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- PMID: 21098702
- UKPMCID: 21098702
- DOI: 10.1158/0008-5472.CAN-10-0352
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Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma.
Bouwes Bavinck, Jan Nico; Neale, Rachel E; Abeni, Damiano; Euvrard, Sylvie; Green, Adele C; Harwood, Catherine A; de Koning, Maurits N C; Naldi, Luigi; Nindl, Ingo; Pawlita, Michael; Pfister, Herbert; Proby, Charlotte M; Quint, Wim G V; ter Schegget, Jan; Waterboer, Tim; Weissenborn, Sönke; Feltkamp, Mariet C W;
Cancer research. 2010;70(23):9777-86.
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Full-text held externally
- PMID: 21098702
- UKPMCID: 21098702
- DOI: 10.1158/0008-5472.CAN-10-0352
Abstract
Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR = 2.8; 95% CI 1.3-5.8) and Italy (OR = 1.7; 95% CI 0.79-3.6), but not in Australia (OR = 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR = 2.2; 95% CI 1.4-3.3), the Netherlands (OR = 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR = 1.6, 95% CI 0.94- 2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma.
Bibliographic metadata
- Bouwes Bavinck, J N
- van der Zwan-Kralt, P
- de Graaf, Y G L
- Vos, L E
- Uphoff-Meijerink, E J
- Willemze, R
- Feltkamp, M C W
- Struijk, L
- Wanningen, P
- van der Meijden, P Z
- Plasmeijer, E I
- Wolterbeek, R
- Euvrard, S
- Butnaru, A C
- Claudy, A
- Kanitakis, J
- Nindl, I
- Stockfleth, E
- Forschner, T
- Naldi, L
- Pizzagalli, A
- Sassi, F
- Tessari, G
- Harwood, C A
- Proby, C M
- Breuer, J
- Mitchell, L
- Purdie, K
- Lambert, S R
- Ran, H
- Pfister, H
- Wieland, U
- Weissenborn, S
- Pawlita, M
- Waterboer, T
- Sehr, P
- Michael, K M
- Quint, W G V
- de Koning, M N C
- ter Schegget, J
- Kleter, B
- van Doorn, L J
- Abeni, D
- Sampogna, F
- Mannooranparampil, T J
- Melo-Salcedo, N
- Simoni, S
- Petasecca Donati, G P
- Masini, C
- Deppermann Fortes, C
- Green, A C
- Neale, R
- Olsen, C
- O'Rourke, P
- Harrison, S
- Buttner, P