Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al

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Abstract

Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the genome. In a previous issue of this journal, Graham and colleagues described their approach to following up the linkage data for one of these regions, 1q41-42. Using methods based on the transmission disequilibrium test, the region likely to harbour a SLE disease gene was refined to 2.3 Mb. This commentary discusses their approach and identifies lessons that may be applicable to the investigation of other complex diseases

Keyword(s)

Animal; Arthritis; Chromosomes,Human,Pair 1; Disease; Disease Models,Animal; Dna; Family Health; Genetic Markers; Haplotypes; Human; Linkage (Genetics); Linkage Disequilibrium; Lupus Erythematosus,Systemic; Physical Chromosome Mapping; Support,Non-U.S.Gov't; analysis; epidemiology; genetics; methods

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