MSc Pharmaceutical Industry Advanced Training (PIAT) / Course details

Year of entry: 2021

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Course unit details:
Solid Oral Dosage Forms (PIAT 4)

Unit code PHAR71040
Credit rating 15
Unit level FHEQ level 7 – master's degree or fourth year of an integrated master's degree
Teaching period(s) Variable teaching patterns
Offered by Pharmacy
Available as a free choice unit? No

Overview

This unit begins with an introduction to the anatomy and physiology of the gastro-intestinal tract as it relates to oral absorption of drugs. It then covers powder technology, followed by the important processes used in the manufacture of tablets and powder-filled capsules, including granulation methods, blending, tablet compression, powder encapsulation and coating.

There is also a section on excipients used in immediate release oral solid dosage forms. In addition, there are sections on setting specifications for the testing of immediate release solid oral dosage forms, and on packaging and stability. 

Aims

The unit aims to introduce students to:

  • the physiology of the gastro intestinal tract relevant to oral administration of medicines;
  • the properties of powders and their behaviour during consolidation and compression;
  • the unit processes used in the manufacture of oral solid dosage forms;
  • setting specifications for and testing of immediate release oral solid dosage forms;
  • aspects of packaging and stability testing as they relate to oral solid dosage forms.

Teaching and learning methods

Students are provided with the learning material in soft copy form. The learning material comprises 12 chapters covering key areas of oral solid dosage forms. Each chapter contains a number of exercises together with suggested answers for students to check their learning as they progress through the unit. A reference list of further reading is provided for each chapter allowing the student to investigate the subject area more deeply, and the unit tutor is available to answer queries and provide guidance as required. The face-to-face workshop at the annual workshop event explores key areas of the unit through a range of hands-on exercises and practical demonstrations.

 

Knowledge and understanding

Students should be able to: 

  • Understand how tablets and capsules are made and the unit processes used to manufacture them. 
  • Understand the common problems encountered during manufacture and be able to suggest ways to remedy them.
  • Understand the testing of oral solid dosage forms, setting specifications and stability and packaging.

Intellectual skills

 Students should be able to: 

  • Advise on the design and development of oral solid dosage forms.
  • Suggest approaches to solving the more common problems that can occur during their manufacture.

Practical skills

Students should be able to:

•    Provide effective solutions to common problems encountered during formulation development of immediate release oral solid dosage forms..
•    Provide effective solutions to problems encountered during manufacture.
•    Demonstrate understanding of the requirements for specifications and testing of immediate release solid oral dosage forms
 

Assessment methods

Method Weight
Written assignment (inc essay) 100%

Assessment task

Length

How and when feedback is provided

Weighting within unit (if relevant)

 

Assignment

3000 words

Feedback returned by email within 15 working days.

100%

Feedback methods

Feedback returned by email within 15 working days.

Recommended reading

References cited, and suggested further reading, are given at the end of the individual Units of the unit.  Eg:

•    References cited, and suggested further reading, are given at the end of the individual chapters of the unit.
•    Staniforth JN and Taylor KMG, Chapter 9: Particle size analysis, in: Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed. Aulton ME and Taylor KMG (eds.), Churchill Livingstone, (2013), pp. 138 – 155.
•    Aulton ME, Chapter 12: Powder flow. in: Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed. Aulton ME and Taylor KMG (eds.), Churchill Livingstone, (2013), pp. 187 – 199.
•    Rhodes M, Chapter 1: Particle size analysis. in: Introduction to Particle Technology, 2nd Ed. Rhodes M (ed.), John Wiley and Sons, (2008), pp. 1 – 27.
•    Rhodes M, Chapter 10: Storage and flow of powders: Hopper design. in: Introduction to Particle Technology, 2nd Ed. Rhodes M (ed.), John Wiley and Sons, (2008), pp. 265 – 292.

Study hours

Independent study hours
Independent study 150

Teaching staff

Staff member Role
Richard Moreton Unit coordinator

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