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Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.
Roe S, Cooper A, Morris I, Hopkins S, Rothwell NJ
Eur Cytokine Netw. 1997;8( 1):45-9.
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Abstract
The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-alpha) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12-17 corresponding to the period of weight loss after induction of leukaemia. IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-alpha plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.
Keyword(s)
Animals; Male; Rats; Support, Non-U.S. Gov't; blood: Interleukin-1; blood: Interleukin-6; complications: Leukemia, T-Cell; etiology: Cachexia; physiology: Tumor Necrosis Factor