Clearing and adjustment 2019

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BSc Biomedical Sciences

Year of entry: 2019

Course unit details:
Clinical Drug Development

Unit code BIOL21302
Credit rating 10
Unit level Level 2
Teaching period(s) Semester 2
Offered by School of Biological Sciences
Available as a free choice unit? No

Overview

Clinical Drug Development explains the appliance of science whereby new drugs are discovered and developed, from initial ideas through to full clinical use in man. You will learn that consideration of how an individuals handling of drugs, i.e. pharmacokinetics; is important in the development of new drugs and about the interplay between business aspects and the biosciences.

Pre/co-requisites

Unit title Unit code Requirement type Description
Drugs: From Molecules to Man BIOL10822 Pre-Requisite Compulsory
BIOL21302 Pre- & Co-requisites are BIOL10822

Aims

  • To explain the appliance of science whereby new drugs are discovered and developed from initial ideas through to full clinical use in man
  • To explain how consideration of how an individual’s handling of drugs, i.e. pharmacokinetics; is important in the development of new drugs
  • Illustrate the interplay between business aspects and the biosciences

Learning outcomes

Students will gain an understanding of:

  • The major approaches to drug discovery
  • Application of molecular biology techniques to identifying lead compounds
  • Methods for determining the pharmacological and toxicological properties of compounds
  • The role of pharmacokinetic principles in the drug discovery process
  • Regulatory requirements for drugs
  • Clinical evaluation of drugs

Syllabus

  • Overview: Medicines: the discovery processes. The pharmaceutical industry.
  • Initial stages: Target discovery. Applications of molecular biology. Lead discovery. Lead optimisation. In silico methods. Biomarkers.
  • Measurement of drug properties: Assay techniques. Agonists (full, partial and inverse). Competitive antagonists. In vivo models. Pharmacokinetic profiles of compounds. Pharmacogenetics. Formulations. Pre-clinical safety assessment.
  • Later stages: Pharmaceutical development. Clinical evaluation: Phase I and II. Concepts in clinical trial design.

e-Learning Activity

  • Discussion board will be open to encourage dialogue between students
  • Additional resources to support the lecture content will be provided.
  • eLearning self-assessment modules: four question sets based on the course content and additional reading will be presented for summative assessment.

Employability skills

Analytical skills
Collaborative PowerPoint poster undertaken by teams of 5 or 6 students. Data is drip-fed to each team on a regular basis. Students are required to analyse this data and determine the next step to be taken in the drug discovery process. Some elearning modules will require students to analyse data and experimental results.
Group/team working
Collaborative presentation. Students work in teams of 5 or 6. Students are randomly allocated to teams and therefore may have to work with students they do not know.
Innovation/creativity
Collaborative presentation undertaken by teams of 5 or 6 students. Opportunity to generate an eye catching poster which also includes the appropriate level of scientific detail.
Leadership
Collaborative presentation undertaken by teams of 5 or 6 students. Each team may identify a team leader.
Project management
Collaborative presentation undertaken by teams of 5 or 6 students. The students spend approximately 9 weeks on this project. Information is drip fed to them throughout the project.
Oral communication
Students encouraged to answer questions during lectures.
Problem solving
Collaborative presentation undertaken by teams of 5 or 6 students. Data is drip-fed to each team on a regular basis. Students are required to analyse this data and determine the next step to be taken in the drug discovery process. This will require analysis of primary sources.. Some elearning modules are based on problem solving.
Research
Collaborative presentation undertaken by teams of 5 or 6 students. See below with regards to problem-solving skills. Students will need to determine appropriate experimental techniques to generate data. Additional reading material provided to students with each lecture.
Written communication
Collaborative presentation (poster, podcast, YouTube video) looking at the drug discovery process. Students work in teams of 5 or 6. Short note questions in examination.
Other
Business awareness. Underpinning this unit is the need to understand the relationship between business aspects and the biosciences. To this end, we have three guest lecturers (AstraZeneca, Gentronix and ICON) who deliver a total of 4 lectures on this unit.

Assessment methods

Method Weight
Other 5%
Written exam 80%
Set exercise 15%

Coursework components include a drug discovery game (15%) and eLearning modules (5%). Summative 1.5 hour examination (80%) comprising MCQs (40% of exam) and short-note questions (60% of exam).

Feedback methods

  • Students will be encouraged to ask questions during lectures and receive immediate feedback from staff and also via the Blackboard Discussion Board, which will be the main vehicle for providing feedback. Staff will also give individual feedback to questions raised by email.
  • Students will receive feedback throughout the drug discovery game.

Recommended reading

Please note Rang HP, Dale MM, Ritter JM, Flower, R & Henderson G. Rang & Dale's Pharmacology (7th edition), 2012, Churchill Livingstone is available as an ebook.

Recommended Reading

  1. Griffin JP & O'Grady J, The Textbook of Pharmaceutical Medicine (5th edition), London BMJ, 2005, Recommended
  2. Rang HP, Drug Discovery and Development: Technology in Transition, Churchill Livingstone, 2005, Recommended
  3. Rang HP, Dale MM, Ritter JM, Flower R & Henderson, G, Rang & Dale's Pharmacology (7th edition), Churchill Livingstone, 2012, Recommended

Study hours

Scheduled activity hours
Assessment written exam 1.3
Lectures 22
Independent study hours
Independent study 76.7

Teaching staff

Staff member Role
Alison Gurney Unit coordinator

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