Related resources
Full-text held externally
- DOI: 10.1359/jbmr.090220
Search for item elsewhere
University researcher(s)
Academic department(s)
Childhood Fractures Do Not Predict Future Fractures: Results From the European Prospective Osteoporosis Study
Pye SR, Tobias J, Silman AJ, Reeve J, O'Neill TW
Journal of Bone and Mineral Research. 2009;24(7):1314.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1359/jbmr.090220
Abstract
Abstract Introduction: Childhood fractures are common. Their clinical relevance to osteoporosis and fractures in later life is unclear. The aim of this study was to determine the predictive risk of childhood fracture on the risk of fracture in later life. Methods: Men and women aged 50 years and over were recruited from population registers for participation in the European Prospective Osteoporosis Study (EPOS). Subjects completed an interviewer administered questionnaire which included questions about previous fractures and the age at which the first of these fractures occurred. Lateral spine radiographs were performed to ascertain prevalent vertebral deformities. Subjects were followed prospectively by postal questionnaire to determine the occurrence of clinical fractures. A sub-sample of subjects had BMD measurements performed. Cox proportional hazards model was used to determine the predictive risk of childhood fracture between the ages of 8 and 18 years on the risk of future limb fracture and logistic regression used to determine the association between reported childhood fractures and prevalent vertebral deformity. Results: 6,451 men, mean age 63.8 years, and 6936 women, mean age 63.1 years were included in the analysis. Mean follow up time was 3 years. Of these 574 (8.9%) men and 313 (4.5%) women reported a first fracture (any site) between the ages of 8 and 18 years. A recalled history of any childhood fracture or forearm fracture was not associated with an increased risk of future limb fracture or prevalent vertebral deformity in either men or women. Among the 4,807 subjects who had DEXA measurements there was no difference in bone mass among those subjects who had reported a childhood fracture and those who did not. Conclusions: Our data suggest that self-reported previous childhood fracture is not associated with an increased risk of future fracture in men or women.