, Unwin RD, Jaworska E, Evans CA, J Gaskell S, Whetton AD. (2010). Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches. Proteomics, 10(18), 3321-3342. eScholarID:96769 | DOI:10.1002/pmic.201000176
Williamson, A and Whetton AD. (2010). Development of approaches for systematic analysis of protein networks in stem cells. Advances in Enzyme Regulation, 50(1), 273-284. eScholarID:144165 | DOI:10.1016/j.advenzreg.2009.10.028
Dobbin E, Graham C, Freeburn RW, Unwin RD, Griffiths JR, Pierce A, Whetton AD, Wheadon H. (2010). Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), 226-243. eScholarID:96768 | DOI:10.1016/j.scr.2010.08.001
Unwin RD, Griffiths JR, Whetton AD. (2010). Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D-nanoLC-MS/MS. Nature Protocols, 5(9), 1574-1582. eScholarID:144161 | DOI:10.1038/nprot.2010.123
Mancini, A., Niemann-Seyde, S., Pankow, R., El Bounkari, O., Klebba-Färber, S., Koch, A., Jaworska, E., Spooncer, E., Gruber, A., Whetton, A. & Tamura, T (2010). THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol, 8, 1. eScholarID:81516 | PMID:20051105 | DOI:10.1186/1741-7007-8-1
Rees-Unwin, K., Faragher, R., Unwin, R., Adams, J., Brown, P., Buckle, A., Pettitt, A., Hutchinson, C., Johnson, S., Pulford, K., Banham, A., Whetton, A., Lucas, G., Mason, D. & Burthem, J (2010). Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia. Br J Haematol, 148(4), 534-43. eScholarID:81515 | PMID:19961478 | DOI:10.1111/j.1365-2141.2009.07979.x
2009
Blankley R, Gaskell SJ, Whetton A, Dive C, Baker PN, Myers JE. (2009). A proof-of-principle study demonstrates a gel-free proteomics strategy which could be applied to the identification of predictive biomarkers for the onset of pre-eclampsia. British Journal Of Obstetrics And Gynaecology, 116, 1473-1480. eScholarID:1d33580 | DOI:10.1111/j.1471-0528.2009.02283.x
Unwin RD, Griffiths J, Whetton A. (2009). A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc, 4( 6), eScholarID:1d19638 | DOI:10.1038/nprot.2009.57
Leverentz MK, Campbell RN, Connolly Y, Whetton A, Reece RJ. (2009). Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner. J Biol Chem, eScholarID:1d20883 | DOI:10.1074/jbc.M109.030361
El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths J, Whetton A, Koch A, Tamura T. (2009). Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). FEBS Lett, 583( 1), eScholarID:1d19641 | DOI:10.1016/j.febslet.2008.11.024
Simpson K, Whetton A, Dive C. (2009). Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification. J Chromatogr B Analyt Technol Biomed Life Sci, 877( 13), eScholarID:1d19642 | DOI:10.1016/j.jchromb.2008.11.023
Woodcock S, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton A, Gorgoulis V, Malliri A. (2009). SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell, 33( 5), eScholarID:1d19640 | DOI:10.1016/j.molcel.2009.02.012
Lu, R, Markowetz, F, Unwin, RD, Leek, JT, Airoldi, EM, MacArthur, BD, Lachmann, A, Rovov, R, Ma’yan, A, Boyer, LA, Troyanskaya, OG, Whetton, AD, Lemischka, IR. (2009). Systems level dynamic analyses of fate change in murine embryonic stem cells. Nature, 462(7271), 358-362. eScholarID:134764 | DOI:10.1038/nature08575
Carney L, Pierce A, Rijnen M, Gonzalez Sanchez M, Hamzah H, Zhang L, Tamura T, Whetton A. (2009). THOC5 couples M-CSF receptor signaling to transcription factor expression. Cell Signal, 21( 2), eScholarID:1d19643 | DOI:10.1016/j.cellsig.2008.10.018
2008
Spooncer, E, Brouard, N, Nilsson, S, Williams, B, Liu, M, Unwin, R, Unwin, RD, Blinco, D, Jaworska, E, Simmons, P, Whetton, A, Whetton, A. (2008). Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting. Mol Cell Proteomics, eScholarID:1d16931 | DOI:10.1074/mcp.M700292-MCP200
Pierce, A, Unwin, RD, Evans, C, Griffiths, S, Carney, L, Zhang, L, Jaworska, E, Lee, C, Blinco, D, Okoniewski, M, Miller, C, Bitton, D, Spooncer, E, Whetton, A, Whetton, A. (2008). Eight-channel iTRAQ enables comparison of the activity of 6 leukaemogenic tyrosine kinases. Mol Cell Proteomics, eScholarID:1d16932 | DOI:10.1074/mcp.M700251-MCP200
Krijgsveld J, Whetton A, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). Proteome Biology of Stem Cells: A New Joint HUPO and ISSCR Initiative. Mol Cell Proteomics, 7( 1), eScholarID:1d31843
Leech S, Evans C, Shaw L, Wong C, Connolly J, Griffiths J, Whetton A, Corfe B. (2008). Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated - implications for colorectal epithelial homeostasis. Proteomics, 8( 2), eScholarID:1d31807
Williamson, A, Smith, D, Blinco, D, Unwin, RD, Pearson, S, Wilson, C, Miller, C, Lancashire, L, Lacaud, G, Kouskoff, V, Whetton, A, Whetton, A. (2008). Quantitative proteomic analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics, 7, 459-72. eScholarID:1d16956 | DOI:10.1074/mcp.M700370-MCP200
Pierce, A, Carney, L, Hamza, H, Griffiths, J, Zhang, L, Whetton, B, Gonzalez Sanchez, M, Tamura, T, Sternberg, D, Whetton, A. (2008). THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. Br J Haematol, 141( 5), eScholarID:1d19645 | DOI:10.1111/j.1365-2141.2008.07090.x
Whetton A, Williamson A, Krijgsveld J, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). The time is right: proteome biology of stem cells. Cell Stem Cell, 2( 3), eScholarID:1d19644
2007
Meyer, S, Fergusson, W, Whetton, A, Moreira-Leite F, Pepper SD, Miller, CCJ, Saunders EK, White, DDJ, Will AM, Eden, OB, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. (2007). Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosome Cancer, 46 (4), 359-372. eScholarID:1d27524 | DOI:10.1002/gcc.20417
Mancini, A, El Bounkari, O, Norrenbrock, A, Scherr, M, Schaefer, D, Eder, M, Banham, A, Pulford, K, Lyne, L, Whetton, A, Tamura, T. (2007). FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha. Oncogene, 26( 7), eScholarID:1d20884 | DOI:10.1038/sj.onc.1209853
Unwin RD, Whetton A. (2007). How will haematologists use proteomics? Blood Rev, 21( 6), eScholarID:1d16957
Welman A, Griffiths J, Whetton A, Dive C. (2007). Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. Protein Sci, 16( 12), eScholarID:1d31844
Griffiths J, Unwin RD, Evans C, Leech S, Corfe B, Whetton A. (2007). The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues. J Am Soc Mass Spectrom, 18( 8), eScholarID:1d16959
Burthem J, Rees-Unwin KKS, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton A, Whetton AD. (2007). The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells. Leukemia, eScholarID:1d31663
Griffiths S, Burthem J, Unwin RD, Holyoake T, Melo J, Lucas G, Whetton A. (2007). The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia. Mol Biotechnol, 36( 2), eScholarID:1d16961
2006
McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton A, Irvine A. (2006). A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood, 108( 5), eScholarID:1d20886 | DOI:10.1182/blood-2006-04-016113
Pierce A, Lu Y, Hamzah H, Thompson S, Owen-Lynch P, Whetton A, Spooncer E. (2006). Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation. Br J Haematol, 133( 3), 345-52. eScholarID:1d31038
Warwood S, Mohammed S, Cristea I, Evans C, Whetton A, Gaskell S. (2006). Guanidination chemistry for qualitative and quantitative proteomics. Rapid Commun Mass Spectrom, 20( 21), 3245-56. eScholarID:1d31078
Unwin, RD, Smith, D, Blinco, D, Wilson, C, Miller, C, Evans, C, Jaworska, E, Baldwin, S, Barnes, K, Pierce, A, Spooncer, E, Whetton, A. (2006). Quantitative proteomics reveals post-translational control as a regulatory factor in primary hematopoietic stem cells. Blood, eScholarID:1d12944 | DOI:10.1182/blood-2005-12-4995
Unwin RD, Evans CL, Whetton A. (2006). Relative quantification in proteomics: new approaches for biochemistry. Trends in Biochemical Sciences, 31, 473-84. eScholarID:1d13562 | DOI:10.1016/j.tibs.2006.06.003
Underhill-Day N, Pierce A, Thompson S, Xenaki D, Whetton A, Owen-Lynch P. (2006). Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance. Br J Haematol, 132( 6), 774-83. eScholarID:1d30366
Unwin RD, Whetton A. (2006). Systematic proteome and transcriptome analysis of stem cell populations. Cell Cycle, 5( 15), 1587-91. eScholarID:1d14854
Bashamboo A, Taylor A, Samuel K, Panthier J, Whetton A, Forrester L. (2006). The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. J Cell Sci, 119( Pt 15), eScholarID:1d20885 | DOI:10.1242/jcs.03038
2005
Chen C, Lorimore SA, Evans CA, Whetton A, Wright EG. (2005). A proteomic analysis of murine bone marrow and its response to ionizing radiation. Proteomics, eScholarID:1d30722
Chen C, Boylan M, Evans C, Whetton A, Wright E. (2005). Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to ionizing radiation. J Proteome Res, 4( 4), 1371-80. eScholarID:1d29850
Barnes K, McIntosh E, Whetton A, Daley G, Bentley J, Baldwin S. (2005). Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene, 24( 20), 3257-67. eScholarID:1d28909
Hamzah H, Pierce A, Stewart W, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton A. (2005). Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P(3)) and lack a PtdIns(3,4,5)P(3) response to cytokines and chemotactic factors; effects reversed by imatinib. Leukemia, 19( 10), 1851-3. eScholarID:1d30714
Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton A. (2005). Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: Identification of the Rho pathway as a target of BCR/ABL. J Biol Chem, 280(8), 6316-6326. eScholarID:1d9392 | DOI:10.1074/jbc.M410598200
Unwin RD, Griffiths J, Leverentz M, Grallert A, Hagan IM, Whetton A. (2005). Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics, 4( 8), 1134-44. eScholarID:1d11460
Unwin RD, Pierce A, Watson R, Sternberg D, Whetton A. (2005). Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics, 4( 7), 924-35. eScholarID:1d11633
2004
Xenaki D, Pierce A, Underhill-Day N, Whetton A, Owen-Lynch P. (2004). Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII. Cell Signal, 16( 2), 145-56. eScholarID:1d29037
Evans, C, Tonge, R, Blinco, D, Pierce, A, Shaw, J, Lu, Y, Hamzah, H, Gray, A, Downes, C, Gaskell, S, Spooncer, E, Whetton, A. (2004). Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood, 103( 10), 3751-9. eScholarID:1d28781 | DOI:10.1182/blood-2003-09-3294
Garwood, K, McLaughlin, T, Garwood, C, Joens, S, Morrison, N, Taylor, C, Carroll, K, Evans, C, Whetton, A, Hart, S, Stead, D, Yin, Z, Brown, A, Hesketh, A, Chater, K, Hansson, L, Mewissen, M, Ghazal, P, Howard, J, Lilley, K, Gaskell, S, Brass, A, Hubbard, S, Oliver, S, Paton, N. (2004). PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics, 5( 1), eScholarID:1d29405
Cristea I, Gaskell S, Whetton A. (2004). Proteomics techniques and their application to hematology. Blood, 103( 10), 3624-34. eScholarID:1d29499
Whetton A. (2004). Stem cells bank on ATM machine. Nat Med, 10( 11), 1166-8. eScholarID:1d29036
Mancini A, Koch A, Whetton A, Tamura T. (2004). The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene, 23( 39), 6581-9. eScholarID:1d28780
2003
Lee C, Evans C, Spooncer E, Pierce A, Mottram R, Whetton A. (2003). Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate. Br J Haematol, 122( 6), 985-95. eScholarID:1d28728
Bentley, J, Itchayanan, D, Barnes, K, McIntosh, E, Tang, X, Downes, C, Holman, G, Whetton, A, Owen-Lynch, P, Baldwin, S. (2003). Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem, 278( 41), 39337-48. eScholarID:1d29329 | DOI:10.1074/jbc.M305689200
Whetton A, Lu Y, Pierce A, Carney L, Spooncer E. (2003). Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood, 102( 8), 2798-802. eScholarID:1d9394 | DOI:10.1182/blood-2002-12-3635
Smith D, Burthem J, Whetton A. (2003). Molecular pathogenesis of chronic myeloid leukaemia. Expert Rev Mol Med, 2003, eScholarID:1d29406
Cochran DA, Evans CA, Blinco D, Burthem J, Burthem J, Stevenson FK, Gaskell SJ, Whetton A. (2003). Proteomic Analysis of Chronic Lymphocytic Leukemia Subtypes with Mutated or Unmutated Ig VH Genes. Mol Cell Proteomics, 2( 12), 1331-1341. eScholarID:1d29153
Unwin RD, Gaskell S, Evans C, Whetton A. (2003). The potential for proteomic definition of stem cell populations. Exp Hematol, 31( 12), 1147-59. eScholarID:1d9393
2002
Pierce A, Spooncer E, Ainsworth S, Whetton A. (2002). BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor. Oncogene, 21( 19), eScholarID:1d29160
Smith D, Evans C, Pierce A, Gaskell S, Whetton A. (2002). Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation. Mol Cell Proteomics, 1( 11), 876-84. eScholarID:1d28729
Evans C, Ariffin S, Pierce A, Whetton A. (2002). Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors. Blood, 100( 9), 3164-74. eScholarID:1d9395 | DOI:10.1182/blood-2001-12-0235
Ross A, Lee P, Smith D, Langridge J, Whetton A, Gaskell S. (2002). Identification of proteins from two-dimensional polyacrylamide gels using a novel acid-labile surfactant. Proteomics, 2( 7), 928-36. eScholarID:1d29038
2001
Bentley J, Walker I, McIntosh E, Whetton A, Owen-Lynch P, Baldwin S. (2001). Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. Br J Haematol, 112( 1), 212-5. eScholarID:1d28788
Pierce A, Smith D, Jakobsen L, Whetton A, Spooncer E. (2001). The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells. Hematol J, 2( 4), 257-64. eScholarID:1d29501
2000
Pierce, A, Spooncer, E, Woolley, S, Dive, C, Francis, JM, Miyan, J, Owen-Lynch, PJ, Dexter, TM, and Whetton, AD. (2000). Bcr-Abl tyrosine kinase activity induces a loss of p53 protein that mediates a delay in differentiation. Oncogene, 19(48), 5487-5497. eScholarID:146323
Broome CS, Whetton AD and Miyan JA. (2000). Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU-GM. Brit J Haematol, 108(1), 140-150. eScholarID:146276
Tang, X, Downes, CP, Whetton, AD and Owen-Lynch, PJ. (2000). Role of Phosphatidylinositol 3 Kinase and specific PKB isoforms in the suppression of apoptosis mediated by the Abelson protein tyrosine kinase. J Biol Chem, 275(17), 13142-13148. eScholarID:146270
Buckle A.-M, Mottram R, Pierce, A, Lucas, GS, Russell, N, Miyan, JA, and Whetton, AD. (2000). The effect of the Bcr-Abl protein tyrosine kinase on maturation and proliferation of human primitive hematopoietic cells. Molecular Medicine, 6(10), 892-902. eScholarID:146272
Francis JM, Heyworth, CM, Spooncer, E, Pierce A, Dexter, TM and Whetton A. (2000). Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells. Journal of Biological Chemistry, 275(50), 39137-39145. eScholarID:146277
1999
Evans, CA, Pierce, A, Winter, SA, Spooncer, E, Heyworth, CM and Whetton AD. (1999). Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development. Blood, 94(5), 1504-1514. eScholarID:146326
Whetton AD, and Graham GJ. (1999). Homing and mobilization in the stem cell niche. Trends Cell Biol, 9(6), 233-238. eScholarID:146327
Nicholls SE, Lucas G, Graham GJ, Russell NH, Mottram R, Whetton AD, and Buckle AM. (1999). Macrophage-inflammatory protein-1 alpha receptor expression on normal and chronic myeloid leukemia CD34(+) cells. J Immunol, 162(10), 6191-6199. eScholarID:146324
1998
Wark.G., Heyworth, C.M., Spooncer, E., Czaplewski, L., Francis, J.M., Dexter, T.M., and A.D. Whetton. (1998). Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha. Oncogene, 16(10), 1319-1324. eScholarID:146328
Pierce, A, Heyworth, CM, Nicholls, SN, Spooncer, E, Dexter, TM, Lord, JM, Owen-Lynch, PJ Wark, G, Whetton AD. (1998). An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks Macrophage-Colony Stimulating Factor-stimulated signalling events. J Cell Biol, 140(6), 1511-1518. eScholarID:146333
Pierce, A, A.D. Whetton, P.J. Owen-Lynch, J. Tavernier, E. Spooncer, T.M. Dexter, C.M. Heyworth. (1998). Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. J Cell Science, 111(pt 6), 815-823. eScholarID:146334
Pearson M.A., O'Farrell A-M, Dexter T.M., Whetton A.D., Owen-Lynch, P.J. and Heyworth C.M. (1998). Investigation of the molecular mechanisms underlying growth factor synergy: The role of MAPK activation in synergy. Growth Factors, 15(4), 293-306. eScholarID:146337
Whetton, A.D., Spooncer, E. (1998). Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells. Current Opinions in Cell Biology, 10(6), 721-726. eScholarID:146331
Nicholls, S.E., S. Winter, R. Mottram, J.A. Miyan, and A.D. Whetton. (1998). The Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells. Experimental Hematology, 27(4), 663-672. eScholarID:146343
Pierce, A., P. J. Owen-Lynch, E. Spooncer. T.M. Dexter, and A.D. Whetton. (1998). p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia. Oncogene, 17(5), 667-672. eScholarID:146340
1997
A.M. Afan, C.S. Broome, S.E. Nicholls, A.D. Whetton, and J.A. Miyan. (1997). Bone marrow innervation regulates cellular retention in the murine haemopoietic system. British Journal of Haematology, 98(3), 569-572. eScholarID:146349
Chen, Q., Benson, R.S.P., Whetton, A.D., Brant, S.R., Donowitz, M., Montrose, M.H., Dive, C., and Watson, A.J.M. (1997). Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. J Cell Science, 110(pt 3), 379-387. eScholarID:146365
1996
Chasty, R, and Whetton, A D and Lucas, G. (1996). A comparison of the effect of bcr\abl breakpoint specific phosphothiorate oligodeoxynucleotides on colony formation by bcr\abl positive and negative , CD34 enriched mononuclear cell populations. Leukaemia Res, 20(5), 391-395. eScholarID:146369
1993
Whetton, A.D. and Dexter T.M. (1993). Influence of growth factors and substrates on the differentiation of haemopoietic stem cells. Current Opinions in Cell Biology, 5(6), 1044-1049. eScholarID:146361
