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- DOI: 10.1039/b518171b
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Effects of stereospecific backbone methylation on the DNA/RNA binding properties of pyrrolidine-amide oligonucleotide mimics (cPOM)
A. Kahn and J. Micklefield
Chemical Communications. 2006;:1436-1438.
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Full-text held externally
- DOI: 10.1039/b518171b
Abstract
The introduction of (7S)-methyl groups into the backbone of pyrrolidine–amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7R)-methylation disrupts hybridisation significantly
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Start page:
1436
End page:
1438
Total:
3
Pagination:
1436-1438
Digital Object Identifier:
10.1039/b518171b
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Active
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Manchester eScholar ID:
uk-ac-man-scw:1a524
Created:
6th August, 2009, 08:53:58
Last modified by:
Micklefield, Jason
Last modified:
25th September, 2009, 17:12:41