BSc Biomedical Sciences
Year of entry: 2019
Course unit details:
Principles of Infectious Disease
|Unit level||Level 2|
|Teaching period(s)||Semester 2|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||No|
Principles of Infectious Disease will provide you with a broad understanding of the biology of microbial infections, with an emphasis on bacterial human infections. You will study the mechanisms of microbial pathogenicity, starting with pathogen transmission and entry into the host, progressing through adhesion and invasion, to cell and tissue damage and host responses to injury. The diseases studied will include tuberculosis, cholera, listeriosis. salmonellosis, gonorrhoea and pseudomembranous colitis.
|Unit title||Unit code||Requirement type||Description|
|Microbes, Man and the Environment||BIOL10532||Pre-Requisite||Compulsory|
To explore the fundamentals of how microorganisms cause disease and the interactions that occur between a pathogen and host during infection. To study the mechanisms of microbial pathogenicity(focussing on bacteria), starting with pathogen transmission and entry into the host, progressing through adhesion, invasion and pathogen survival strategies within a host, to cell and tissue damage and host responses to infection. To gain a detailed understanding of the mechanisms of pathogenesis and disease for exemplary human pathogens.
On successful completion of this unit, students should be able to:
• Outline the key host defences in preventing microbial infections
• Describe the various strategies used by bacteria to penetrate host external defences and explain their role in host colonisation and/or invasion
• Outline the role of bacterial products in the pathology of infectious disease (including endotoxin, exotoxins, lipoarabinommannan, pili, polysaccharide capsules, urease, invasins and secreted effector proteins)
• Describe the physiological adaptations that allow microorganisms to survive in a host
• Explain the mechanisms of pathogenesis of selected human pathogens in detail (these representing paradigms of pathogen-host interactions)
Describe the main classes of antibiotics and their targets and discuss examples of antibiotic resistance
Basic concepts of microbial pathogenicity and virulence
- Colonisation and invasion of the host: Routes of entry and exit.
- Host surface defences and bacterial mechanisms of colonisation and invasion
- Specific examples of diseases associated with colonisation via pili: uropathogenic Escherichia coli and Neisseria gonorrhoea
- The normal microbiota & opportunistic infections
- Encounter with innate immunity: Phagocytic effector cells and complement, mechanisms of microbial killing. Microbial strategies for overcoming innate immune defences
- Encounter with adaptive immunity: Pathogen adaptation to growth in the host and antibody avoidance
Mechanisms of cell and tissue damage
- Introduction to toxin types and septic shock
- Toxins in specific diseases (diphtheria, botulism, tetanus, cholera & whooping cough)
Selected human infectious diseases in detail
- Survival in macrophages: Mycobacterium tuberculosis and the disease TB
- Gastro-intestinal disease: Diarrheagenic Escherichia coli
- Salmonellosis: Salmonella enterica serovars Typhimurium and Typhi
- Colonisation of the stomach mucosa by Helicobacter pylori
- Intracellular survival and spread: The food-borne pathogen Listeria monocytogenes and listeriosis
- Clostridium difficile and pseudomembranous colitis
- Borrelia burgdorferi and Lyme disease
Infectious disease treatment
- The main classes of antibiotics: History, targets and resistance
An eLearning (ePBL) based coursework module will be set using Blackboard and will be based upon a published research article on a topical subject related to course content. This should be undertaken during week 5 of the course. This eLearning exercise will form part (10%) of the overall assessment of the unit. In addition, lecture slides and materials that support the lecture material will also be will be posted on Blackboard.
- Analytical skills
- Discussion of a research paper and e-learning exercise require students to analyse experimental data and interpret results.
- Oral communication
- Students encouraged to answer questions during lectures
- Problem solving
- e-learning questions based on problem solving
- Discussion of a research paper and e-learning exercise focused on primary research papers. Students encouraged to read research papers and review articles.
- Written communication
- Short note and essay questions in examination
Written examination (90%)
1 hour 30 minute written examination consisting of two sections; A, short answer questions (50%, 4 out of 6 questions) and B, essay (50%, 1 out of 4 questions)
Set exercise – Online coursework assessment (10%)
Online e-learning assignment based upon reading a research paper (single online test regarding comprehension of the paper comprising 10 multiple answer and true/false questions)
Feedback will be given on the eLearning coursework exercise and by end of semester exam marks. This will include: (i) formative individual feedback to all students regarding performance in the eLearning activity, and (ii) general feedback on exam performance by releasing a document addressing general strengths and weaknesses of answers and how questions were answered, and (iii) individual feedback on exam performance will be given by a drop-in session run by the unit coordinator or by individual correspondence (written or verbal) upon request.
Students will also be provided with the opportunity (non-assessed) to write a practice exam essay/short answer prior to the exam and will be given individual formative feedback. Optional (non-assessed) e-learning quizzes will also be available throughout the course for students to gain formative feedback on their understanding of lecture material.
Wilson, BA, Salyers, AA, Whitt, DD & Winkler, ME, Bacterial Pathogenesis: A Molecular approach (3rd edition), ASM Press, 2010, Chapters 1, 2, 3, 4, 5, 6, 7, 11, 12, 13, 15, 16, 18 & 19 (Recommended)
Details of up-to-date relevant reviews will also be provided during the course as optional reading
|Scheduled activity hours|
|Assessment written exam||1.5|
|Independent study hours|
|Jennifer Cavet||Unit coordinator|