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Professor Jacky Smith (MB, ChB, MRCP, PhD) - research

Research interests

Research interests include:

  • Measurement of cough and the cough reflex
  • The role of gastro-oesophageal reflux in chronic cough
  • Mechanisms of sensitisation of the cough reflex
  • Testing of novel anti-tussive agents

Collaborators and affiliated staff

Affiliated Staff

Clinical Team

  • Ms Danielle Yuill (Research Project Co-ordinator)
  • Dr Angela Kelsall (Post doctoral Pulmonary Physiologist)
  • Dr Imran Satia (Clinical Fellow)
  • Dr Huda Badri (Clinical Fellow)
  • Dr Amelie Harle (NIHR Clinical Research Fellow)
  • Ms Kimberly Holt (Research Assistant)
  • Ms Rachel Dockry (Research Assisstant)
  • Dr Demi Valdramidou (Research Associate)
  • Dr Basma Issa (Research Associate)
  • Ms Carmen Gibbard (Research Assisstant)
  • Ms Kitty Ahern (Research Technician)
  • Mrs Shilpi Sen (Research Technician)

Laboratory Team

  • Dr Peter West (Research Associate)

Engineering Team

  • Dr Kevin McGuinness (Senior Clinical Engineer)
  • Mr Zbigniew Koziel (Research Assistant)

Academic Collaborators

  • Prof Lesley Houghton, Mayo Clinic, Florida, US
  • Prof Maria Belvisi, National Heart and Lung Institute, Imperial College, London
  • Dr Brendan Canning, Johns Hopkins Medical Institutions, Balitmore, Maryland
  • Prof Doug Corfield, University of Manchester
  • Mr Andy Camilleri, ENT Surgery, UHSM
  • Mr Simon Galloway, GI Surgery, UHSM
  • Professor Peter Calverley and Dr John Earis, University Hospital Aintree, University of Liverpool
  • Professor Neil Thomson, Division of Immunology, Infection & Inflammation, University of Glasgow
  • Prof Jeff Pearson and Dr Chris Ward, School of Clinical Medical Sciences, Newcastle University
  • Dr Andrea Aliverti, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy

Methodological knowledge

Clinical research skills: bronchial challenge testing, cough reflex sensitivity testing, pulmonary function testing, exhaled nitric oxide measurement, sputum induction, endo-bronchial biopsy, brushing and lavage, optico-electronic plethysmography, intra-oesophageal and gastric balloon pressure measurements

Clinical trials experience: design, applying for ethical approval, patient recruitment, data collection and analysis, including clinical trials of investigational medicinal products for the treatment of cough.

Statistics and data analysis skills: I have an interest in advanced statistical techniques such as factor analysis, cluster analysis and recently structural equation modelling.

Signal Processing Skills: I have a basic understanding of acoustic signal processing and speech recognition techniques from a close collaboration with computer scientists and engineers