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Dr Robert Clarke (PhD) - publications

List of publications

2016

  • Harvie, M., Sims, A., Pegington, M., Spence, K., Mitchell, A., Vaughan, A. A., ... Howell, A. (2016). Intermittent energy restriction induces changes in breast gene expression and systemic metabolism. Breast Cancer Research. . Publication link: bc215581-3d0c-4b7e-9a42-15bdba143cd4
  • Giordano, C., Chemi, F., Panza, S., Bonofiglio, D., Lanzino, M., Cordella, A., ... Andò, S. (2016). Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.Oncotarget, 7(2), 1262-1275. DOI:10.18632/oncotarget.6014. Publication link: 4b8d0538-3639-4abe-bafb-3b57a2a31c6c | PubMed:26556856
  • Smit, L., Berns, K., Spence, K., Ryder, W. D., Zeps, N., Madiredjo, M., ... Clarke, R. B. (2016). An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation. Oncotarget, 7(3), 2596-2610. . Publication link: 74941b21-5ac0-447a-a02f-3b2bec62fe89
  • Yu, L., Fan, Z., Fang, S., Yang, J., Gao, T., Simões, B. M., ... Clarke, R. B. (2016). Cisplatin selects for stem-like cells in osteosarcoma by activating notch signaling. Oncotarget. DOI:10.18632/oncotarget.8849. Publication link: 86abb69b-1131-4f61-bb3a-1f122b37d523 | PubMed:27102300
  • Aires, A., Ocampo, S. M., Simões, B. M., Josefa Rodríguez, M., Couleaud, P., Spence, K., ... Cortajarena, A. L. (2016). Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.Nanotechnology, 27(6), 065103. DOI:10.1088/0957-4484/27/6/065103. Publication link: 9ffd9bbb-88fe-40fc-93e1-e50cdc4fe149 | PubMed:26754042

2015

  • M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., ... Clarke, R. B. (2015). Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.Cell Reports, 12(12), 1968-1977. DOI:10.1016/j.celrep.2015.08.050. Publication link: 4c96d908-cc5d-413c-98fa-489038ba57a3 | PubMed:26387946
  • Simões, B. M., Alferez, D., Howell, S., & Clarke, R. (2015). The role of steroid hormones in breast cancer stem cells. Endocrine-related cancer, 22 (6):T177-86(6), 177-186. [ERC-15-0350]. DOI:10.1530/ERC-15-0350. Publication link: 56b51916-f47e-4c64-9f03-b1d6f0633d97 | PubMed:26381288
  • Lamb, R., Fiorillo, M., Chadwick, A., Ozsvari, B., Reeves, K. J., Smith, D., ... Lisanti, M. (2015). Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.Oncotarget, 6(16), 14005-1425. DOI:10.18632/oncotarget.4159. Publication link: 8e11e623-b715-469c-a88e-852996a43505 | PubMed:26087309
  • Williams, K. E., Bundred, N. J., Landberg, G., Clarke, R., & Farnie, G. (2015). Focal Adhesion Kinase and Wnt Signaling Regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells (Durham), 33(2), 327-341. DOI:10.1002/stem.1843.. Publication link: d6abc945-9da3-4e79-994e-1e50c8d59ffd

2014

  • Hidalgo, M., Amant, F., Biankin, A. V., Budinská, E., Byrne, A. T., Caldas, C., ... Villanueva, A. (2014). Patient Derived Xenograft Models: An Emerging Platform For Translational Cancer Research. Cancer Discovery, 4(9), 998-1013. DOI:10.1158/2159-8290.CD-14-0001. Publication link: dfa1c299-c5b8-40d2-af0a-85adc181cfdc
  • Howell, A., Anderson, A. S., Clarke, R., Duffy, S. W., Evans, G., Garcia-Closas, M., ... Harvie, M. (2014). Risk Determination and Prevention of Breast Cancer. Breast Cancer Research (Print), 16(5), 446. DOI:10.1186/s13058-014-0446-2. Publication link: 639310e8-4aea-4427-b3fe-369f78beaa8e | PubMed:25467785
  • Lamb, R., Lisanti, M. P., Clarke, R. B., & Landberg, G. (2014). Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer. Oncotarget, 5(17), 7833-7842. . Publication link: 6c524989-dc3e-4cc5-9bdb-330dc4a9576c
  • Vieira, A. F., Ribeiro, A. S., Dionísio, M. R., Sousa, B., Nobre, R., Albergaria, A., ... Paredes, J. (2014). P-cadherin intracellular signalling is dependent on α6β4 integrin activation inducing stem cell and invasive properties in human breast cancer cells. Oncotarget, 5(3), 679-692. . Publication link: 5491a930-eee0-4866-bd3f-c1e4296e1242
  • Wright, P. K., Jones, S. B., Ardern, N., Ward, R., Clarke, R. B., Sotgia, F., ... Lamb, R. (2014). 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells.Oncotarget, 5(10), 3055-3065. . Publication link: 4deaf6a9-0099-4858-87ca-ba1be3fde65f | PubMed:24931391
  • Ablett, M. P., O'Brien, C. S., Sims, A. H., Farnie, G., & Clarke, R. B. (2014). A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget, 5(3), 599-612. . Publication link: 32ac69a1-91f0-4a39-a46f-695b0f2c8f82
  • Farnie, G., Johnson, R. L., Williams, K. E., Clarke, R. B., Johnson, R. L., Williams, K. E., ... Bundred, N. J. (2014). Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).Cell Cycle, 13(3), 418-425. DOI:10.4161/cc.27201. Publication link: 3c8af09d-4164-422c-9230-be08e085c931
  • Howell, S. J., Alferez, D., Spence, K., Eyre, R., Shaw, F., Simões, B. M., ... Clarke, R. (2014). Breast cancer stem-like cell activity correlates with tumour progression to metastasis but not with clinical or tumour characteristics. Poster session presented at San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, .. Publication link: 1e980b94-155f-4e57-91ab-5595ada85d93

2013

  • Yu, L., Liu, S., Zhang, C., Zhang, B., Simões, B. M., Eyre, R., ... Clarke, R. (2013). Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity. Oncotarget, 4(12), 2326-2338. . Publication link: 147e3b6c-53ce-4676-9c37-c42e80a04971 | PubMed:24334332
  • Lamb, R., Ablett, M. P., Spence, K., Landberg, G., Sims, A. H., & Clarke, R. B. (2013). Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells. PLoS ONE, 8(7), [e67811]. DOI:10.1371/journal.pone.0067811. Publication link: 33a82c9e-0e42-4466-aef1-69543aa7495d | PubMed:23861811
  • McClements, L., Yakkundi, A., Papaspyropoulos, A., Harrison, H., Ablett, M. P., Jithesh, P. V., ... Robson, T. (2013). Targeting treatment-resistant breast cancer stem cells with FKBPL and Its peptide derivative, AD-01, via the CD44 pathway. Clinical Cancer Research, 19(14), 3881-3893. DOI:10.1158/1078-0432.CCR-13-0595. Publication link: 5300e7ab-78ff-4023-b08b-5e265f04d8d1
  • Lamb, R., Lehn, S., Rogerson, L., Clarke, R. B., Landberg, G., & Hodgson, L. (2013). Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.Cell cycle (Georgetown, Tex.), 12(15), 2384-2394. DOI:10.4161/cc.25403. Publication link: 4b545cc4-4da6-40fc-9678-03bef05e7563 | PubMed:23839043
  • Singh, J. K., Simões, B. M., Howell, S. J., Farnie, G., & Clarke, R. (2013). Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells. Breast Cancer Research, 15(4), [210]. DOI:10.1186/bcr3436. Publication link: 4813b204-9c62-4d17-abfd-1a20e77aa4a7 | PubMed:24041156
  • Singh, J., Simões, B. M., Howell, S., Farnie, G., & Clarke, R. B. (2013). Recent Advances Reveal IL-8 Signalling as a Potential Key to Targeting Breast Cancer Stem Cells. Breast Cancer Research, 15, 210. DOI:10.1186/bcr3436. Publication link: 831562ca-3eb3-4301-913c-f4833db3cb15
  • Farnie, G., Willan, P. M., Clarke, R. B., & Bundred, N. J. (2013). Combined Inhibition of ErbB1/2 and Notch Receptors Effectively Targets Breast Ductal Carcinoma In Situ (DCIS) Stem/Progenitor Cell Activity Regardless of ErbB2 Status. PLoS ONE, 8(2), [e56840]. DOI:10.1371/journal.pone.0056840. Publication link: 891b726c-dffb-4304-8633-d088b745b89a
  • Singh, J. K., Simões, B. M., Clarke, R. B., & Bundred, N. J. (2013). Targeting IL-8 signalling to inhibit breast cancer stem cell activity. Expert Opinion on Therapeutic Targets, 17(11), 1235-1241. DOI:10.1517/14728222.2013.835398. Publication link: 9dcf4e58-929b-49a0-b5f6-7000f757e1ae
  • Eccles, S. A., Aboagye, E. O., Ali, S., Anderson, A. S., Armes, J., Berditchevski, F., ... Thompson, A. M. (2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15(5), [R92]. DOI:10.1186/bcr3493. Publication link: 73696075-0c5f-47ea-8b4c-76294cf57f07 | PubMed:24286369
  • Brennan, K., & Clarke, R. B. (2013). Combining Notch inhibition with current therapies for breast cancer treatment. Therapeutic Advances in Medical Oncology, 5(1), 17-24. DOI:10.1177/1758834012457437. Publication link: 60ee8b2f-5e03-4eab-a007-5a25977a110f | PubMed:23323144
  • Harrison, H., Rogerson, L., Gregson, H. J., Brennan, K. R., Clarke, R., & Landberg, G. (2013). Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status. Cancer Research, 73(4), 1420-1433. DOI:10.1158/0008-5472.CAN-12-2505. Publication link: 582ab543-d4f1-40c1-aed2-4bed1d59383b | PubMed:23248117
  • Singh, J. K., Farnie, G., Bundred, N. J., Simões, B. M., Shergill, A., Landberg, G., ... Clarke, R. B. (2013). Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.Clinical cancer research : an official journal of the American Association for Cancer Research, 19(3), 643-656. DOI:10.1158/1078-0432.CCR-12-1063. Publication link: ef655c4f-25fa-40eb-84d2-2c2755c681c9 | PubMed:23149820
  • Harrison, H., Simões, B. M., Rogerson, L., Howell, S. J., Landberg, G., & Clarke, R. B. (2013). Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Research, 15(2), [R21]. DOI:10.1186/bcr3396. Publication link: b067ff7b-f20b-4058-8bdc-017bf10ae981 | PubMed:23497505
  • Clarke, R. B., Stingl, J., Vivanco, M., & Bentires-Alj, M. (2013). "The charmingest place": Non-coding RNA, lineage tracing, tumour heterogeneity, metastasis and metabolism - new methods in mammary gland development and cancer: the fifth ENBDC Workshop. Breast Cancer Research, 515(5), 313. . Publication link: bb56dc6a-d0a0-4ccb-958c-91cc7b404217

2012

  • Vieira, A. F., Ricardo, S., Ablett, M. P., Dionísio, M. R., Mendes, N., Albergaria, A., ... Paredes, J. (2012). P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer. Stem Cells, 30(5), 854-864. DOI:10.1002/stem.1075. Publication link: 938d2449-f580-48be-987d-0d261c54731d
  • Ferraldeschi, R., Latif, A., Clarke, R. B., Spence, K., Ashton, G., O'Sullivan, J., ... Newman, W. G. (2012). Lack of caveolin-1 (P132L) somatic mutations in breast cancer. Breast Cancer Research and Treatment, 132(3), 1185-1186. DOI:10.1007/s10549-012-1981-0. Publication link: 61ede9d9-5540-4ffe-8aff-88ca5fa42e8e | PubMed:22310961
  • Shaw, F. L., Harrison, H., Spence, K., Ablett, M. P., Simões, B. M., Farnie, G., & Clarke, R. B. (2012). A detailed mammosphere assay protocol for the quantification of breast stem cell activity. Journal of Mammary Gland Biology and Neoplasia, 17(2), 111-117. DOI:10.1007/s10911-012-9255-3. Publication link: 551eb06c-bd73-41ea-a34b-77ec99cabfd4 | PubMed:22665270
  • Ablett, M. P., Singh, J. K., & Clarke, R. B. (2012). Stem cells in breast tumours: Are they ready for the clinic?. European Journal of Cancer, 48(14), 2104-2116. DOI:10.1016/j.ejca.2012.03.019. Publication link: d67aa3c7-779d-4ff7-8b2d-7b9325e1f3cf

2011

  • Agur, Z., Kirnasovsky, O. U., Vasserman, G., Tencer-Hershkowicz, L., Kogan, Y., Harrison, H., ... Clarke, R. B. (2011). Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: An experimentally supported mathematical model. PLoS ONE, 6(9), [e24225]. DOI:10.1371/journal.pone.0024225. Publication link: 9807c89b-8085-49b4-bf92-a5939e4066e7 | PubMed:21915302
  • Thompson, A. M., Johnson, A., Quinlan, P., Hillman, G., Fontecha, M., Bray, S. E., ... Newman, W. G. (2011). Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy. Breast Cancer Research and Treatment, 125(1), 279-287. DOI:10.1007/s10549-010-1139-x. Publication link: 8795234d-6ed3-4c11-add7-7c7516d321c0 | PubMed:20809362
  • O'Brien, C., Howell, S., Farnie, G., & Clarke, R. (2011). Resistance to Endocrine Therapy in Breast Cancer: Are Breast Cancer Stem Cells Implicated?: Ciara S. O’Brien, Sacha J. Howell, Gillian Farnie and Robert B. Clarke. In Stem Cell Biology and Regenerative Medicine: Cancer Stem Cells in Solid Cancers. (pp. 381-402). Springer Science+Business Media. . Publication link: 23c62793-e193-4ae1-b6e8-a5d7595aee2e

2010

  • Agur, Z., Kogan, Y., Levi, L., Harrison, H., Lamb, R., Kirnasovsky, O. U., & Clarke, R. B. (2010). Disruption of a Quorum Sensing mechanism triggers tumorigenesis: A simple discrete model corroborated by experiments in mammary cancer stem cells. Biology Direct, 5, [20]. DOI:10.1186/1745-6150-5-20. Publication link: 5c045bb5-5e25-4310-b766-4a118fa87150 | PubMed:20406437
  • Harrison, H., Farnie, G., Brennan, K. R., & Clarke, R. B. (2010). Breast cancer stem cells: something out of notching?. Cancer Research, 70(22), 8973-8976. DOI:10.1158/0008-5472.CAN-10-1559. Publication link: 6095fb91-8fe3-4fca-898e-ec135c0750ec | PubMed:21045140
  • Harrison, H., Farnie, G., Howell, S. J., Rock, R. E., Stylianou, S., Brennan, K. R., ... Clarke, R. B. (2010). Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Research, 70(2), 709-718. DOI:10.1158/0008-5472.CAN-09-1681. Publication link: f40c35c7-fd19-49d0-866d-a60927566d8a | PubMed:20068161
  • Rieger, M. E., Sims, A. H., Coats, E. R., Clarke, R. B., & Briegel, K. J. (2010). The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Molecular and Cellular Biology, 30(17), 4267-4279. DOI:10.1128/MCB.01418-09. Publication link: cc2d2b58-2947-4820-a9d2-40439b7494a4

2009

  • Blance, R. N., Sims, A. H., Anderson, E., Howell, A., & Clarke, R. B. (2009). Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prevention Research, 2(3), 257-264. DOI:10.1158/1940-6207.CAPR-08-0161. Publication link: f175406f-cc13-49b6-a419-bf7984cbd9a9
  • O'Brien, C. S., Howell, S. J., Farnie, G., & Clarke, R. B. (2009). Resistance to endocrine therapy: Are breast cancer stem cells the culprits?. Journal of Mammary Gland Biology and Neoplasia, 14(1), 45-54. DOI:10.1007/s10911-009-9115-y. Publication link: f3d9a131-4553-42fc-88ce-7c9f992fb6f6 | PubMed:19252972
  • Bentires-Alj, M., Clarke, R. B., Jonkers, J., Smalley, M., & Stein, T. (2009). It's all in the details: methods in breast development and cancer. Breast Cancer Research, 11(4), 305. DOI:10.1186/bcr2346. Publication link: d54d77c9-2736-4e5c-b5ac-5fc0771ea9b3
  • Ong, K. R., Sims, A. H., Harvie, M., Chapman, M., Dunn, W. B., Broadhurst, D., ... Howell, A. (2009). Biomarkers of dietary energy restriction in women at increased risk of breast cancer. Cancer Prevention Research, 2(8), 720-731. DOI:10.1158/1940-6207.CAPR-09-0008. Publication link: adb1ba0f-2d58-442b-8d6e-998276243b18 | PubMed:19656771
  • Foster, F. M., Owens, T. W., Tanianis-Hughes, J., Clarke, R. B., Brennan, K., Bundred, N. J., & Streuli, C. H. (2009). Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer. Breast Cancer Research, 11(3), [R41]. DOI:10.1186/bcr2328. Publication link: 8bc02389-49d9-410a-bc2e-0d53e37f5120 | PubMed:19563669

2008

  • Rice, L., Waters, C. E., Eccles, J., Garside, H., Sommer, P., Kay, P., ... Ray, D. W. (2008). Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. Journal of Endocrinology, 198(3), 499-509. DOI:10.1677/JOE-08-0019. Publication link: 92e14224-3a0e-4a79-af70-01b602e6b544 | PubMed:18583474
  • Huu, N. S. N., Ryder, W. D. J., Zeps, N., Flasza, M., Chiu, M., Hanby, A. M., ... Baron, M. (2008). Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator. Journal of Pathology, 216(1), 93-102. DOI:10.1002/path.2385. Publication link: 0ed93e6b-97cc-436e-9ec0-bf868f4073d0
  • Howell, S. J., Anderson, E., Hunter, T., Farnie, G., & Clarke, R. B. (2008). Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.Breast cancer research : BCR, 10(4), [R68]. DOI:10.1186/bcr2129. Publication link: c411c044-97a8-454d-946f-bb16ec499d26 | PubMed:18681966

2007

  • Coppock, H. A., Gilham, D. E., Howell, A., & Clarke, R. (2007). Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis. Cell Proliferation, 40(5), 721-740. DOI:10.1111/j.1365-2184.2007.00463.x. Publication link: eee41e34-d490-40b2-9882-05a57c6c97a7
  • Farnie, G., Clarke, R. B., Spence, K., Pinnock, N., Brennan, K., Anderson, N. G., & Bundred, N. J. (2007). Novel cell culture technique for primary ductal carcinoma in situ: Role of notch and epidermal growth Factor Receptor Signaling Pathways. Journal of the National Cancer Institute, 99(8), 616-627. DOI:10.1093/jnci/djk133. Publication link: 1b1f960e-416b-4062-9ace-0abd24fba57d | PubMed:17440163
  • Howell, S., Sims, A. H., Howell, A., Howell, S. J., & Clarke, R. B. (2007). Origins of breast cancer subtypes and therapeutic implications. Nature Clinical Practice Oncology, 4(9), 516-525. DOI:10.1038/ncponc0908. Publication link: 2e50ae78-96c5-4863-ab65-16d6bd4cbc1f | PubMed:17728710
  • Farnie, G., & Clarke, R. B. (2007). Mammary stem cells and breast cancer - Role of notch signalling. Stem Cell Reviews, 3(2), 169-175. DOI:10.1007/s12015-007-0023-5. Publication link: a1031cd2-0392-4d2b-b2ba-0bfeb690b0c0
  • Sims, A. H., Finnon, P., Miller, C. J., Bouffler, S. D., Howell, A., Scott, D., & Clarke, R. B. (2007). TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer. International Journal of Radiation Biology, 83(6), 409-420. DOI:10.1080/09553000701317366. Publication link: 8f57f991-e8ff-40b9-abee-2afc4daefda0 | PubMed:17487680

2006

  • Bramley, M., Clarke, R., Howell, A., Evans, D. G. R., Armer, T., Baildam, A. D., & Anderson, E. (2006). Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations. British Journal of Cancer, 94(7), 1021-1028. DOI:10.1038/sj.bjc.6603042. Publication link: a32de9fd-edcf-4a25-9c54-71c06c139f70
  • Sims, A. H., Ong, K. R., Clarke, R. B., & Howell, A. (2006). High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: Is it ready for the clinic?. Breast Cancer Research, 8(5), [214]. DOI:10.1186/bcr1605. Publication link: 61aead8a-be7d-4903-9614-0ed0fa4fbe82
  • Kalirai, H., & Clarke, R. B. (2006). Human breast epithelial stem cells and their regulation. Journal of Pathology, 208(1), 7-16. DOI:10.1002/path.1881. Publication link: 7959c7b2-d61e-4700-a295-5b40bc766d53
  • Stylianou, S., Clarke, R. B., & Brennan, K. (2006). Aberrant activation of Notch signaling in human breast cancer. Cancer Research, 66(3), 1517-1525. DOI:10.1158/0008-5472.CAN-05-3054. Publication link: 097fa401-945c-42bd-b44c-25d84cc80c27
  • Wilson, C. L., Sims, A. H., Howell, A., Miller, C. J., & Clarke, R. B. (2006). Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue. Endocrine-Related Cancer, 13(2), 617-628. DOI:10.1677/erc.1.01165. Publication link: 173750a3-7e1f-4c86-9f42-3dbabdb70fe7 | PubMed:16728587
  • Wilson, G. R., Cramer, A., Welman, A., Knox, F., Swindell, R., Kawakatsu, H., ... Bundred, N. J. (2006). Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. British Journal of Cancer, 95(10), 1410-1414. DOI:10.1038/sj.bjc.6603444. Publication link: 3debb5a6-02bb-4733-8fb7-26647047519d
  • Flasza, M., Nguyen Huu, N. S., Mazaleyrat, S., Clémence, S., Villemant, C., Clarke, R., & Baron, M. (2006). Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. Molecular Membrane Biology, 23(3), 269-276. DOI:10.1080/09687860600665010. Publication link: 2fae4f21-c71d-4f26-899c-1776b2ea8f8d
  • Wärnberg, F., White, D., Anderson, E., Knox, F., Clarke, R. B., Morris, J., & Bundred, N. (2006). Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.Breast Cancer Res., 8(2). DOI:10.1186/bcr1395. Publication link: ee20341d-6e28-4297-a001-b7fb80299fa2

2005

2004

2003

2002

2001

  • McIntyre, I. G., Clarke, R., Anderson, E., Clarke, N., & George, N. N. J. (2001). Molecular prediction of progression of prostate cancer in conservatively managed patients.Urology, 58. . Publication link: 90c3c5f6-d987-454c-a0ae-9fff7aa14453

2000

1999

  • Anderson, E., & Clarke, R. B. (1999). Epithelial stem cells in the mammary gland: Casting light into dark corners. Breast Cancer Research, 1(1), 11-13. DOI:10.1186/bcr5. Publication link: 8bec11d8-409d-4d5f-8d7f-379c183436c3
  • Shoker, B. S., Jarvis, C., Clarke, R. B., Anderson, E., Hewlett, J., Davies, M. P. A., ... Sloane, J. P. (1999). Estrogen receptor-positive proliferating cells in the normal and precancerous breast. American Journal of Pathology, 155(6), 1811-1815. . Publication link: 3d8ebc26-62f0-433d-9008-11efbec332cc

1998

  • Anderson, E., Clarke, R. B., & Howell, A. (1998). Estrogen Responsiveness and Control of Normal Human Breast Proliferation. Journal of Mammary Gland Biology and Neoplasia, 3(1), 23-35. . Publication link: 7dcae5e2-b579-412e-875e-42d5d53c5a43

1997

  • Clarke, R. B., Howell, A., & Anderson, E. (1997). Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone. British Journal of Cancer, 75(2), 251-257. . Publication link: 1e830b8a-8415-466c-a27d-c896f99bdf8c
  • Clarke, R. B., Howell, A., & Anderson, E. (1997). Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: Analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression. Breast Cancer Research and Treatment, 45(2), 121-133. DOI:10.1023/A:1005805831460. Publication link: db91aab1-fca8-4089-9f4e-ea12acaf7d67
  • Clarke, R., Howell, A., Potten, C. S., & Anderson, E. (1997). Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Research, 57(22), 4987-4991. . Publication link: c377fa65-9bc9-42a8-8a2a-536bdc2f7fbf

1996

1995

  • Laidlaw, I. J., Clarke, R. B., Howell, A., Owen, A. W. M. C., Potten, C. S., & Anderson, E. (1995). The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. Endocrinology, 136(1), 164-171. . Publication link: 5247d671-3bf4-4030-915d-081c09a3bca3

1993

  • Clarke, R. B., Laidlaw, I. J., Jones, L. J., Howell, A., & Anderson, E. (1993). Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status. British Journal of Cancer, 67(3), 606-611. . Publication link: 371c38ea-0f70-41e7-88e5-14d78439deaf

1992