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Professor Angela Simpson - publications

List of publications


  • Grabiec, A. M., Denny, N., Doherty, J., Happonen, K. E., Hankinson, J., Connolly, E., ... Hussell, T. (2017). Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.Journal of Allergy and Clinical Immunology. . Publication link: 54f2622a-4489-4583-b4ad-0af3a10761d8
  • Murray, C. S., Foden, P., Sumner, H., Shepley, E., Custovic, A., & Simpson, A. (2017). Preventing Severe Asthma Exacerbations in Children: A Randomised Trial of Mite Impermeable Bedcovers. American Journal of Respiratory and Critical Care Medicine. DOI: 10.1164/rccm.201609-1966OC. Publication link: 6007ea9a-2b58-4786-96fa-bcac80aaabd4 | PubMed:28282501
  • Overton, N., Simpson, A., Bowyer, P., & Denning, D. (2017). Genetic Susceptibility to Severe Asthma with Fungal Sensitisation. International Journal of Immunogenetics. . Publication link: c129feda-2fac-4eee-838d-4629eb942d48


  • Belgrave, D., Henderson, J., Simpson, A., Buchan, I., Bishop, C., & Custovic, A. (2016). Disaggregating asthma: Big investigation versus big data. Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2016.11.003. Publication link: 18ffb1c1-b40f-4780-91c4-dc68ca0c2f87
  • Overton, N., Denning, D., Bowyer, P., & Simpson, A. (2016). Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 12, [47]. DOI: 10.1186/s13223-016-0152-y. Publication link: 3e574e36-6b7e-4255-bb60-a97a0c8ffa1d
  • Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., ... Zemel, B. S. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.Human molecular genetics, 25(2), 389-403. DOI: 10.1093/hmg/ddv472. Publication link: 280ee72a-b873-45b8-8d51-bf649c31c00d | PubMed:26604143
  • Mohammad, H. R., Belgrave, D., Kopec-Harding, K., Murray, C., Simpson, A., & Custovic, A. (2016). Age, sex, and the association between skin test responses and IgE titres with asthma. Pediatric Allergy and Immunology, 27(3), 313-319. DOI: 10.1111/pai.12534. Publication link: 8537247c-4e13-46db-99ab-1b461608b3dd
  • Sayers, R., Gethings, L., Wallace, A., Semic-Jusufagic, A., Simpson, A., Barran, P., ... Mills, C. (2016). How Much of a Problem Is Peanut in Ground Cumin for Individuals with Peanut Allergy?Journal of Allergy and Clinical Immunology, 137(2). DOI: 10.1016/j.jaci.2015.12.597. Publication link: 83b2ad98-4c49-457c-98df-e32fe82d7f31
  • Downs, M. L., Simpson, A., Custovic, A., Semic-Jusufagic, A., Bartra, J., Fernandez-Rivas, M., ... Mills, E. N. C. (2016). Insoluble and soluble roasted walnut proteins retain antibody reactivity.Food Chemistry, 194, 1013-1021. DOI: 10.1016/j.foodchem.2015.08.119. Publication link: 4e51541a-41b3-49a0-8eba-1236b1700680 | PubMed:26471647


  • Custovic, A., Ainsworth, J., Arshad, H., Bishop, C., Buchan, I., Cullinan, P., ... Simpson, A. (2015). The Study Team for Early Life Asthma Research (STELAR) consortium 'Asthma e-lab': team science bringing data, methods and investigators together.Thorax, 70(8), 799-801. DOI: 10.1136/thoraxjnl-2015-206781, 10.1136/thoraxjnl-2015-206781. Publication link: efa4d291-ecd7-48aa-9233-f678de558d27 | PubMed:25805205
  • Guerra, S., Halonen, M., Vasquez, M. M., Spangenberg, A., Stern, D. A., Morgan, W. J., ... Martinez, F. D. (2015). Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study.The Lancet. Respiratory medicine, 3(8), 613-20. DOI: 10.1016/S2213-2600(15)00196-4. Publication link: af3491eb-0ca4-48c5-abca-a2b2de0fe69a | PubMed:26159408
  • Custovic, A., Sonntag, H-J., Buchan, I. E., Belgrave, D., Simpson, A., & Prosperi, M. C. F. (2015). Evolution pathways of IgE responses to grass and mite allergens throughout childhood. The Journal of allergy and clinical immunology, 136(6), 1645-52. DOI: 10.1016/j.jaci.2015.03.041. Publication link: a607f5d6-301a-4c22-b663-b4342be1d9e5 | PubMed:25962900
  • Munro, C., Semic-Jusufagic, A., Pyrz, K., Couch, P., Dunn-Galvin, A., Peek, N., ... Simpson, A. (2015). An eHealth Approach to Reporting Allergic Reactions to Food and Closing the Knowledge Gap.Studies in health technology and informatics, 216, 320-4. . Publication link: 9a5d8ba4-31ed-458b-b246-756ed2125a94 | PubMed:26262063
  • Holt, P. G., Strickland, D., Bosco, A., Belgrave, D., Hales, B., Simpson, A., ... Custovic, A. (2015). Distinguishing benign from pathologic TH2 immunity in atopic children.The Journal of allergy and clinical immunology, 137(2), 379-87. DOI: 10.1016/j.jaci.2015.08.044. Publication link: 816e309f-a3e5-4ba3-acaa-c70041ddd82b | PubMed:26518094
  • Wu, J., Prosperi, M. C. F., Simpson, A., Hollams, E. M., Sly, P. D., Custovic, A., & Holt, P. G. (2015). Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(12), 1801-11. DOI: 10.1111/cea.12579. Publication link: 8280631b-5df3-4812-9119-4f52229b67f8 | PubMed:26061524
  • Simpson, A., Lazic, N., Belgrave, D. C. M., Johnson, P., Bishop, C., Mills, C., & Custovic, A. (2015). Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.The Journal of allergy and clinical immunology, 136(5). DOI: 10.1016/j.jaci.2015.03.027. Publication link: 7e45fdb8-643b-4c99-b63e-8e1360809c7f | PubMed:25935108
  • Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., ... Aagc, A. A. G. C. (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.Nature Genetics, 47(12), 1449-56. DOI: 10.1038/ng.3424. Publication link: 40967af0-e60f-4f39-a420-58fff93b4eeb | PubMed:26482879
  • Belgrave, D., Simpson, A., Buchan, I. E., & Custovic, A. (2015). Atopic Dermatitis and Respiratory Allergy: What is the Link.Current dermatology reports, 4(4). DOI: 10.1007/s13671-015-0121-6. Publication link: 10907def-ce36-46bd-8384-81ca22fae842 | PubMed:26566461
  • Smith, N. L. D., Bromley, M., Denning, D., Simpson, A., & Bowyer, P. (2015). Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.The Journal of infectious diseases, 211(4), 651-60. DOI: 10.1093/infdis/jiu490. Publication link: 25e3c2fa-b4a0-4320-8d00-983d8c7eabb7 | PubMed:25193981
  • Molter, A., Simpson, A., Berdel, D., Brunekreef, B., Custovic, A., Cyrys, J., ... Agius, R. (2015). A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project.The European respiratory journal, 45(3), 610-24. [00836-2014]. DOI: 10.1183/09031936.00083614. Publication link: 18034416-9361-40fe-86b4-d8f21b669f88 | PubMed:25323237


  • MacIntyre, E. A., Gehring, U., Molter, A., Fuertes, E., Klümper, C., Krämer, U., ... Heinrich, J. (2014). Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project.Environmental Health Perspectives, 122(1), 107-13. DOI: 10.1289/ehp.1306755. Publication link: 0e8861e3-a413-4b79-aa3d-1bd9a3a22a5b | PubMed:24149084
  • Brough, H. A., Simpson, A., Makinson, K., Hankinson, J., Brown, S., Douiri, A., ... Lack, G. (2014). Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations.The Journal of allergy and clinical immunology, 134(4), 867-875. DOI: 10.1016/j.jaci.2014.08.011. Publication link: 439e74eb-ce59-4a7b-99a5-99dfb19570ca | PubMed:25282568
  • Fuertes, E., MacIntyre, E., Agius, R., Beelen, R., Brunekreef, B., Bucci, S., ... Heinrich, J. (2014). Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects.International journal of hygiene and environmental health, 217(8). DOI: 10.1016/j.ijheh.2014.05.004. Publication link: 34539759-2936-4682-a2d0-a8cd961a765c | PubMed:24948353
  • Downs, M. L., Semic-Jusufagic, A., Simpson, A., Bartra, J., Fernandez-Rivas, M., Rigby, N. M., ... Mills, E. N. C. (2014). Characterization of Low Molecular Weight Allergens from English Walnut (Juglans regia).Journal of agricultural and food chemistry, 62(48), 11767-11775. DOI: 10.1021/jf504672m. Publication link: 5a407159-677a-4b89-9d0b-faa26124441b | PubMed:25388987
  • Patel, S., Custovic, A., Smith, J., Simpson, A., Kerry, G., & Murray, C. (2014). Cross-sectional association of dietary patterns with asthma and atopic sensitization in childhood - in a cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(6), 565-71. DOI: 10.1111/pai.12276, 10.1111/pai.12276. Publication link: 55812728-49da-4d51-9abc-3d41d01b8c66 | PubMed:25201630
  • Gruzieva, O., Gehring, U., Aalberse, R., Agius, R., Beelen, R., Behrendt, H., ... Pershagen, G. (2014). Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts.Journal of Allergy and Clinical Immunology, 133(3), 767-776. DOI: 10.1016/j.jaci.2013.07.048. Publication link: 558de01a-22fc-4191-a113-ba270285e273 | PubMed:24094547
  • Eeftens, M., Hoek, G., Gruzieva, O., Molter, A., Agius, R., Beelen, R., ... Gehring, U. (2014). Elemental composition of particulate matter and the association with lung function. Epidemiology, 25(5), 648-657. DOI: 10.1097/EDE.0000000000000136. Publication link: 75736036-a229-4da2-a742-f89fa3c2c4b0 | PubMed:25061921
  • Semic-Jusufagic, A., Belgrave, D., Pickles, A., Telcian, A. G., Bakhsoliani, E., Sykes, A., ... Custovic, A. (2014). Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: A population-based birth cohort study. The Lancet Respiratory Medicine, 2(8), 621-630. DOI: 10.1016/S2213-2600(14)70096-7. Publication link: 6804f892-4676-4cd8-90d5-9cc4e11b09ff | PubMed:24835835
  • Bousquet, J., Gern, J., Martinez, F. D., Anto, J. M., Johnson, C., Holt, P. G., ... Gergen, P. J. (2014). Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop. Journal of Allergy and Clinical Immunology, 133(6), 1535-46. DOI: 10.1016/j.jaci.2014.01.018. Publication link: 93e9785a-8091-492e-9284-5195c517beae
  • Deliu, M., Belgrave, D., Simpson, A., Murray, C. S., Kerry, G., & Custovic, A. (2014). Impact of rhinitis on asthma severity in school-age children.Allergy, 69(11), 1515-1521. DOI: 10.1111/all.12467. Publication link: 980efb95-c9e2-43d3-a3f1-e023f9de6bd1 | PubMed:24958195
  • Prosperi, M. C., Marinho, S., Simpson, A., Custovic, A., & Buchan, I. E. (2014). Predicting phenotypes of asthma and eczema with machine learning. BMC Medical Genomics, 7(1), [S7]. DOI: 10.1186/1755-8794-7-S1-S7. Publication link: ba32860f-c52c-49b6-b037-08f811007df2 | PubMed:25077568
  • Prosperi, M. C. F., Belgrave, D., Buchan, I., Simpson, A., & Custovic, A. (2014). Challenges in interpreting allergen microarrays in relation to clinical symptoms:: A machine learning approach. Pediatric Allergy and Immunology, 25(1), 71-79. DOI: 10.1111/pai.12139, 10.1111/pai.12139. Publication link: b56fc10e-9cdd-4d2c-a874-b760252c6307 | PubMed:24131308
  • Smith, N. L. D., Hankinson, J., Simpson, A., Bowyer, P., & Denning, D. W. (2014). A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), O480-O488. DOI: 10.1111/1469-0691.12473. Publication link: bd3dc1b3-057e-4f60-9b69-f69f5eec9e6f | PubMed:24274595
  • Belgrave, D. C. M., Buchan, I., Bishop, C., Lowe, L., Simpson, A., & Custovic, A. (2014). Trajectories of lung function during childhood. American Journal of Respiratory and Critical Care Medicine, 189(9), 1101-1109. DOI: 10.1164/rccm.201309-1700OC. Publication link: a9da2603-b320-4a2b-a8ce-516f70abfe56 | PubMed:24606581
  • Kljaic-Bukvic, B., Blekic, M., Aberle, N., Curtin, J. A., Hankinson, J., Semic-Jusufagic, A., ... Custovic, A. (2014). Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(6), 552-7. DOI: 10.1111/pai.12258. Publication link: ae97d926-b8bc-4b6f-a011-90a0f0e5e427 | PubMed:24902762
  • Belgrave, D. C. M., Granell, R., Simpson, A., Guiver, J., Bishop, C., Buchan, I., ... Custovic, A. (2014). Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies.PL o S Medicine, 11(10). DOI: 10.1371/journal.pmed.1001748. Publication link: aefce497-5a8d-4585-9a41-795dc5ecc086 | PubMed:25335105
  • Nieto, A., Wahn, U., Bufe, A., Eigenmann, P., Halken, S., Hedlin, G., ... Mazon, A. (2014). Allergy and asthma prevention 2014.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(6). DOI: 10.1111/pai.12272. Publication link: af576884-be8c-4b23-9ec2-0b25d1b52e98 | PubMed:25224992
  • Bønnelykke, K., Sleiman, P., Nielsen, K., Kreiner-Møller, E., Mercader, J. M., Belgrave, D., ... Bisgaard, H. (2014). A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nature Genetics, 46(1), 51-55. DOI: 10.1038/ng.2830. Publication link: d7ce82ed-64de-4bef-b8c0-d6283157fa5d | PubMed:24241537
  • van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., ... Jaddoe, V. W. V. (2014). A novel common variant in DCST2 is associated with length in early life and height in adulthood.Human molecular genetics, 24(4), 1155-68. DOI: 10.1093/hmg/ddu510, 10.1093/hmg/ddu510. Publication link: c918f535-0b1a-42bf-bd0c-47d297adf63a | PubMed:25281659
  • Sahiner, U. M., Semic-Jusufagic, A., Curtin, J. A., Birben, E., Belgrave, D., Sackesen, C., ... Kalayci, O. (2014). Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort.Allergy, 69(12), 1648-58. DOI: 10.1111/all.12504. Publication link: e08b893f-abfd-4aa1-83bf-01bdd1d0990e | PubMed:25102764
  • Smith, N. L. D., Hankinson, J., Simpson, A., Denning, D. W., & Bowyer, P. (2014). Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in CCPA, and novel associations of VEGFA, DENND1B and PLAT. Clinical Microbiology and Infection, 20(11). DOI: 10.1111/1469-0691.12643. Publication link: fab56443-a7b9-4388-8a8e-84e362ef72cf | PubMed:24712925
  • van der Valk, R. J. P., Duijts, L., Timpson, N. J., Salam, M. T., Standl, M., Curtin, J. A., ... de Jongste, J. C. (2014). Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.The Journal of allergy and clinical immunology, 134(1), 46-55. DOI: 10.1016/j.jaci.2013.08.053. Publication link: f66badf6-fb8a-40d1-8411-af1db68127ac | PubMed:24315451


  • Simpson, A. (2013). Unravelling the relationship between Dermatophagoides pteronyssinus and asthma. In Landmark Papers in Allergy: Seminal Papers in Allergy with Expert Commentaries. Oxford University Press. . Publication link: d80ae420-95a9-458e-9391-1b816c6e7d14
  • Bukvic, B. K., Blekic, M., Simpson, A., Marinho, S., Curtin, J. A., Hankinson, J., ... Custovic, A. (2013). Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure. Pediatric Allergy and Immunology, 24(1), 10-18. DOI: 10.1111/pai.12019. Publication link: b7f33567-e243-4abc-b770-717b6322c29c | PubMed:23331525
  • Belgrave, D. C., Simpson, A., Semic-Jusufagic, A., Murray, C. S., Buchan, I., Pickles, A., & Custovic, A. (2013). Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing. Journal of Allergy and Clinical Immunology, 132(3), 575-583. DOI: 10.1016/j.jaci.2013.05.041. Publication link: 803dfa14-2d59-427c-9d81-290e8d086597 | PubMed:23906378
  • Wang, R., Custovic, A., Simpson, A., Belgrave, D. C., Lowe, L. A., & Murray, C. (2013). Differing associations of bmi and body fat with asthma and lung function in children. Pediatric Pulmonology, 49(11), 1049-57. DOI: 10.1002/ppul.22927. Publication link: 8a230864-0aa8-466c-8b5a-9b25c1016956 | PubMed:24166845
  • Belgrave, D. C. M., Custovic, A., & Simpson, A. (2013). Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management. Expert Review of Clinical Immunology, 9(10), 921-936. DOI: 10.1586/1744666X.2013.836450. Publication link: 6c9939e0-5c3e-45da-9f47-48814cfd333d | PubMed:24128156
  • Gehring, U., Gruzieva, O., Agius, R., Beelen, R., Custovic, A., Cyrys, J., ... Brunekreef, B. (2013). Air pollution exposure and lung function in children: The ESCAPE project. Environmental Health Perspectives, 121(11-12), 1357-1364. DOI: 10.1289/ehp.1306770. Publication link: 5550c045-753c-4af9-8b84-80e2f8bdc95c | PubMed:24076757
  • Prosperi, M. C. F., Sahiner, U. M., Belgrave, D., Sackesen, C., Buchan, I., Simpson, A., ... Custovic, A. (2013). Challenges in identifying asthma subgroups using unsupervised statistical learning techniques.American Journal of Respiratory and Critical Care Medicine, 188(11), 1303-1312. DOI: 10.10.1164/rccm.201304-0694OC, 10.1164/rccm.201304-0694OC. Publication link: 5e0546ce-d522-481f-99a9-6c6a2812594a | PubMed:24180417
  • Wu, J., Hankinson, J., Kopec-Harding, K., Custovic, A., & Simpson, A. (2013). Interaction between glutathione S-transferase variants, maternal smoking and childhood wheezing changes with age. Pediatric Allergy and Immunology, 24(5), 501-508. DOI: 10.1111/pai.12086. Publication link: 5dbbe511-707a-4408-ab16-1f47e55726c3 | PubMed:23879774
  • Lazic, N., Roberts, G., Custovic, A., Belgrave, D., Bishop, C. M., Winn, J., ... Simpson, A. (2013). Multiple atopy phenotypes and their associations with asthma: Similar findings from two birth cohorts. Allergy: European Journal of Allergy and Clinical Immunology, 68(6), 764-770. DOI: 10.1111/all.12134. Publication link: 385ebbf3-ad79-4681-8fe4-16dc3017cd23 | PubMed:23621120
  • Curtin, J. A., Simpson, A., Belgrave, D., Semic-Jusufagic, A., Custovic, A., & Martinez, F. D. (2013). Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood. Clinical and Experimental Allergy, 43(3), 304-311. DOI: 10.1111/cea.12046. Publication link: 36ba9624-2c8b-4232-933e-8a6993bc2173 | PubMed:23414538
  • Bønnelykke, K., Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., ... Henderson, A. J. (2013). Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45(8), 902-906. DOI: 10.1038/ng.2694. Publication link: 3f778d0c-1c76-4da0-af15-ad2aeafa9450 | PubMed:23817571
  • Mölter, A., Agius, R., De Vocht, F., Lindley, S., Gerrard, W., Custovic, A., & Simpson, A. (2013). Effects of long-term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort.Journal of Epidemiology and Community Health, 68(1), 21-28. DOI: 10.1136/jech-2013-202681. Publication link: 163c28f4-fe7d-4a34-b7bb-97b68a9227a6 | PubMed:23999376
  • Custovic, A., Lazic, N., & Simpson, A. (2013). Pediatric asthma and development of atopy. Current opinion in allergy and clinical immunology, 13(2), 173-180. DOI: 10.1097/ACI.0b013e32835e82b6. Publication link: 1c37def9-0512-41e9-8ef8-f17e10e68097 | PubMed:23385287
  • Mölter, A., Agius, R. M., de Vocht, F., Lindley, S., Gerrard, W., Lowe, L., ... Simpson, A. (2013). Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort.Environmental Health Perspectives, 121(10), 1232-1238. DOI: 10.1289/ehp.1205961. Publication link: 23424e03-5dc3-43ac-b493-a1b82100914b | PubMed:23777813
  • Blekic, M., Kljaic Bukvic, B., Aberle, N., Marinho, S., Hankinson, J., Custovic, A., & Simpson, A. (2013). 17q12-21 and asthma: interactions with early-life environmental exposures.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(5), 347-353. DOI: 10.1016/j.anai.2013.01.021. Publication link: 0813900c-f2f2-4ecf-a1de-7b021d1f496d | PubMed:23622005


  • Custovic, A., Marinho, S., & Simpson, A. (2012). Gene-environment interactions in the development of asthma and atopy. Expert Review of Respiratory Medicine, 6(3), 301-308. DOI: 10.1586/ers.12.24. Publication link: 6defc9ce-ca0b-48d9-b75e-aeb614950bb4 | PubMed:22788944
  • Marinho, S., Custovic, A., Marsden, P., Smith, J. A., & Simpson, A. (2012). 17q12-21 Variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. Annals of Allergy, Asthma, & Immunology , 108(6), 402-411. DOI: 10.1016/j.anai.2012.03.002. Publication link: 63542c9f-9d5d-400f-8652-a0398d2b1c75 | PubMed:22626592
  • Molter, A., Lindley, S., De Vocht, F., Agius, R., Kerry, G., Johnson, K., ... Simpson, A. (2012). Performance of a microenviromental model for estimating personal NO2 exposure in children. Atmospheric Environment, 51, 225-233. . Publication link: 902caae8-1453-4bfb-ae9f-f17d9f9ca520
  • Custovic, A., & Simpson, A. (2012). The role of inhalant allergens in allergic airways disease. Journal of Investigational Allergology and Clinical Immunology, 22(6), 393-401. . Publication link: 1b1c05af-ba5e-49ae-b294-96a594ddcfae | PubMed:23101182
  • Mölter, A., Lindley, S., de Vocht, F., Agius, R., Kerry, G., Johnson, K., ... Simpson, A. (2012). Performance of a microenviromental model for estimating personal NO 2 exposure in children. Atmospheric Environment, 51, 225-233. DOI: 10.1016/j.atmosenv.2012.01.030. Publication link: 172d2c8a-381b-4df9-b232-9d2db97a6489
  • Wan, Y. I., Shrine, N. R. G., Soler Artigas, M., Wain, L. V., Blakey, J. D., Moffatt, M. F., ... Consortium, T. A. A. G. (2012). Genome-wide association study to identify genetic determinants of severe asthma.Thorax, 67(9), 762-768. DOI: 10.1136/thoraxjnl-2011-201262. Publication link: 26f87879-ddcd-473a-8977-e19595b372b0 | PubMed:22561531
  • Richards, D. A., Bower, P., Pagel, C., Weaver, A., Utley, M., Cape, J., ... Vasilakis, C. (2012). Delivering stepped care: An analysis of implementation in routine practice. Implementation Science, 7(1), [3]. DOI: 10.1186/1748-5908-7-3. Publication link: 46bf25da-fe6f-4567-ac70-8cf20c21d4b6 | PubMed:22248385
  • Simpson, A., Custovic, A., Tepper, R., Graves, P., Stern, D. A., Jones, M., ... Martinez, F. D. (2012). Genetic variation in vascular endothelial growth factor-A and lung function. American Journal of Respiratory and Critical Care Medicine, 185(11), 1197-1204. DOI: 10.1164/rccm.201112-2191OC. Publication link: 2eedd3b8-e9ec-4f47-b501-b671c26f4d44 | PubMed:22461367
  • Paternoster, L., Standl, M., Chen, C. M., Ramasamy, A., Bøpnnelykke, K., Duijts, L., ... Weidinger, S. (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44(2), 187-192. DOI: 10.1038/ng.1017. Publication link: fad2b96e-24b7-4260-b048-fdbd442e76ea | PubMed:22197932
  • Fernandes, B. N., Boyle, R. J., Gore, C., Simpson, A., & Custovic, A. (2012). Food protein-induced enterocolitis syndrome can occur in adults. Journal of Allergy and Clinical Immunology, 130(5), 1199-1200. DOI: 10.1016/j.jaci.2012.06.017. Publication link: a088084d-5030-4dbf-a6c4-4d90597f460a


  • Custovic, A., Soderstrom, L., Ahlstedt, S., SlyPD, . U., Simpson, A., & Holt, P. G. (2011). Allergen-specific IgG Antibody Levels Modify The Relationship Between-Allergen Specific IgE And Wheezing In Childhood In Two Population-Based Birth Cohort Studies.J Allergy Clin Immunol, 127(6), 1480-1485. . Publication link: fc8ee7db-45c2-4433-ad18-b7aec82f2001
  • Nicolaou, N., Murray, C., Belgrave, D., Poorafshar, M., Simpson, A., & Custovic, A. (2011). Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. Journal of Allergy and Clinical Immunology, 127(3), 684-685. DOI: 10.1016/j.jaci.2010.12.012. Publication link: 854f7243-4f57-4199-9b92-f5dddb7f310e | PubMed:21272928
  • Custovic, A., Rothers, J., Stern, D., Simpson, A., Woodcock, A., Wright, A. L., ... Martinez, F. D. (2011). Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies.The Journal of allergy and clinical immunology, 127(2), 390-397. DOI: 10.1016/j.jaci.2010.10.050. Publication link: 74d25051-4df0-47d3-b17c-43e78d6407ce | PubMed:21281869
  • Semic-Jusufagic, A., Simpson, A., Hankinson, J., & Custovic, A. (2011). A Polymorphism in Gasdermin B (GSDMB) gene is associated with severe asthma exacerbations in childhood: A population-based birth cohort study.Acta Medica Academica, 40(2), 110-121. DOI: 10.5644/ama2006-124.14. Publication link: 67e1016e-c51c-4a16-a5c6-8fb842179729
  • Marinho, S., Simpson, A., Marsden, P., Smith, J. A., & Custovic, A. (2011). Quantification of atopy, lung function and airway hypersensitivity in adults. Clinical and Translational Allergy, 1(16), 16. DOI: 10.1186/2045-7022-1-16. Publication link: 670d6946-a567-4a9e-90c8-2d9e443219ab
  • Murray, C. S., Canoy, D., Buchan, I., Woodcock, A., Simpson, A., & Custovic, A. (2011). Body mass index in young children and allergic disease: Gender differences in a longitudinal study. Clinical and Experimental Allergy, 41(1), 78-85. DOI: 10.1111/j.1365-2222.2010.03598.x. Publication link: 6dcf5ad9-6a7c-4472-b575-f191f2908862 | PubMed:20718779


  • Simpson, A., & Martinez, F. D. (2010). The role of lipopolysaccharide in the development of atopy in humans: Review. Clinical and Experimental Allergy, 40(2), 209-223. DOI: 10.1111/j.1365-2222.2009.03391.x. Publication link: d2cd1c9f-66fa-4469-b151-153eb565aa62
  • Niven, R., Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., ... Simpson, A. (2010). A large-scale, consortium-based genomewide association study of asthma. New England Journal of Medicine, 363(13), 1211-1221. DOI: 10.1056/NEJMoa0906312. Publication link: 4f9002a5-9da3-4cf8-8336-2e503f026eed | PubMed:20860503
  • Semic-Jusufagic, A., Simpson, A., Murray, C., Marinho, S., & Custovic, A. (2010). Breastfeeding and the Development of Asthma and Atopy during Childhood: a Birth Cohort Study.Acta Medica Academica, 39(2), 132-143. . Publication link: 52e679aa-45fd-44b1-853c-edc78be8dae4
  • Molter, A., Lindley, S., de Vocht, F., Simpson, A., & Agius, R. (2010). Modelling air pollution for epidemiologic research - Part II: Predicting temporal variation through land use regression. Science of the Total Environment, 409(1), 211-217. DOI: 10.1016/j.scitotenv.2010.10.005. Publication link: 346688f8-2ed8-4033-bc90-637aec782744 | PubMed:20970170
  • Simpson, A., Tan, V. Y. F., Winn, J., Svensén, M., Bishop, C. M., Heckerman, D. E., ... Custovic, A. (2010). Beyond atopy: Multiple patterns of sensitization in relation to asthma in a birth cohort study. American Journal of Respiratory and Critical Care Medicine, 181(11), 1200-1206. DOI: 10.1164/rccm.200907-1101OC. Publication link: 48869e39-e696-4704-96e5-7b9fa7ed1847 | PubMed:20167852



  • Simpson, A., & Custovic, A. (2008). Avoiding exposure to indoor allergens. In ABC of allergies. (2nd ed.). London: Blackwell Publishing. . Publication link: 7eefd34c-5a13-4592-b687-0304625be990
  • Henderson, J., Granell, R., Heron, J., Sheriff, A., Simpson, A., Woodcock, A., ... Sterne, J. A. C. (2008). Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax, 63(11), 974-980. DOI: 10.1136/thx.2007.093187. Publication link: 7a0a616e-d929-48c2-ab0f-4afcf3c06eef
  • Custovic, A., & Simpson, A. (2008). Animal Allergens. In Allergy and Allergic Diseases. (pp. 997-1016). London : Wiley-Blackwell. . Publication link: f80e0308-9a49-48fb-8544-4687336e64cf
  • Smith, J. A., Drake, R., Simpson, A., Woodcock, A., Pickles, A., & Custovic, A. (2008). Dimensions of respiratory symptoms in preschool children: Population-based birth cohort study. American Journal of Respiratory and Critical Care Medicine, 177(12), 1358-1363. DOI: 10.1164/rccm.200709-1419OC. Publication link: a6a97121-10e6-4589-b531-1feeb1383b9a | PubMed:18356563
  • Bisgaard, H., Simpson, A., Palmer, C. N. A., Bønnelykke, K., McLean, I., Mukhopadhyay, S., ... Custovic, A. (2008). Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.PL o S Medicine, 5(6), 0934-0940. DOI: 10.1371/journal.pmed.0050131. Publication link: a6a8d117-1b36-405c-870f-da1560744d44 | PubMed:18578563
  • Nicolaou, N. C., Simpson, A., Lowe, L. A., Murray, C. S., Woodcock, A., & Custovic, A. (2008). Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. Journal of Allergy and Clinical Immunology, 122(3), 500-506. DOI: 10.1016/j.jaci.2008.06.033. Publication link: d724cdab-8aae-4f94-8b66-ea45cf29c547 | PubMed:18774386




  • Simpson, A., & Custovic, A. (2005). Pets and the development of allergic sensitization. Current Allergy and Asthma Reports, 5(3), 212-220. . Publication link: 149ea864-6c3e-4db6-9649-29426145ce28
  • van der Wouden, J. C., Bernsen, R. M. D., Custovic, A., & Simpson, A. (2005). Pet ownership and exposure to indoor allergens. Archives of Pediatrics and Adolescent Medicine, 159(4). . Publication link: 40581766-39b8-4177-a398-9d9461f9bcdd
  • Simpson, A., Maniatis, N., Jury, F., Cakebread, J. A., Lowe, L. A., Holgate, S. T., ... John, S. L. (2005). Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. American Journal of Respiratory and Critical Care Medicine, 172(1), 55-60. DOI: 10.1164/rccm.200412-1708OC. Publication link: 4a2e9fe0-30a0-4d02-9280-2b921861d0ff
  • Simpson, A., & Custovic, A. (2005). The role of allergen avoidance in the secondary prevention of atopic disorders. Current opinion in allergy and clinical immunology, 5(3), 223-227. . Publication link: 2fdfa431-a546-46b1-bb96-2c831d15503f
  • Simpson, A., Soderstrom, L., Ahlstedt, S., Murray, C. S., Woodcock, A., & Custovic, A. (2005). IgE antibody quantification and the probability of wheeze in preschool children. Journal of Allergy and Clinical Immunology, 116(4), 744-749. DOI: 10.1016/j.jaci.2005.06.032. Publication link: 6f072eaf-1231-470f-91ba-9a4f85743dfd | PubMed:16210045
  • Calam, R., Gregg, L., Simpson, A., Simpson, B., Woodcock, A., & Custovic, A. (2005). Behavior problems antecede the development of wheeze in childhood: A birth cohort study. American Journal of Respiratory and Critical Care Medicine, 171(4), 323-327. DOI: 10.1164/rccm.200406-791OC. Publication link: 844bd2a3-5751-45bf-9bd2-787539d55936 | PubMed:15557132
  • Lowe, L. A., Simpson, A., Woodcock, A., Morris, J., Murray, C. S., & Custovic, A. (2005). Wheeze phenotypes and lung function in preschool children.American Journal of Respiratory and Critical Care Medicine, 171(3), 231-237. DOI: 10.1164/rccm.200406-695OC. Publication link: e99a3bb0-829d-41a6-bdc1-32df0b78b1c2 | PubMed:15502115
  • Custovic, A., Murray, C., & Simpson, A. (2005). Allergy and infection: Understanding their relationship. Allergy: European Journal of Allergy and Clinical Immunology, Supplement, 60(79), 10-13. . Publication link: ced7b630-8271-45c1-9731-767c3e3f8d92



  • Simpson, A., Simpson, B., Custovic, A., Craven, M., & Woodcock, A. (2003). Stringent environmental control in pregnancy and early life: The long-term effects on mite, cat and dog allergen. Clinical and Experimental Allergy, 33(9), 1183-1189. DOI: 10.1046/j.1365-2745.2003.01651.x. Publication link: 2dcdf2be-218b-4dd6-99e2-54cddfad2b7c
  • Simpson, A., & Custovic, A. (2003). Early pet exposure: Friend or foe?Current opinion in allergy and clinical immunology, 3(1), 7-14. DOI: 10.1097/00130832-200302000-00002. Publication link: c183b790-17ba-492e-8ec9-9bc6ebb31d09
  • Simpson, A., Green, R., Custovic, A., Woodcock, A., Arruda, L. K., & Chapman, M. D. (2003). Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK. Allergy: European Journal of Allergy and Clinical Immunology, 58(1), 53-56. DOI: 10.1034/j.1398-9995.2003.23354.x. Publication link: ef81ce82-36fd-41f9-876c-debef472bd37
  • Custovic, A., Simpson, B. M., Simpson, A., Hallam, C. L., Marolia, H., Walsh, D., ... Woodcock, A. (2003). Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults. Journal of Allergy and Clinical Immunology, 111(2), 402-407. DOI: 10.1067/mai.2003.55. Publication link: f5e1cdf1-b88f-4fe0-9859-031a30861c46




  • Custovic, A., Hallam, C., Woodcock, H., Simpson, B., Houghton, N., Simpson, A., & Woodcock, A. (2000). Synthetic pillows contain higher levels of cat and dog allergen than feather pillows. Pediatric Allergy and Immunology, 11(2), 71-73. DOI: 10.1034/j.1399-3038.2000.00072.x. Publication link: f518b2c6-1c8e-4560-80bf-e14361196f07
  • Custovic, A., Simpson, B. M., Simpson, A., Hallam, C., Craven, M., Brutsche, M., & Woodcock, A. (2000). Manchester asthma and allergy study: Low-allergen environment can be achieved and maintained during pregnancy and in early life. Journal of Allergy and Clinical Immunology, 105(2 II), 252-258. . Publication link: d647a0bd-be24-4dde-9931-ec68768d3c92


  • Green, R., Simpson, A., Custovic, A., Faragher, B., Chapman, M., & Woodcock, A. (1999). The effect-of air filtration on airborne dog allergen. Allergy: European Journal of Allergy and Clinical Immunology, 54(5), 484-488. DOI: 10.1034/j.1398-9995.1999.00029.x. Publication link: 6f533f18-dfaf-4e1c-815c-b96e8c5024bb
  • Tunnicliffe, W. S., Fletcher, T. J., Hammond, K., Roberts, K., Custovic, A., Simpson, A., ... Ayres, J. G. (1999). Sensitivity and exposure to indoor allergens in adults with differing asthma severity. European Respiratory Journal, 13(3), 654-659. . Publication link: 50bcc8c2-5964-492a-b8d6-2fa3b47e3590
  • Custovic, A., Woodcock, H., Craven, M., Hassall, R., Hadley, E., Simpson, A., & Woodcock, A. (1999). Dust mite allergens are carried on not only large particles. Pediatric Allergy and Immunology, 10(4), 258-260. DOI: 10.1034/j.1399-3038.1999.00050.x. Publication link: 9bcf9890-2f34-4468-803a-d1b5f55e34f5
  • Green, R., Simpson, A., Custovic, A., & Woodcock, A. (1999). Vacuum cleaners and airborne dog allergen. Allergy: European Journal of Allergy and Clinical Immunology, 54(4), 403-405. DOI: 10.1034/j.1398-9995.1999.00154.x. Publication link: 82755d68-9820-4bad-a38e-8e7c6f2bf6e6
  • Hallam, C., Custovic, A., Simpson, B., Houghton, N., Simpson, A., & Woodcock, A. (1999). Mite allergens in feather and synthetic pillows. Allergy: European Journal of Allergy and Clinical Immunology, 54(4), 407-408. DOI: 10.1034/j.1398-9995.1999.00066.x. Publication link: 2ed5082d-9456-451e-b1ae-e9af61975a6e
  • Custovic, A., Simpson, A., & Woodcock, A. (1999). Benefits of allergen avoidance. In Atlas of asthma. (pp. 76-78). Parthenon Publishing Ltd. . Publication link: 45b53e6d-4e6e-44b5-a9d5-4e00aaef9c7a
  • Custovic, A., Simpson, B., Simpson, A., Hallam, C., Craven, M., & Woodcock, A. (1999). Relationship between mite, cat, and dog allergens in reservoir dust and ambient air. Allergy: European Journal of Allergy and Clinical Immunology, 54(6), 612-616. DOI: 10.1034/j.1398-9995.1999.00062.x. Publication link: eb0f7489-6a13-4033-8049-d9ccffb07e82
  • Hodson, T., Custovic, A., Simpson, A., Chapman, M., Woodcock, A., & Green, R. (1999). Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. Journal of Allergy and Clinical Immunology, 103(4), 581-585. DOI: 10.1016/S0091-6749(99)70227-7. Publication link: e64c35b2-3d7a-4871-ad47-61ad3fa685ff | PubMed:10200004
  • Simpson, A., Custovic, A., Pipis, S., Adisesh, A., Faragher, B., & Woodcock, A. (1999). Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids. American Journal of Respiratory and Critical Care Medicine, 160(1), 45-49. . Publication link: d60bcdff-602c-41aa-bd44-db4426318666


  • Custovic, A., Simpson, A., Chapman, M. D., & Woodcock, A. (1998). Allergen avoidance in the treatment of asthma and atopic disorders. Thorax, 53(1), 63-72. . Publication link: f6862173-8487-4a6c-96e4-64837ad16d0f
  • Custovic, A., Simpson, A., Pahdi, H., Green, R. M., Chapman, M. D., & Woodcock, A. (1998). Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes. Thorax, 53(1), 33-38. . Publication link: b6b90ccb-6a0f-4a8b-9611-7961bcad2545
  • Custovic, A., Simpson, A., & Woodcock, A. (1998). Importance of indoor allergens in the induction of allergy and elicitation of allergic disease. Allergy: European Journal of Allergy and Clinical Immunology, Supplement, 53(48), 115-120. . Publication link: ec686234-a828-4e0f-809d-74d88891575c
  • Simpson, A., Hassall, R., Custovic, A., & Woodcock, A. (1998). Variability of house-dust-mite allergen levels within carpets. Allergy: European Journal of Allergy and Clinical Immunology, 53(6), 602-607. . Publication link: 3179573b-336e-4b21-a6af-f36458dc7c90
  • Custovic, A., Fletcher, A., Pickering, C. A. C., Francis, H. C., Green, R., Smith, A., ... Simpson, A. (1998). Domestic allergens in public places III: House dust mite, cat, dog and cockroach allergens in British hospitals. Clinical and Experimental Allergy, 28(1), 53-59. DOI: 10.1046/j.1365-2222.1998.00183.x. Publication link: 70487ca0-a5ba-4e4b-91be-499c88faf048 | PubMed:9537780


  • Simpson, A., Arruda, K., & Chapman, M. (1997). Antigenic interrelationships among mite allergens (blomia and dermatophagoides spp). Clin Rev Allergy Immunol, 15(4), 461-9. . Publication link: 4b0f0092-dc9e-45a9-bdca-b2d635038b20


  • Simpson, A., Custovic, A., Green, R., Taggart, S. C., Smith, A., Pickering, C. A., ... Woodcock, A. (1996). Domestic allergens in public places. II: Dog (Can f1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings.Clin Exp Allergy, 26(11), 1246-52. . Publication link: 6f4ff867-ccd3-450c-87fe-2fe679ea3663 | PubMed:8955573
  • Custovic, A., Green, R., Smith, A., Chapman, M. D., Woodcock, A., & Simpson, A. (1996). New mattresses: How fast do they become a significant source of exposure to house dust mite allergens?Clinical and Experimental Allergy, 26(11), 1243-1245. DOI: 10.1111/j.1365-2222.1996.tb00520.x. Publication link: 313b4a69-53e4-4dc8-8d6b-a49c8e396035 | PubMed:8955572