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Professor Jacky Smith (MB, ChB, MRCP, PhD) - publications

List of publications


  • Smith, J. (2016). TRPV4 and sensory afferent activation: role of ATP. Journal of Allergy and Clinical Immunology.. Publication link: c9982541-2338-4719-bc4e-8b589ccbded7
  • Smith, J. A., Marsden, P. A., Satia, I., Ibrahim, B., Fowler, S. J., Woodcock, A., ... Thompson, N. (2016). Objective Cough Frequency, Airway Inflammation and Disease Control in Asthma. Chest.. Publication link: d3d676e0-433f-4a5b-ac34-351e6278cc27
  • Smith, J. A., Horsley, A., O'Neill, K., Downey, D. G., Elborn, J. S., Bell, N. J., & Owers-Bradley, J. (2016). Closed circuit rebreathing wash-in as an effective and efficient method of achieving inert gas equilibrium for multiple breath washout. Unknown Journal.. Publication link: 3760dcda-de1c-4bac-840f-02ef5fa72019
  • Smith, J. A., Belvisi, M. G., Birrell, M. A., Khalid, S., Wortley, M. A., Dockry, R., ... Woodcock, A. (2016). Neuro-phenotypes in Airway Diseases: insights from translational studies.American Journal of Respiratory and Critical Care Medicine.. Publication link: 6ccc1744-12b3-44cf-9a3b-64c6c2254bf1


  • Smith, J. A., West, P. W., Canning, B. J., Merlo-Pich, E., & Woodcock, A. A. (2015). Morphological Characterisation of Nerves in Whole Mount Airway Biopsies. American Journal of Respiratory and Critical Care Medicine, 192(1), 30-39.. Publication link: 149fc889-e133-46f2-a65d-81202fdfe38a
  • Smith, J. A., Bonvini, S. J., Birrell, M. A., & Belvisi, M. G. (2015). Targeting TRP Channels for Chronic Cough. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(4), 401-420.. Publication link: 228133a4-da30-4ec4-8385-57a4e6da48fb
  • Smith, J. A., Almansa, C., Morris, J., Crowell, M. D., Valdramidou, D., Lee, A., ... Houghton, L. A. (2015). Weak Peristalsis with Large Breaks In Chronic Cough: Association With Poor Esophageal Clearance. Neurogastroenterology and Motility, 27(3), 431-442.. Publication link: 9f751870-be79-4e47-96a5-b0bd078d3501
  • Smith, J. A., Morice, A. H., Millqvist, E., Belvisi, M. G., Bieksiene, K., Birring, S. S., ... Sakalauskas, R. (2015). Cough hypersensitivity syndrome: clinical measurement is the key to progress, authors reply.European Respiratory Journal, 45(5), 1509-1510.. Publication link: f7a67c31-6bbc-4fac-92c3-6b3eff69f53a
  • Smith, J., Boulet, . U., L, . U., Coeytaux, . U., R, . U., McCrory, . U., ... Irwin, R. (2015). Tools for Assessing Outcomes in Studies of Chronic Cough: CHEST Guideline and Expert Panel Report. Chest, 147(3), 804-814.. Publication link: 6a9441e1-4fa1-4af8-bb2c-947e17d21db3
  • Smith, J., Yorke, J., Lloyd-Williams, M., Blackhall, F., Harle, A., Warden, J., ... Molassiotis, A. (2015). Management of the respiratory distress symptom cluster in lung cancer: a randomised controlled feasibility study. Supportive Care in Cancer, 23(11), 3373-3384.. Publication link: 44403bf3-defc-4982-9730-46317d81432a
  • Smith, J. A., Abdulqawi, R., Dockry, R., Holt, K., Layton, G., McCarthy, B. G., & Ford, A. P. (2015). P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. The Lancet, 385(9974), 1198-1205.. Publication link: 3a35f895-dba8-4302-bc0c-f8b7a5bcba5d
  • Smith, J. A., Abdulqawi, R., Dockry, R., Holt, K., Layton, G., McCarthy, B. G., & Ford, A. P. (2015). A P2X3 receptor antagonist in chronic cough: author’s reply. Lancet, 386(9990), 244-245.. Publication link: bc0d23fb-2f40-4a55-b145-5531a0ae36f0
  • Smith, J., Hilton, E., Marsden, P., Thurston, A., Kennedy, S., & Decalmer, S. (2015). Features of the Urge-To-Cough in Patients with Chronic Cough. Respiratory Medicine, 109(6), 701-707.. Publication link: cabcd330-8644-48f0-8097-fa35672f84d1


  • Smith, J., Lewis, S. Z., Diekemper, R. L., French, C. T., Gold, P. M., Irwin, R. S., & Panel, C. H. E. S. T. E. C. (2014). Methodologies for the Development of the Management of Cough: CHEST Guideline and Expert Panel Report.Unknown Journal.. Publication link: de806895-5a7f-426e-98a9-d5641818715c
  • Smith, J. A., Morice, A. H., Jakes, A. D., Faruqi, S., Birring, S. S., McGarvey, L., ... Dicpinigaitis, P. (2014). A worldwide survey of chronic cough: A manifestation of enhanced somatosensory response?. The European respiratory journal.. Publication link: 855f0749-897e-4748-b00f-c3a5e3f640e3
  • Smith, J. A., Khalid, S., Murdoch, R., Newlands, A., Smart, K., Kelsall, A., ... Woodcock, A. (2014). TRPV1 Antagonism in Refractory Chronic Cough: A Double Blind Randomised Controlled Trial. Journal of Allergy and Clinical Immunology, 56-62.. Publication link: dda43f9c-77fc-4147-a316-a74fb750b8eb
  • Smith, J. A., Morice, A. H., Millqvist, E., Belvisi, M. G., Bieksiene, K., Birring, S. S., ... Sakalauskas, R. (2014). Expert opinion on the cough hypersensitivity syndrome in respiratory medicine.The European respiratory journal.. Publication link: 0da8f4c2-c4d6-4319-8ccf-f6117621ea54
  • Smith, J. A., Canning, B. J., Chang, A. B., Mazzone, S. B., & McGarvey, L. (2014). Anatomy and Neurophysiology of Cough: CHEST Guideline and Expert Panel Report. Chest.. Publication link: 2c81e427-52d1-48c0-98f6-4faf0b8554ac
  • Hoffmann, B., Gullett, J. P., Hill, H. F., Fuller, D., Westergaard, M. C., Hosek, W. T., & Smith, J. A. (2014). Ultraschall während der Notfallintubation bestätigt korrekte Tubuslokalisation. Ultraschall in der Medizin. 10.1055/s-0034-1366014. Publication link: bb6b40a0-f644-44b0-8b7d-066e2a5b7850 | DOI:10.1055/s-0034-1366014
  • Kahrilas, P. J., Smith, J. A., & Dicpinigaitis, P. V. (2014). A causal relationship between cough and gastroesophageal reflux disease (GERD) has been established: A Pro/Con debate. Lung, 192(1), 39-46. 10.1007/s00408-013-9528-7. Publication link: 2ddce506-5e72-4ae0-bf01-0fa99646329c | DOI:10.1007/s00408-013-9528-7
  • Smith, J. A., Patel, S., Custovic, A., Simpson, A., Kerry, G., & Murray, C. S. (2014). The Relationship Between Dietary Patterns In Childhood With Asthma and Atopic Sensitisation. Pediatric Allergy and Immunology.. Publication link: 8851ea23-280a-4a19-a856-a30664fbdc8b
  • Khosravi, M., Collins, P. B., Lin, R. L., Hayes, D., Smith, J. A., & Lee, L. Y. (2014). Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis. Respiratory Physiology and Neurobiology, 198(1), 13-19. 10.1016/j.resp.2014.03.013. Publication link: 4955a3aa-2cb6-444f-98a5-dcb197e4c016 | DOI:10.1016/j.resp.2014.03.013
  • Smith, J. A., Dicpinigaitis, P., Morice, A. H., Birring, S., McGarvey, L., Canning, B. J., & Page, C. P. (2014). Anti-tussive drugs – past, present and future. Pharmacological Reviews, 66(2), 468-512.. Publication link: 357e4bbe-1913-4ed2-964a-3c9beba167ce
  • Irwin, R. S., French, C. T., Lewis, S. Z., Diekemper, R. L., Gold, P. M., Adams, T. M., ... Wiener, R. S. (2014). Overview of the management of cough CHEST guideline and expert panel report. Chest, 146(4), 885-889. 10.1378/chest.14-1485. Publication link: 1b674bd8-841d-49fe-a3a0-212bbb58883e | DOI:10.1378/chest.14-1485


  • Smith, J. A., Barton, A., Gaydecki, P., & Holt, K. (2013). Data minimisation in the detection of cough from sound recordings. Cough, 8(12).. Publication link: 8b620869-fef0-49c1-a2fd-905b4fefec0e
  • Smith, J. A., Molassiotis, A., Ellis, J., Wagland, R., Lloyd, W. M., Bailey, C. B., ... Blackhall, F. (2013). The Manchester Cough in Lung Cancer Scale: the development and validation of a new assessment tool. Journal of Pain and Symptom Management, 45(2), 179-190.. Publication link: 9e388376-d958-4201-9513-09ad371f7696
  • Vestbo, J., Sumner, H., Woodcock, A., Kolsum, U., Dockry, R., Lazaar, A. L., ... Singh, S. (2013). Predictors of objective cough frequency in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 187(9), 943-949. 10.1164/rccm.201211-2000OC. Publication link: 76337dcc-0e75-46ca-be89-50a8d084d8bd | DOI:10.1164/rccm.201211-2000OC | PubMed:23471467
  • Smith, J., Abdulqawi, R., Houghton, L. A., & Smith, J. A. (2013). Gastro-oesophageal reflux and cough. Journal of Association of Physicians of India, 61(3), 17-19.. Publication link: ec88ae74-1a86-4dd8-a4f6-8349b9cda12b
  • Smith, J., Smith, J. A., & Houghton, L. A. (2013). The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes. Cough, 9(1), [12]. 10.1186/1745-9974-9-12. Publication link: 4d089aa6-b427-49dd-ab0e-a09d9eb62016 | DOI:10.1186/1745-9974-9-12
  • Smith, J. A., Ibrahim, B., Marsden, P., Morris, J., Custovic, A., Nilsson, M., & Fowler, S. J. (2013). Exhaled Breath Condensate Metabolomic Profiling by Nuclear Magnetic Resonance Spectroscopy in Asthma. Allergy.. Publication link: 103c081e-5a42-46df-a2d3-e5e7b95d52fa
  • Sunger, K., Powley, W., Kelsall, A., Sumner, H., Murdoch, R., & Smith, J. A. (2013). Objective measurement of cough in otherwise healthy volunteers with acute cough. European Respiratory Journal, 41(2), 277-284. 10.1183/09031936.00190111. Publication link: b29ffc97-6d65-4e4c-985c-251d924b8daa | DOI:10.1183/09031936.00190111 | PubMed:22743673
  • Hilton, E. C. Y., Baverel, P. G., Woodcock, A., Van Der Graaf, P. H., & Smith, J. A. (2013). Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point. Journal of Allergy and Clinical Immunology, 132(4), 847-e5. 10.1016/j.jaci.2013.04.042. Publication link: 8e3855b1-9dc6-43be-b468-951254dacedf | DOI:10.1016/j.jaci.2013.04.042 | PubMed:23777849
  • Smith, J. A., Abdulqwai, R., & Woodcock, A. (2013). Gabapentin in Refractory Chronic Cough. Lancet, 381, 623.. Publication link: b108b971-e1cb-4b94-bb15-b15e9f6f2725


  • Decalmer, S., Stovold, R., Houghton, L. A., Pearson, J., Ward, C., Kelsall, A., ... Smith, J. A. (2012). Chronic cough: Relationship between microaspiration, gastroesophageal reflux, and cough frequency. Chest, 142(4), 958-964. 10.1378/chest.12-0044. Publication link: 129ce6d7-3be9-4810-a325-5c6712d391a3 | DOI:10.1378/chest.12-0044 | PubMed:22797535
  • Smith, J., Smith, J. A., Hilton, E. C. Y., Saulsberry, L., & Canning, B. J. (2012). Antitussive effects of memantine in guinea pigs. Chest, 141(4), 996-1002. 10.1378/chest.11-0554. Publication link: 19d1a3fe-a7fa-417c-92c6-f86785e6f287 | DOI:10.1378/chest.11-0554
  • Wagland, R., Ellis, J., Bailey, C. D., Haines, J., Caress, A., Williams, M. L., ... Molassiotis, A. (2012). Considerations in developing and delivering a non-pharmacological intervention for symptom management in lung cancer: The views of health care professionals. Supportive Care in Cancer, 20(10), 2565-2574. 10.1007/s00520-011-1362-y. Publication link: 1b186447-f56f-4da6-a309-f345d4100a3e | DOI:10.1007/s00520-011-1362-y | PubMed:22270088
  • Smith, J., West, P. W., Kelsall, A., Decalmer, S., Dove, W., Bishop, P. W., ... Smith, J. A. (2012). PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study. Cough, 8(1), [5]. 10.1186/1745-9974-8-5. Publication link: 129ee508-1ead-446d-81c0-e5ca3243ade0 | DOI:10.1186/1745-9974-8-5 | PubMed:22978556
  • Marinho, S., Custovic, A., Marsden, P., Smith, J. A., & Simpson, A. (2012). 17q12-21 Variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. Annals of Allergy, Asthma and Immunology, 108(6), 402-e9. 10.1016/j.anai.2012.03.002. Publication link: 63542c9f-9d5d-400f-8652-a0398d2b1c75 | DOI:10.1016/j.anai.2012.03.002 | PubMed:22626592
  • Smith, J., Houghton, L. A., & Smith, J. A. (2012). Editorial: Breaking the sound barrier pitfalls and benefits of acoustic cough monitoring. American Journal of Gastroenterology, 107(12), 1833-1836. 10.1038/ajg.2012.345. Publication link: ec45be81-fa34-468f-b28d-6cb7bb6a2e38 | DOI:10.1038/ajg.2012.345
  • Harle, A. S. M., Blackhall, F. H., Smith, J. A., & Molassiotis, A. (2012). Understanding cough and its management in lung cancer. Current Opinion in Supportive and Palliative Care, 6(2), 153-162. 10.1097/SPC.0b013e328352b6a5. Publication link: 588baf5e-9420-4a4f-9d81-4904f5d5c2ee | DOI:10.1097/SPC.0b013e328352b6a5 | PubMed:22469666
  • Molassiotis, A., Emsley, R., Ashcroft, D., Caress, A., Ellis, J., Wagland, R., ... Blackhall, F. (2012). Applying Best-Worst scaling methodology to establish delivery preferences of a symptom supportive care intervention in patients with lung cancer. Lung Cancer, 77(1), 199-204. 10.1016/j.lungcan.2012.02.001. Publication link: c77ae485-c425-47e8-9075-a3385e024789 | DOI:10.1016/j.lungcan.2012.02.001 | PubMed:22385926
  • Smith, J. A., Aliverti, A., Quaranta, M., Mcguinness, K., Kelsall, A., Earis, J., & Calverley, P. M. (2012). Chest wall dynamics during voluntary and induced cough in healthy volunteers. Journal of Physiology, 590(3), 563-574. 10.1113/jphysiol.2011.213157. Publication link: a8f4bb8c-d716-40f4-be86-4d703a8a59c3 | DOI:10.1113/jphysiol.2011.213157
  • Ellis, J., Wagland, R., Tishelman, C., Williams, M. L., Bailey, C. D., Haines, J., ... Molassiotis, A. (2012). Considerations in developing and delivering a nonpharmacological intervention for symptom management in lung cancer: The views of patients and informal caregivers. Journal of Pain and Symptom Management, 44(6), 831-842. 10.1016/j.jpainsymman.2011.12.274. Publication link: 5659a7d1-36e8-4d56-a413-94003273e8ca | DOI:10.1016/j.jpainsymman.2011.12.274 | PubMed:22672922





  • Heil, M., Hazel, A. L., & Smith, J. A. (2008). The mechanics of airway closure. Respiratory Physiology and Neurobiology, 163(1-3), 214-221. 10.1016/j.resp.2008.05.013. Publication link: d562a5c0-fb42-4f72-84dd-6ee9975f3f0c | DOI:10.1016/j.resp.2008.05.013
  • Kelsall, A., Decalmer, S., Webster, D., Brown, N., McGuinness, K., Woodcock, A., & Smith, J. (2008). How to quantify coughing: Correlations with quality of life in chronic cough. European Respiratory Journal, 32(1), 175-179. 10.1183/09031936.00101307. Publication link: d068bc39-34e3-40fb-84e8-7c757b4aab3e | DOI:10.1183/09031936.00101307
  • Marsden, P. A., Smith, J. A., Kelsall, A. A., Owen, E., Naylor, J. R., Webster, D., ... Woodcock, A. A. (2008). A comparison of objective and subjective measures of cough in asthma. Journal of Allergy and Clinical Immunology, 122(5), 903-907. 10.1016/j.jaci.2008.08.029. Publication link: 9a8d0d23-bf8c-43f1-8702-d9fec1bfb14c | DOI:10.1016/j.jaci.2008.08.029 | PubMed:18842290


  • Morice, A. H., Fontana, G. A., Belvisi, M. G., Birring, S. S., Chung, K. F., Dicpinigaitis, P. V., ... Widdicombe, J. (2007). ERS guidelines on the assessment of cough. European Respiratory Journal, 29(6), 1256-1276. 10.1183/09031936.00101006. Publication link: 9f6f2093-91af-4a38-a999-990ba86d222d | DOI:10.1183/09031936.00101006
  • Decalmer, S., Woodcock, A. A., & Smith, J. A. (2007). Patient misreporting may lead to underestimation of cough events [1]. Chest, 132(1), 358. 10.1378/chest.06-2300. Publication link: a6e8a4f9-6910-4186-83da-31b64eabe11c | DOI:10.1378/chest.06-2300
  • Smith, J. (2007). Ambulatory methods for recording cough. Pulmonary Pharmacology and Therapeutics, 20(4), 313-318. 10.1016/j.pupt.2006.10.016. Publication link: e141912b-b8a3-4b6e-a446-1ff5b3d58fdf | DOI:10.1016/j.pupt.2006.10.016
  • Stovold, R., Forrest, I. A., Corris, P. A., Murphy, D. M., Smith, J. A., Decalmer, S., ... Ward, C. (2007). Pepsin, a biomarker of gastric aspiration in lung allografts: A putative association with rejection. American Journal of Respiratory and Critical Care Medicine, 175(12), 1298-1303. 10.1164/rccm.200610-1485OC. Publication link: 31e08a45-e7ab-432f-a0c4-1d1f33e787e5 | DOI:10.1164/rccm.200610-1485OC
  • Smith, J. A., & Woodcock, A. A. (2007). New Developments in the Objective Assessment of Cough.Lung, 186(Supp 1), S48-S54.. Publication link: 5eb39c02-0dea-439d-ba03-ea45c6a22dd4
  • Decalmer, S. C., Webster, D., Kelsall, A. A., McGuinness, K., Woodcock, A. A., & Smith, J. A. (2007). Chronic cough: How do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?. Thorax, 62(4), 329-334. 10.1136/thx.2006.067413. Publication link: 7bd9bfdd-2bf4-49cd-a986-1de6a51c17b9 | DOI:10.1136/thx.2006.067413 | PubMed:17101736
  • Decalmer, S., Woodcock, A., Greaves, M., Howe, M., & Smith, J. (2007). Airway abnormalities at flexible bronchoscopy in patients with chronic cough. European Respiratory Journal, 30(6), 1138-1142. 10.1183/09031936.00034807. Publication link: 325971ed-1d96-4fc3-a616-9496cad5d41a | DOI:10.1183/09031936.00034807


  • Smith, J., Owen, E., Earis, J., & Woodcock, A. (2006). Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology, 117(4), 831-835. 10.1016/j.jaci.2005.09.055. Publication link: af43aa44-23bd-4080-9050-34e311d02cd2 | DOI:10.1016/j.jaci.2005.09.055
  • Smith, J., Smith, J. A., Owen, E. C., Jones, A. M., Dodd, M. E., Webb, A. K., & Woodcock, A. (2006). Objective measurement of cough during pulmonary exacerbations in adults with cystic fibrosis. Thorax, 61(5), 425-429. 10.1136/thx.2005.050963. Publication link: c15b7274-aada-4554-8ca0-bc7eefd21d18 | DOI:10.1136/thx.2005.050963
  • Smith, J. A. (2006). Cough frequency and patterns of cough in cystic fibrosis. Journal of the Royal Society of Medicine, Supplement, 99(46), 17-22.. Publication link: 424da8c8-f649-4d41-8c0c-295a07009ed4
  • Smith, J., Owen, E., Earis, J., & Woodcock, A. (2006). Cough in COPD: Correlation of objective monitoring with cough challenge and subjective assessments. Chest, 130(2), 379-385. 10.1378/chest.130.2.379. Publication link: a7be97af-91a1-4e06-934b-7e5fe4660c60 | DOI:10.1378/chest.130.2.379
  • Smith, J. A., Borrill, Z., Naylor, J., Woodcock, A., & Singh, S. D. (2006). The effect of gas standardisation on exhaled breath condensate pH.Eur Respir J, 28(1), 251-252.. Publication link: 34e79c80-3d1d-4a4c-841c-85d5e984c4e7
  • Smith, J., & Woodcock, A. (2006). Cough and its importance in COPD.International Journal of COPD, 1(3), 305-314. 10.2147/copd.2006.1.3.305. Publication link: 6248bc6e-1e1f-40a6-9cdb-2eec9f42d610 | DOI:10.2147/copd.2006.1.3.305
  • Smith, J. A., Earis, J., & Woodcock, A. (2006). Establishing a gold standard for manual cough counting: video versus digital audio recordings.Cough, 2(6).. Publication link: 9f280213-5455-4512-8220-3e2d50e9ad0b
  • Smith, J. A., Ashurst, H., Jack, S., Woodcock, A. A., & Earis, J. (2006). The description of cough sounds by healthcare professionals.Cough, 2(1).. Publication link: f3e89842-eb68-4e9f-8072-b21ed2e0d8aa


  • Smith, J. A. (2005). Analysis of the Cough Sound. In Acute and Chronic Cough, Lung Biology in Health and Disease Series. (Vol. 205). Taylor & Francis.. Publication link: bab1b9a8-3386-4a10-ae8d-765aa6fe1b69