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Multiple-Bolus Dynamic Contrast-Enhanced MRI in the Pancreas During a Glucose Challenge
Naish, J H; Hutchinson, C E; Caunce, A; Roberts, C; Waterton, J C; Hockings, P D; Taylor, C J; Parker, G J M
Journal of Magnetic Resonance Imaging. 2010;32(3):622-628.
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Abstract
Purpose: To assess the feasibility of multiple-bolus dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate application of the method to a glucose challenge in type 2 diabetes. Materials and Methods: A 4-bolus DCE-MRI protocol was performed on five patients with type 2 diabetes and 11 healthy volunteers during free-breathing. Motion during the dynamic time series was corrected for using a model-driven nonlinear registration. A glucose challenge was administered intravenously between the first and second DCE-MRI acquisition in all patients and in seven of the healthy controls. Results: Image registration improved the reproducibility. of the DCE-MRI model parameters across the repeated bolus-acquisitions in the healthy controls with no glucose challenge (eg, coefficient of variation for K-trans improved from 38% to 28%). Native tissue T-1 was significantly lower in patients (374 +/- 68 msec) compared with volunteers (519 +/- 41 msec) but there was no significant difference in any of the baseline DCE-MRI parameters. No effect of glucose challenge was observed in either the patients or healthy volunteers. Conclusion: Multiple bolus DCE-MRI is feasible in the pancreas and is improved by nonlinear image registration but is not sensitive to the effects of an intravenous glucose challenge.
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- Related website <Go to ISI>://000281532700012
- Naish, J. H. Hutchinson, C. E. Caunce, A. Roberts, C. Waterton, J. C. Hockings, P. D. Taylor, C. J. Parker, G. J. M.