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No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
Payton, A, Turic, D, Langley, K, Mills, S, Lawson, D, Van den Bree, M, Owen, M, O'Donovan, M, Ollier, WER, Worthington, J, Thapar, A
Psychiatr Genet. 2003;13( 3):183-5.
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Abstract
OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.
Keyword(s)
Case-Control Studies; Chi-Square Distribution; Child; Human; Linkage Disequilibrium; Support, Non-U.S. Gov't; genetics: Attention Deficit Disorder with Hyperactivity; genetics: HLA-DR Antigens