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Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues

A. Powell, M. Al Nakeeb, B. Wilkinson and J. Micklefield

Chemical Communications. 2007;:2683-2685.

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Abstract

Precursor-directed biosynthesis of calcium dependent antibiotics (CDAs) with modified 3-trifluoromethyl and 3-ethyl glutamate residues was achieved by feeding synthetic glutamate analogues to a mutant strain of Streptomyces coelicolor impaired in the biosynthesis of the natural precursor (2S,3R)-3-methyl glutamic acid.

Bibliographic metadata

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Start page:
2683
End page:
2685
Total:
3
Pagination:
2683-2685
Digital Object Identifier:
10.1039/b706224a
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1a6720
Created:
6th August, 2009, 11:13:37
Last modified by:
Micklefield, Jason
Last modified:
25th September, 2009, 16:32:35

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