Dr Alexander Golovanov (MSc, PhD) - postgraduate opportunities
Characterising surface properties of protein biopharmaceutical molecules
Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability. Therefore, a better understanding of the molecular basis of protein aggregation, along with the development of formulations to improve protein stability and solubility, would have a major impact on the generation of new therapeutics. Protein aggregation and self-association, as any protein-protein interaction, is primarily mediated by the surface of the molecules. Therefore, understanding the surface properties of proteins (including biopharmaceuticals), and how protein surface interacts with the chemicals used in formulations, is the key for producing improved therapeutics.
The aim of this project is to develop new approaches for the characterisation and probing of protein surface properties using solution NMR spectroscopy, and correlate these with theoretical calculations using the 3D structure of these proteins and development of computational algorithms.
This multidisciplinary project will be carried out under the supervision of Drs Alexander Golovanov and Jim Warwicker. The student will receive extensive training in modern high-resolution multi-dimensional NMR techniques, protein modelling and computational biology. The Faculty of Life Sciences has state-of-the-art research facilities, including recent investment in the NMR facility that is now equipped with multichannel 500, 600 and 800 MHz spectrometers with cyroprobes. The supervisory team has strong links with industry, which will help to disseminate/ commercialise the discoveries made in this project to the biotechnology and biopharmaceutical sectors.
- Computational Chemistry
- Structural Biology
This project is to be funded under the BBSRC Doctoral Training Programme. Projects under this scheme are competitively funded; ie there are more projects advertised than are available. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form, full details on how to apply can be found on the BBSRC DTP website http://www.dtpstudentships.manchester.ac.uk/