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Dr Denis Alferez-Castro (BSc, PhD) - publications

List of publications


  • Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., ... Trusolino, L. (2017). Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature reviews. Cancer. DOI: 10.1038/nrc.2016.140. Publication link: cf0de037-43c4-4c1f-bc9b-84b1b7fc3418 | PubMed:28104906


  • Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., ... Clarke, R. B. (2016). Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis. Journal of Mammary Gland Biology and Neoplasia. DOI: 10.1007/s10911-016-9361-8. Publication link: 0e6dba5e-e368-4422-84ba-63eea0e79dff | PubMed:27680982
  • Dobrolecki, L. E., Airhart, S. D., Alferez, D. G., Aparicio, S., Behbod, F., Bentires-Alj, M., ... Lewis, M. T. (2016). Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer and Metastasis Reviews, 35(4), 547-573. DOI: 10.1007/s10555-016-9653-x. Publication link: 6d84b893-5552-4dc8-8ce5-7b13d535b23d | PubMed:28025748



  • Holt, S. V., Logie, A., Davies, B. R., Alferez, D., Runswick, S., Fenton, S., ... Smith, P. D. (2012). Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055). Cancer research, 72(7), 1804-13. DOI: 10.1158/0008-5472.CAN-11-1780. Publication link: ad43144f-c9e2-4789-b2a3-7436e2f8d3d0 | PubMed:22271687
  • Schlicker, A., Beran, G., Chresta, C. M., McWalter, G., Pritchard, A., Weston, S., ... Wessels, L. F. A. (2012). Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Medical Genomics, 5, 66. DOI: 10.1186/1755-8794-5-66. Publication link: 252d51f8-c17a-4189-a80a-a7b874b5ec2c | PubMed:23272949
  • Alferez, D. G., Goodlad, R. A., Odedra, R., Sini, P., Crafter, C., Ryan, A. J., ... Wilkinson, R. W. (2012). Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia. International Journal of Oncology, 41(4), 1475-85. DOI: 10.3892/ijo.2012.1580. Publication link: 1211347e-fbbb-4b47-88ed-6cb43e0403b1 | PubMed:22858681
  • Holt, S. V., Logié, A., Odedra, R., Heier, A., Heaton, S. P., Alferez, D., ... Smith, P. D. (2012). The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models. British Journal of Cancer, 106(5), 858-66. DOI: 10.1038/bjc.2012.8. Publication link: 12286708-de92-4f2d-b820-963536537b36 | PubMed:22343622


  • Alferez, D. G., Ryan, A. J., Goodlad, R. A., Wright, N. A., & Wilkinson, R. W. (2010). Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model. International Journal of Oncology, 37(4), 767-72. . Publication link: a99ed89a-c03f-46cc-82d0-4e89c285ae8e | PubMed:20811697


  • Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A., & Keun, H. C. (2009). Detection of metabolic alterations in non-tumor gastrointestinal tissue of the Apc(Min/+) mouse by (1)H MAS NMR spectroscopy. Journal of Proteome Research, 8(3), 1423-30. DOI: 10.1021/pr800793w. Publication link: 4ae33aeb-6d67-47e5-b02c-bc5ac7838f29 | PubMed:19159281


  • Alferez, D., Wilkinson, R. W., Watkins, J., Poulsom, R., Mandir, N., Wedge, S. R., ... Goodlad, R. A. (2008). Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice. Molecular cancer therapeutics, 7(3), 590-8. DOI: 10.1158/1535-7163.MCT-07-0433. Publication link: 32018b73-d557-4c73-a04a-9c09c1558c13 | PubMed:18347145



  • Goodlad, R. A., Ryan, A. J., Wedge, S. R., Pyrah, I. T., Alferez, D., Poulsom, R., ... Wilkinson, R. W. (2006). Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis, 27(10), 2133-9. DOI: 10.1093/carcin/bgl113. Publication link: c18e7dbd-e5c4-466c-9a41-1f61ce7bdf4e | PubMed:16782971


  • Fraser, P. J., Araujo, R., Alferez, D., Carneiro, M. J., & Pollard, M. (2004). Effects of gravity, hypergravity and microgravity on vestibular neurones of the crab. Journal of Gravitational Physiology , 11(2), P1-4. . Publication link: 91a3422a-a4b5-495c-b395-dddc589a3e6e | PubMed:16229107