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- PMID: 15246603
- UKPMCID: 15246603
- DOI: 10.1016/j.vaccine.2004.01.049
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Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).
Davidson, E J; Faulkner, R L; Sehr, P; Pawlita, M; Smyth, L J C; Burt, D J; Tomlinson, A E; Hickling, J; Kitchener, H C; Stern, P L
Vaccine. 2004;22(21-22):2722-9.
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Full-text held externally
- PMID: 15246603
- UKPMCID: 15246603
- DOI: 10.1016/j.vaccine.2004.01.049
Abstract
Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy of human papillomavirus (HPV) type 16-associated vulval intraepithelial neoplasia (VIN). In the present study, 10 women with HPV 16-positive high grade VIN, previously primed with TA-HPV, received three booster immunisations with TA-CIN. All but one demonstrated HPV 16-specific proliferative T-cell and/or serological responses following vaccination. Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen.