MSci Developmental Biology
Year of entry: 2022
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Course unit details:
Biochemical Basis of Disease (E)
|Unit level||Level 3|
|Teaching period(s)||Semester 2|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||No|
Major diseases of man such as diabetes, obesity, atherosclerosis, and fibrosis, are increasingly significant contributors to morbidity and mortality in the western world. Developing treatments for these diseases is a major challenge to the pharmaceutical industry and there is great interest in the biochemistry underlying their pathogenesis.
|Unit title||Unit code||Requirement type||Description|
|Cell Metabolism & Metabolic Control||BIOL21132||Pre-Requisite||Recommended|
This unit aims to describe the biochemistry of these common diseases and highlight how our current understanding of disease mechanisms informs the development of novel therapies.
Students should have an understanding of the biochemical basis of a number of major diseases of man and appreciate how and why specific disease mechanisms are being targeted in the development of new treatments.
A significant proportion of this course will be delivered in the form of directed reading supported by lectures and will focus on biochemical aspects of disease mechanisms and potential therapies relating to:
• Diabetes and Obesity: metabolic syndrome, beta cells and insulin secretion, insulin resistance, type II diabetes, secondary complications of diabetes.
• Vascular disease: Atherosclerosis, dyslipidaemia, vascular calcification, aberrant angiogenesis
• Fibrotic disease: ECM biology in tissue homeostasis, remodelling, repair and fibrosis.
• Protein folding/misfolding diseases: amyloid diseases, prion disease, gain and loss of function diseases caused by protein misfolding at the endoplasmic reticulum, the unfolded protein response and its role in disease, therapeutic strategies for protein folding diseases.
- Students encouraged to read around the lecture material including recommended primary literature and review papers.
- Written communication
- Students have the opportunity to submit and receive feedback on an exam style essay outline which is based on relevant questions from past papers.
Group feedback will be given for the assessment and an online discussion forum on Blackboard or Padlet will be available to facilitate communication amongst students and teaching staff.
The final lecture of the course will be attended by all lecturers. The focus will be to provide a review of the previous year’s exam paper and guidance on exam preparation.
Review papers and some primary literature will be provided on Blackboard to compliment the lecture topics.
|Scheduled activity hours|
|Assessment written exam||2|
|Independent study hours|
|Susan Taylor||Unit coordinator|