BSc Biotechnology / Course details
Year of entry: 2020
Course unit details:
Drugs: From Molecules to Man
|Unit level||Level 1|
|Teaching period(s)||Semester 2|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||No|
This unit introduces pharmacology - the science of drugs: their preparation, properties, uses and effects. You will learn about the molecular interactions of drugs with their targets in the body, focusing on the actions of the drugs acting on the cardiorespiratory system which treat conditions such as angina and asthma.
|Unit title||Unit code||Requirement type||Description|
To introduce the major concepts underpinning pharmacology. To describe the main molecular mechanisms of action of some important classes of drugs acting on the cardiorespiratory system and relate these mechanisms to their cellular, tissue, organ and whole animal effects.
To understand: the molecular targets for drugs and examples of drugs acting at several target types; the basic concepts of drug receptor interactions; the importance of drug structure in their ability to interact with their targets; the mechanisms of the major drug classes used to treat hypertension, angina, cardiac failure, cardiac dysrhythmias and asthma.
Introduction to pharmacology: History and scope of pharmacology. How drugs are discovered.
Introduction to drug targets: Structure, function and cellular location of ligand-gated channels, voltage gated channels, enzymes, nuclear hormone receptors, transporters and pumps, G-protein coupled receptors.
Nature of drug receptor interactions: Agonists, antagonists and partial agonists, efficacy, drug structures, pharmacophores and selectivity. Concentration-response relationships. Gaddum, Schild analysis.
Role of specialized disciplines within pharmacology: toxins from animal and plant sources, molecular and cellular techniques in pharmacology, discovering the structure of G protein coupled receptors.
Drugs acting on the cardiovascular/respiratory systems: Antihypertensive drugs, antidysrhythmic drugs, drugs used to treat angina and cardiac failure, lipid lowering drugs, drugs used to treat and prevent thrombosis, drugs used to treat asthma.
- Analytical skills
- Data handling ePBL
- Problem solving
- Data handling ePBL
- Handling complex data, time management
80% awarded for a one hour examination, which will include 47 MCQs and one short note question (from a choice of three) in the semester 2 examination period, and 20% awarded for an electronically marked exercise.
Feedback will be provided via automated ePBL responses; mid-semester mini exam; post-examination guidance (if requested).
Titles below are also available as an eBook via JRUL website.
Title below is also available as an eBook via JRUL website.
Rang HP, Ritter JM, Flower R & Henderson, G, Rang & Dale’s Pharmacology (8th edition), Churchill Livingstone, 2015 Chapters: 1,2,3,13,14,15, 20-24, 28, 33
|Scheduled activity hours|
|Assessment written exam||1|
|Independent study hours|
|Richard Prince||Unit coordinator|