Related resources
Search for item elsewhere
University researcher(s)
Academic department(s)
Allergen avoidance in the primary prevention of asthma.
Simpson A, Custovic A
Curr Opin Allergy Clin Immunol. 2004;4( 1):45-51.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.
Abstract
PURPOSE OF REVIEW: Six primary prevention studies trialing environmental modifications to reduce asthma in children have published results of clinical outcomes.All are still in progress.RECENT FINDINGS: In the Isle of Wight study, mite and food avoidance wereevaluated to age 9 months. At 8 years, children in the active group hadless current wheeze, wheeze with bronchial hyperresponsiveness and atopy(P < or = 0.05). The Canadian Primary Prevention Study examinedavoidance of inhalant and food allergens. At 1 year there was a reductionin probable asthma and rhinitis in the active group. The Study on thePrevention of Allergy in Children in Europe tested avoidance of inhalantand food allergens. At 1 year there was less atopy and sensitization tomites in the active group. In the Childhood Asthma Prevention Study bothmite avoidance and a dietary supplement of omega 3 fatty acids wereanalysed in a factorial design. At age 18 months, children in the dietaryintervention group had significantly less wheeze. Eczema was more commonamongst children using the mite avoidance measures. The Prevention andIncidence of Asthma and Mite Allergy Study is a placebo-controlled studyof mite avoidance. At 2 years, there was a small reduction in nocturnalcough without a cold in the active group. The Manchester Asthma andAllergy Study included stringent environmental control. At 1 yearprescribed medication for wheeze and wheeze with shortness of breath weresignificantly less common in the active group than the control group.SUMMARY: Although initial results look promising, further follow up of theongoing cohorts is required before any recommendations can be made withinthe public health context.
Keyword(s)
Child; Child, Preschool; Clinical Trials; Humans; Incidence; Infant; Infant, Newborn; Primary Prevention; adverse effects: Allergens; adverse effects: Antigens, Dermatophagoides; adverse effects: Inhalation Exposure; epidemiology: Asthma