Related resources
Full-text held externally
- DOI: 10.1038/ng.1017
- PMID: 22197932
- UKPMCID: 22197932
Search for item elsewhere
University researcher(s)
Academic department(s)
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
Paternoster, Lavinia; Standl, Marie; Chen, Chih-Mei; Ramasamy, Adaikalavan; Bønnelykke, Klaus; Duijts, Liesbeth; Ferreira, Manuel A; Alves, Alexessander Couto; Thyssen, Jacob P; Albrecht, Eva; Baurecht, Hansjörg; Feenstra, Bjarke; Sleiman, Patrick M A; Hysi, Pirro; Warrington, Nicole M; Curjuric, Ivan; Myhre, Ronny; Curtin, John A; Groen-Blokhuis, Maria M; Kerkhof, Marjan; Sääf, Annika; Franke, Andre; Ellinghaus, David; Fölster-Holst, Regina; Dermitzakis, Emmanouil; Montgomery, Stephen B; Prokisch, Holger; Heim, Katharina; Hartikainen, Anna-Liisa; Pouta, Anneli; Pekkanen, Juha; Blakemore, Alexandra I F; Buxton, Jessica L; Kaakinen, Marika; Duffy, David L; Madden, Pamela A; Heath, Andrew C; Montgomery, Grant W; Thompson, Philip J; Matheson, Melanie C; Le SouĂ«f, Peter; ; Pourcain, Beate St; Smith, George Davey; Henderson, John; Kemp, John P; Timpson, Nicholas J; Deloukas, Panos; Ring, Susan M; Wichmann, H-Erich; MĂĽller-Nurasyid, Martina; Novak, Natalija; Klopp, Norman; RodrĂguez, Elke; McArdle, Wendy; Linneberg, Allan; MennĂ©, Torkil; Nohr, Ellen A; Hofman, Albert; Uitterlinden, AndrĂ© G; van Duijn, CornĂ©lia M; Rivadeneira, Fernando; de Jongste, Johan C; van der Valk, Ralf J P; Wjst, Matthias; Jogi, Rain; Geller, Frank; Boyd, Heather A; Murray, Jeffrey C; Kim, Cecilia; Mentch, Frank; March, Michael; Mangino, Massimo; Spector, Tim D; Bataille, Veronique; Pennell, Craig E; Holt, Patrick G; Sly, Peter; Tiesler, Carla M T; Thiering, Elisabeth; Illig, Thomas; Imboden, Medea; Nystad, Wenche; Simpson, Angela; Hottenga, Jouke-Jan; Postma, Dirkje; Koppelman, Gerard H; Smit, Henriette A; Söderhäll, Cilla; Chawes, Bo; Kreiner-Møller, Eskil; Bisgaard, Hans; MelĂ©n, Erik; Boomsma, Dorret I; Custovic, Adnan; Jacobsson, Bo; Probst-Hensch, Nicole M; Palmer, Lyle J; Glass, Daniel; Hakonarson, Hakon; Melbye, Mads; Jarvis, Deborah L; Jaddoe, Vincent W V; Gieger, Christian; ; Strachan, David P; Martin, Nicholas G; Jarvelin, Marjo-Riitta; Heinrich, Joachim; Evans, David M; ; Weidinger, Stephan
Nature genetics. 2011;44(2):187.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1038/ng.1017
- PMID: 22197932
- UKPMCID: 22197932
Abstract
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 Ă— 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 Ă— 10(-9)), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 Ă— 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
Bibliographic metadata
- Paternoster, Lavinia
- Standl, Marie
- Chen, Chih-Mei
- Ramasamy, Adaikalavan
- Bønnelykke, Klaus
- Duijts, Liesbeth
- Ferreira, Manuel A
- Alves, Alexessander Couto
- Thyssen, Jacob P
- Albrecht, Eva
- Baurecht, Hansjörg
- Feenstra, Bjarke
- Sleiman, Patrick M A
- Hysi, Pirro
- Warrington, Nicole M
- Curjuric, Ivan
- Myhre, Ronny
- Curtin, John A
- Groen-Blokhuis, Maria M
- Kerkhof, Marjan
- Sääf, Annika
- Franke, Andre
- Ellinghaus, David
- Fölster-Holst, Regina
- Dermitzakis, Emmanouil
- Montgomery, Stephen B
- Prokisch, Holger
- Heim, Katharina
- Hartikainen, Anna-Liisa
- Pouta, Anneli
- Pekkanen, Juha
- Blakemore, Alexandra I F
- Buxton, Jessica L
- Kaakinen, Marika
- Duffy, David L
- Madden, Pamela A
- Heath, Andrew C
- Montgomery, Grant W
- Thompson, Philip J
- Matheson, Melanie C
- Le Souëf, Peter
- Pourcain, Beate St
- Smith, George Davey
- Henderson, John
- Kemp, John P
- Timpson, Nicholas J
- Deloukas, Panos
- Ring, Susan M
- Wichmann, H-Erich
- MĂĽller-Nurasyid, Martina
- Novak, Natalija
- Klopp, Norman
- RodrĂguez, Elke
- McArdle, Wendy
- Linneberg, Allan
- Menné, Torkil
- Nohr, Ellen A
- Hofman, Albert
- Uitterlinden, André G
- van Duijn, Cornélia M
- Rivadeneira, Fernando
- de Jongste, Johan C
- van der Valk, Ralf J P
- Wjst, Matthias
- Jogi, Rain
- Geller, Frank
- Boyd, Heather A
- Murray, Jeffrey C
- Kim, Cecilia
- Mentch, Frank
- March, Michael
- Mangino, Massimo
- Spector, Tim D
- Bataille, Veronique
- Pennell, Craig E
- Holt, Patrick G
- Sly, Peter
- Tiesler, Carla M T
- Thiering, Elisabeth
- Illig, Thomas
- Imboden, Medea
- Nystad, Wenche
- Simpson, Angela
- Hottenga, Jouke-Jan
- Postma, Dirkje
- Koppelman, Gerard H
- Smit, Henriette A
- Söderhäll, Cilla
- Chawes, Bo
- Kreiner-Møller, Eskil
- Bisgaard, Hans
- Melén, Erik
- Boomsma, Dorret I
- Custovic, Adnan
- Jacobsson, Bo
- Probst-Hensch, Nicole M
- Palmer, Lyle J
- Glass, Daniel
- Hakonarson, Hakon
- Melbye, Mads
- Jarvis, Deborah L
- Jaddoe, Vincent W V
- Gieger, Christian
- Strachan, David P
- Martin, Nicholas G
- Jarvelin, Marjo-Riitta
- Heinrich, Joachim
- Evans, David M
- Weidinger, Stephan