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Full-text held externally
- DOI: 10.1038/ng.686
- PMID: 20935630
- UKPMCID: 20935630
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Jackson, Anne U; Lango Allen, Hana; Lindgren, Cecilia M; Luan, Jian'an; Mägi, Reedik; Randall, Joshua C; Vedantam, Sailaja; Winkler, Thomas W; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris M; Steinthorsdottir, Valgerdur; Stringham, Heather M; Weedon, Michael N; Wheeler, Eleanor; Wood, Andrew R; Ferreira, Teresa; Weyant, Robert J; Segrè, Ayellet V; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Gustafsson, Stefan; Kilpeläinen, Tuomas O; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tõnu; Feitosa, Mary F; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K; Absher, Devin M; Amin, Najaf; Dixon, Anna L; Fisher, Eva; Glazer, Nicole L; Goddard, Michael E; Heard-Costa, Nancy L; Hoesel, Volker; Hottenga, Jouke-Jan; Johansson, Asa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F; Myers, Richard H; Narisu, Narisu; Perry, John R B; Peters, Marjolein J; Preuss, Michael; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J; Timpson, Nicholas J; Tyrer, Jonathan P; van Wingerden, Sophie; Watanabe, Richard M; White, Charles C; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I; Cooper, Matthew N; Jansson, John-Olov; Lawrence, Robert W; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helene; Alibrandi, Maria T S; Almgren, Peter; Arnold, Alice M; Aspelund, Thor; Atwood, Larry D; Balkau, Beverley; Balmforth, Anthony J; Bennett, Amanda J; Ben-Shlomo, Yoav; Bergman, Richard N; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I F; Boes, Tanja; Bonnycastle, Lori L; Bornstein, Stefan R; Brown, Morris J; Buchanan, Thomas A; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P; Cavalcanti-Proença, Christine; Chen, Yii-Der Ida; Chen, Chih-Mei; Chines, Peter S; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian N M; den Heijer, Martin; Duan, Jubao; Ebrahim, Shah; Elliott, Paul; Elosua, Roberto; Eiriksdottir, Gudny; Erdos, Michael R; Eriksson, Johan G; Facheris, Maurizio F; Felix, Stephan B; Fischer-Posovszky, Pamela; Folsom, Aaron R; Friedrich, Nele; Freimer, Nelson B; Fu, Mao; Gaget, Stefan; Gejman, Pablo V; Geus, Eco J C; Gieger, Christian; Gjesing, Anette P; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Grässler, Jürgen; Greenawalt, Danielle M; Groves, Christopher J; Gudnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hall, Alistair S; Havulinna, Aki S; Hayward, Caroline; Heath, Andrew C; Hengstenberg, Christian; Hicks, Andrew A; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B; Jarick, Ivonne; Jewell, Elizabeth; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kaplan, Lee M; Kathiresan, Sekar; Kettunen, Johannes; Kinnunen, Leena; Knowles, Joshua W; Kolcic, Ivana; König, Inke R; Koskinen, Seppo; Kovacs, Peter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J; Lecoeur, Cecile; Lehtimäki, Terho; Lettre, Guillaume; Liu, Jianjun; Lokki, Marja-Liisa; Lorentzon, Mattias; Luben, Robert N; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G; McArdle, Wendy L; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant W; Morken, Mario A; Morris, Andrew P; Mulic, Rosanda; Ngwa, Julius S; Nelis, Mari; Neville, Matt J; Nyholt, Dale R; O'Donnell, Christopher J; O'Rahilly, Stephen; Ong, Ken K; Oostra, Ben; Paré, Guillaume; Parker, Alex N; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H; Platou, Carl G P; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R; Sandhu, Manjinder S; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S; Smit, Jan H; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Teder-Laving, Maris; Teslovich, Tanya M; Thompson, John R; Thomson, Brian; Tönjes, Anke; Tuomi, Tiinamaija; van Meurs, Joyce B J; van Ommen, Gert-Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie; Vitart, Veronique; Vogel, Carla I G; Voight, Benjamin F; Waite, Lindsay L; Wallaschofski, Henri; Walters, G Bragi; Widen, Elisabeth; Wiegand, Susanna; Wild, Sarah H; Willemsen, Gonneke; Witte, Daniel R; Witteman, Jacqueline C; Xu, Jianfeng; Zhang, Qunyuan; Zgaga, Lina; Ziegler, Andreas; Zitting, Paavo; Beilby, John P; Farooqi, I Sadaf; Hebebrand, Johannes; Huikuri, Heikki V; James, Alan L; Kähönen, Mika; Levinson, Douglas F; Macciardi, Fabio; Nieminen, Markku S; Ohlsson, Claes; Palmer, Lyle J; Ridker, Paul M; Stumvoll, Michael; Beckmann, Jacques S; Boeing, Heiner; Boerwinkle, Eric; Boomsma, Dorret I; Caulfield, Mark J; Chanock, Stephen J; Collins, Francis S; Cupples, L Adrienne; Smith, George Davey; Erdmann, Jeanette; Froguel, Philippe; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B; Hattersley, Andrew T; Hayes, Richard B; Heinrich, Joachim; Hu, Frank B; Hveem, Kristian; Illig, Thomas; Jarvelin, Marjo-Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay-Tee; Kiemeney, Lambertus A; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A; Metspalu, Andres; Munroe, Patricia B; Ouwehand, Willem H; Pedersen, Oluf; Penninx, Brenda W; Peters, Annette; Pramstaller, Peter P; Quertermous, Thomas; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Samani, Nilesh J; Schwarz, Peter E H; Shuldiner, Alan R; Spector, Timothy D; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, André; Valle, Timo T; Wabitsch, Martin; Waeber, Gérard; Wareham, Nicholas J; Watkins, Hugh; Wilson, James F; Wright, Alan F; Zillikens, M Carola; Chatterjee, Nilanjan; McCarroll, Steven A; Purcell, Shaun; Schadt, Eric E; Visscher, Peter M; Assimes, Themistocles L; Borecki, Ingrid B; Deloukas, Panos; Fox, Caroline S; Groop, Leif C; Haritunians, Talin; Hunter, David J; Kaplan, Robert C; Mohlke, Karen L; O'Connell, Jeffrey R; Peltonen, Leena; Schlessinger, David; Strachan, David P; van Duijn, Cornelia M; Wichmann, H-Erich; Frayling, Timothy M; Thorsteinsdottir, Unnur; Abecasis, Gonçalo R; Barroso, Inês; Boehnke, Michael; Stefansson, Kari; North, Kari E; McCarthy, Mark I; Hirschhorn, Joel N; Ingelsson, Erik; Loos, Ruth J F
Nature genetics. 2010;42(11):937-48.
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Full-text held externally
- DOI: 10.1038/ng.686
- PMID: 20935630
- UKPMCID: 20935630
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ⼠2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 Ă— 10â»â¸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Bibliographic metadata
- Speliotes, Elizabeth K
- Willer, Cristen J
- Berndt, Sonja I
- Monda, Keri L
- Thorleifsson, Gudmar
- Jackson, Anne U
- Lango Allen, Hana
- Lindgren, Cecilia M
- Luan, Jian'an
- Mägi, Reedik
- Randall, Joshua C
- Vedantam, Sailaja
- Winkler, Thomas W
- Qi, Lu
- Workalemahu, Tsegaselassie
- Heid, Iris M
- Steinthorsdottir, Valgerdur
- Stringham, Heather M
- Weedon, Michael N
- Wheeler, Eleanor
- Wood, Andrew R
- Ferreira, Teresa
- Weyant, Robert J
- Segrè, Ayellet V
- Estrada, Karol
- Liang, Liming
- Nemesh, James
- Park, Ju-Hyun
- Gustafsson, Stefan
- Kilpeläinen, Tuomas O
- Yang, Jian
- Bouatia-Naji, Nabila
- Esko, Tõnu
- Feitosa, Mary F
- Kutalik, Zoltán
- Mangino, Massimo
- Raychaudhuri, Soumya
- Scherag, Andre
- Smith, Albert Vernon
- Welch, Ryan
- Zhao, Jing Hua
- Aben, Katja K
- Absher, Devin M
- Amin, Najaf
- Dixon, Anna L
- Fisher, Eva
- Glazer, Nicole L
- Goddard, Michael E
- Heard-Costa, Nancy L
- Hoesel, Volker
- Hottenga, Jouke-Jan
- Johansson, Asa
- Johnson, Toby
- Ketkar, Shamika
- Lamina, Claudia
- Li, Shengxu
- Moffatt, Miriam F
- Myers, Richard H
- Narisu, Narisu
- Perry, John R B
- Peters, Marjolein J
- Preuss, Michael
- Ripatti, Samuli
- Rivadeneira, Fernando
- Sandholt, Camilla
- Scott, Laura J
- Timpson, Nicholas J
- Tyrer, Jonathan P
- van Wingerden, Sophie
- Watanabe, Richard M
- White, Charles C
- Wiklund, Fredrik
- Barlassina, Christina
- Chasman, Daniel I
- Cooper, Matthew N
- Jansson, John-Olov
- Lawrence, Robert W
- Pellikka, Niina
- Prokopenko, Inga
- Shi, Jianxin
- Thiering, Elisabeth
- Alavere, Helene
- Alibrandi, Maria T S
- Almgren, Peter
- Arnold, Alice M
- Aspelund, Thor
- Atwood, Larry D
- Balkau, Beverley
- Balmforth, Anthony J
- Bennett, Amanda J
- Ben-Shlomo, Yoav
- Bergman, Richard N
- Bergmann, Sven
- Biebermann, Heike
- Blakemore, Alexandra I F
- Boes, Tanja
- Bonnycastle, Lori L
- Bornstein, Stefan R
- Brown, Morris J
- Buchanan, Thomas A
- Busonero, Fabio
- Campbell, Harry
- Cappuccio, Francesco P
- Cavalcanti-Proença, Christine
- Chen, Yii-Der Ida
- Chen, Chih-Mei
- Chines, Peter S
- Clarke, Robert
- Coin, Lachlan
- Connell, John
- Day, Ian N M
- den Heijer, Martin
- Duan, Jubao
- Ebrahim, Shah
- Elliott, Paul
- Elosua, Roberto
- Eiriksdottir, Gudny
- Erdos, Michael R
- Eriksson, Johan G
- Facheris, Maurizio F
- Felix, Stephan B
- Fischer-Posovszky, Pamela
- Folsom, Aaron R
- Friedrich, Nele
- Freimer, Nelson B
- Fu, Mao
- Gaget, Stefan
- Gejman, Pablo V
- Geus, Eco J C
- Gieger, Christian
- Gjesing, Anette P
- Goel, Anuj
- Goyette, Philippe
- Grallert, Harald
- Grässler, Jürgen
- Greenawalt, Danielle M
- Groves, Christopher J
- Gudnason, Vilmundur
- Guiducci, Candace
- Hartikainen, Anna-Liisa
- Hassanali, Neelam
- Hall, Alistair S
- Havulinna, Aki S
- Hayward, Caroline
- Heath, Andrew C
- Hengstenberg, Christian
- Hicks, Andrew A
- Hinney, Anke
- Hofman, Albert
- Homuth, Georg
- Hui, Jennie
- Igl, Wilmar
- Iribarren, Carlos
- Isomaa, Bo
- Jacobs, Kevin B
- Jarick, Ivonne
- Jewell, Elizabeth
- John, Ulrich
- Jørgensen, Torben
- Jousilahti, Pekka
- Jula, Antti
- Kaakinen, Marika
- Kajantie, Eero
- Kaplan, Lee M
- Kathiresan, Sekar
- Kettunen, Johannes
- Kinnunen, Leena
- Knowles, Joshua W
- Kolcic, Ivana
- König, Inke R
- Koskinen, Seppo
- Kovacs, Peter
- Kuusisto, Johanna
- Kraft, Peter
- Kvaløy, Kirsti
- Laitinen, Jaana
- Lantieri, Olivier
- Lanzani, Chiara
- Launer, Lenore J
- Lecoeur, Cecile
- Lehtimäki, Terho
- Lettre, Guillaume
- Liu, Jianjun
- Lokki, Marja-Liisa
- Lorentzon, Mattias
- Luben, Robert N
- Ludwig, Barbara
- Manunta, Paolo
- Marek, Diana
- Marre, Michel
- Martin, Nicholas G
- McArdle, Wendy L
- McCarthy, Anne
- McKnight, Barbara
- Meitinger, Thomas
- Melander, Olle
- Meyre, David
- Midthjell, Kristian
- Montgomery, Grant W
- Morken, Mario A
- Morris, Andrew P
- Mulic, Rosanda
- Ngwa, Julius S
- Nelis, Mari
- Neville, Matt J
- Nyholt, Dale R
- O'Donnell, Christopher J
- O'Rahilly, Stephen
- Ong, Ken K
- Oostra, Ben
- Paré, Guillaume
- Parker, Alex N
- Perola, Markus
- Pichler, Irene
- Pietiläinen, Kirsi H
- Platou, Carl G P
- Polasek, Ozren
- Pouta, Anneli
- Rafelt, Suzanne
- Raitakari, Olli
- Rayner, Nigel W
- RidderstrĂĄle, Martin
- Rief, Winfried
- Ruokonen, Aimo
- Robertson, Neil R
- Rzehak, Peter
- Salomaa, Veikko
- Sanders, Alan R
- Sandhu, Manjinder S
- Sanna, Serena
- Saramies, Jouko
- Savolainen, Markku J
- Scherag, Susann
- Schipf, Sabine
- Schreiber, Stefan
- Schunkert, Heribert
- Silander, Kaisa
- Sinisalo, Juha
- Siscovick, David S
- Smit, Jan H
- Soranzo, Nicole
- Sovio, Ulla
- Stephens, Jonathan
- Surakka, Ida
- Swift, Amy J
- Tammesoo, Mari-Liis
- Tardif, Jean-Claude
- Teder-Laving, Maris
- Teslovich, Tanya M
- Thompson, John R
- Thomson, Brian
- Tönjes, Anke
- Tuomi, Tiinamaija
- van Meurs, Joyce B J
- van Ommen, Gert-Jan
- Vatin, Vincent
- Viikari, Jorma
- Visvikis-Siest, Sophie
- Vitart, Veronique
- Vogel, Carla I G
- Voight, Benjamin F
- Waite, Lindsay L
- Wallaschofski, Henri
- Walters, G Bragi
- Widen, Elisabeth
- Wiegand, Susanna
- Wild, Sarah H
- Willemsen, Gonneke
- Witte, Daniel R
- Witteman, Jacqueline C
- Xu, Jianfeng
- Zhang, Qunyuan
- Zgaga, Lina
- Ziegler, Andreas
- Zitting, Paavo
- Beilby, John P
- Farooqi, I Sadaf
- Hebebrand, Johannes
- Huikuri, Heikki V
- James, Alan L
- Kähönen, Mika
- Levinson, Douglas F
- Macciardi, Fabio
- Nieminen, Markku S
- Ohlsson, Claes
- Palmer, Lyle J
- Ridker, Paul M
- Stumvoll, Michael
- Beckmann, Jacques S
- Boeing, Heiner
- Boerwinkle, Eric
- Boomsma, Dorret I
- Caulfield, Mark J
- Chanock, Stephen J
- Collins, Francis S
- Cupples, L Adrienne
- Smith, George Davey
- Erdmann, Jeanette
- Froguel, Philippe
- Grönberg, Henrik
- Gyllensten, Ulf
- Hall, Per
- Hansen, Torben
- Harris, Tamara B
- Hattersley, Andrew T
- Hayes, Richard B
- Heinrich, Joachim
- Hu, Frank B
- Hveem, Kristian
- Illig, Thomas
- Jarvelin, Marjo-Riitta
- Kaprio, Jaakko
- Karpe, Fredrik
- Khaw, Kay-Tee
- Kiemeney, Lambertus A
- Krude, Heiko
- Laakso, Markku
- Lawlor, Debbie A
- Metspalu, Andres
- Munroe, Patricia B
- Ouwehand, Willem H
- Pedersen, Oluf
- Penninx, Brenda W
- Peters, Annette
- Pramstaller, Peter P
- Quertermous, Thomas
- Reinehr, Thomas
- Rissanen, Aila
- Rudan, Igor
- Samani, Nilesh J
- Schwarz, Peter E H
- Shuldiner, Alan R
- Spector, Timothy D
- Tuomilehto, Jaakko
- Uda, Manuela
- Uitterlinden, André
- Valle, Timo T
- Wabitsch, Martin
- Waeber, GĂ©rard
- Wareham, Nicholas J
- Watkins, Hugh
- Wilson, James F
- Wright, Alan F
- Zillikens, M Carola
- Chatterjee, Nilanjan
- McCarroll, Steven A
- Purcell, Shaun
- Schadt, Eric E
- Visscher, Peter M
- Assimes, Themistocles L
- Borecki, Ingrid B
- Deloukas, Panos
- Fox, Caroline S
- Groop, Leif C
- Haritunians, Talin
- Hunter, David J
- Kaplan, Robert C
- Mohlke, Karen L
- O'Connell, Jeffrey R
- Peltonen, Leena
- Schlessinger, David
- Strachan, David P
- van Duijn, Cornelia M
- Wichmann, H-Erich
- Frayling, Timothy M
- Thorsteinsdottir, Unnur
- Abecasis, Gonçalo R
- Barroso, InĂŞs
- Boehnke, Michael
- Stefansson, Kari
- North, Kari E
- McCarthy, Mark I
- Hirschhorn, Joel N
- Ingelsson, Erik
- Loos, Ruth J F