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Dr Kevin Couper (PhD) - publications

List of publications


  • Besnard, A-G., Guabiraba, R., Niedbala, W., Palomo, J., Reverchon, F., Shaw, T. N., ... Liew, F. Y. (2015). IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.PLoS pathogens, 11(2). DOI:10.1371/journal.ppat.1004607. Publication link: 37af76b2-9a3d-4289-a613-afaad5dc2fa1 | PubMed:25659095
  • Shaw, T. N., Stewart-Hutchinson, P. J., Strangward, P., Dandamudi, D. B., Coles, J. A., Villegas-Mendez, A., ... Dustin, M. L. (2015). Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.PLoS pathogens, 11(11). DOI:10.1371/journal.ppat.1005210. Publication link: 83db700b-6701-4ba2-b9ae-c46a65601a10 | PubMed:26562533
  • Villegas-Mendez, A., Shaw, T. N., Inkson, C. A., Strangward, P., de Souza, J. B., & Couper, K. N. (2015). Parasite-specific CD4+IFN-γ+IL-10+ T cells distribute within both lymphoid and non-lymphoid compartments and are controlled systemically by IL-27 and ICOS during blood-stage malaria infection.Infection and immunity. DOI:10.1128/IAI.01100-15. Publication link: 968d4936-f11d-424c-91b9-a6dc81de737e | PubMed:26459508


  • Findlay, E. G., Villegas-Mendez, A., O'Regan, N., Brian de Souza, J., Grady, L. M., Saris, C. J., ... Couper, K. N. (2014). IL-27 receptor signaling regulates memory CD4+ t cell populations and suppresses rapid inflammatory responses during secondary malaria infection. Infection and Immunity, 82(1), 10-20. DOI:10.1128/IAI.01091-13. Publication link: 85c829bb-5d86-4198-86c9-ccc43c835df4 | PubMed:24101691
  • Lin, J-W., Shaw, T. N., Annoura, T., Fougère, A., Bouchier, P., Chevalley-Maurel, S., ... Khan, S. M. (2014). The subcellular location of ovalbumin in Plasmodium berghei blood stages influences the magnitude of T-cell responses.Infection and immunity, 82(11). DOI:10.1128/IAI.01940-14. Publication link: b48bae3e-e5f0-46c4-849a-28057d85c12f | PubMed:25156724


  • Villegas-Mendez, A., de Souza, J. B., Lavelle, S. W., Gwyer Findlay, E., Shaw, T. N., van Rooijen, N., ... Couper, K. N. (2013). IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals. PLoS pathogens, 9(4), [e1003293]. DOI:10.1371/journal.ppat.1003293. Publication link: 785232d8-1be5-40e1-8b81-58827de02b8d
  • Villegas-Mendez, A., Findlay, E. G., De Souza, J. B., Grady, L. M., Saris, C. J., Lane, T. E., ... Couper, K. N. (2013). WSX-1 signalling inhibits CD4+ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways. PLoS ONE, 8(11), [e78486]. DOI:10.1371/journal.pone.0078486. Publication link: 0805c010-093b-40d3-8986-d1124cf4b69b | PubMed:24244314
  • Findlay, E. G., Villegas-Mendez, A., De Souza, B. J., Inkson, C. A., Shaw, T. N., Saris, C. J., ... Couper, K. N. (2013). IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection. Journal of Immunology, 190(9), 4553-4561. DOI:10.4049/jimmunol.1202916. Publication link: bea5c017-b82e-4ed8-8bfb-8b46f58e3f15 | PubMed:23536628


  • Villegas-Mendez, A., Greig, R., Shaw, T. N., De Souza, J. B., Findlay, E. G., Stumhofer, J. S., ... Couper, K. N. (2012). IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. Journal of Immunology, 189(2), 968-979. DOI:10.4049/jimmunol.1200688. Publication link: 72bb5a3a-4e63-498c-94aa-87d2316aaa62
  • Hafalla, J. C. R., Claser, C., Couper, K. N., Grau, G. E., Renia, L., de Souza, J. B., & Riley, E. M. (2012). The CTLA-4 and PD-1/PD-l1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS pathogens, 8(2), [e1002504]. DOI:10.1371/journal.ppat.1002504. Publication link: 95a0cd69-3cf8-4fad-a07b-1599f4db47b2 | PubMed:22319445


  • Villegas-Mendez, A., De Souza, J. B., Murungi, L., Hafalla, J. C. R., Shaw, T. N., Greig, R., ... Couper, K. N. (2011). Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-γ during Plasmodium berghei ANKA infection. Journal of Immunology, 187(6), 2885-2897. DOI:10.4049/jimmunol.1100241. Publication link: d69d6ec6-bd2b-4651-b1ac-a3e1030690a3 | PubMed:21880980


  • Couper, K. N., Barnes, T., Hafalla, J. C. R., Combes, V., Ryffel, B., Secher, T., ... De Souza, J. B. (2010). Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. PLoS pathogens, 6(1), [e1000744]. DOI:10.1371/journal.ppat.1000744. Publication link: 4c70e770-cb94-4ed9-b6c0-1c6750271f1b | PubMed:20126448
  • Findlay, E. G., Greig, R., Stumhofer, J. S., Hafalla, J. C. R., De Souza, J. B., Saris, C. J., ... Couper, K. N. (2010). Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection. Journal of Immunology, 185(4), 2482-2492. DOI:10.4049/jimmunol.0904019. Publication link: 85df1574-6254-40a9-9cbe-3e94826faa02 | PubMed:20631310
  • Brian De Souza, J., Hafalla, J. C. R., Riley, E. M., & Couper, K. N. (2010). Cerebral malaria: Why experimental murine models are required to understand the pathogenesis of disease. Parasitology, 137(5), 755-772. DOI:10.1017/S0031182009991715. Publication link: 5e1b9bcb-e602-4113-a13b-f746f78c59d8 | PubMed:20028608
  • Riley, E. M., Couper, K. N., Helmby, H., Hafalla, J. C. R., Souza, J. B. D., Langhorne, J., ... Zavala, F. (2010). Neuropathogenesis of human and murine malaria. Trends in Parasitology, 26(6), 277-278. DOI:10.1016/ Publication link: 8b6907cd-fb04-4980-8bcc-0ea2ea806c35
  • De Souza, J. B., Runglall, M., Corran, P. H., Okell, L. C., Kumar, S., Gowda, D. C., ... Riley, E. M. (2010). Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals. Infection and Immunity, 78(9), 3920-3929. DOI:10.1128/IAI.00359-10. Publication link: a1380915-efe4-49ae-a5e1-dcd67c89191c | PubMed:20566691


  • Couper, K. N., Lanthier, P. A., Perona-Wright, G., Kummer, L. W., Chen, W., Smiley, S. T., ... Johnson, L. L. (2009). Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic toxoplasma gondii infection. Journal of Immunology, 182(7), 3985-3994. DOI:10.4049/jimmunol.0803053. Publication link: 28b4b601-551b-403f-a8f3-12902c36d2cf | PubMed:19299696


  • Couper, K. N., Blount, D. G., Wilson, M. S., Hafalla, J. C., Belkaid, Y., Kamanaka, M., ... Riley, E. M. (2008). IL-10 from CD4+CD25-Foxp3-CD127 - adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS pathogens, 4(2). DOI:10.1371/journal.ppat.1000004. Publication link: 7c57b298-42b6-443c-9a8a-db4b8b47ad96 | PubMed:18401464
  • Couper, K. N., Blount, D. G., & Riley, E. M. (2008). IL-10: The master regulator of immunity to infection. Journal of Immunology, 180(9), 5771-5777. . Publication link: eb59990c-ddbf-419d-a058-7e741e861dfd | PubMed:18424693


  • Couper, K. N., Blount, D. G., Hafalla, J. C. R., Van Rooijen, N., De Souza, J. B., & Riley, E. M. (2007). Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia. Infection and Immunity, 75(12), 5806-5818. DOI:10.1128/IAI.01005-07. Publication link: cd7aac2f-1f6a-48e9-86b0-39d460319f7a | PubMed:17923512
  • Couper, K. N., Blount, D. G., De Souza, J. B., Suffia, I., Belkaid, Y., & Riley, E. M. (2007). Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. Journal of Immunology, 178(7), 4136-4146. . Publication link: bcbac095-26a4-4f50-b27d-0a25fb7d4849 | PubMed:17371969



  • Couper, K. N., Nielsen, H. V., Petersen, E., Roberts, F., Roberts, C. W., & Alexander, J. (2003). DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission. Vaccine, 21(21-22), 2813-2820. DOI:10.1016/S0264-410X(03)00163-4. Publication link: 2ebf21af-4199-4d32-971a-756810740f44 | PubMed:12798622