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Dr Mark Ashe (BSc, DPhil) - personal details

Contact details

Dr Mark Ashe

Role: Reader

Tel: +44161 306 4164

Location: Faculty of Life Sciences,A2029 Michael Smith Building, Oxford Road, Manchester, M13 9PT




Mark Ashe was brought up in Cannock, Staffordshire where he attended Cardinal Griffin Comprehensive School. He obtained a first class honours degree in Biochemistry from Liverpool University, and decided at this point that he most enjoyed the practical side of the subject.  Hence, he started to apply for PhD positions.  Professor Nick Proudfoot gave him the opportunity to perform his doctoral studies at Oxford University working on RNA processing.  Mark obtained his DPhil in 1995 and continued his work with Prof. Proudfoot as a post-doctoral research scientist until 1997. The single most important factor in Mark's decision to pursue a career in academic science was the mentoring and support he received from Prof Proudfoot and other lab members during this period.  Mark published four papers from his time in the Proudfoot lab, which enabled him to successfully apply for an EMBO long term fellowship to work with Professor Alan Sachs at the University of California, Berkeley.  Here he worked on protein synthesis and RNA stability in yeast.  He also developed an interest in various stress responses and how these impact upon the post-transcriptional control of gene expression.  This interest remains to this day and in 2000, Mark moved to Manchester to take up a University Lectureship within the Biomolecular Sciences Department at UMIST. Following the 2004 merger of UMIST and the Victoria University of Manchester, Mark joined the new Faculty of Life Sciences, where he was promoted to Senior Lecturer in 2006 and Reader in 2011.

Mark's research group have been funded by The Wellcome Trust, the BBSRC and the Leverhulme Trust.  He has focussed on understanding mechanisms of post-transcriptional control and more recently this has led towards a more defined interest in the localisation and dynamics of mRNAs and translation initiation factors. Mark has co-organised several national conferences and he serves on the editorial board of the Journal of Biological Chemistry.