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The effect of air filtration on airborne dog allergen.
Green R, Simpson A, Custovic A, Faragher B, Chapman M, Woodcock A
Allergy. 1999;54( 5):484-8.
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Abstract
BACKGROUND: Effective methods of reducing dog allergen are required to help alleviate symptoms in asthmatic patients sensitized to dog who refuse to part with their pet.The aim of this study was to investigate the use of the high efficiencyparticulate air (HEPA) filter air cleaner to reduce airborne Can f 1 inhomes with a dog. METHODS: The effect of a HEPA air cleaner wasinvestigated in nine homes with a dog. Samples were collected from tworooms of each house concurrently, one of which contained the dog, on twoseparate days (active day - HEPA air cleaner on - and control day). Eightconsecutive 1-h samples were collected from each room with a high-volumeair sampler (airflow rate 60 l/ min). Can f 1 was determined bymonoclonal-polyclonal antibody-based ELISA. RESULTS: Baseline airborne Canf 1 levels were 3.8-fold greater when sampling was performed with a dog inthe room (GM 27.1 ng Can f 1/m3, range 2.63-329) than when the dog waselsewhere in the house (GM 7.1 ng Can f 1/m3, range 0.69-27.2). When thedog was elsewhere in the house, airborne Can f 1 levels fell on bothactive and control days, but the magnitude of the reduction wassignificantly greater on the active days (P<0.05), and wasapproximately 90% from baseline. With the dog in the room, a significantfall in airborne Can f 1 was observed only on active days (75% frombaseline), but not on control days (active vs control P<0.001).CONCLUSIONS: HEPA air cleaners reduce airborne Can f 1 in homes with dogs.Furthermore, preventing the access of the dog to the bedroom and possiblythe living room may reduce the total allergen load inhaled.
Keyword(s)
Animals; Dogs; Enzyme-Linked Immunosorbent Assay; Household Articles; Housing; Humans; Micropore Filters; analysis: Air Pollution, Indoor; analysis: Allergens; methods: Filtration; prevention & control: Asthma; prevention & control: Hypersensitivity