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Professor Carlo Berzuini (PhD) - personal details

Contact details

Professor Carlo Berzuini

Role: Professor of Biostatistics

Tel: +44 (0)161 276 7950

Location:

Centre of Biostatistics

Institute of Population Health

Jean McFarlane Building, Oxford Road

Manchester M13 9PL

Websites

 

Biography

I got the secondary studies Diploma from the Liceo Scientifico "Giovio", Como, Italy, with top grades (60/60).

The Collegio Ghislieri of Pavia - founded in 1567 to open the doors of «ingenium» to young students with limited financial resources - fully supported my undergraduate and MSc studies, completed in 1974 with a «cum laude» degree in bioengineering. I started studying statistics and promoting it in an academic environment where the need for a proper methodological foundation of data analysis was not given for granted. The University of Pavia employed me for 34 years (24 with a professorial appointment) in which I did research and enthusiastically taught biostatistics to undergraduates and MSc/PhD students from mathematical, engineering and medical faculties, locally and internationally.

During second half of the 80s, the start of my collaboration with Cambridge statisticians opened my work to international recognition, and marked the beginning of an exciting period of research. During this period I became responsible of advances in bayesian modelling and computation whose scientific implications have become clearer ever since.  My british link grew stronger and stronger. Between 2001 and 2007 I was a visitor at Cambridge's Medical Research Council Biostatistics Unit, with capacity of principal investigator in a european project. There I formed a group of statisticians, geneticists and bioinformaticians as a model of future interdisciplinary research.

Following an invitation to work in the Statistics Department of the University of Cambridge, in 2008,  I packed my bags and waved good-bye to italian academia. Working in the new environment made me smaller, but younger, and set me back to the real height of being a researcher. Support and inspiration by scientists like Philip Dawid and David Cox propelled my work in causal inference and statistical prediction.

In Cambridge I was the lead editor of the landmark book "Causality: Statistical Perspectives and Applications" (Wiley, 2012), one of the first attempts to provide a wide-angle view of causal inference, and its scientific implications. And now ... Manchester ... a place which might witness modern statistical methodology teaming up with the scientific muscle of a thriving medical research community. Success of this marriage will depend on scientific insight at leastas much as on managerial ability. In Manchester I lead a small group of young biostatisticians involved in such research themes as causal inference from longitudinal data, joint modelling of biomarker and time-to-event data and gene-disease causality. Our research is strongly motivated by the scientific questions that emerge from medical research.

Qualifications

2014: invited talk on "Biomarker based early ptediction of pre-clinical cancer", InterOmics Annual Meeting, September 23-26, 2014, Rome.

2014: invited talk on "Causal Mediation and Mechanistic Interaction Analysis, with applications in Genomic Medicine", UNAM/ITAM Universities, Mexico DF, Mexico, 30th of July, 2014.

2014: invited talk on "Causal Inference methods to probe the molecular mechanisms of disease", International Conference on "Bringing Maths to Life", 27-29 october 2014 , Centro Congressi Federico II, Napoli, Italy

2014: one-week Course on "Causality in Health Sciences",  Department of Brain and  Behavioural Sciences, University of Pavia, Italy,  26-30 may 2014 

2014: invited talk on "Mechanistic interaction and other causal inference tools, with an application in the investigation of molecular mechanisms in Multiple Sclerosis". one-dayorkshop on "The Statistical Contributions of A. Philip Dawid: Causal Inference, Graphical Models and Prediction", Wednesday 30th
April 2014, Centre for Mathematical Sciences of the University of Cambridge

2014: invited lecturer on the topic of “Causality in Genomics” at the International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB2014), Cambridge 26-28 June 2014.  

2013: invited discussant at the International Workshop on "Recent Advances in Statistical Inference: Theory and Case Studies", University of Padova, Italy, march 21–23, 2013.

2012; Vote Seconder and Discussant at the Read Paper on by Imai et al., Royal Statistical Society, London

2012: Isaac Newton Institute of Mathematics, Cambridge: ... (video)

2011 Invited Lecture on "Mechanistic Interaction", International Workshop "Causal Inference in the Health Sciences", University of Bologna, May 27-28.

2010 Invited talk : ”Causal Inference in Genetic Epidemiology”, Leiden University Medical Center. Department of Medical Statistics and Bioinformatics. 21 september.

2010 Invited Discussant. Ninth Valencia International Meeting on Bayesian Statistics, Benidorm (Alicante, Spain). June 2010. Discussant of the paper ”Incorporating Biological Information in Bayesian Models for the Selection of Pathways and Genes”, by Vannucci and Stingo.

2010 Invited Lecture at the Workshop on ”Epidemiology, Risk and Genomics”, organized by the Department of History and Biomedical Science in Society, University of Cambridge. January 2010.

2009 Invited lecture on "The investigation of genetic patterns of coronary artery disease within a predictive and a causal perspective", Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge. Monday 11 May 2009, 16:30-17:30

March 2009 Invited talk : ”Identifiability of Sequential Action Plans”. International Meeting on ”Causal Inference : the State of the Art”, Cambridge.

2008 Invited talk : ”Development and Prequential Validation of a genome wide predictor of disease occurrence : a Sequential Monte Carlo approach”. XXIVth International Biometric Conference, July 13-18t, 2008, Dublin.

 

RECENT AWARDS:

2012: recipient of an award from the Isaac Newton Trust for research in statistical methods for causal inference at the Centre for Mathematical Science of Cambridge University

2009-2012: awarded MRC Research Grant G0802320, for methodological research on "Genetic Variation, Disease Prediction and Causation"

Role

 

  • 2014: co-winner of a HORIZON 2020 European Commission Grant for the development of new early cancer diagnostics
  • since 2012:   Visiting Professor, Statistical Laboratory, Centre for Mathematical  Sciences, University of Cambridge,  UK
  • since 2012:   Visiting Professor, Department of Brain and Behavioural Sciences, University of Pavia, Italy
  • 2013-:            Master Course in Medical and Genomic Statistics, University of Pavia, Italy; teacher and Faculty member
  • since 2012:  University of Manchester, Professor of Biostatistics
  • since 2012:   Principal Investigator of  european research collaboration in Methods of Causal Inference for genomic epidemiology, within the MIMOmics Project, supported by the European Community under the FP7-HEALTH-2012-INNOVATION scheme
  • since 2013 :   Statistical Reviewer for Translational Research applications to Cancer Research UK
  • since 2013 :   involved in the creation and organization of a MSc in Biostatistics of the Faculty of Medical and Human Sciences of the University of Manchester.
  • (2007 - 2013)      Royal Statistical Society Study Group in Bioinformatics, proponent and chair
  • (2010-2012)   Master Course in Genetic and Molecular Epidemiology, University of Pavia, Pavia, Italy; teacher and Faculty member
  • (2001-2008) Visiting Professor, and Research Associate with Core Honorarium and Project Leader capacity, at the Biostatistics Unit of the Medical Research Council, Cambridge, United Kingdom (2006 MRC Biostatistics Unit QQR Review Committee Report)

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