Related resources
Full-text held externally
- DOI: 10.1038/ng.970
- PMID: 22001757
- UKPMCID: 22001757
Search for item elsewhere
University researcher(s)
Academic department(s)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Chambers, John C; Zhang, Weihua; Sehmi, Joban; Li, Xinzhong; Wass, Mark N; Van der Harst, Pim; Holm, Hilma; Sanna, Serena; Kavousi, Maryam; Baumeister, Sebastian E; Coin, Lachlan J; Deng, Guohong; Gieger, Christian; Heard-Costa, Nancy L; Hottenga, Jouke-Jan; Kühnel, Brigitte; Kumar, Vinod; Lagou, Vasiliki; Liang, Liming; Luan, Jian'an; Vidal, Pedro Marques; Mateo Leach, Irene; O'Reilly, Paul F; Peden, John F; Rahmioglu, Nilufer; Soininen, Pasi; Speliotes, Elizabeth K; Yuan, Xin; Thorleifsson, Gudmar; Alizadeh, Behrooz Z; Atwood, Larry D; Borecki, Ingrid B; Brown, Morris J; Charoen, Pimphen; Cucca, Francesco; Das, Debashish; de Geus, Eco J C; Dixon, Anna L; Döring, Angela; Ehret, Georg; Eyjolfsson, Gudmundur I; Farrall, Martin; Forouhi, Nita G; Friedrich, Nele; Goessling, Wolfram; Gudbjartsson, Daniel F; Harris, Tamara B; Hartikainen, Anna-Liisa; Heath, Simon; Hirschfield, Gideon M; Hofman, Albert; Homuth, Georg; Hyppönen, Elina; Janssen, Harry L A; Johnson, Toby; Kangas, Antti J; Kema, Ido P; Kühn, Jens P; Lai, Sandra; Lathrop, Mark; Lerch, Markus M; Li, Yun; Liang, T Jake; Lin, Jing-Ping; Loos, Ruth J F; Martin, Nicholas G; Moffatt, Miriam F; Montgomery, Grant W; Munroe, Patricia B; Musunuru, Kiran; Nakamura, Yusuke; O'Donnell, Christopher J; Olafsson, Isleifur; Penninx, Brenda W; Pouta, Anneli; Prins, Bram P; Prokopenko, Inga; Puls, Ralf; Ruokonen, Aimo; Savolainen, Markku J; Schlessinger, David; Schouten, Jeoffrey N L; Seedorf, Udo; Sen-Chowdhry, Srijita; Siminovitch, Katherine A; Smit, Johannes H; Spector, Timothy D; Tan, Wenting; Teslovich, Tanya M; Tukiainen, Taru; Uitterlinden, Andre G; Van der Klauw, Melanie M; Vasan, Ramachandran S; Wallace, Chris; Wallaschofski, Henri; Wichmann, H-Erich; Willemsen, Gonneke; Würtz, Peter; Xu, Chun; Yerges-Armstrong, Laura M; Abecasis, Goncalo R; Ahmadi, Kourosh R; Boomsma, Dorret I; Caulfield, Mark; Cookson, William O; van Duijn, Cornelia M; Froguel, Philippe; Matsuda, Koichi; McCarthy, Mark I; Meisinger, Christa; Mooser, Vincent; Pietiläinen, Kirsi H; Schumann, Gunter; Snieder, Harold; Sternberg, Michael J E; Stolk, Ronald P; Thomas, Howard C; Thorsteinsdottir, Unnur; Uda, Manuela; Waeber, Gérard; Wareham, Nicholas J; Waterworth, Dawn M; Watkins, Hugh; Whitfield, John B; Witteman, Jacqueline C M; Wolffenbuttel, Bruce H R; Fox, Caroline S; Ala-Korpela, Mika; Stefansson, Kari; Vollenweider, Peter; Völzke, Henry; Schadt, Eric E; Scott, James; Järvelin, Marjo-Riitta; Elliott, Paul; Kooner, Jaspal S
Nature genetics. 2011;43(11):1131-8.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1038/ng.970
- PMID: 22001757
- UKPMCID: 22001757
Abstract
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
Bibliographic metadata
- Chambers, John C
- Zhang, Weihua
- Sehmi, Joban
- Li, Xinzhong
- Wass, Mark N
- Van der Harst, Pim
- Holm, Hilma
- Sanna, Serena
- Kavousi, Maryam
- Baumeister, Sebastian E
- Coin, Lachlan J
- Deng, Guohong
- Gieger, Christian
- Heard-Costa, Nancy L
- Hottenga, Jouke-Jan
- Kühnel, Brigitte
- Kumar, Vinod
- Lagou, Vasiliki
- Liang, Liming
- Luan, Jian'an
- Vidal, Pedro Marques
- Mateo Leach, Irene
- O'Reilly, Paul F
- Peden, John F
- Rahmioglu, Nilufer
- Soininen, Pasi
- Speliotes, Elizabeth K
- Yuan, Xin
- Thorleifsson, Gudmar
- Alizadeh, Behrooz Z
- Atwood, Larry D
- Borecki, Ingrid B
- Brown, Morris J
- Charoen, Pimphen
- Cucca, Francesco
- Das, Debashish
- de Geus, Eco J C
- Dixon, Anna L
- Döring, Angela
- Ehret, Georg
- Eyjolfsson, Gudmundur I
- Farrall, Martin
- Forouhi, Nita G
- Friedrich, Nele
- Goessling, Wolfram
- Gudbjartsson, Daniel F
- Harris, Tamara B
- Hartikainen, Anna-Liisa
- Heath, Simon
- Hirschfield, Gideon M
- Hofman, Albert
- Homuth, Georg
- Hyppönen, Elina
- Janssen, Harry L A
- Johnson, Toby
- Kangas, Antti J
- Kema, Ido P
- Kühn, Jens P
- Lai, Sandra
- Lathrop, Mark
- Lerch, Markus M
- Li, Yun
- Liang, T Jake
- Lin, Jing-Ping
- Loos, Ruth J F
- Martin, Nicholas G
- Moffatt, Miriam F
- Montgomery, Grant W
- Munroe, Patricia B
- Musunuru, Kiran
- Nakamura, Yusuke
- O'Donnell, Christopher J
- Olafsson, Isleifur
- Penninx, Brenda W
- Pouta, Anneli
- Prins, Bram P
- Prokopenko, Inga
- Puls, Ralf
- Ruokonen, Aimo
- Savolainen, Markku J
- Schlessinger, David
- Schouten, Jeoffrey N L
- Seedorf, Udo
- Sen-Chowdhry, Srijita
- Siminovitch, Katherine A
- Smit, Johannes H
- Spector, Timothy D
- Tan, Wenting
- Teslovich, Tanya M
- Tukiainen, Taru
- Uitterlinden, Andre G
- Van der Klauw, Melanie M
- Vasan, Ramachandran S
- Wallace, Chris
- Wallaschofski, Henri
- Wichmann, H-Erich
- Willemsen, Gonneke
- Würtz, Peter
- Xu, Chun
- Yerges-Armstrong, Laura M
- Abecasis, Goncalo R
- Ahmadi, Kourosh R
- Boomsma, Dorret I
- Caulfield, Mark
- Cookson, William O
- van Duijn, Cornelia M
- Froguel, Philippe
- Matsuda, Koichi
- McCarthy, Mark I
- Meisinger, Christa
- Mooser, Vincent
- Pietiläinen, Kirsi H
- Schumann, Gunter
- Snieder, Harold
- Sternberg, Michael J E
- Stolk, Ronald P
- Thomas, Howard C
- Thorsteinsdottir, Unnur
- Uda, Manuela
- Waeber, Gérard
- Wareham, Nicholas J
- Waterworth, Dawn M
- Watkins, Hugh
- Whitfield, John B
- Witteman, Jacqueline C M
- Wolffenbuttel, Bruce H R
- Fox, Caroline S
- Ala-Korpela, Mika
- Stefansson, Kari
- Vollenweider, Peter
- Völzke, Henry
- Schadt, Eric E
- Scott, James
- Järvelin, Marjo-Riitta
- Elliott, Paul
- Kooner, Jaspal S
- Voight, Benjamin F
- Scott, Laura J
- Steinthorsdottir, Valgerdur
- Morris, Andrew P
- Dina, Christian
- Welch, Ryan P
- Zeggini, Eleftheria
- Huth, Cornelia
- Aulchenko, Yurii S
- Thorleifsson, Gudmar
- McCulloch, Laura J
- Ferreira, Teresa
- Grallert, Harald
- Amin, Najaf
- Wu, Guanming
- Willer, Cristen J
- Raychaudhuri, Soumya
- McCarroll, Steve A
- Langenberg, Claudia
- Hofmann, Oliver M
- Dupuis, Josée
- Qi, Lu
- Segrè, Ayellet V
- van Hoek, Mandy
- Navarro, Pau
- Ardlie, Kristin
- Balkau, Beverley
- Benediktsson, Rafn
- Bennett, Amanda J
- Blagieva, Roza
- Boerwinkle, Eric
- Bonnycastle, Lori L
- Bengtsson Boström, Kristina
- Bravenboer, Bert
- Bumpstead, Suzannah
- Burtt, Noël P
- Charpentier, Guillaume
- Chines, Peter S
- Cornelis, Marilyn
- Couper, David J
- Crawford, Gabe
- Doney, Alex S F
- Elliott, Katherine S
- Elliott, Amanda L
- Erdos, Michael R
- Fox, Caroline S
- Franklin, Christopher S
- Ganser, Martha
- Gieger, Christian
- Grarup, Niels
- Green, Todd
- Griffin, Simon
- Groves, Christopher J
- Guiducci, Candace
- Hadjadj, Samy
- Hassanali, Neelam
- Herder, Christian
- Isomaa, Bo
- Jackson, Anne U
- Johnson, Paul R V
- Jørgensen, Torben
- Kao, Wen H L
- Klopp, Norman
- Kong, Augustine
- Kraft, Peter
- Kuusisto, Johanna
- Lauritzen, Torsten
- Li, Man
- Lieverse, Aloysius
- Lindgren, Cecilia M
- Lyssenko, Valeriya
- Marre, Michel
- Meitinger, Thomas
- Midthjell, Kristian
- Morken, Mario A
- Narisu, Narisu
- Nilsson, Peter
- Owen, Katharine R
- Payne, Felicity
- Perry, John R B
- Petersen, Ann-Kristin
- Platou, Carl
- Proença, Christine
- Prokopenko, Inga
- Rathmann, Wolfgang
- William Rayner, N
- Robertson, Neil R
- Rocheleau, Ghislain
- Roden, Michael
- Sampson, Michael J
- Saxena, Richa
- Shields, Beverley M
- Shrader, Peter
- Sigurdsson, Gunnar
- Sparsø, Thomas
- Strassburger, Klaus
- Stringham, Heather M
- Sun, Qi
- Swift, Amy J
- Thorand, Barbara
- Tichet, Jean
- Tuomi, Tiinamaija
- van Dam, Rob M
- van Haeften, Timon W
- van Herpt, Thijs
- van Vliet-Ostaptchouk, Jana V
- Walters, G Bragi
- Weedon, Michael N
- Wijmenga, Cisca
- Witteman, Jacqueline
- Bergman, Richard N
- Cauchi, Stephane
- Collins, Francis S
- Gloyn, Anna L
- Gyllensten, Ulf
- Hansen, Torben
- Hide, Winston A
- Hitman, Graham A
- Hofman, Albert
- Hunter, David J
- Hveem, Kristian
- Laakso, Markku
- Mohlke, Karen L
- Morris, Andrew D
- Palmer, Colin N A
- Pramstaller, Peter P
- Rudan, Igor
- Sijbrands, Eric
- Stein, Lincoln D
- Tuomilehto, Jaakko
- Uitterlinden, Andre
- Walker, Mark
- Wareham, Nicholas J
- Watanabe, Richard M
- Abecasis, Goncalo R
- Boehm, Bernhard O
- Campbell, Harry
- Daly, Mark J
- Hattersley, Andrew T
- Hu, Frank B
- Meigs, James B
- Pankow, James S
- Pedersen, Oluf
- Wichmann, H-Erich
- Barroso, Inês
- Florez, Jose C
- Frayling, Timothy M
- Groop, Leif
- Sladek, Rob
- Thorsteinsdottir, Unnur
- Wilson, James F
- Illig, Thomas
- Froguel, Philippe
- van Duijn, Cornelia M
- Stefansson, Kari
- Altshuler, David
- Boehnke, Michael
- McCarthy, Mark I
- Lango Allen, H
- Estrada, K
- Lettre, G
- Berndt, S I
- Weedon, M N
- Rivadeneira, F
- Willer, C J
- Jackson, A U
- Vedantam, S
- Raychaudhuri, S
- Ferreira, T
- Wood, A R
- Weyant, R J
- Segrè, A V
- Speliotes, E K
- Wheeler, E
- Soranzo, N
- Park, J H
- Yang, J
- Gudbjartsson, D
- Heard-Costa, N L
- Randall, J C
- Qi, L
- Smith, A Vernon
- Mägi, R
- Pastinen, T
- Liang, L
- Heid, I M
- Luan, J
- Thorleifsson, G
- Winkler, T W
- Goddard, M E
- Sin Lo, K
- Palmer, C
- Workalemahu, T
- Aulchenko, Y S
- Johansson, A
- Zillikens, M C
- Feitosa, M F
- Esko, T
- Johnson, T
- Ketkar, S
- Kraft, P
- Mangino, M
- Prokopenko, I
- Absher, D
- Albrecht, E
- Ernst, F
- Glazer, N L
- Hayward, C
- Hottenga, J J
- Jacobs, K B
- Knowles, J W
- Kutalik, Z
- Monda, K L
- Polasek, O
- Preuss, M
- Rayner, N W
- Robertson, N R
- Steinthorsdottir, V
- Tyrer, J P
- Voight, B F
- Wiklund, F
- Xu, J
- Zhao, J Hua
- Nyholt, D R
- Pellikka, N
- Perola, M
- Perry, J R
- Surakka, I
- Tammesoo, M L
- Altmaier, E L
- Amin, N
- Aspelund, T
- Bhangale, T
- Boucher, G
- Chasman, D I
- Chen, C
- Coin, L
- Cooper, M N
- Dixon, A L
- Gibson, Q
- Grundberg, E
- Hao, K
- Juhani Junttila, M
- Kaplan, L M
- Kettunen, J
- König, I R
- Kwan, T
- Lawrence, R W
- Levinson, D F
- Lorentzon, M
- McKnight, B
- Morris, A P
- Müller, M
- Suh Ngwa, J
- Purcell, S
- Rafelt, S
- Salem, R M
- Salvi, E
- Sanna, S
- Shi, J
- Sovio, U
- Thompson, J R
- Turchin, M C
- Vandenput, L
- Verlaan, D J
- Vitart, V
- White, C C
- Ziegler, A
- Almgren, P
- Balmforth, A J
- Campbell, H
- Citterio, L
- De Grandi, A
- Dominiczak, A
- Duan, J
- Elliott, P
- Elosua, R
- Eriksson, J G
- Freimer, N B
- Geus, E J
- Glorioso, N
- Haiqing, S
- Hartikainen, A L
- Havulinna, A S
- Hicks, A A
- Hui, J
- Igl, W
- Illig, T
- Jula, A
- Kajantie, E
- Kilpeläinen, T O
- Koiranen, M
- Kolcic, I
- Koskinen, S
- Kovacs, P
- Laitinen, J
- Liu, J
- Lokki, M L
- Marusic, A
- Maschio, A
- Meitinger, T
- Mulas, A
- Paré, G
- Parker, A N
- Peden, J F
- Petersmann, A
- Pichler, I
- Pietiläinen, K H
- Pouta, A
- Ridderstråle, M
- Rotter, J I
- Sambrook, J G
- Sanders, A R
- Schmidt, C Oliver
- Sinisalo, J
- Smit, J H
- Stringham, H M
- Walters, G Bragi
- Widen, E
- Wild, S H
- Willemsen, G
- Zagato, L
- Zgaga, L
- Zitting, P
- Alavere, H
- Farrall, M
- McArdle, W L
- Nelis, M
- Peters, M J
- Ripatti, S
- van Meurs, J B
- Aben, K K
- Ardlie, K G
- Beckmann, J S
- Beilby, J P
- Bergman, R N
- Bergmann, S
- Collins, F S
- Cusi, D
- den Heijer, M
- Eiriksdottir, G
- Gejman, P V
- Hamsten, A
- Huikuri, H V
- Iribarren, C
- Kähönen, M
- Kaprio, J
- Kathiresan, S
- Kiemeney, L
- Kocher, T
- Launer, L J
- Lehtimäki, T
- Melander, O
- Mosley, T H
- Musk, A W
- Nieminen, M S
- O'Donnell, C J
- Ohlsson, C
- Oostra, B
- Palmer, L J
- Raitakari, O
- Ridker, P M
- Rioux, J D
- Rissanen, A
- Rivolta, C
- Schunkert, H
- Shuldiner, A R
- Siscovick, D S
- Stumvoll, M
- Tönjes, A
- Tuomilehto, J
- van Ommen, G J
- Viikari, J
- Heath, A C
- Martin, N G
- Montgomery, G W
- Province, M A
- Kayser, M
- Arnold, A M
- Atwood, L D
- Boerwinkle, E
- Chanock, S J
- Deloukas, P
- Gieger, C
- Grönberg, H
- Hall, P
- Hattersley, A T
- Hengstenberg, C
- Hoffman, W
- Lathrop, G Mark
- Salomaa, V
- Schreiber, S
- Uda, M
- Waterworth, D
- Wright, A F
- Assimes, T L
- Barroso, I
- Hofman, A
- Mohlke, K L
- Boomsma, D I
- Caulfield, M J
- Cupples, L Adrienne
- Erdmann, J
- Fox, C S
- Gudnason, V
- Gyllensten, U
- Harris, T B
- Hayes, R B
- Jarvelin, M R
- Mooser, V
- Munroe, P B
- Ouwehand, W H
- Penninx, B W
- Pramstaller, P P
- Quertermous, T
- Rudan, I
- Samani, N J
- Spector, T D
- Völzke, H
- Watkins, H
- Wilson, J F
- Groop, L C
- Haritunians, T
- Hu, F B
- Kaplan, R C
- Metspalu, A
- North, K E
- Schlessinger, D
- Wareham, N J
- Hunter, D J
- O'Connell, J R
- Strachan, D P
- Wichmann, H E
- Borecki, I B
- van Duijn, C M
- Schadt, E E
- Thorsteinsdottir, U
- Peltonen, L
- Uitterlinden, A G
- Visscher, P M
- Chatterjee, N
- Loos, R J
- Boehnke, M
- McCarthy, M I
- Ingelsson, E
- Lindgren, C M
- Abecasis, G R
- Stefansson, K
- Frayling, T M
- Hirschhorn, J N
- Teslovich, T M
- Musunuru, K
- Smith, A V
- Edmondson, A C
- Stylianou, I M
- Koseki, M
- Pirruccello, J P
- Ripatti, S
- Chasman, D I
- Willer, C J
- Johansen, C T
- Fouchier, S W
- Isaacs, A
- Peloso, G M
- Barbalic, M
- Ricketts, S L
- Bis, J C
- Aulchenko, Y S
- Thorleifsson, G
- Feitosa, M F
- Chambers, J
- Orho-Melander, M
- Melander, O
- Johnson, T
- Li, X
- Guo, X
- Li, M
- Cho, Y Shin
- Go, M Jin
- Kim, Y Jin
- Lee, J Y
- Park, T
- Kim, K
- Sim, X
- Ong, R Twee-Hee
- Croteau-Chonka, D C
- Lange, L A
- Smith, J D
- Song, K
- Zhao, J Hua
- Yuan, X
- Luan, J
- Lamina, C
- Ziegler, A
- Zhang, W
- Zee, R Y
- Wright, A F
- Witteman, J C
- Wilson, J F
- Willemsen, G
- Wichmann, H E
- Whitfield, J B
- Waterworth, D M
- Wareham, N J
- Waeber, G
- Vollenweider, P
- Voight, B F
- Vitart, V
- Uitterlinden, A G
- Uda, M
- Tuomilehto, J
- Thompson, J R
- Tanaka, T
- Surakka, I
- Stringham, H M
- Spector, T D
- Soranzo, N
- Smit, J H
- Sinisalo, J
- Silander, K
- Sijbrands, E J
- Scuteri, A
- Scott, J
- Schlessinger, D
- Sanna, S
- Salomaa, V
- Salomaa, J
- Sabatti, C
- Ruokonen, A
- Rudan, I
- Rose, L M
- Roberts, R
- Rieder, M
- Psaty, B M
- Pramstaller, P P
- Pichler, I
- Perola, M
- Penninx, B W
- Pedersen, N L
- Pattaro, C
- Pare, G
- Oostra, B A
- O'Donnell, C J
- Nieminen, M S
- Nickerson, D A
- Montgomery, G W
- Meitinger, T
- McPherson, R
- McCarthy, M I
- McArdle, W
- Masson, D
- Martin, N G
- Marroni, F
- Mangino, M
- Magnusson, P K
- Lucas, G
- Luben, R
- Loos, R J
- Lokki, M L
- Lettre, G
- Langenberg, C
- Launer, L J
- Lakatta, E G
- Laaksonen, R
- Kyvik, K O
- Kronenberg, F
- König, I R
- Khaw, K T
- Kaprio, J
- Kaplan, L M
- Johansson, A
- Jarvelin, M R
- Janssens, A C
- Ingelsson, E
- Igl, W
- Hovingh, G Kees
- Hottenga, J J
- Hofman, A
- Hicks, A A
- Hengstenberg, C
- Heid, I M
- Hayward, C
- Havulinna, A S
- Hastie, N D
- Harris, T B
- Haritunians, T
- Hall, A S
- Gyllensten, U
- Guiducci, C
- Groop, L C
- Gonzalez, E
- Gieger, C
- Gieger, N B
- Ferrucci, L
- Erdmann, J
- Elliott, P
- Ejebe, K G
- Döring, A
- Dominiczak, A F
- Demissie, S
- Deloukas, P
- de Geus, E J
- de Faire, U
- Crawford, G
- Collins, F S
- Chen, Y D
- Caulfield, M J
- Campbell, H
- Burtt, N P
- Bonnycastle, L L
- Boomsma, D I
- Boekholdt, S M
- Bergman, R N
- Barroso, I
- Bandinelli, S
- Ballantyne, C M
- Ballantyne, T L
- Quertermous, T
- Altshuler, D
- Seielstad, M
- Wong, T Y
- Tai, E S
- Feranil, A B
- Kuzawa, C W
- Adair, L S
- Taylor, H A
- Borecki, I B
- Gabriel, S B
- Wilson, J G
- Holm, H
- Thorsteinsdottir, U
- Gudnason, V
- Krauss, R M
- Mohlke, K L
- Ordovas, J M
- Munroe, P B
- Kooner, J S
- Tall, A R
- Hegele, R A
- Kastelein, J J
- Schadt, E E
- Rotter, J I
- Boerwinkle, E
- Strachan, D P
- Mooser, V
- Stefansson, K
- Reilly, M P
- Samani, N J
- Schunkert, H
- Cupples, L A
- Sandhu, M S
- Ridker, P M
- Rader, D J
- van Duijn, C M
- Peltonen, L
- Abecasis, G R
- Boehnke, M
- Kathiresan, S
- Speliotes, Elizabeth K
- Yerges-Armstrong, Laura M
- Hernaez, Ruben
- Kim, Lauren J
- Palmer, Cameron D
- Gudnason, Vilmundur
- Eiriksdottir, Gudny
- Garcia, Melissa E
- Launer, Lenore J
- Nalls, Michael A
- Clark, Jeanne M
- Mitchell, Braxton D
- Shuldiner, Alan R
- Butler, Johannah L
- Tomas, Marta
- Hoffmann, Udo
- Hwang, Shih-Jen
- Massaro, Joseph M
- O'Donnell, Christopher J
- Sahani, Dushyant V
- Salomaa, Veikko
- Schadt, Eric E
- Schwartz, Stephen M
- Siscovick, David S
- Voight, Benjamin F
- Carr, J Jeffrey
- Feitosa, Mary F
- Harris, Tamara B
- Fox, Caroline S
- Smith, Albert V
- Kao, W H Linda
- Hirschhorn, Joel N
- Borecki, Ingrid B
- Ehret, Georg B
- Munroe, Patricia B
- Rice, Kenneth M
- Bochud, Murielle
- Johnson, Andrew D
- Chasman, Daniel I
- Smith, Albert V
- Tobin, Martin D
- Verwoert, Germaine C
- Hwang, Shih-Jen
- Pihur, Vasyl
- Vollenweider, Peter
- O'Reilly, Paul F
- Amin, Najaf
- Bragg-Gresham, Jennifer L
- Teumer, Alexander
- Glazer, Nicole L
- Launer, Lenore
- Zhao, Jing Hua
- Aulchenko, Yurii
- Heath, Simon
- Sober, Siim
- Parsa, Afshin
- Luan, Jian'an
- Arora, Pankaj
- Dehghan, Abbas
- Zhang, Feng
- Lucas, Gavin
- Hicks, Andrew A
- Jackson, Anne U
- Peden, John F
- Tanaka, Toshiko
- Wild, Sarah H
- Rudan, Igor
- Igl, Wilmar
- Milaneschi, Yuri
- Parker, Alex N
- Fava, Cristiano
- Chambers, John C
- Fox, Ervin R
- Kumari, Meena
- Go, Min Jin
- van der Harst, Pim
- Kao, Wen Hong Linda
- Sjogren, Marketa
- Vinay, D G
- Alexander, Myriam
- Tabara, Yasuharu
- Shaw-Hawkins, Sue
- Whincup, Peter H
- Liu, Yongmei
- Shi, Gang
- Kuusisto, Johanna
- Tayo, Bamidele
- Seielstad, Mark
- Sim, Xueling
- Nguyen, Khanh-Dung Hoang
- Lehtimaki, Terho
- Matullo, Giuseppe
- Wu, Ying
- Gaunt, Tom R
- Onland-Moret, N Charlotte
- Cooper, Matthew N
- Platou, Carl G P
- Org, Elin
- Hardy, Rebecca
- Dahgam, Santosh
- Palmen, Jutta
- Vitart, Veronique
- Braund, Peter S
- Kuznetsova, Tatiana
- Uiterwaal, Cuno S P M
- Adeyemo, Adebowale
- Palmas, Walter
- Campbell, Harry
- Ludwig, Barbara
- Tomaszewski, Maciej
- Tzoulaki, Ioanna
- Palmer, Nicholette D
- Aspelund, Thor
- Garcia, Melissa
- Chang, Yen-Pei C
- O'Connell, Jeffrey R
- Steinle, Nanette I
- Grobbee, Diederick E
- Arking, Dan E
- Kardia, Sharon L
- Morrison, Alanna C
- Hernandez, Dena
- Najjar, Samer
- McArdle, Wendy L
- Hadley, David
- Brown, Morris J
- Connell, John M
- Hingorani, Aroon D
- Day, Ian N M
- Lawlor, Debbie A
- Beilby, John P
- Lawrence, Robert W
- Clarke, Robert
- Collins, Rory
- Hopewell, Jemma C
- Ongen, Halit
- Dreisbach, Albert W
- Li, Yali
- Young, J H
- Bis, Joshua C
- Kahonen, Mika
- Viikari, Jorma
- Adair, Linda S
- Lee, Nanette R
- Chen, Ming-Huei
- Olden, Matthias
- Pattaro, Cristian
- Bolton, Judith A Hoffman
- Kottgen, Anna
- Bergmann, Sven
- Mooser, Vincent
- Chaturvedi, Nish R
- Frayling, Timothy M
- Islam, Muhammad
- Jafar, Tazeen H
- Erdmann, Jeanette
- Kulkarni, Smita R
- Bornstein, Stefan R
- Grassler, Jurgen
- Groop, Leif
- Voight, Benjamin F
- Kettunen, Johannes
- Howard, Philip
- Taylor, Andrew
- Guarrera, Simonetta
- Ricceri, Fulvio
- Emilsson, Valur
- Plump, Andrew
- Barroso, Ines
- Khaw, Kay-Tee
- Weder, Alan B
- Hunt, Steven C
- Sun, Yan V
- Bergman, Richard N
- Collins, Francis S
- Bonnycastle, Lori L
- Scott, Laura J
- Stringham, Heather M
- Peltonen, Leena
- Perola, Markus
- Vartiainen, Erkki
- Brand, Stefan-Martin
- Staessen, Jan A
- Wang, Thomas J
- Burton, Paul R
- Artigas, Maria Soler
- Dong, Yanbin
- Snieder, Harold
- Wang, Xiaoling
- Zhu, Haidong
- Lohman, Kurt K
- Rudock, Megan E
- Heckbert, Susan R
- Smith, Nicholas L
- Wiggins, Kerri L
- Doumatey, Ayo
- Shriner, Daniel
- Veldre, Gudrun
- Viigimaa, Margus
- Kinra, Sanjay
- Prabhakaran, Dorairajan
- Tripathy, Vikal
- Langefeld, Carl D
- Rosengren, Annika
- Thelle, Dag S
- Corsi, Anna Maria
- Singleton, Andrew
- Forrester, Terrence
- Hilton, Gina
- McKenzie, Colin A
- Salako, Tunde
- Iwai, Naoharu
- Kita, Yoshikuni
- Ogihara, Toshio
- Ohkubo, Takayoshi
- Okamura, Tomonori
- Ueshima, Hirotsugu
- Umemura, Satoshi
- Eyheramendy, Susana
- Meitinger, Thomas
- Wichmann, H-Erich
- Cho, Yoon Shin
- Kim, Hyung-Lae
- Lee, Jong-Young
- Scott, James
- Sehmi, Joban S
- Zhang, Weihua
- Hedblad, Bo
- Nilsson, Peter
- Smith, George Davey
- Wong, Andrew
- Narisu, Narisu
- StanÄakova, Alena
- Raffel, Leslie J
- Yao, Jie
- Kathiresan, Sekar
- O'Donnell, Chris
- Schwartz, Steven M
- Ikram, M Arfan
- Longstreth, Will T
- Mosley, Thomas H
- Seshadri, Sudha
- Shrine, Nick R G
- Wain, Louise V
- Morken, Mario A
- Swift, Amy J
- Laitinen, Jaana
- Prokopenko, Inga
- Zitting, Paavo
- Cooper, Jackie A
- Humphries, Steve E
- Danesh, John
- Rasheed, Asif
- Goel, Anuj
- Hamsten, Anders
- Watkins, Hugh
- Bakker, Stephan J L
- van Gilst, Wiek H
- Janipalli, Charles S
- Mani, K Radha
- Yajnik, Chittaranjan S
- Hofman, Albert
- Mattace-Raso, Francesco U S
- Oostra, Ben A
- Demirkan, Ayse
- Isaacs, Aaron
- Rivadeneira, Fernando
- Lakatta, Edward G
- Orru, Marco
- Scuteri, Angelo
- Ala-Korpela, Mika
- Kangas, Antti J
- Lyytikainen, Leo-Pekka
- Soininen, Pasi
- Tukiainen, Taru
- Wurz, Peter
- Ong, Rick Twee-Hee
- Dorr, Marcus
- Kroemer, Heyo K
- Volker, Uwe
- Volzke, Henry
- Galan, Pilar
- Hercberg, Serge
- Lathrop, Mark
- Zelenika, Diana
- Deloukas, Panos
- Mangino, Massimo
- Spector, Tim D
- Zhai, Guangju
- Meschia, James F
- Nalls, Michael A
- Sharma, Pankaj
- Terzic, Janos
- Kumar, M J Kranthi
- Denniff, Matthew
- Zukowska-Szczechowska, Ewa
- Wagenknecht, Lynne E
- Fowkes, F Gerald R
- Charchar, Fadi J
- Schwarz, Peter E H
- Hayward, Caroline
- Guo, Xiuqing
- Rotimi, Charles
- Bots, Michiel L
- Brand, Eva
- Samani, Nilesh J
- Polasek, Ozren
- Talmud, Philippa J
- Nyberg, Fredrik
- Kuh, Diana
- Laan, Maris
- Hveem, Kristian
- Palmer, Lyle J
- van der Schouw, Yvonne T
- Casas, Juan P
- Mohlke, Karen L
- Vineis, Paolo
- Raitakari, Olli
- Ganesh, Santhi K
- Wong, Tien Y
- Tai, E Shyong
- Cooper, Richard S
- Laakso, Markku
- Rao, Dabeeru C
- Harris, Tamara B
- Morris, Richard W
- Dominiczak, Anna F
- Kivimaki, Mika
- Marmot, Michael G
- Miki, Tetsuro
- Saleheen, Danish
- Chandak, Giriraj R
- Coresh, Josef
- Navis, Gerjan
- Salomaa, Veikko
- Han, Bok-Ghee
- Zhu, Xiaofeng
- Kooner, Jaspal S
- Melander, Olle
- Ridker, Paul M
- Bandinelli, Stefania
- Gyllensten, Ulf B
- Wright, Alan F
- Wilson, James F
- Ferrucci, Luigi
- Farrall, Martin
- Tuomilehto, Jaakko
- Pramstaller, Peter P
- Elosua, Roberto
- Soranzo, Nicole
- Sijbrands, Eric J G
- Altshuler, David
- Loos, Ruth J F
- Shuldiner, Alan R
- Gieger, Christian
- Meneton, Pierre
- Uitterlinden, Andre G
- Wareham, Nicholas J
- Gudnason, Vilmundur
- Rotter, Jerome I
- Rettig, Rainer
- Uda, Manuela
- Strachan, David P
- Witteman, Jacqueline C M
- Hartikainen, Anna-Liisa
- Beckmann, Jacques S
- Boerwinkle, Eric
- Vasan, Ramachandran S
- Boehnke, Michael
- Larson, Martin G
- Jarvelin, Marjo-Riitta
- Psaty, Bruce M
- Abecasis, Goncalo R
- Chakravarti, Aravinda
- Elliott, Paul
- van Duijn, Cornelia M
- Newton-Cheh, Christopher
- Levy, Daniel
- Caulfield, Mark J
- Johnson, Toby
- Dupuis, J
- Langenberg, C
- Prokopenko, I
- Saxena, R
- Soranzo, N
- Jackson, A U
- Wheeler, E
- Glazer, N L
- Bouatia-Naji, N
- Gloyn, A L
- Lindgren, C M
- Mägi, R
- Morris, A P
- Randall, J
- Johnson, T
- Elliott, P
- Rybin, D
- Thorleifsson, G
- Steinthorsdottir, V
- Henneman, P
- Grallert, H
- Dehghan, A
- Hottenga, J J
- Franklin, C S
- Navarro, P
- Song, K
- Goel, A
- Perry, J R
- Egan, J M
- Lajunen, T
- Grarup, N
- Sparsø, T
- Doney, A
- Voight, B F
- Stringham, H M
- Li, M
- Kanoni, S
- Shrader, P
- Cavalcanti-Proença, C
- Kumari, M
- Qi, L
- Timpson, N J
- Gieger, C
- Zabena, C
- Rocheleau, G
- Ingelsson, E
- An, P
- O'Connell, J
- Luan, J
- Elliott, A
- McCarroll, S A
- Payne, F
- Roccasecca, R M
- Pattou, F
- Sethupathy, P
- Ardlie, K
- Ariyurek, Y
- Balkau, B
- Barter, P
- Beilby, J P
- Ben-Shlomo, Y
- Benediktsson, R
- Bennett, A J
- Bergmann, S
- Bochud, M
- Boerwinkle, E
- Bonnefond, A
- Bonnycastle, L L
- Borch-Johnsen, K
- Böttcher, Y
- Brunner, E
- Bumpstead, S J
- Charpentier, G
- Chen, Y D
- Chines, P
- Clarke, R
- Coin, L J
- Cooper, M N
- Cornelis, M
- Crawford, G
- Crisponi, L
- Day, I N
- de Geus, E J
- Delplanque, J
- Dina, C
- Erdos, M R
- Fedson, A C
- Fischer-Rosinsky, A
- Forouhi, N G
- Fox, C S
- Frants, R
- Franzosi, M G
- Galan, P
- Goodarzi, M O
- Graessler, J
- Groves, C J
- Grundy, S
- Gwilliam, R
- Gyllensten, U
- Hadjadj, S
- Hallmans, G
- Hammond, N
- Han, X
- Hartikainen, A L
- Hassanali, N
- Hayward, C
- Heath, S C
- Hercberg, S
- Herder, C
- Hicks, A A
- Hillman, D R
- Hingorani, A D
- Hofman, A
- Hui, J
- Hung, J
- Isomaa, B
- Johnson, P R
- Jørgensen, T
- Jula, A
- Kaakinen, M
- Kaprio, J
- Kesaniemi, Y A
- Kivimaki, M
- Knight, B
- Koskinen, S
- Kovacs, P
- Kyvik, K O
- Lathrop, G M
- Lawlor, D A
- Le Bacquer, O
- Lecoeur, C
- Li, Y
- Lyssenko, V
- Mahley, R
- Mangino, M
- Manning, A K
- MartÃnez-Larrad, M T
- McAteer, J B
- McCulloch, L J
- McPherson, R
- Meisinger, C
- Melzer, D
- Meyre, D
- Mitchell, B D
- Morken, M A
- Mukherjee, S
- Naitza, S
- Narisu, N
- Neville, M J
- Oostra, B A
- Orrù, M
- Pakyz, R
- Palmer, C N
- Paolisso, G
- Pattaro, C
- Pearson, D
- Peden, J F
- Pedersen, N L
- Perola, M
- Pfeiffer, A F
- Pichler, I
- Polasek, O
- Posthuma, D
- Potter, S C
- Pouta, A
- Province, M A
- Psaty, B M
- Rathmann, W
- Rayner, N W
- Rice, K
- Ripatti, S
- Rivadeneira, F
- Roden, M
- Rolandsson, O
- Sandbaek, A
- Sandhu, M
- Sanna, S
- Sayer, A A
- Scheet, P
- Scott, L J
- Seedorf, U
- Sharp, S J
- Shields, B
- Sigurethsson, G
- Sijbrands, E J
- Silveira, A
- Simpson, L
- Singleton, A
- Smith, N L
- Sovio, U
- Swift, A
- Syddall, H
- Syvänen, A C
- Tanaka, T
- Thorand, B
- Tichet, J
- Tönjes, A
- Tuomi, T
- Uitterlinden, A G
- van Dijk, K W
- van Hoek, M
- Varma, D
- Visvikis-Siest, S
- Vitart, V
- Vogelzangs, N
- Waeber, G
- Wagner, P J
- Walley, A
- Walters, G B
- Ward, K L
- Watkins, H
- Weedon, M N
- Wild, S H
- Willemsen, G
- Witteman, J C
- Yarnell, J W
- Zeggini, E
- Zelenika, D
- Zethelius, B
- Zhai, G
- Zhao, J H
- Zillikens, M C
- Borecki, I B
- Loos, R J
- Meneton, P
- Magnusson, P K
- Nathan, D M
- Williams, G H
- Hattersley, A T
- Silander, K
- Salomaa, V
- Smith, G D
- Bornstein, S R
- Schwarz, P
- Spranger, J
- Karpe, F
- Shuldiner, A R
- Cooper, C
- Dedoussis, G V
- Serrano-RÃos, M
- Morris, A D
- Lind, L
- Palmer, L J
- Hu, F B
- Franks, P W
- Ebrahim, S
- Marmot, M
- Kao, W H
- Pankow, J S
- Sampson, M J
- Kuusisto, J
- Laakso, M
- Hansen, T
- Pedersen, O
- Pramstaller, P P
- Wichmann, H E
- Illig, T
- Rudan, I
- Wright, A F
- Stumvoll, M
- Campbell, H
- Wilson, J F
- Hamsten, Anders
- Bergman, R N
- Buchanan, T A
- Collins, F S
- Mohlke, K L
- Tuomilehto, J
- Valle, T T
- Altshuler, D
- Rotter, J I
- Siscovick, D S
- Penninx, B W
- Boomsma, D I
- Deloukas, P
- Spector, T D
- Frayling, T M
- Ferrucci, L
- Kong, A
- Thorsteinsdottir, U
- Stefansson, K
- van Duijn, C M
- Aulchenko, Y S
- Cao, A
- Scuteri, A
- Schlessinger, D
- Uda, M
- Ruokonen, A
- Jarvelin, M R
- Waterworth, D M
- Vollenweider, P
- Peltonen, L
- Mooser, V
- Abecasis, G R
- Wareham, N J
- Sladek, R
- Froguel, P
- Watanabe, R M
- Meigs, J B
- Groop, L
- Boehnke, M
- McCarthy, M I
- Florez, J C
- Barroso