MSc Pharmaceutical Industrial Advanced Training (PIAT) / Course details

Year of entry: 2020

Course unit details:
Solid Oral Dosage Forms 2 (PIAT 7)

Unit code PHAR71070
Credit rating 15
Unit level FHEQ level 7 – master's degree or fourth year of an integrated master's degree
Teaching period(s) Variable teaching patterns
Offered by Pharmacy
Available as a free choice unit? No

Overview

This unit builds on the teaching from Oral Solid Dosage Forms – 1. It begins by covering the basic pharmacokinetic concepts associated with oral controlled release and continues with an introduction to polymer science. This is followed by sections on matrix release systems and reservoir systems.

Further topics include the manufacture of soft gelatin capsule, the formulation of poorly soluble compounds, formulation and process design, evaluation of oral solid dosage forms, experimental design and design of experiments, continuous manufacturing of oral solid dosage forms and expert systems. 

Aims

The unit aims to build on what was learned in the PHAR17040: Solid Oral Dosage forms - 1 by introducing students to:

  • pharmacokinetics of multiple dosing and modified release;
  • formulation of modified release oral solid dosage forms;
  • polymer chemistry;
  • formulation and manufacture of soft gelatin capsules;
  • formulation of poorly soluble drugs;
  • evaluation of oral solid dosage forms;
  • formulation and process design and development;
  • experimental design;
  • continuous manufacturing for oral solid dosage forms;
  • expert systems.

Teaching and learning methods

Use of a work book with exercises to work through to help students evaluate how well they understand the different topics.

Tutor support is also available to the students via email or telephone.

 

Knowledge and understanding

  • Understand the reasons for and the formulation of modified release oral solid dosage forms.
  • Understand sufficient polymer chemistry to work efficiently with polymer chemists.
  • Understand the formulation and manufacture of soft gelatin capsules.
  • Be able to assess the applicability of different delivery technologies for the formulation of poorly soluble drugs.
  • Understand the requirements for the formulation design and development process and experimental designs.
  • Understand the differences between traditional manufacture and continuous manufacturing for oral solid dosage forms.
  • Understand the evaluation of oral solid dosage forms.
  • Be aware of expert systems and how they can be applied in pharmaceutical formulation.

Intellectual skills

  • Be able to advise on the formulation design and development of modified release oral solid dosage forms, and the formulation of poorly soluble compounds (including soft gelatin capsule).
  • Provide input on the evaluation and control of oral solid dosage forms.
  • Be able to advise on current trends in the design, development and manufacture of oral solid dosage.

Assessment methods

Method Weight
Written exam 70%
Written assignment (inc essay) 30%

Feedback methods

Provisional marks and feedback for coursework returned within 15 working days.

Exam marks and final marks returned after ratification at exam board. 

Study hours

Scheduled activity hours
Assessment written exam 2
Independent study hours
Independent study 148

Teaching staff

Staff member Role
Matthew Shaw Unit coordinator

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