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- DOI: 10.1530/EJE-11-0353
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Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS).
Boonen S, Pye SR, O'Neill TW, Szulc P, Gielen E, Borghs H, Verschueren S, Claessens F, Adams JE, Ward KA, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TA, Huhtaniemi I, Kula K, Labrie F, Lean M, Pendleton N, Punab M, Silman AJ, Tajar A, Wu FCW and Vanderschueren D
European Journal of Endocrinology. 2011;165(6):977-986.
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Full-text held externally
- DOI: 10.1530/EJE-11-0353
Abstract
Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: Cross-sectional population based survey. Methods: Men aged 40-79 years were recruited from population registers in 8 European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to attend for quantitative ultrasound (QUS) of the calcaneus and a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β-cTX), total testosterone (T), total oestradiol (E2), sex hormone-binding globulin (SHBG) and insulin-like growth factor (IGF)-I were measured. Dual energy x-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: 3120 men, mean age 59.9 years (standard deviation [SD]=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E2 were negatively associated with β-cTX but not P1NP while SHBG, IGF-I and PTH were positively associated with both β-cTX and P1NP. Total or free T were not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: Oestradiol, SHBG, IGF-I and PTH contribute significantly to the regulation / rate of bone turnover in middle-aged and older European men. Higher rates of bone remodeling are negatively associated with male bone health.