Farnie G, Willan PM, Clarke RB, Bundred NJ. (2013). Combined Inhibition of ErbB1/2 and Notch Receptors Effectively Targets Breast Ductal Carcinoma In Situ (DCIS) Stem/Progenitor Cell Activity Regardless of ErbB2 Status. PLoS One, 8(2), e56840. eScholarID:189570
Brennan KR, Clarke RB. (2013). Combining Notch inhibition with current therapies for breast cancer treatment. Therapeutic Advances in Medical Oncology, 5(1), 17-24. eScholarID:189573
Harrison H, Rogerson L, Gregson HJ, Brennan KR, Clarke RB and Landberg G. (2013). Contrasting hypoxic effect on breast cancer stem cell hierarchy is dependent on ERα status. Cancer Research, 73(4), 1420-1433. eScholarID:183505
Harrison H, Simões BM, Rogerson L, Howell SJ, Landberg G, Clarke RB. (2013). Oestrogen increases the activity of oestrogen receptor-negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Research, 15, R21. eScholarID:189572
Singh JK, Farnie G, Bundred NJ, Simões BM, Shergill A, Landberg G, Howell SJ and Clarke RB. (2013). Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-dependent and -independent Mechanisms. Clinical Cancer Research, 19(3), 643-656. eScholarID:180333
2012
Shaw FL, Harrison H, Spence K, Ablett MP, Simões BM, Farnie G, Clarke RB. (2012). A detailed mammosphere assay protocol for the quantification of breast stem cell activity. Journal of Mammary Gland Biology and Neoplasia, 17(2), 111-117. eScholarID:168643 | DOI:10.1007/s10911-012-9255-3
Ferraldeschi R, Latif A, Clarke RB, Spence K, Ashton G, O'Sullivan J, Evans DG, Howell A, and Newman WG. (2012). Lack of caveolin-1 (P132L) somatic mutations in breast cancer. Breast Cancer Research and Treatment, 132(3), 1185-1186. eScholarID:183504
Vieira AF, Ricardo S, Ablett MP, Dionísio MR, Mendes N, Albergaria A, Farnie G, Gerhard R, Cameselle-Teijeiro JF, Seruca R, Schmitt F, Clarke RB and Paredes J. (2012). P-Cadherin Is Coexpressed with CD44 and CD49f and Mediates Stem Cell Properties in Basal-like Breast Cancer. Stem Cells, 30(5), 854-864. eScholarID:160736 | DOI:10.1002/stem.1075
Ablett MP, Singh JK and Clarke RB. (2012). Stem cells in breast tumours: Are they ready for the clinic? European Journal of Cancer, 48(14), 2104-2116. eScholarID:160735 | DOI:10.1016/j.ejca.2012.03.019
2011
Thompson AM, Quinlan P, Bray SE, Johnson AM, Nikoloff DM, Purdie CA, Jordan LB, Ferraldeschi R, Latif A, Hadfield K, Clarke RB, Ashcroft L, Evans DG, Fontecha M, Hillman G, Howell A, Lawrence HJ and Newman WG. (2011). Comprehensive CYP2D6 genotype, adherence and co-medication affect outcome in breast cancer patients treated with tamoxifen monotherapy. Breast Cancer Research and Treatment, 125(1), 279-287. eScholarID:96492 | DOI:10.1007/s10549-010-1139-x
Agur Z, Kirnasovsky OU, Vasserman G, Tencer-Hershkowicz L, Kogan Y, Harrison H, Lamb R and Clarke RB. (2011). Dickkopf1 Regulates Fate Decision and Drives Breast Cancer Stem Cells to Differentiation: An Experimentally Supported Mathematical Model. PLoS One, 6(9), e24225. eScholarID:155452 | DOI:10.1371/journal.pone.0024225
2010
Harrison H, Farnie G, Brennan KR and Clarke RB. (2010). Breast cancer stem cells: something out of Notching. Cancer Research, 70(22), 8973-8976. eScholarID:96493 | DOI:10.1158/0008-5472.CAN-10-1559
Agur Z, Kogan Y, Levi L, Harrison H, Lamb R, Kirnasovsky OU and Clarke RB. (2010). Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biology Direct, 5(1), 20. eScholarID:80141 | DOI:10.1186/1745-6150-5-20
Harrison H, Farnie G, Howell SJ, Rock R, Stylianou S, Brennan KR, Bundred NJ, Clarke RB. (2010). Regulation of breast cancer stem cell activity by signalling through the Notch4 receptor. Cancer Research, 70(2), 709-718. eScholarID:75908 | DOI:10.1158/0008-5472.CAN-09-1681
Rieger ME., Sims AH, Coats ER, Clarke RB and Briegel KJ. (2010). The embryonic transcription cofactor LBH is a target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Molecular and Cellular Biology, 30(17), 4267-4279. eScholarID:87736 | DOI:10.1128/MCB.01418-09
2009
Ong KR, Sims AH, Harvie M, Chapman M, Dunn WB, Broadhurst D, Goodacre R, Wilson M, Thomas N, Clarke RB, Howell A. (2009). Biomarkers of dietary energy restriction in women at increased risk of breast cancer. Cancer Prevention Research, 2(8), 720-731. eScholarID:75907 | DOI:10.1158/1940-6207.CAPR-09-0008
Bentires-Alj M, Clarke RB, Jonkers J, Smalley M and Stein T. (2009). It's all in the details: methods in breast development and cancer. Breast Cancer Research, 11(4), 305. eScholarID:80140 | DOI:10.1186/bcr2346
Blance RR, Sims A, Anderson E, Howell A-, Clarke RB. (2009). Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prev Res (Phila Pa), 2( 3), 257-64. eScholarID:1d32440 | DOI:10.1158/1940-6207.CAPR-08-0161
O'Brien C, Howell S, Farnie G, Clarke RB. (2009). Resistance to endocrine therapy: are breast cancer stem cells the culprits? J Mammary Gland Biol Neoplasia, 14( 1), 45-54. eScholarID:1d19675 | DOI:10.1007/s10911-009-9115-y
Foster FM, Owens TW, Tanianis-Hughes J, Clarke RB, Brennan K, Bundred NJ, Streuli CH. (2009). Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer. Breast Cancer Res, 11( 3), eScholarID:1d19674 | DOI:10.1186/bcr2328
2008
Rice L, Waters C, Eccles J, Garside H, Sommer P, Kay P, Blackhall F, Zeef L, Telfer B, Stratford I, Clarke RB, Singh SD, Stevens A, White A, Ray DW. (2008). Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. J Endocrinol, 198, 499-509. eScholarID:1d17833 | DOI:10.1677/JOE-08-0019
Howell SJ, Anderson E, Hunter T, Farnie G, Clarke RB. (2008). Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity. Breast Cancer Res, 10( 4), eScholarID:1d32170 | DOI:10.1186/bcr2129
Sims AH, Smethurst GJ, Hey Y, Okoniewski MJ, Pepper SD, Howell A, Miller CJ, Clarke RB. (2008). The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis. BMC Med Genomics, 1( 1), eScholarID:1d32394 | DOI:10.1186/1755-8794-1-42
Nguyen Huu N, Ryder W, Zeps N, Flasza M, Chiu M, Hanby A, Poulsom R, Clarke RB, Baron M. (2008). Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator. J Pathol, 216( 1), 93-102. eScholarID:1d32182 | DOI:10.1002/path.2385
2007
Coppock H, Gilham DE, Howell A-, Clarke RB. (2007). Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis. Cell Prolif, 40( 5), 721-40. eScholarID:1d20077 | DOI:10.1111/j.1365-2184.2007.00463.x
Farnie G, Clarke RB. (2007). Mammary stem cells and breast cancer--role of Notch signalling. Stem Cell Rev, 3( 2), 169-75. eScholarID:1d32606
Farnie G, Clarke RB, Spence K, Pinnock N, Brennan K, Anderson N, Bundred NJ. (2007). Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst, 99(8), 616-627. eScholarID:1d15720 | DOI:10.1093/jnci/djk133
Sims A, Howell A-, Howell S, Clarke RB. (2007). Origins of breast cancer subtypes and therapeutic implications. Nat Clin Pract Oncol, 4( 9), 516-25. eScholarID:1d20075 | DOI:10.1038/ncponc0908
Sims A, Finnon P, Miller C, Bouffler S, Howell A, Scott D, Clarke RB. (2007). TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer. Int J Radiat Biol, 83( 6), 409-20. eScholarID:1d31299
2006
Stylianou S, Clarke RB, Brennan K. (2006). Aberrant activation of notch signaling in human breast cancer. Cancer Res, 66( 3), 1517-25. eScholarID:1d12967 | DOI:10.1158/0008-5472.CAN-05-3054
Wilson C, Sims AH, Howell A-, Miller C, Clarke RB. (2006). Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue. Endocr Relat Cancer, 13( 2), 617-28. eScholarID:1d29980
Bramley M, Clarke RB, Howell A-, Evans DDGR, Armer T, Baildam AD, Anderson E. (2006). Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations. Br J Cancer, 94( 7), 1021-8. eScholarID:1d12966 | DOI:10.1038/sj.bjc.6603042
Kalirai H, Clarke RB. (2006). Human breast epithelial stem cells and their regulation. J Pathol, 208( 1), 7-16. eScholarID:1d22528
2005
Clarke RB, Spence K, Anderson E, Howell A-, Okano H, Potten C. (2005). A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol, 277( 2), 443-56. eScholarID:1d9267 | DOI:10.1016/j.ydbio.2004.07.044
Clarke RB. (2005). Isolation and characterization of human mammary stem cells. Cell Prolif, 38( 6), 375-86. eScholarID:1d22527
Smalley M, Clarke RB. (2005). The mammary gland "side population": a putative stem/progenitor cell marker? J Mammary Gland Biol Neoplasia, 10( 1), 37-47. eScholarID:1d22497
2004
Clarke RB. (2004). Complementary yet distinct roles for oestrogen receptor-alpha and oestrogen receptor-beta in mouse mammary epithelial proliferation. Breast Cancer Res, 6( 3), 135-6. eScholarID:1d29277
Anderson E, Clarke RB. (2004). Steroid receptors and cell cycle in normal mammary epithelium. J Mammary Gland Biol Neoplasia, 9( 1), 3-13. eScholarID:1d22442
Hayward D, Clarke RB, Faragher A, Pillai M, Hagan IM, Fry A. (2004). The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res, 64( 20), 7370-6. eScholarID:1d9269 | DOI:10.1158/0008-5472.CAN-04-0960
2003
Potten CS, Booth, C, Tudor GL, Booth D, Brady G, Hurley P, Ashton G, Clarke, RB, Sakakibara S-I, Okano H. (2003). Identification of a putative intestinal stem cell and early lineage marker: musashi-1. Differentiation, 71, 28-41. eScholarID:1d2635 | DOI:10.1046/j.1432-0436.2003.700603.x
Clarke RB, Anderson E, Howell A, Potten C. (2003). Regulation of human breast epithelial stem cells. Cell Prolif, 36 Suppl 1, 45-58. eScholarID:1d22444
2002
Clarke RB. (2002). Mutations in DNA damage response genes and breast cancer susceptibility. Breast Cancer Research, eScholarID:1d2636
2001
McIntyre IG, Clarke RB, Anderson E, Clarke N, George NN J. (2001). Molecular prediction of progression of prostate cancer in conservatively managed patients. Urology, 58, eScholarID:1d2638
1999
Anderson E, Clarke RB. (1999). Epithelial stem cells in the mammary gland: Casting light into dark corners. Breast Cancer Res, 1, 11-13. eScholarID:1d2647
Shoker B. S, Jarvis C, Clarke RB, Anderson E, Hewlett J, Davies M. P, Sibson D. R, Sloane J. P. (1999). Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am. J. Pathol, 155, 6, 1811-1815. eScholarID:1d2645
1998
Anderson E, Clarke RB, Howell A. (1998). Estrogen responsiveness and control of normal human breast proliferation. J Mammary Gland Biol Neoplasia, 3, 1, eScholarID:1d22513
1997
Clarke RB, Howell A, Potten C. S, Anderson E. (1997). Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res, 57, 22, eScholarID:1d22515
Clarke RB, Howell A, Anderson E. (1997). Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression. Breast Cancer Res Treat, 45, 2, eScholarID:1d22516
Clarke RB, Howell A, Anderson E. (1997). Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone. Br J Cancer, 75, 2, eScholarID:1d22517
1995
Laidlaw I. J, Clarke RB, Howell A, Owen A. W, Potten C. S, Anderson E. (1995). The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. Endocrinology, 136, 1, eScholarID:1d22521
1993
Clarke RB, Laidlaw I. J, Jones L. J, Howell A, Anderson E. (1993). Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status. Br J Cancer, 67, 3, eScholarID:1d22514
