MRes Experimental Medicine (Hearing Health) / Course details

Year of entry: 2021

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Course description

Our MRes Experimental Medicine (Hearing Health) programme will give nurses, doctors, audiologists, clinical researchers and research programme managers the skills needed to work in early phase clinical studies.

You will learn how to master experimental medicine with a focus on Hearing Health through a combination of traditional teaching and hands-on learning, through spending a year working closely with the Experimental Medicine Hearing Health Team of the Biomedical Research Centre while also taking four structured taught units.

The taught units will see you learn the details of designing and delivering Phase 1 clinical studies, understanding the pre-clinical data required before a clinical programme can commence, and how to optimise early clinical studies to provide evidence for progressing a promising drug or intervention into Phase II/III clinical testing.

Alongside the taught elements, you will have a named supervisor and be exposed to tasks required in the setup, delivery, interpretation and audit of a clinical study.

Nursing, physician and audiology students may participate in patient care, including new and follow-on patient clinics, treatment and care-giving episodes with patients.

For non-registered clinical researchers and research programme managers, no direct patient contact is envisaged and you may participate in clinical trial setup, protocol amendments, database setup, data entry, costing and billing for clinical research.

You will be able to choose two aspects of your direct clinical trial research experience to write up for your two research projects in a dissertation format. This will give you the skills and knowledge required to critically report medical, scientific and clinically related sciences for peer review.

Aims

The primary purpose of the MRes in Experimental Medicine (Hearing Health) is to provide you with the opportunity to work within a premier Biomedical Research Centre and, through a mix of taught and experiential learning, master the discipline of experimental medicine related to hearing health.

Special features

Extensive practical experience

You will spend most of your time gaining hands-on experience through completion of two research projects working closely with the Experimental Medicine Hearing Health Team of the Manchester Biomedical Research Centre.

Taught by experts in Experimental Medicine within dedicated research and clinical trials facilities

You will also have opportunities to interact with and learn from experimental medicine researchers across a range of different fields within the Manchester Biomedical Research Centre and the Manchester Clinical Research Facility and thereby broaden your knowledge and experience of experimental medicine.

Additional course information

Meet the course team

Dr Kai Uus (Hearing Health Pathway Lead)

Dr Kai Uus is a Reader in Audiology at the University and the Head of Manchester Centre for Audiology and Deafness (ManCAD) Teaching; she is a Programme Director Programme Director of MSc Clin Sci (Neurosensory Sciences)and Academic Lead for D Clin Sci in Audiological Science. She is a qualified paediatrician and has a PhD in Audiological Medicine. Her area of expertise is in paediatric audiology, with particular interest in newborn hearing screening, family engagement and Auditory Neuropathy Spectrum Disorder.

Professor Kevin Munro

Prof Kevin J Munro is Director (research) of the Manchester Centre for Audiology and Deafness (ManCAD). He is also an Honorary Consultant Clinical Scientist at Central Manchester University Hospitals NHS Foundation Trust. He has held a variety of professional positions including Chief Examiner for the British Association of Audiological Scientists and Chair of the British Society of Audiology. He is currently the early member of the NICE guideline committee on assessment and management of adult hearing loss and is Secretary on the Council of the International Journal of Audiology. He is the NIHR Manchester BRC deputy head and is leading the Hearing Health Theme.

Dr Piers Dawes

Dr Piers Dawes is a Senior Lecturer in Audiology with the Manchester Centre for Audiology and Deafness. His research interests include epidemiology of hearing impairment, hearing loss and mental well-being, and audiology service provision.

Teaching and learning

Our course is structured around a 2:1 split between clinical-based research projects and taught elements respectively.

Taught course units will predominantly use lectures and workshops. For the research projects, teaching and learning will take place through one-to-one mentoring from a member of the Experimental Medicine Hearing Health team.

The clinical and academic experience of contributors to this course will provide you with an exceptional teaching and learning experience.

Coursework and assessment

You will be assessed through oral presentations, single best answer exams, written reports and dissertation. For each research project, you will write a dissertation of 10,000 to 15,000 words. Examples of suitable practical projects include the following.

Research proposal

  • Compilation of a research proposal to research council/charity
  • Writing a protocol and trial costings for sponsor
  • Research and write a successful expression of interest selected by grant funder for full development

Publication-based/dissertation by publication

  • Writing a clinical study report
  • Authoring a peer-review journal review/original article

Service development/professional report/ report based dissertation

  • Public health report/outbreak report/health needs assessment/health impact assessment
  • Proposal for service development/organisational change
  • Audit/evaluate service delivery/policy
  • Implement recommended change from audit report

Adapted systematic review (qualitative data)

  • Compiling the platform of scientific evidence for a new drug indication from literature
  • Review of alternative research methodologies from literature

Full systematic review that includes data collection (quantitative data)

  • Referral patterns for Phase 1 patients

Qualitative or quantitative empirical research

  • Design, conduct, analyse and report an experiment

Qualitative secondary data analysis/analysis of existing quantitative data

  • Compilation, mining and analysis of existing clinical data sets

Quantitative secondary data analysis/analysis of existing qualitative data/theoretical study/narrative review

  • Policy analysis or discourse analysis/content analysis
  • A critical review of policy using framework analysis

Course unit details

This course consists of four taught 15-credit units and two practical 60-credit research projects. Students achieving 180 credits will be awarded the MRes; students may receive a PGDip in Experimental Medicine (Hearing Health) upon achievement of 120 credits. There is also an option for students to register for a PGCert and complete only the four taught units on a part-time basis for 60 credits.

The four taught units run as follows:

  • Research Methods (October)
  • Introduction to Experimental Medicine (November/December)
  • Assembling Pre-clinical and Early Clinical Development Strategies for a new Candidate Drug (February/March)
  • Designing a Translational Medicine Strategy for a Clinical therapy or Intervention (June)

Please see the course unit list below for more information on each unit and project.

Course unit list

The course unit details given below are subject to change, and are the latest example of the curriculum available on this course of study.

TitleCodeCredit ratingMandatory/optional
Laboratory Skills Unit MEDN66111 15 Mandatory
Assembling preclinical and translational medicine strategies for a new candidate drug MEDN66212 15 Mandatory
Research Project 1 MEDN66230 60 Mandatory
Research Project 2 MEDN66242 60 Mandatory
Introduction to Experimental Medicine MEDN69631 15 Mandatory
Designing a translational medicine strategy for a clinical intervention MEDN69632 15 Mandatory
Research Methods MEDN69910 15 Mandatory

Facilities

Teaching will take place within The Christie NHS Foundation Trust, the Manchester Clinical Research Facility and The University of Manchester campus.

Projects may be conducted within one of the Biomedical Research Centre affiliated NHS Trusts.

Disability support

Practical support and advice for current students and applicants is available from the Disability Advisory and Support Service .