BSc Pharmacology with Industrial/Professional Experience / Course details
Year of entry: 2020
Course unit details:
Advanced Ion Transport (E)
|Unit level||Level 3|
|Teaching period(s)||Semester 1|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||No|
Ion channels and transporters are crucial to cellular definition and function. This unit will explore how these proteins are studied, explain their structural diversity and illustrate their importance in electrically active and non-electrically active cells using specific physiological examples. You will develop transferable skills in evaluating published material and in information gathering whilst also gaining knowledge in how the architecture of ion channels and transporters enables control of discrete cellular functions.
|Unit title||Unit code||Requirement type||Description|
|Membrane Excitability: Ion Channels & Transporters in Action||BIOL21321||Pre-Requisite||Recommended|
Any ONE of the following RSM units is strongly recommended:
- BIOL 20922 Neuroscience RSM
- BIOL 20932 Pharmacology RSM
- BIOL 20942 Physiology RSM
Ion channels and transporters are ubiquitous membrane proteins that transport ions and other small molecules in cells. They are crucial to cellular definition and function. This unit will explore how these proteins are studied, explain their structural diversity and illustrate their importance in electrically active and non-electrically active cells, using specific physiological examples.
On completion of the course it is expected students will
- understand how ion channels and transporters are assembled into unique complexes to enable control of discrete cellular functions.
- have developed transferable skills in evaluating published material and, information gathering.
- Transporters and aquaporins: Structures, functions and regulation of acid-base transporters, solute transporters and aquaporins in physiological systems. Co-operative interactions of channels and transporters in epithelial ion transport.
- Ion channel trafficking: Advanced principles of ion channel biosynthesis, assembly, trafficking, degradation and targeting/distribution, described using specific examples.
- Voltage-gated ion channels: Basic structures of membrane potential sensitive channels exemplified by review of voltage-gated K+ and Ca2+ channels. Their roles in controlling neuronal, cardiovascular and endocrine cell function.
- Ligand-gated ion channels: Review of ligand-gated channel families, their physiological roles and pharmacological regulation.
- Ion channel integration and cell function: How channels work together to regulate cell function e.g. excitation-contraction coupling in muscle.
- Analytical skills
- Critical evaluation of published material
- Problem solving
- Online problem solving and questions relating to lecture material
- Self-directed reading of additional materials, development of information gathering skills.
- Written communication
- Essay questions in exam
2 hour Examination (95%),
Other - completion of online feedback questions (5%)
- Online problem solving and questions related to lecture material (5% of final mark).
- Discussion Board (Unit Blackboard site).
|Scheduled activity hours|
|Assessment written exam||2|
|Independent study hours|
|Elizabeth Fitzgerald||Unit coordinator|