BSc Zoology with Industrial/Professional Experience / Course details

Year of entry: 2019

Course unit details:
Drugs: From Molecules to Man

Unit code BIOL10822
Credit rating 10
Unit level Level 1
Teaching period(s) Semester 2
Offered by School of Biological Sciences
Available as a free choice unit? No

Overview

This unit introduces pharmacology - the science of drugs: their preparation, properties, uses and effects. You will learn about the molecular interactions of drugs with their targets in the body, focusing on the actions of the drugs acting on the cardiorespiratory system which treat conditions such as angina and asthma.

Pre/co-requisites

Unit title Unit code Requirement type Description
Body Systems BIOL10811 Co-Requisite Recommended

Aims

To introduce the major concepts underpinning pharmacology. To describe the main molecular mechanisms of action of some important classes of drugs acting on the cardiorespiratory system and relate these mechanisms to their cellular, tissue, organ and whole animal effects.

Learning outcomes

To understand: the molecular targets for drugs and examples of drugs acting at several target types; the basic concepts of drug receptor interactions; the importance of drug structure in their ability to interact with their targets; the mechanisms of the major drug classes used to treat hypertension, angina, cardiac failure, cardiac dysrhythmias and asthma.

Syllabus

Introduction to pharmacology: History and scope of pharmacology. How drugs are discovered.

Introduction to drug targets: Structure, function and cellular location of ligand-gated channels, voltage gated channels, enzymes, nuclear hormone receptors, transporters and pumps, G-protein coupled receptors.

Nature of drug receptor interactions: Agonists, antagonists and partial agonists, efficacy, drug structures, pharmacophores and selectivity. Concentration-response relationships. Gaddum, Schild analysis.

Role of specialized disciplines within pharmacology: toxins from animal and plant sources, molecular and cellular techniques in pharmacology, discovering the structure of G protein coupled receptors.

Drugs acting on the cardiovascular/respiratory systems: Antihypertensive drugs, antidysrhythmic drugs, drugs used to treat angina and cardiac failure, lipid lowering drugs, drugs used to treat and prevent thrombosis, drugs used to treat asthma.

Employability skills

Analytical skills
Data handling ePBL
Problem solving
Data handling ePBL
Other
Handling complex data, time management

Assessment methods

Method Weight
Other 20%
Written exam 80%

80% awarded for a one hour examination, which will include 47 MCQs and one short note question (from a choice of three) in the semester 2 examination period, and 20% awarded for an electronically marked exercise.

Feedback methods

Feedback will be provided via automated ePBL responses; mid-semester mini exam; post-examination guidance (if requested).

Recommended reading

Titles below are also available as an eBook via JRUL website.

Recommended Reading

Title below is also available as an eBook via JRUL website.

Recommended Reading

Rang HP, Ritter JM, Flower R & Henderson, G, Rang & Dale’s Pharmacology (8th edition), Churchill Livingstone, 2015 Chapters: 1,2,3,13,14,15, 20-24, 28, 33

Study hours

Scheduled activity hours
Assessment written exam 1
Lectures 22
Independent study hours
Independent study 77

Teaching staff

Staff member Role
Richard Prince Unit coordinator

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