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FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study
Morgan,A.W., Keyte,V.H., Babbage,S.J., Robinson,J.I., Ponchel,F., Barrett,J.H., Bhakta,B.B., Bingham,S.J., Buch,M.H., Conaghan,P.G., Gough,A., Green,M., Lawson,C.A., Pease,C.T., Markham,A.F., Ollier, WER, Emery,P., Worthington, J, Isaacs,J.D
Rheumatology. 2003;42, 4:528-533.
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Abstract
OBJECTIVES: To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA). METHODS: This allelic association study examined the FcgammaRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. RESULTS: The FcgammaRIIIA-158V allele was associated with both RA (P=0.02) and nodules (P=0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. CONCLUSIONS: We have developed a novel assay to genotype the FcgammaRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se
Keyword(s)
Adolescent; Adult; Alleles; Arthritis; Arthritis,Rheumatoid; Cohort Studies; Disease; Female; Genetic Predisposition to Disease; Genotype; HLA-DR Antigens; Human; Male; Middle Age; Polymerase Chain Reaction; Polymorphism (Genetics); Polymorphism,Single-Stranded Conformational; Receptors,IgG; Research; Rheumatology; Risk; Role; Support,Non-U.S.Gov't; analysis; genetics; methods; rehabilitation
Bibliographic metadata
- UI - 22536502DA - 20030321IS - 1462-0324LA - engPT - Journal ArticleRN - 0 (HLA-DR Antigens)RN - 0 (Receptors, IgG)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM