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Dr Mark Ashe (BSc, DPhil) - personal details

Contact details

Dr Mark Ashe

Role: Reader

Tel: +44161 306 4164

Location: Faculty of Life Sciences,A2029 Michael Smith Building, Oxford Road, Manchester, M13 9PT




Mark Ashe was brought up in Cannock, Staffordshire where he attended Cardinal Griffin Comprehensive School. He obtained a first class honours degree in Biochemistry from Liverpool University and Professor Nick Proudfoot gave him the opportunity to perform his doctoral studies at Oxford University working on RNA processing.  Mark obtained his DPhil in 1995 and continued his work with Prof. Proudfoot as a post-doctoral research scientist until 1997. The single most important factor in Mark's decision to pursue a career in academic science was the mentoring and support he received from Prof Proudfoot and other lab members during this period.  Mark published four papers from his time in the Proudfoot lab, which enabled him to successfully apply for an EMBO long term fellowship to work with Professor Alan Sachs at the University of California, Berkeley.  

Here he worked on protein synthesis and RNA stability in yeast.  He also developed an interest in various stress responses and how these impact upon the post-transcriptional control of gene expression: an interest that remains to this day. In 2000, Mark moved to Manchester to take up a University Lectureship; he was promoted to Senior Lecturer in 2006 and Reader in 2011.

Mark's research group have been funded by The Wellcome Trust, the BBSRC and the Leverhulme Trust.  He has focussed on understanding mechanisms of post-transcriptional control and  this has led towards a more defined interest in the localisation and dynamics of mRNAs and translation initiation factors. More recently, Mark has applied his knowledge of gene expression and stress tolerance to synthetic biology approaches with a view to the production of biofuels and commodity chemicals in yeast. Mark has co-organised several national conferences and he serves on the editorial board of Molecular Biology of the Cell.