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Dr Simon Webb - publications

List of publications


  • Jones, J.; Diemer, V.; Adam, C.; Raftery, J.; Ruscoe, R.; Sengel, J.; Wallace, M.; Bader, A.; Cockroft, S.; Clayden, J.; Webb, S. Length-dependent formation of transmembrane pores by 3-10 helical Aib foldamers. American Chemical Society. Journal. 2016 January; eScholarID:294100 | DOI:10.1021/jacs.5b12057


  • King, P. J. S.; Lizio, M. G.; Booth, A.; Collins, R. F.; Gough, J. E.; Miller, A. F.; Webb, S.J. A modular self-assembly approach to functionalised β-sheet peptide hydrogel biomaterials. Soft Matter. 2015 December; eScholarID:293594 | DOI:10.1039/C5SM02039E
  • Coxon, T. P.; Fallows, T. W.; Gough J. E.; Webb S. J. A versatile approach towards multivalent saccharide displays on magnetic nanoparticles and phospholipid vesicles. Organic & Biomolecular Chemistry. 2015 September; 13(43): 10751-10761. eScholarID:272328 | DOI:10.1039/C5OB01591J
  • Brioche, J.; Pike, S.J.; Tshepelevitsh, S.; Leito, I.; Morris, G.A.; Webb, S.J.; Clayden, J. Conformational switching of a foldamer in a multi-component system by pH-filtered selection between competing non-covalent interactions. American Chemical Society. Journal. 2015 April; 137: 6680-6691. eScholarID:264370 | DOI:10.1021/jacs.5b03284
  • Pike, S.J.; Jones, J.E.; Raftery, J.; Clayden, J.; Webb, S.J. Helical peptaibol mimics are better ionophores when racemic than when enantiopure. Organic & Biomolecular Chemistry. 2015 August; 13(37): 9580-9584. eScholarID:272327 | DOI:10.1039/C5OB01652E
  • Pike, S.J.; Boddaert, T.; Raftery, J.; Webb, S.J.; Clayden, J. Participation of Non-Aminoisobutyric Acid (Aib) Residues in the 310 Helical Conformation of Aib-Rich Foldamers: A Solid State Study. New Journal of Chemistry. 2015; 39: 3288-3294. eScholarID:261369 | DOI:10.1039/c4nj01547a
  • Booth, A.; Pintre, I.C.; Y. Lin, Y.; Gough J.; Webb, S.J. Release of proteins and enzymes from vesicular compartments by alternating magnetic fields. Physical Chemistry Chemical Physics. 2015; 17: 15579-15588. eScholarID:261457 | DOI:10.1039/C4CP05872K


  • Coxon, T.; Almond, A.; Gough, J.E.; Webb, S.J. Catechol-hydrazone conjugates for the rapid functionalization of magnetite nanoparticles with cell targeting groups. Materials Research Society Symposium Proceedings. 2014; 1688: eScholarID:238331 | DOI:10.1557/opl.2014.433
  • Pike, S.J.; Raftery, J.; Webb, S.J.; Clayden, J. Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs. Organic & Biomolecular Chemistry. 2014; 12: 4124-4131. eScholarID:238330 | DOI:10.1039/c4ob00268g
  • Pike, S.J.; Diemer, V.; Raftery, J.; Webb, S.J.; Clayden, J. Designing Foldamer-Foldamer Interactions in Solution: The Roles of Helix Length and Terminus Functionality in Promoting the Self-Association of Aminoisobutyric Acid Oligomers. Chemistry: A European Journal. 2014; 20: 15981-15990. eScholarID:238334 | DOI:10.1002/chem.201403626
  • Brown, J.R.D.; Pintre, I.C.; Webb, S.J. Fructose controlled ionophoric activity of a cholate–boronic acid. Organic & Biomolecular Chemistry. 2014 February; (12): 2576-2583. eScholarID:221770 | DOI:10.1039/C4OB00165F
  • Noble, GT; Craven, FL; Segarra-Maset, MD; Reyes Martínez, JE; Šardzík, R; Flitsch, SL; Webb, SJ. Sialylation of lactosyl lipids in membrane microdomains by T. cruzi trans-sialidase. Organic & Biomolecular Chemistry. 2014; 12: 9272-9278. eScholarID:238338
  • Booth, A.; Coxon, T.; Gough, J.E.; Webb, S.J. Targeting of a magnetic bionanomaterial to HepG2 human hepatocellular carcinoma cells using a galactose terminated lipid. Materials Research Society Symposium Proceedings. 2014; 1688: eScholarID:238332 | DOI:10.1557/opl.2014.517


  • Pintre, I.C.; Webb, S.J. Binding and Reactivity at Bilayer Membranes. Adv. Phys. Org. Chem. 2013 November; 47: 129-183. eScholarID:214117
  • Pike S.J.; De Poli, M.; Zawodny, W.; Raftery, J.; Webb, S.J.; Clayden, J. Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers. Org. Biomol. Chem. 2013; 11: 3168-3176. eScholarID:194739 | DOI:10.1039/C3OB40463C
  • Brown, R.A.; Diemer, V.; Webb, S.J.; Clayden, J. End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching. Nature Chemistry. 2013; 5(10): 853-860. eScholarID:208129 | DOI:10.1038/nchem.1747
  • Lin, I-H.; Birchall, L.S.; Hodson, N.; Ulijn, R.V.; Webb, S.J. Interfacing biodegradable molecular hydrogels with liquid crystals. Soft Matter. 2013; 9: 1188-1193. eScholarID:194735 | DOI:10.1039/C2SM27160E
  • de Cogan, F.; A. Booth, A.; Gough, J.E.; Webb, S.J. Spatially-controlled apoptosis induced by released nickel(II) within a magnetically responsive nanostructured biomaterial. Soft Matter. 2013; 9: 2245-2253. eScholarID:194738 | DOI:10.1039/C2SM27379A
  • Webb S.J. Supramolecular approaches to combining membrane transport with adhesion. Acc. Chem. Res. 2013; eScholarID:208127 | DOI:10.1021/ar400032c


  • Gavin T. Noble , Faye L. Craven, Josef Voglmeir, Robert Šardzík, Sabine L. Flitsch, and Simon J. Webb. Accelerated Enzymatic Galactosylation of N-Acetylglucosaminolipids in Lipid Microdomains. J. Am. Chem. Soc. 2012 July; 134(31): 13010-13017. eScholarID:175626 | DOI:10.1021/ja302506t
  • Meghan Hughes, Pim W. J. M. Frederix, Jaclyn Raeburn, Louise S. Birchall, Jan Sadownik, Fiona C. Coomer, I-Hsin Lin, Edmund J. Cussen, Neil T. Hunt, Tell Tuttle, Simon J. Webb, Dave J. Adams and Rein V. Ulijn. Sequence/structure relationships in aromatic dipeptide hydrogels formed under thermodynamic control by enzyme-assisted self-assembly. 2012 January; 8: 5595-5602. eScholarID:175638 | DOI:10.1039/c2sm25224d
  • Noble, GT; Mart, RJ; Liem, KP; Webb, SJ. Supramolecular Chemistry of Membranes. In: Philip A. Gale and Jonathan W. Steed, ed. Supramolecular Chemistry: From Molecules to Nanomaterials. 4. Chichester, John Wiley & Sons.2012: eScholarID:175632


  • de Cogan, F; Gough, JE; Webb, SJ. Adhesive interactions between cells and biotinylated phospholipid vesicles in alginate: towards new responsive biomaterials. J. Mater. Sci.-Mater. M. 2011; 22: 1045-1051. eScholarID:138771 | DOI:10.1007/s10856-011-4271-1
  • Felicity de Cogan, Andrew Booth, Dr. Julie E. Gough and Dr. Simon J. Webb. Conversion of Magnetic Impulses into Cellular Responses by Self-Assembled Nanoparticle–Vesicle Hydrogels. Angewandte Chemie International Edition. 2011 December; 50(51): 12290-12293. eScholarID:141143 | DOI:10.1002/anie.201103469
  • Wilson, CP; Boglio, C; Ma, L; Cockroft, SL; Webb, SJ. Palladium(II)-mediated assembly of biotinylated ion channels. Chem. Eur. J. 2011; 17: 3465-3473. eScholarID:138770 | DOI:10.1002/chem.201002031
  • Devi, U; Brown, JRD; Almond, A; Webb, SJ. Pd(II)-mediated assembly of porphyrin channels in bilayer membranes. Langmuir. 2011 January; 27: 1448-1456. eScholarID:138769 | DOI:10.1021/la104152s


  • Leng, F; Gough, JE; Webb, SJ. Enhancing cell culture in magnetic vesicle gels. Mater. Res. Soc. Symp. Proc. 2010; 1272: . eScholarID:108240 | DOI:10.1557/PROC-1272-PP07-02
  • Saunders, RE; Liem, KP; Mart, RJ; Webb, SJ; Derby B. Novel Gelation System For Fabricating 3-D Structures via Ink Jet Printing. Mater. Res. Soc. Symp. Proc. 2010; 1239: . eScholarID:108242 | DOI:10.1557/PROC-1239-VV06-10
  • Šardzík, R; Noble, GT; Weissenborn, MJ; Martin, A; Webb, SJ; Flitsch, SL. Preparation of aminoethyl glycosides for glycoconjugation. Beilstein J. Org. Chem. 2010; 6: eScholarID:108239 | DOI:10.3762/bjoc.6.81
  • Liem, KP; Noble, GT; Flitsch, SL; Webb, SJ. The effect of multivalent binding on the lateral phase separation of adhesive lipids. Faraday Discuss. 2010; 145: 219-233. eScholarID:76635 | DOI:10.1039/b907114h


  • Noble, GT; Liem, KP; Flitsch, SL; Webb, SJ. Assessing the cluster glycoside effect during the binding of concanavalin A to mannosylated artificial lipid rafts. Org. Biomol. Chem. 2009; 7: 5245-5254. eScholarID:76610 | DOI:10.1039/b910976e
  • Mart, RJ; Liem, KP; Webb, SJ. Creating functional vesicle assemblies from vesicles and nanoparticles. Pharm. Res. 2009; 26: 1701-1710. eScholarID:76633 | DOI:10.1007/s11095-009-9880-8
  • Mart, RJ; Liem, KP; Webb, SJ. Magnetically-Controlled Release from Hydrogel-Supported Vesicle Assemblies. Chemical Communications. 2009; 2009(17): 2287-2289. eScholarID:76607 | DOI:10.1039/b901472a


  • Birchall L, Ulijn R, Webb S. A combined SPS-LCD sensor for screening protease specificity. Chem. Commun. 2008; (25): 2861-2863. eScholarID:69070 | DOI:10.1039/b805321a
  • Mart R, Webb S. Bioinspired organic chemistry. Annu. Rep. Prog. Chem., Sect. B: Org. Chem. 2008; 104: 370-393. eScholarID:69076 | DOI:10.1039/b716609p
  • Thornton P, Mart R, Webb S, Ulijn R. Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload. Soft Matter. 2008; 4(4): 821-827. eScholarID:69077 | DOI:10.1039/b714750c
  • Wilson C, Webb S. Palladium(II)-gated ion channels. Chemical Communications. 2008; 2008(34): 4007-4009. eScholarID:69084 | DOI:10.1039/b809087d


  • Dijkstra H, Hutchinson J, Hunter C, Qin H, Tomas S, Webb S, Williams N. Transmission of binding information across lipid bilayers. Chem.- Eur. J. 2007; 13(25): 7215-7222. eScholarID:69072
  • Liem K, Mart R, Webb S. Magnetic Assembly and Patterning of Vesicle/Nanoparticle Aggregates. J. Am. Chem. Soc. 2007; 129(40): 12080-12081. eScholarID:69074
  • Wang X, Mart R, Webb S. Vesicle aggregation by multivalent ligands: relating crosslinking ability to surface affinity. Org. Biomol. Chem. 2007; 5(15): 2498-2505. eScholarID:69079
  • Webb S. Bioinspired organic chemistry. Annu. Rep. Prog. Chem., Sect. B: Org. Chem. 2007; 103: 392-415. eScholarID:69081


  • Mart R, Liem K, Wang X, Webb S. The Effect of Receptor Clustering on Vesicle-Vesicle Adhesion. J. Am. Chem. Soc. 2006; 128(45): 14462-14463. eScholarID:69075 | DOI:10.1021/ja0657612
  • Walton J, Tiddy G, Webb S. Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins. Tetrahedron Lett. 2006; 47(5): 737-741. eScholarID:69078 | DOI:10.1016/j.tetlet.2005.11.103
  • Webb S. Bioinspired organic chemistry. Annu. Rep. Prog. Chem., Sect. B: Org. Chem. 2006; 102: 377-400. eScholarID:69080 | DOI:10.1039/b515108m
  • Webb S, Greenaway K, Bayati M, Trembleau L. Lipid fluorination enables phase separation from fluid phospholipid bilayers. Org. Biomol. Chem. 2006; 4(12): 2399-2407. eScholarID:69082 | DOI:10.1039/b603373n


  • Webb S, Trembleau L, Mart R, Wang X. Membrane composition determines the fate of aggregated vesicles. Org. Biomol. Chem. 2005; 3(20): 3615-3617. eScholarID:69083 | DOI:10.1039/b510647h