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- DOI: 10.1002/art.33344
- PMID: 22094921
- UKPMCID: 22094921
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Prevalence of MRI-defined atrophic and hypertrophic phenotypes of knee osteoarthritis in a population-based cohort.
Roemer, Frank W; Guermazi, Ali; Niu, Jingbo; Zhang, Yuqing; Mohr, Andreas; Felson, David T
Arthritis and rheumatism. 2012;64(2):429-437.
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Full-text held externally
- DOI: 10.1002/art.33344
- PMID: 22094921
- UKPMCID: 22094921
Abstract
OBJECTIVES: To describe the association of osteophytes with concomitant cartilage damage in a population-based cohort using semiquantitative MRI assessment and to describe the prevalence of atrophic and hypertrophic phenotypes of tibio-femoral knee osteoarthritis. METHODS: Participants of the Framingham Knee Osteoarthritis Study were examined with a 1.5 T MRI system using triplanar intermediate-weighted fat suppressed sequences. Cartilage and osteophytes were assessed according to the WORMS scoring system. Overall prevalence of knees with severe cartilage damage and concomitant osteophyte status was described. The odds ratios of severe cartilage damage according to osteophyte size were estimated using a logistic regression model. An additional analysis assessed knees with absent or only tiny osteophytes (≤2 on a 0-7 scale) in all 10 tibio-femoral subregions but with severe cartilage damage (atrophic phenotype) and knees with large osteophytes (≥5 on a 0-7 scale) and without substantial cartilage damage (hypertrophic phenotype) in regard to radiographic osteoarthritis status. RESULTS: 1597 knees of 1248 subjects were included. 54 of 67 (80.6%) knees with large osteophytes exhibited severe cartilage damage. The risk of severe cartilage damage increased markedly with increasing osteophyte size. 21 knees (1.3%) showed an atrophic phenotype. Only 3 knees (0.2%) exhibited a hypertrophic phenotype. CONCLUSIONS: The majority of knees with severe tibio-femoral cartilage damage exhibit moderate to large osteophytes. The larger the osteophyte, the more likely there was severe cartilage damage. A minority of knees exhibits the so-called atrophic phenotype, which also includes knees without radiographic osteoarthritis. The hypertrophic phenotype is extremely rare © 2011 American College of Rheumatology.